Maria Selmer
Professor at Department of Cell and Molecular Biology; Structural Biology
- Telephone:
- +46 18 471 41 77
- Mobile phone:
- +46 70 167 97 61
- E-mail:
- maria.selmer@icm.uu.se
- Visiting address:
- Husargatan 3
752 37 Uppsala - Postal address:
- Box 596
75124 Uppsala
Professor at Department of Cell and Molecular Biology; Uppsala RNA Research Centre - URRC
- Telephone:
- +46 18 471 41 77
- Mobile phone:
- +46 70 167 97 61
- E-mail:
- Maria.Selmer@icm.uu.se
- Visiting address:
- Husargatan 3
752 37 Uppsala - Postal address:
- Box 596
751 24 Uppsala
Short presentation
Professor Maria Selmer is a structural biologist that investigates structural mechanisms in bacterial ribosome biogenesis, function and inhibition. Recent work has provided insights in structural mechanisms of antibiotic resistance against inhibitors of protein synthesis. Another line of research is the evolution of protein structure and function.
Keywords
- antibiotic resistance
- ribosome
- antibiotic
- structural biology
- bacteriophage
Biography
- MSc in Chemistry and Chemical Engineering, Lund University 1995
- PhD in Chemistry with specialization in Molecular Biophysics 2002. Supervisor: Anders Liljas
- Postdoc, Wenner-Gren Fellow at MRC-LMB, Cambridge, UK 2002-2006. Supervisor: Venki Ramakrishnan.
- Assistant Professor, Department of Cell and Molecular Biology, Uppsala University 2006
- Docent in Structural Biology 2009
- Senior Lecturer in Structural Biology 2012
- Professor in Structural Biology 2015
Research
The Selmer lab uses integrated structural biology in two different areas, protein synthesis coupled to antibiotic resistance and evolution of protein structure and function. We use X-ray crystallography and single-particle cryo-EM complemented by a variety of biochemical and biophysical methods. Our research is described here.

Publications
Selection of publications
Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family
Part of eLIFE, 2021
- DOI for Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family
- Download full text (pdf) of Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family
Part of Journal of Biological Chemistry, p. 15948-15956, 2020
- DOI for Structure and kinetics of indole-3-glycerol phosphate synthase from Pseudomonas aeruginosa: Decarboxylation is not essential for indole formation
- Download full text (pdf) of Structure and kinetics of indole-3-glycerol phosphate synthase from Pseudomonas aeruginosa: Decarboxylation is not essential for indole formation
Part of Biomolecules, 2020
- DOI for Structure and Characterization of Phosphoglucomutase 5 from Atlantic and Baltic Herring: An Inactive Enzyme with Intact Substrate Binding
- Download full text (pdf) of Structure and Characterization of Phosphoglucomutase 5 from Atlantic and Baltic Herring: An Inactive Enzyme with Intact Substrate Binding
Structural Recognition of Spectinomycin by Resistance Enzyme ANT(9) from Enterococcus faecalis
Part of Antimicrobial Agents and Chemotherapy, 2020
Crystal structure of ErmE-23S rRNA methyltransferase in macrolide resistance
Part of Scientific Reports, 2019
- DOI for Crystal structure of ErmE-23S rRNA methyltransferase in macrolide resistance
- Download full text (pdf) of Crystal structure of ErmE-23S rRNA methyltransferase in macrolide resistance
Part of Journal of Biological Chemistry, p. 11481-11490, 2018
- DOI for Structural mechanism of AadA, a dual specificity aminoglycoside adenylyltransferase from Salmonella enterica
- Download full text (pdf) of Structural mechanism of AadA, a dual specificity aminoglycoside adenylyltransferase from Salmonella enterica
Part of Nature Ecology & Evolution, p. 1321-1330, 2018
Structural and functional innovations in the real-time evolution of new (βα)8 barrel enzymes
Part of Proceedings of the National Academy of Sciences of the United States of America, p. 4727-4732, 2017
- DOI for Structural and functional innovations in the real-time evolution of new (βα)8 barrel enzymes
Part of Journal of Biological Chemistry, p. 24657-24668, 2015
Part of Open Biology, p. 120016, 2012
Crystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA
Part of Nucleic Acids Research, p. 10507-20, 2012
- DOI for Crystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA
- Download full text (pdf) of Crystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA
Part of Journal of Biological Chemistry, p. 30257-30267, 2012
Ribosome engineering to promote new crystal forms
Part of Acta Crystallographica Section D, p. 578-583, 2012
The structure of the ribosome with elongation factor G trapped in the posttranslocational state
Part of Science, p. 694-699, 2009
Part of RNA, p. 817-823, 2007
Recent publications
Structural mechanism of FusB-mediated rescue from fusidic acid inhibition of protein synthesis
Part of Nature Communications, 2025
- DOI for Structural mechanism of FusB-mediated rescue from fusidic acid inhibition of protein synthesis
- Download full text (pdf) of Structural mechanism of FusB-mediated rescue from fusidic acid inhibition of protein synthesis
Structural mechanism of FusB-mediated rescue from fusidic acid inhibition of protein synthesis
Part of Nature Communications, 2025
Part of Scientific Reports, 2024
- DOI for Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane
- Download full text (pdf) of Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane
Part of Cell Reports, 2023
- DOI for Phage T3 overcomes the BREX defense through SAM cleavage and inhibition of SAM synthesis by SAM lyase
- Download full text (pdf) of Phage T3 overcomes the BREX defense through SAM cleavage and inhibition of SAM synthesis by SAM lyase
Structural Consequences of Deproteinating the 50S Ribosome
Part of Biomolecules, 2022
- DOI for Structural Consequences of Deproteinating the 50S Ribosome
- Download full text (pdf) of Structural Consequences of Deproteinating the 50S Ribosome
All publications
Articles in journal
Structural mechanism of FusB-mediated rescue from fusidic acid inhibition of protein synthesis
Part of Nature Communications, 2025
- DOI for Structural mechanism of FusB-mediated rescue from fusidic acid inhibition of protein synthesis
- Download full text (pdf) of Structural mechanism of FusB-mediated rescue from fusidic acid inhibition of protein synthesis
Structural mechanism of FusB-mediated rescue from fusidic acid inhibition of protein synthesis
Part of Nature Communications, 2025
Part of Scientific Reports, 2024
- DOI for Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane
- Download full text (pdf) of Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane
Part of Cell Reports, 2023
- DOI for Phage T3 overcomes the BREX defense through SAM cleavage and inhibition of SAM synthesis by SAM lyase
- Download full text (pdf) of Phage T3 overcomes the BREX defense through SAM cleavage and inhibition of SAM synthesis by SAM lyase
Structural Consequences of Deproteinating the 50S Ribosome
Part of Biomolecules, 2022
- DOI for Structural Consequences of Deproteinating the 50S Ribosome
- Download full text (pdf) of Structural Consequences of Deproteinating the 50S Ribosome
Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family
Part of eLIFE, 2021
- DOI for Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family
- Download full text (pdf) of Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family
Part of Journal of Biological Chemistry, 2021
- DOI for Structures and kinetics of Thermotoga maritima MetY reveal new insights into the predominant sulfurylation enzyme of bacterial methionine biosynthesis
- Download full text (pdf) of Structures and kinetics of Thermotoga maritima MetY reveal new insights into the predominant sulfurylation enzyme of bacterial methionine biosynthesis
Oligomerization and characteristics of phosphoenolpyruvate carboxylase in Synechococcus PCC 7002
Part of Scientific Reports, 2020
- DOI for Oligomerization and characteristics of phosphoenolpyruvate carboxylase in Synechococcus PCC 7002
- Download full text (pdf) of Oligomerization and characteristics of phosphoenolpyruvate carboxylase in Synechococcus PCC 7002
Part of Journal of Biological Chemistry, p. 15948-15956, 2020
- DOI for Structure and kinetics of indole-3-glycerol phosphate synthase from Pseudomonas aeruginosa: Decarboxylation is not essential for indole formation
- Download full text (pdf) of Structure and kinetics of indole-3-glycerol phosphate synthase from Pseudomonas aeruginosa: Decarboxylation is not essential for indole formation
Part of Biomolecules, 2020
- DOI for Structure and Characterization of Phosphoglucomutase 5 from Atlantic and Baltic Herring: An Inactive Enzyme with Intact Substrate Binding
- Download full text (pdf) of Structure and Characterization of Phosphoglucomutase 5 from Atlantic and Baltic Herring: An Inactive Enzyme with Intact Substrate Binding
Structural Recognition of Spectinomycin by Resistance Enzyme ANT(9) from Enterococcus faecalis
Part of Antimicrobial Agents and Chemotherapy, 2020
Crystal structure of ErmE-23S rRNA methyltransferase in macrolide resistance
Part of Scientific Reports, 2019
- DOI for Crystal structure of ErmE-23S rRNA methyltransferase in macrolide resistance
- Download full text (pdf) of Crystal structure of ErmE-23S rRNA methyltransferase in macrolide resistance
Part of Journal of Biological Chemistry, p. 11481-11490, 2018
- DOI for Structural mechanism of AadA, a dual specificity aminoglycoside adenylyltransferase from Salmonella enterica
- Download full text (pdf) of Structural mechanism of AadA, a dual specificity aminoglycoside adenylyltransferase from Salmonella enterica
Part of Nature Ecology & Evolution, p. 1321-1330, 2018
Structural and functional innovations in the real-time evolution of new (βα)8 barrel enzymes
Part of Proceedings of the National Academy of Sciences of the United States of America, p. 4727-4732, 2017
- DOI for Structural and functional innovations in the real-time evolution of new (βα)8 barrel enzymes
Two proofreading steps amplify the accuracy of genetic code translation
Part of Proceedings of the National Academy of Sciences of the United States of America, p. 13744-13749, 2016
Part of Journal of Biological Chemistry, p. 24657-24668, 2015
Structure of AadA from Salmonella enterica: a monomeric aminoglycoside (3'')(9) adenyltransferase
Part of Acta Crystallographica Section D, p. 2267-2277, 2015
- DOI for Structure of AadA from Salmonella enterica: a monomeric aminoglycoside (3'')(9) adenyltransferase
- Download full text (pdf) of Structure of AadA from Salmonella enterica: a monomeric aminoglycoside (3'')(9) adenyltransferase
Investigating Ribosome Conformations with Multi-Resolution Modeling
Part of Biophysical Journal, 2014
Part of PLOS ONE, 2014
- DOI for Resistance to beta-Lactam Antibiotics Conferred by Point Mutations in Penicillin-Binding Proteins PBP3, PBP4 and PBP6 in Salmonella enterica
- Download full text (pdf) of Resistance to beta-Lactam Antibiotics Conferred by Point Mutations in Penicillin-Binding Proteins PBP3, PBP4 and PBP6 in Salmonella enterica
Energetic pathway sampling in a protein interaction domain
Part of Structure, p. 1193-1202, 2013
- DOI for Energetic pathway sampling in a protein interaction domain
- Download full text (pdf) of Energetic pathway sampling in a protein interaction domain
Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ
Part of Nucleic Acids Research, p. 9537-9548, 2013
- DOI for Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ
- Download full text (pdf) of Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ
Part of Acta Crystallographica. Section F, p. 1001-1003, 2013
- DOI for Purification, crystallization and preliminary X-ray diffraction analysis of the 23S rRNA methyltransferase RlmJ from Escherichia coli
- Download full text (pdf) of Purification, crystallization and preliminary X-ray diffraction analysis of the 23S rRNA methyltransferase RlmJ from Escherichia coli
Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain
Part of PLOS ONE, 2012
- DOI for Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain
- Download full text (pdf) of Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain
Part of Open Biology, p. 120016, 2012
Crystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA
Part of Nucleic Acids Research, p. 10507-20, 2012
- DOI for Crystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA
- Download full text (pdf) of Crystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA
Part of Journal of Biological Chemistry, p. 30257-30267, 2012
Ribosome engineering to promote new crystal forms
Part of Acta Crystallographica Section D, p. 578-583, 2012
Staphylococcus aureus elongation factor G - structure and analysis of a target for fusidic acid
Part of The FEBS Journal, p. 3789-3803, 2010
Part of Journal of Biological Chemistry, p. 18051-18059, 2010
The structure of the ribosome with elongation factor G trapped in the posttranslocational state
Part of Science, p. 694-699, 2009
Crystal structure of the ribosome recycling factor bound to the ribosome
Part of Nature Structural & Molecular Biology, p. 733-737, 2007
Part of RNA, p. 817-823, 2007
Articles, review/survey
Exit biology: battle for the nascent chain
Part of Structure, p. 498-500, 2008