Rolf Larsson

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Mansoori, Sharmineh; Blom, Kristin; Andersson, Claes; Fryknäs, Mårten et al.

Part of Oncology Reports, 2026

• DOI for Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model
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Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus

Eloranta, Maija-Leena; Nygren, Peter; Larsson, Rolf; Loskog, Angelica et al.

Part of Scientific Reports, 2026

• DOI for Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus
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Ex vivo drug responses and molecular profiles of 597 pediatric acute lymphoblastic leukemia patients

Enblad, Anna Pia; Krali, Olga; Gezelius, Henrik; Lundmark, Anders et al.

Part of HemaSphere, 2025

• DOI for Ex vivo drug responses and molecular profiles of 597 pediatric acute lymphoblastic leukemia patients
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Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models

Selvin, Tove; Berglund, Malin; Akerstrom, Anders; Zia, Marco et al.

Part of SLAS TECHNOLOGY, 2024

• DOI for Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models
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Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment

Selvin, Tove; Berglund, Malin; Lenhammar, Lena; Lindskog, Magnus et al.

Part of BMC Pharmacology & Toxicology, 2024

• DOI for Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment
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Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Mansoori, Sharmineh; Blom, Kristin; Andersson, Claes; Fryknäs, Mårten et al.

Part of Oncology Reports, 2026

• DOI for Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model
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Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus

Eloranta, Maija-Leena; Nygren, Peter; Larsson, Rolf; Loskog, Angelica et al.

Part of Scientific Reports, 2026

• DOI for Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus
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Ex vivo drug responses and molecular profiles of 597 pediatric acute lymphoblastic leukemia patients

Enblad, Anna Pia; Krali, Olga; Gezelius, Henrik; Lundmark, Anders et al.

Part of HemaSphere, 2025

• DOI for Ex vivo drug responses and molecular profiles of 597 pediatric acute lymphoblastic leukemia patients
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Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models

Selvin, Tove; Berglund, Malin; Akerstrom, Anders; Zia, Marco et al.

Part of SLAS TECHNOLOGY, 2024

• DOI for Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models
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Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment

Selvin, Tove; Berglund, Malin; Lenhammar, Lena; Lindskog, Magnus et al.

Part of BMC Pharmacology & Toxicology, 2024

• DOI for Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment
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Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death

Selvin, Tove; Berglund, Malin; Lenhammar, Lena; Jarvius, Malin et al.

Part of BMC Cancer, 2023

• DOI for Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death
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Ex vivo assessment of chemotherapy sensitivity of colorectal cancer peritoneal metastases

Cashin, Peter; Söderström, Maria; Blom, Kristin; Artursson, Sara et al.

Part of British Journal of Surgery, p. 1080-1083, 2023

• DOI for Ex vivo assessment of chemotherapy sensitivity of colorectal cancer peritoneal metastases
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Assessment in vitro of interactions between anti-cancer drugs and noncancer drugs commonly used by cancer patients

Andersson, Claes; Ye, Jiawei; Blom, Kristin; Fryknäs, Mårten et al.

Part of Anti-Cancer Drugs, p. 92-102, 2023

• DOI for Assessment in vitro of interactions between anti-cancer drugs and noncancer drugs commonly used by cancer patients
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Ex vivo assessment of cancer drug sensitivity in epithelial ovarian cancer and its association with histopathological type, treatment history and clinical outcome

Bjersand, Kathrine; Blom, Kristin; Sundström Poromaa, Inger; Stålberg, Karin et al.

Part of International Journal of Oncology, 2022

• DOI for Ex vivo assessment of cancer drug sensitivity in epithelial ovarian cancer and its association with histopathological type, treatment history and clinical outcome
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Selective radiosensitization by nitazoxanide of quiescent clonogenic colon cancer tumour cells

Karlsson, Henning; Fryknäs, Mårten; Senkowski, Wojciech; Larsson, Rolf et al.

Part of Oncology Letters, 2022

• DOI for Selective radiosensitization by nitazoxanide of quiescent clonogenic colon cancer tumour cells
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Single-cell transcriptional pharmacodynamics of trifluridine in a tumor-immune model

Selvin, Tove; Fasterius, Erik; Jarvius, Malin; Fryknäs, Mårten et al.

Part of Scientific Reports, 2022

• DOI for Single-cell transcriptional pharmacodynamics of trifluridine in a tumor-immune model
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Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival

Lu, Xi; Maturi, Naga Prathyusha; Jarvius, Malin; Yildirim, Irem et al.

Part of Nature Communications, 2022

• DOI for Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival
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Sorafenib and nitazoxanide disrupt mitochondrial function and inhibit regrowth capacity in three-dimensional models of hepatocellular and colorectal carcinoma

Nyberg, Frida; Blom, Kristin; Selvin, Tove; Rudfeldt, Jakob et al.

Part of Scientific Reports, 2022

• DOI for Sorafenib and nitazoxanide disrupt mitochondrial function and inhibit regrowth capacity in three-dimensional models of hepatocellular and colorectal carcinoma
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DNA Methylation Signatures Predict Cytogenetic Subtype and Outcome in Pediatric Acute Myeloid Leukemia (AML)

Krali, Olga; Palle, J; Bäcklin, Christofer; Abrahamsson, Jonas et al.

Part of Genes, 2021

• DOI for DNA Methylation Signatures Predict Cytogenetic Subtype and Outcome in Pediatric Acute Myeloid Leukemia (AML)
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Increased levels of plasma cytokines and correlations to organ failure and 30-day mortality in critically ill Covid-19 patients

Bülow Anderberg, Sara; Luther, Tomas; Berglund, Malin; Larsson, Rolf et al.

Part of Cytokine, 2021

• DOI for Increased levels of plasma cytokines and correlations to organ failure and 30-day mortality in critically ill Covid-19 patients
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Melphalan flufenamide inhibits osteoclastogenesis by suppressing proliferation of monocytes

Byrgazov, Konstantin; Lind, Thomas; Rasmusson, Annica J.; Andersson, Claes et al.

Part of Bone Reports, 2021

• DOI for Melphalan flufenamide inhibits osteoclastogenesis by suppressing proliferation of monocytes

A phase 2a clinical study on the safety and efficacy of individualized dosed mebendazole in patients with advanced gastrointestinal cancer

Mansoori, Sharmineh; Fryknäs, Mårten; Alvfors, Carina; Loskog, Angelica et al.

Part of Scientific Reports, 2021

• DOI for A phase 2a clinical study on the safety and efficacy of individualized dosed mebendazole in patients with advanced gastrointestinal cancer
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Targeting aggressive osteosarcoma with a peptidase-enhanced cytotoxic melphalan flufenamide

Byrgazov, Konstantin; Andersson, Claes; Salzer, Benjamin; Bozsaky, Eva et al.

Part of Therapeutic Advances in Medical Oncology, 2020

• DOI for Targeting aggressive osteosarcoma with a peptidase-enhanced cytotoxic melphalan flufenamide
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Antibacterial pyrrolidinyl and piperidinyl substituted 2,4-diacetylphloroglucinols from Pseudomonas protegens UP46

Levenfors, Jolanta J.; Nord, Christina; Bjerketorp, Joakim; Stahlberg, Jerry et al.

Part of Journal of antibiotics (Tokyo. 1968), p. 739-747, 2020

• DOI for Antibacterial pyrrolidinyl and piperidinyl substituted 2,4-diacetylphloroglucinols from Pseudomonas protegens UP46

Isopedopeptins A-H: Cationic Cyclic Lipodepsipeptides from Pedobacter cryoconitis UP508 Targeting WHO Top-Priority Carbapenem-Resistant Bacteria

Nord, Christina; Bjerketorp, Joakim; Levenfors, Jolanta J.; Cao, Sha et al.

Part of ACS Chemical Biology, p. 2937-2944, 2020

• DOI for Isopedopeptins A-H: Cationic Cyclic Lipodepsipeptides from Pedobacter cryoconitis UP508 Targeting WHO Top-Priority Carbapenem-Resistant Bacteria
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Mebendazole is unique among tubulin-active drugs in activating the MEK-ERK pathway

Andersson, Claes; Selvin, Tove; Blom, Kristin; Rubin, Jenny et al.

Part of Scientific Reports, 2020

• DOI for Mebendazole is unique among tubulin-active drugs in activating the MEK-ERK pathway
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Rational Design of Azastatin as a Potential ADC Payload with Reduced Bystander Killing.

Hartmann, Rafael; Fahrner, Raphael; Shevshenko, Denys; Fryknäs, Mårten et al.

Part of ChemMedChem, p. 2500-2512, 2020

• DOI for Rational Design of Azastatin as a Potential ADC Payload with Reduced Bystander Killing.
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Descriptive Proteome Analysis to Investigate Context-Dependent Treatment Responses to OXPHOS Inhibition in Colon Carcinoma Cells Grown as Monolayer and Multicellular Tumor Spheroids

Steinmetz, Julia; Senkowski, Wojciech; Lengqvist, Johan; Rubin, Jenny et al.

Part of ACS Omega, p. 17242-17254, 2020

• DOI for Descriptive Proteome Analysis to Investigate Context-Dependent Treatment Responses to OXPHOS Inhibition in Colon Carcinoma Cells Grown as Monolayer and Multicellular Tumor Spheroids
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Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition

Blom, Kristin; Eriksson, Jenny; Berglund, Malin; Jarvius, Malin et al.

Part of BMC Research Notes, 2019

• DOI for Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition
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Mesenchymal transition and increased therapy resistance of glioblastoma cells is related to astrocyte reactivity

Niklasson, Mia; Bergström, Tobias; Jarvius, Malin; Sundström, Anders et al.

Part of Journal of Pathology, p. 295-307, 2019

• DOI for Mesenchymal transition and increased therapy resistance of glioblastoma cells is related to astrocyte reactivity

Ex vivo activity of cytotoxic drugs and targeted agents in small intestinal neuroendocrine tumors

Daskalakis, Kosmas; Norlén, Olov; Karakatsanis, Andreas; Hellman, Per et al.

Part of Endocrine-Related Cancer, p. 471-480, 2018

• DOI for Ex vivo activity of cytotoxic drugs and targeted agents in small intestinal neuroendocrine tumors

Ex Vivo Activity of Cytotoxic Drugs and Targeted Agents in Small Intestinal Neuroendocrine Tumors

Daskalakis, Kosmas; Norlén, Olov; Karakatsanis, Andreas; Hellman, Per et al.

Part of Neuroendocrinology, p. 189-189, 2018

• DOI for Ex Vivo Activity of Cytotoxic Drugs and Targeted Agents in Small Intestinal Neuroendocrine Tumors

Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin

Jiang, Yiwen; Marinescu, Voichita Dana; Xie, Yuan; Jarvius, Malin et al.

Part of Cell Reports, p. 977-990, 2017

• DOI for Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin
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Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects.

Eriksson, Anna; Chantzi, Efthymia; Fryknäs, Mårten; Gullbo, Joachim et al.

Part of Leukemia Research, p. 41-46, 2017

• DOI for Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects.
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Bliss and Loewe interaction analyses of clinically relevant drug combinations in human colon cancer cell lines reveal complex patterns of synergy and antagonism

Kashif, Muhammad; Andersson, Claes; Mansoori, Sharmineh; Larsson, Rolf et al.

Part of Oncotarget, p. 103952-103967, 2017

• DOI for Bliss and Loewe interaction analyses of clinically relevant drug combinations in human colon cancer cell lines reveal complex patterns of synergy and antagonism
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Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity

Karlsson, Henning; Fryknäs, Mårten; Strese, Sara; Gullbo, Joachim et al.

Part of Oncotarget, p. 30217-30234, 2017

• DOI for Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity
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In vitro and in vivo anti-leukemic activity of the peptidase-potentiated alkylator melflufen in acute myeloid leukemia

Strese, Sara; Hassan, Saadia Bashir; Velander, Ebba; Haglund, Caroline et al.

Part of Oncotarget, p. 6341-6352, 2017

• DOI for In vitro and in vivo anti-leukemic activity of the peptidase-potentiated alkylator melflufen in acute myeloid leukemia

Mouse models of pediatric supratentorial high-grade glioma reveal how cell-of-origin influences tumor development and phenotype

Sreedharan, Smitha; Maturi, Naga Prathyusha; Xie, Yuan; Sundström, Anders et al.

Part of Cancer Research, p. 802-812, 2017

• DOI for Mouse models of pediatric supratentorial high-grade glioma reveal how cell-of-origin influences tumor development and phenotype

Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)

De Rosa, Maria; Lu, Lu; Zamaratski, Edouard; Szałaj, Natalia et al.

Part of Bioorganic & Medicinal Chemistry, p. 897-911, 2017

• DOI for Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)
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Mass spectrometry based metabolomics for in vitro systems pharmacology: pitfalls, challenges, and computational solutions.

Herman, Stephanie; Emami Khoonsari, Payam; Aftab, Obaid; Krishnan, Shibu et al.

Part of Metabolomics, 2017

• DOI for Mass spectrometry based metabolomics for in vitro systems pharmacology: pitfalls, challenges, and computational solutions.
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Targeting tumor cells based on Phosphodiesterase 3A expression

Nazir, Madiha; Senkowski, Wojciech; Nyberg, Frida; Blom, Kristin et al.

Part of Experimental Cell Research, p. 308-315, 2017

• DOI for Targeting tumor cells based on Phosphodiesterase 3A expression

The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation

Blom, Kristin; Senkowski, Wojciech; Jarvius, Malin; Berglund, Malin et al.

Part of Immunopharmacology and immunotoxicology, p. 199-210, 2017

• DOI for The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation

Predictive Value of Ex Vivo Chemosensitivity Assays for Individualized Cancer Chemotherapy: A Meta-Analysis

Blom, Kristin; Nygren, Peter; Larsson, Rolf; Andersson, Claes R.

Part of SLAS TECHNOLOGY, p. 306-314, 2017

• DOI for Predictive Value of Ex Vivo Chemosensitivity Assays for Individualized Cancer Chemotherapy: A Meta-Analysis

Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition

Segerman, Anna; Niklasson, Mia; Haglund, Caroline; Bergström, Tobias et al.

Part of Cell Reports, p. 2994-3009, 2016

• DOI for Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition
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Characterizing the effects of epigenetic regulation in assays using peripheral blood mononuclear cells from patients with inflammatory diseases

Berg, L.; Sundström, Y.; Aftab, Obaid; Bergqvist, F. et al.

Part of Scandinavian Journal of Rheumatology, p. 44-45, 2016

In vitro and in vivo activity of melflufen (J1) in lymphoma

Delforoush, Maryam; Strese, Sara; Wickström, Malin; Larsson, Rolf et al.

Part of BMC Cancer, 2016

• DOI for In vitro and in vivo activity of melflufen (J1) in lymphoma

Preclinical activity of melflufen (J1) in ovarian cancer

Carlier, Charlotte; Strese, Sara; Viktorsson, Kristina; Velander, Ebba et al.

Part of Oncotarget, p. 59322-59335, 2016

• DOI for Preclinical activity of melflufen (J1) in ovarian cancer

Iron chelators target both proliferating and quiescent cancer cells

Fryknäs, Mårten; Zhang, Xiaonan; Bremberg, Ulf; Senkowski, Wojciech et al.

Part of Scientific Reports, 2016

• DOI for Iron chelators target both proliferating and quiescent cancer cells
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Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids

Senkowski, Wojciech; Jarvius, Malin; Rubin, Jenny; Lengqvist, Johan et al.

Part of CELL CHEMICAL BIOLOGY, p. 1428-1438, 2016

• DOI for Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids

Repositioning Of Quinacrine For Treatment Of Acute Myeloid Leukemia - Synergies And In Vivo Effects

Eriksson, Anna; Gustafsson, Mats; Fryknäs, Mårten; Gullbo, Joachim et al.

Part of Haematologica, p. 367-368, 2016

Ex Vivo Assessment of Drug Activity in Patient Tumor Cells as a Basis for Tailored Cancer Therapy

Blom, Kristin; Nygren, Peter; Alvarsson, Jonathan; Larsson, Rolf et al.

Part of JALA, p. 178-187, 2016

• DOI for Ex Vivo Assessment of Drug Activity in Patient Tumor Cells as a Basis for Tailored Cancer Therapy

Vascular repair utilising immobilised heparin conjugate for protection against early activation of inflammation and coagulation

Nordling, Sofia; Hong, Jaan; Fromell, Karin; Edin, Fredrik et al.

Part of Thrombosis and Haemostasis, p. 1312-1322, 2015

• DOI for Vascular repair utilising immobilised heparin conjugate for protection against early activation of inflammation and coagulation

The Mutational Landscape in Pediatric Acute Lymphoblastic Leukemia Deciphered by Whole Genome Sequencing

Lindqvist, C Mårten; Nordlund, Jessica; Ekman, Diana; Johansson, Anna et al.

Part of Human Mutation, p. 118-128, 2015

• DOI for The Mutational Landscape in Pediatric Acute Lymphoblastic Leukemia Deciphered by Whole Genome Sequencing

Label free quantification of time evolving morphologies using time-lapse video microscopy enables identity control of cell lines and discovery of chemically induced differential activity in iso-genic cell line pairs

Aftab, Obaid; Fryknäs, Mårten; Hassan, Saadia; Nygren, Peter et al.

Part of Chemometrics and Intelligent Laboratory Systems, p. 24-32, 2015

• DOI for Label free quantification of time evolving morphologies using time-lapse video microscopy enables identity control of cell lines and discovery of chemically induced differential activity in iso-genic cell line pairs

Spheroid-based high throughput screening for identification of molecules targeting different tumor microenvironment characteristics

Senkowski, Wojciech; Zhang, Xiaonan; Nygren, Peter; Olofsson, Maria Hagg et al.

Part of Cancer Research, 2015

• DOI for Spheroid-based high throughput screening for identification of molecules targeting different tumor microenvironment characteristics

Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

Senkowski, Wojciech; Zhang, Xiaonan; Olofsson, Maria Hagg; Isacson, Ruben et al.

Part of Molecular Cancer Therapeutics, p. 1504-1516, 2015

• DOI for Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

The anticancer activity of the DUB inhibitor b-AP15 is associated with accumulation of proteasome bound ubiquitin and oxidative stress

Mazurkiewicz, Magdalena; Brnjic, Slavica; Fryknas, Marten; Sun, Chao et al.

Part of Cancer Research, 2015

• DOI for The anticancer activity of the DUB inhibitor b-AP15 is associated with accumulation of proteasome bound ubiquitin and oxidative stress

Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia

Eriksson, Anna; Österroos, Albin; Hassan, Sadia Bashir; Gullbo, Joachim et al.

Part of Blood Cancer Journal, 2015

• DOI for Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia
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In vitro discovery of promising anti-cancer drug combinations using iterative maximisation of a therapeutic index

Kashif, Muhammad; Andersson, Claes; Hassan, Sadia; Karlsson, Henning et al.

Part of Scientific Reports, 2015

• DOI for In vitro discovery of promising anti-cancer drug combinations using iterative maximisation of a therapeutic index
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DNA methylation-based subtype prediction for pediatric acute lymphoblastic leukemia

Nordlund, Jessica; Bäcklin, Christofer; Zachariadis, Vasilios; Cavelier, Lucia et al.

Part of Clinical Epigenetics, 2015

• DOI for DNA methylation-based subtype prediction for pediatric acute lymphoblastic leukemia
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Perfusion Of Porcine Kidneys With Macromolecular Heparin Ameliorates Early Ischemia Reperfusion Injury

Sedigh, Amir; Nordling, Sofia; Larsson, Rolf; Larsson, Erik et al.

Part of Transplant International, p. 94-95, 2015

Drug Sensitivity Testing in Cytoreductive Surgery and Intraperitoneal Chemotherapy of Pseudomyxoma Peritonei

Bjersand, Kathrine; Mahteme, Haile; Sundström Poromaa, Inger; Andreasson, Håkan et al.

Part of Annals of Surgical Oncology, 2015

• DOI for Drug Sensitivity Testing in Cytoreductive Surgery and Intraperitoneal Chemotherapy of Pseudomyxoma Peritonei

Detection of cell aggregation and altered cell viability by automated label-free video microscopy: A promising alternative to endpoint viability assays in high throughput screening

Aftab, Obaid; Fryknäs, Mårten; Hammerling, Ulf; Larsson, Rolf et al.

Part of Journal of Biomolecular Screening, p. 372-381, 2015

• DOI for Detection of cell aggregation and altered cell viability by automated label-free video microscopy: A promising alternative to endpoint viability assays in high throughput screening

Cell crowding induces interferon regulatory factor 9, which confers resistance to chemotherapeutic drugs

Kolosenko, Iryna; Fryknäs, Mårten; Forsberg, Sofi; Johnsson, Per et al.

Part of International Journal of Cancer, 2015

• DOI for Cell crowding induces interferon regulatory factor 9, which confers resistance to chemotherapeutic drugs

A spheroid-based screen identifies mitochondrial targeting as a promising strategy for cancer treatment and drug repositioning

Senkowski, Wojciech; Zhang, Xiaonan; Olofsson, Maria Hagg; Linder, Stig et al.

Part of Cancer Research, 2014

• DOI for A spheroid-based screen identifies mitochondrial targeting as a promising strategy for cancer treatment and drug repositioning

Induction of Tumor Cell Apoptosis by a Proteasome Deubiquitinase Inhibitor Is Associated with Oxidative Stress

Brnjic, Slavica; Mazurkiewicz, Magdalena; Fryknäs, Mårten; Sun, Chao et al.

Part of Antioxidants and Redox Signaling, p. 2271-2285, 2014

• DOI for Induction of Tumor Cell Apoptosis by a Proteasome Deubiquitinase Inhibitor Is Associated with Oxidative Stress

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Zhang, Xiaonan; Fryknäs, Mårten; Hernlund, Emma; Fayad, Walid et al.

Part of Nature Communications, p. 3295, 2014

The 19S Deubiquitinase Inhibitor b-AP15 Is Enriched in Cells and Elicits Rapid Commitment to Cell Death

Wang, Xin; Stafford, William; Mazurkiewicz, Magdalena; Fryknäs, Mårten et al.

Part of Molecular Pharmacology, p. 932-945, 2014

• DOI for The 19S Deubiquitinase Inhibitor b-AP15 Is Enriched in Cells and Elicits Rapid Commitment to Cell Death

Label-free detection and dynamic monitoring of drug-induced intracellular vesicle formation enabled using a 2-dimensional matched filter

Aftab, Obaid; Fryknäs, Mårten; Zhang, Xiaonan; De Milito, Angelo et al.

Part of Autophagy, p. 57-69, 2014

• DOI for Label-free detection and dynamic monitoring of drug-induced intracellular vesicle formation enabled using a 2-dimensional matched filter

Benchmarking of gastric cancer sensitivity to anti-cancer drugs ex vivo as a basis for drug selection in systemic and intraperitoneal therapy

Hultman, Bo; Mahteme, Haile; Sundbom, Magnus; Ljungman, Martin et al.

Part of Journal of Experimental & Clinical Cancer Research, 2014

• DOI for Benchmarking of gastric cancer sensitivity to anti-cancer drugs ex vivo as a basis for drug selection in systemic and intraperitoneal therapy
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Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Zhang, Xiaonan; Fryknäs, Mårten; Hernlund, Emma; Fayad, Walid et al.

Part of Nature Communications, p. 3295, 2014

• DOI for Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments
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Antigen Signaling Enhances Proliferation and Cytotoxic Capacity of CD19-Targeting CD28/4-1BB CAR T Cells During Expansion Without Inducing Exhaustion

Karlsson, Hannah; Gigg, Camilla; Svensson, Emma; Larsson, Rolf et al.

Part of Molecular Therapy, 2014

Chemotherapeutic drug sensitivity of primary cultures of epithelial ovarian cancer cells from patients in relation to tumour characteristics and therapeutic outcome

von Heideman, Anne; Tholander, Bengt; Grundmark, Birgitta; Cajander, Stefan et al.

Part of Acta Oncologica, p. 242-250, 2014

• DOI for Chemotherapeutic drug sensitivity of primary cultures of epithelial ovarian cancer cells from patients in relation to tumour characteristics and therapeutic outcome

Modifying the vessel walls in porcine kidneys during machine perfusion

Sedigh, Amir; Larsson, Rolf; Brännström, Johan; Magnusson, Peetra et al.

Part of Journal of Surgical Research, p. 455-462, 2014

• DOI for Modifying the vessel walls in porcine kidneys during machine perfusion

Beneficial Effects of Coating Alginate Microcapsules with Macromolecular Heparin Conjugates-In Vitro and In Vivo Study

Vaithilingam, Vijayaganapathy; Kollarikova, Gabriela; Qi, Meirigeng; Larsson, Rolf et al.

Part of Tissue Engineering. Part A, p. 324-334, 2014

• DOI for Beneficial Effects of Coating Alginate Microcapsules with Macromolecular Heparin Conjugates-In Vitro and In Vivo Study

AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and a dose dependent reduction of kinase activity in acute myeloid leukemia

Eriksson, Anna; Kalushkova, Antonia; Jarvius, Malin; Hilhorst, Riet et al.

Part of Biochemical Pharmacology, p. 284-291, 2014

• DOI for AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and a dose dependent reduction of kinase activity in acute myeloid leukemia
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Label free high throughput screening for apoptosis inducing chemicals using time-lapse microscopy signal processing

Aftab, Obaid; Nazir, Madiha; Fryknäs, Mårten; Hammerling, Ulf et al.

Part of Apoptosis (London), p. 1411-1418, 2014

• DOI for Label free high throughput screening for apoptosis inducing chemicals using time-lapse microscopy signal processing

Drug repositioning from bench to bedside: Tumour remission by the antihelmintic drug mebendazole in refractory metastatic colon cancer

Nygren, Peter; Larsson, Rolf

Part of Acta Oncologica, p. 427-428, 2014

• DOI for Drug repositioning from bench to bedside: Tumour remission by the antihelmintic drug mebendazole in refractory metastatic colon cancer

Identification of an inhibitor of the ubiquitin-proteasome system that induces accumulation of polyubiquitinated proteins in the absence of blocking of proteasome function

Haglund, Caroline; Mohanty, Chitralekha; Fryknäs, Mårten; D'Arcy, Padraig et al.

Part of MedChemComm, p. 376-385, 2014

• DOI for Identification of an inhibitor of the ubiquitin-proteasome system that induces accumulation of polyubiquitinated proteins in the absence of blocking of proteasome function
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A Pragmatic Definition of Therapeutic Synergy Suitable for Clinically Relevant In Vitro Multicompound Analyses

Kashif, Muhammad; Andersson, Claes; Åberg, Magnus; Nygren, Peter et al.

Part of Molecular Cancer Therapeutics, p. 1964-1976, 2014

• DOI for A Pragmatic Definition of Therapeutic Synergy Suitable for Clinically Relevant In Vitro Multicompound Analyses

Repositioning of Quinacrine for Treatment of Acute Myeloid Leukemia

Eriksson, Anna; Osterros, Albin; Hassan, Sadia Bashir; Gullbo, Joachim et al.

Part of Blood, 2014

Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia

Nordlund, Jessica; Bäcklin, Christofer L; Wahlberg, Per; Busche, Stephan et al.

Part of Genome Biology, 2013

• DOI for Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia

Activity ex vivo of cytotoxic drugs in patient samples of peritoneal carcinomatosis with special focus on colorectal cancer

Cashin, Peter H; Mahteme, Haile; Graf, Wilhelm; Karlsson, Henning et al.

Part of BMC Cancer, p. 435, 2013

• DOI for Activity ex vivo of cytotoxic drugs in patient samples of peritoneal carcinomatosis with special focus on colorectal cancer
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Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance

Fryknäs, Mårten; Gullbo, Joachim; Wang, Xin; Rickardson, Linda et al.

Part of BMC Cancer, p. 374, 2013

• DOI for Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance
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Effects of hypoxia on human cancer cell line chemosensitivity

Strese, Sara; Fryknäs, Mårten; Larsson, Rolf; Gullbo, Joachim

Part of BMC Cancer, p. 331, 2013

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Attachment of macromolecular heparin conjugate to gelatin scaffolds improves endothelial cell infiltration

Leijon, Jonas; Carlsson, Fredrik; Brännström, Johan; Sanchez, Javier et al.

Part of Tissue Engineering. Parts A, B and C, p. 1336-1348, 2013

• DOI for Attachment of macromolecular heparin conjugate to gelatin scaffolds improves endothelial cell infiltration
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Evaluation of the blood compatibility of materials, cells and tissues: Basic concepts, test models and practical guidelines

Nilsson Ekdahl, Kristina; Hong, Jaan; Hamad, Osama; Larsson, Rolf et al.

Part of Advances in Experimental Medicine and Biology, p. 257-270, 2013

• DOI for Evaluation of the blood compatibility of materials, cells and tissues: Basic concepts, test models and practical guidelines

Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system

Felth, Jenny; Lesiak-Mieczkowska, Karolina; Haglund, Caroline; Gullbo, Joachim et al.

Part of Investigational new drugs, p. 587-598, 2013

• DOI for Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system

Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo

Wickstrom, Malin; Dyberg, Cecilia; Shimokawa, Takashi; Milosevic, Jelena et al.

Part of International Journal of Cancer, p. 1516-1524, 2013

• DOI for Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo

Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells

Jarvius, Malin; Fryknäs, Mårten; D'Arcy, Padraig; Sun, Chao et al.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 117-123, 2013

• DOI for Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells

Association of interferon stimulated genes and IRF9 upregulation with drug resistance in multicellular spheroids and monolayer cells upon crowding

Tamm, Katia Pokrovskaja; Kolosenko, Iryna; Fryknäs, Mårten; Johnsson, Per et al.

Part of Cytokine, p. 303-303, 2013

• DOI for Association of interferon stimulated genes and IRF9 upregulation with drug resistance in multicellular spheroids and monolayer cells upon crowding

The novel alkylating prodrug melflufen (J1) inhibits angiogenesis in vitro and in vivo

Strese, Sara; Wickström, Malin; Fuchs, Peder Fredlund; Fryknäs, Mårten et al.

Part of Biochemical Pharmacology, p. 888-895, 2013

• DOI for The novel alkylating prodrug melflufen (J1) inhibits angiogenesis in vitro and in vivo

Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer

Nygren, Peter; Fryknäs, Mårten; Anagel, Bengt; Larsson, Rolf

Part of Journal of Cancer Research and Clinical Oncology, p. 2133-2140, 2013

• DOI for Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer
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The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy

Hernlund, Emma; Olofsson, Maria Hägg; Fayad, Walid; Fryknäs, Mårten et al.

Part of European Journal of Cancer, p. 396-406, 2012

• DOI for The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy

Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma

Dimberg, Lina Y.; Dimberg, Anna; Ivarsson, Karolina; Fryknäs, Mårten et al.

Part of BMC Cancer, p. 318, 2012

• DOI for Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma
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Conducting Nanocellulose Polypyrrole Membranes Intended for Hemodialysis

Carlsson, Daniel O; Ferraz, Natalia; Hong, Jaan; Larsson, Rolf et al.

Part of European Cells & Materials, p. 32-32, 2012

The novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia

Eriksson, Anna; Hermanson, Monica; Wickström, Malin; Lindhagen, Elin et al.

Part of Blood Cancer Journal, 2012

• DOI for The novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia

Loss of cancer drug activity in colon cancer HCT-116 cells during spheroid formation in a new 3-D spheroid cell culture system

Karlsson, Henning; Fryknäs, Mårten; Larsson, Rolf; Nygren, Peter

Part of Experimental Cell Research, p. 1577-1585, 2012

• DOI for Loss of cancer drug activity in colon cancer HCT-116 cells during spheroid formation in a new 3-D spheroid cell culture system

Haemocompatibility and ion exchange capability of nanocellulose polypyrrole membranes intended for blood purification

Ferraz, Natalia; Carlsson, Daniel O.; Hong, Jaan; Larsson, Rolf et al.

Part of Journal of the Royal Society Interface, p. 1943-1955, 2012

• DOI for Haemocompatibility and ion exchange capability of nanocellulose polypyrrole membranes intended for blood purification

In vitro evaluation of clinical activity and toxicity of anticancer drugs using tumor cells from patients and cells representing normal tissues

Haglund, Caroline; Åleskog, Anna; Nygren, Peter; Gullbo, Joachim et al.

Part of Cancer Chemotherapy and Pharmacology, p. 697-707, 2012

• DOI for In vitro evaluation of clinical activity and toxicity of anticancer drugs using tumor cells from patients and cells representing normal tissues

In vitro cellular drug resistance adds prognostic information to other known risk-factors in childhood acute lymphoblastic leukemia

Lönnerholm, Gudmar; Thörn, Ingrid; Sundström, Christer; Frost, Britt-Marie et al.

Part of Leukemia Research, p. 472-478, 2011

• DOI for In vitro cellular drug resistance adds prognostic information to other known risk-factors in childhood acute lymphoblastic leukemia

Brunn: an open source laboratory information system for microplates with a graphical plate layout design process

Alvarsson, Jonathan; Andersson, Claes; Spjuth, Ola; Larsson, Rolf et al.

Part of BMC Bioinformatics, 2011

• DOI for Brunn: an open source laboratory information system for microplates with a graphical plate layout design process
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Identification of Agents that Induce Apoptosis of Multicellular Tumour Spheroids: Enrichment for Mitotic Inhibitors with Hydrophobic Properties

Fayad, Walid; Rickardson, Linda; Haglund, Caroline; Hägg Olofsson, Maria et al.

Part of Chemical Biology and Drug Design, p. 547-557, 2011

• DOI for Identification of Agents that Induce Apoptosis of Multicellular Tumour Spheroids: Enrichment for Mitotic Inhibitors with Hydrophobic Properties

Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment

Gullbo, Joachim; Fryknäs, Mårten; Rickardson, Linda; Darcy, Padraig et al.

Part of Biochemical Pharmacology, p. 139-147, 2011

• DOI for Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment

Ex Vivo Activity of Cardiac Glycosides in Acute Leukaemia

Hallböök, Helene; Felth, Jenny; Eriksson, Anna; Fryknäs, Mårten et al.

Part of PLOS ONE, 2011

• DOI for Ex Vivo Activity of Cardiac Glycosides in Acute Leukaemia

Antimicrobial and antineoplastic activities of Agelasine analogs modified in the purine 2-position

Roggen, Heidi; Charnock, Colin; Burman, Robert; Felth, Jenny et al.

Part of Archiv der Pharmazie, p. 50-55, 2011

• DOI for Antimicrobial and antineoplastic activities of Agelasine analogs modified in the purine 2-position

Novel activity of acriflavine against colorectal cancer tumor cells

Hassan, Saadia; Laryea, Daniel; Mahteme, Haile; Felth, Jenny et al.

Part of Cancer Science, p. 2206-2213, 2011

• DOI for Novel activity of acriflavine against colorectal cancer tumor cells

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

D'Arcy, Padraig; Brnjic, Slavica; Olofsson, Maria Hägg; Fryknäs, Mårten et al.

Part of Nature Medicine, p. 1636-1640, 2011

• DOI for Inhibition of proteasome deubiquitinating activity as a new cancer therapy

High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligation

Leuchowius, Karl-Johan; Jarvius, Malin; Wickström, Malin; Rickardson, Linda et al.

Part of Molecular & Cellular Proteomics, p. 178-183, 2010

• DOI for High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligation

Anchoring of vascular endothelial growth factor to surface-immobilized heparin on pancreatic islets: implications for stimulating islet angiogenesis

Cabric, Sanja; Sanchez, Javier; Johansson, Ulrika; Larsson, Rolf et al.

Part of Tissue engineering. Part A, p. 961-970, 2010

• DOI for Anchoring of vascular endothelial growth factor to surface-immobilized heparin on pancreatic islets: implications for stimulating islet angiogenesis

The FMCA-GM assays, high throughput non-clonogenic alternatives to CFU-GM in preclinical hematotoxicity testing

Haglund, Caroline; Åleskog, Anna; Håkansson, Lena Douhan; Höglund, Martin et al.

Part of Toxicology Letters, p. 102-107, 2010

• DOI for The FMCA-GM assays, high throughput non-clonogenic alternatives to CFU-GM in preclinical hematotoxicity testing

Characterization of the cytotoxic properties of the benzimidazole fungicides, benomyl and carbendazim, in human tumour cell lines and primary cultures of patient tumour cells

Laryea, Daniel; Gullbo, Joachim; Isaksson, Anders; Larsson, Rolf et al.

Part of Anti-Cancer Drugs, p. 33-42, 2010

• DOI for Characterization of the cytotoxic properties of the benzimidazole fungicides, benomyl and carbendazim, in human tumour cell lines and primary cultures of patient tumour cells

Nanoparticulate Quillaja saponin induces apoptosis in human leukemia cell lines with a high therapeutic index

Hu, Kefei; Berenjian, Saideh; Larsson, Rolf; Gullbo, Joachim et al.

Part of International Journal of Nanomedicine, p. 51-62, 2010

The alkylating prodrug J1 can be activated by aminopeptidase N, leading to a possible target directed release of melphalan

Wickström, Malin; Viktorsson, Kristina; Lundholm, Lovisa; Aesoy, Reidun et al.

Part of Biochemical Pharmacology, p. 1281-1290, 2010

• DOI for The alkylating prodrug J1 can be activated by aminopeptidase N, leading to a possible target directed release of melphalan

Alpha Terpineol: A Potential Anticancer Agent which Acts through Suppressing NF-kappa B Signalling

Hassan, Saadia Bashir; Gali-Muhtasib, Hala; Göransson, Hanna; Larsson, Rolf

Part of Anticancer Research, p. 1911-1919, 2010

Safety and efficacy of NAD depleting cancer drugs: results of a phase I clinical trial of CHS 828 and overview of published data

von Heideman, Anne; Berglund, Åke; Larsson, Rolf; Nygren, Peter

Part of Cancer Chemotherapy and Pharmacology, p. 1165-1172, 2010

• DOI for Safety and efficacy of NAD depleting cancer drugs: results of a phase I clinical trial of CHS 828 and overview of published data

Identification of AKN-032, a novel 2-aminopyrazine tyrosine kinase inhibitor, with significant preclinical activity in acute myeloid leukemia

Eriksson, Anna; Höglund, Martin; Lindhagen, Elin; Åleskog, Anna et al.

Part of Biochemical Pharmacology, p. 1507-1516, 2010

• DOI for Identification of AKN-032, a novel 2-aminopyrazine tyrosine kinase inhibitor, with significant preclinical activity in acute myeloid leukemia

In vitro cellular drug sensitivity at diagnosis is correlated to minimal residual disease at end of induction therapy in childhood acute lymphoblastic leukemia

Lönnerholm, Gudmar; Thörn, Ingrid; Sundström, Christer; Frost, Britt-Marie et al.

Part of Leukemia Research, p. 46-53, 2009

• DOI for In vitro cellular drug sensitivity at diagnosis is correlated to minimal residual disease at end of induction therapy in childhood acute lymphoblastic leukemia

Effects of streptozotocin-induced diabetes in domestic pigs with focus on the amino acid metabolism

Jensen-Waern, M.; Andersson, M.; Kruse, R.; Nilsson, Bo et al.

Part of Laboratory Animals, p. 249-254, 2009

• DOI for Effects of streptozotocin-induced diabetes in domestic pigs with focus on the amino acid metabolism

ChemGPS-NP mapping of chemical compounds for prediction of anticancer mode of action

Rosén, Josefin; Rickardson, Linda; Backlund, Anders; Gullbo, Joachim et al.

Part of QSAR & combinatorial science (Print), p. 436-446, 2009

• DOI for ChemGPS-NP mapping of chemical compounds for prediction of anticancer mode of action

In vitro activity of bortezomib in cultures of patient tumour cells-potential utility in haematological malignancies

Wiberg, Kristina; Carlson, Kristina; Åleskog, Anna; Larsson, Rolf et al.

Part of Medical Oncology, p. 193-201, 2009

• DOI for In vitro activity of bortezomib in cultures of patient tumour cells-potential utility in haematological malignancies

Characterization of the cytotoxic activity of the indoloquinoline alkaloid cryptolepine in human tumour cell lines and primary cultures of tumour cells from patients

Laryea, Daniel; Isaksson, Anders; Wright, Colin; Larsson, Rolf et al.

Part of Investigational new drugs, p. 402-411, 2009

• DOI for Characterization of the cytotoxic activity of the indoloquinoline alkaloid cryptolepine in human tumour cell lines and primary cultures of tumour cells from patients

Combination analyses of anti-cancer drugs on human neuroendocrine tumor cell lines

Larsson, Dhana E.; Hassan, Sadia; Larsson, Rolf; Öberg, Kjell et al.

Part of Cancer Chemotherapy and Pharmacology, p. 5-12, 2009

• DOI for Combination analyses of anti-cancer drugs on human neuroendocrine tumor cell lines

Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system

Berndtsson, Maria; Beaujouin, Melanie; Rickardson, Linda; Havelka, Aleksandra Mandic et al.

Part of International Journal of Cancer, p. 1463-1469, 2009

• DOI for Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system

Utilization of a right-handed coiled-coil protein from archaebacterium Staphylothermus marinus as a carrier for cisplatin

Eriksson, Mathilda; Hassan, Saadia; Larsson, Rolf; Linder, Stig et al.

Part of Anticancer Research, p. 11-18, 2009

Dic(9;20)(p13;q11) in childhood acute lymphoblastic leukaemia is related to low cellular resistance to asparaginase, cytarabine and corticosteroids

Lönnerholm, Gudmar; Nordgren, A.; Frost, Britt-Marie; Jonsson, O. G. et al.

Part of Leukemia, p. 209-212, 2009

• DOI for Dic(9;20)(p13;q11) in childhood acute lymphoblastic leukaemia is related to low cellular resistance to asparaginase, cytarabine and corticosteroids

Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters

Fayad, Walid; Fryknäs, Mårten; Brnjic, Slavica; Olofsson, Maria Hägg et al.

Part of PLOS ONE, 2009

• DOI for Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters

Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1

Ahlin, Gustav; Karlsson, Johan; Pedersen, Jenny M; Gustavsson, Lena et al.

Part of Journal of Medicinal Chemistry, p. 5932-5942, 2008

• DOI for Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1

A new method for incorporating functional heparin onto the surface of islets of Langerhans

Cabric, Sanja; Eich, Torsten; Sanchez, Javier; Nilsson, Bo et al.

Part of Tissue Engineering. Part C, Methods, p. 141-147, 2008

• DOI for A new method for incorporating functional heparin onto the surface of islets of Langerhans

Significant cytotoxic activity in vitro of the EGFR tyrosine kinase inhibitor gefitinib in acute myeloblastic leukaemia

Lindhagen, Elin; Eriksson, Anna; Wickström, Malin; Danielsson, Katarina et al.

Part of European Journal of Haematology, p. 344-353, 2008

• DOI for Significant cytotoxic activity in vitro of the EGFR tyrosine kinase inhibitor gefitinib in acute myeloblastic leukaemia

The fluorometric microculture cytotoxicity assay

Lindhagen, Elin; Nygren, Peter; Larsson, Rolf

Part of Nature Protocols, p. 1364-1369, 2008

• DOI for The fluorometric microculture cytotoxicity assay

Anti colon cancer components from lebanese sage (Salvia libanotica) essential oil: Mechanistic basis

Itani, Wafica; El-Banna, Sarah; Hassan, Saadia; Larsson, Rolf et al.

Part of Cancer Biology & Therapy, p. 1765-1773, 2008

• DOI for Anti colon cancer components from lebanese sage (Salvia libanotica) essential oil: Mechanistic basis

Gene expression signature-based chemcial genomics and activity pattern in a panel of tumour cell lines propose linalyl acetate as a protein kinase/NF-κB inhibitor

Hassan, Saadia; Lindhagen, Elin; Göransson, Hanna; Fryknäs, Mårten et al.

Part of Gene Therapy and Molecular Biology, p. 359-370, 2008

Surface-adsorbed fibrinogen and fibrin may activate the contact activation system

Sanchez, Javier; Elgue, Graciela; Larsson, Rolf; Nilsson, Bo et al.

Part of Thrombosis Research, p. 257-263, 2008

• DOI for Surface-adsorbed fibrinogen and fibrin may activate the contact activation system

The novel alkylating prodrug J1: diagnosis directed activity profile ex vivo and combination analyses in vitro

Wickström, Malin; Haglund, Caroline; Lindman, Henrik; Nygren, Peter et al.

Part of Investigational new drugs, p. 195-204, 2008

• DOI for The novel alkylating prodrug J1: diagnosis directed activity profile ex vivo and combination analyses in vitro

Towards high-throughput single cell/clone cultivation and analysis

Lindström, Sara; Larsson, Rolf; Svahn, Helene Andersson

Part of Electrophoresis, p. 1219-1227, 2008

• DOI for Towards high-throughput single cell/clone cultivation and analysis

Heterogeneous activity of cytotoxic drugs in patient samples of peritoneal carcinomatosis

Mahteme, Haile; von Heideman, Anne; Grundmark, Birgitta; Tholander, B. et al.

Part of European Journal of Surgical Oncology, p. 547-552, 2008

• DOI for Heterogeneous activity of cytotoxic drugs in patient samples of peritoneal carcinomatosis

The novel melphalan prodrug J1 inhibits neuroblastoma growth in vitro and in vivo

Wickström, Malin; Johnsen, John Inge; Ponthan, Frida; Segerström, Lova et al.

Part of Molecular Cancer Therapeutics, p. 2409-2417, 2007

• DOI for The novel melphalan prodrug J1 inhibits neuroblastoma growth in vitro and in vivo

Allelic imbalance in gene expression as a guide to cis-acting regulatory single nucleotide polymorphisms in cancer cells

Milani, Lili; Gupta, Manu; Andersen, M.; Dhar, Sumeer et al.

Part of Nucleic Acids Research, 2007

• DOI for Allelic imbalance in gene expression as a guide to cis-acting regulatory single nucleotide polymorphisms in cancer cells

STAT1 signaling is associated with acquired crossresistance to doxorubicin and radiation in myeloma cell lines

Fryknäs, Mårten; Dhar, Sumeer; Öberg, Fredrik; Rickardson, Linda et al.

Part of International Journal of Cancer, p. 189-195, 2007

• DOI for STAT1 signaling is associated with acquired crossresistance to doxorubicin and radiation in myeloma cell lines

Image-based screening for the identification of novel proteasome inhibitors

Rickardson, Linda; Wickström, Malin; Larsson, Rolf; Lövborg, Henrik

Part of Journal of Biomolecular Screening, p. 203-210, 2007

• DOI for Image-based screening for the identification of novel proteasome inhibitors

R-etodolac (SDX-101) and the related indole-pyran analogues SDX-308 and SDX-309 potentiate the antileukemic activity of standard cytotoxic agents in primary chronic lymphocytic leukaemia cells

Lindhagen, Elin; Nissle, Sara; Leoni, L.; Elliott, G. et al.

Part of Cancer Chemotherapy and Pharmacology, p. 545-553, 2007

• DOI for R-etodolac (SDX-101) and the related indole-pyran analogues SDX-308 and SDX-309 potentiate the antileukemic activity of standard cytotoxic agents in primary chronic lymphocytic leukaemia cells

Antimicrobial and cytotoxic activity of agelasine and agelasimine analogs

Vik, Anders; Hedner, Erik; Charnock, Colin; Tangen, Linda et al.

Part of Bioorganic & Medicinal Chemistry, p. 4016-4037, 2007

• DOI for Antimicrobial and cytotoxic activity of agelasine and agelasimine analogs

The functional heterogeneity of eosinophil cationic protein is determined by a gene polymorphism and post-translational modifications

Trulson, Agneta; Byström, Jonas; Engström, Åke; Larsson, Rolf et al.

Part of Clinical and Experimental Allergy, p. 208-218, 2007

• DOI for The functional heterogeneity of eosinophil cationic protein is determined by a gene polymorphism and post-translational modifications

Modeling of in vitro drug activity and prediction of clinical outcome in acute myeloid leukemia

Quartino, Angelica; Karlsson, Mats O.; Freijs, Agneta; Jonsson, Niclas et al.

Part of Journal of clinical pharmacology, p. 1014-1021, 2007

• DOI for Modeling of in vitro drug activity and prediction of clinical outcome in acute myeloid leukemia

Pharmacological profiling of novel non-COX-inhibiting indole-pyran analogues of etodolac reveals high solid tumour activity of SDX-308 in vitro

Lindhagen, Elin; Rickardson, Linda; Elliott, Gary; Leoni, Lorenzo et al.

Part of Investigational new drugs, p. 297-303, 2007

• DOI for Pharmacological profiling of novel non-COX-inhibiting indole-pyran analogues of etodolac reveals high solid tumour activity of SDX-308 in vitro

Primary lymphocytes as predictors for species differences in cytotoxic drug sensitivity

Hassan, Saadia B.; Haglund, Caroline; Åleskog, Anna; Larsson, Rolf et al.

Part of Toxicology in Vitro, p. 1174-1181, 2007

• DOI for Primary lymphocytes as predictors for species differences in cytotoxic drug sensitivity

Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients

Wickström, Malin; Danielsson, Katarina; Rickardson, Linda; Gullbo, Joachim et al.

Part of Biochemical Pharmacology, p. 25-33, 2007

• DOI for Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients

In vitro drug sensitivity-gene expression correlations involve a tissue of origin dependency

Andersson, Claes R.; Fryknäs, Mårten; Rickardson, Linda; Larsson, Rolf et al.

Part of Journal of chemical information and modeling, p. 239-248, 2007

• DOI for In vitro drug sensitivity-gene expression correlations involve a tissue of origin dependency

Inhibition of proteasome activity, nuclear factor-KB translocation and cell survival by the antialcoholism drug disulfiram

Lövborg, Henrik; Öberg, Fredrik; Rickardson, Linda; Gullbo, Joachim et al.

Part of International Journal of Cancer, p. 1577-1580, 2006

• DOI for Inhibition of proteasome activity, nuclear factor-KB translocation and cell survival by the antialcoholism drug disulfiram

Effects on blood compatibility in vitro by combining a direct P2Y(12) receptor inhibitor and heparin coating of stents

Christensen, Kjeld; Larsson, Rolf; Emanuelsson, Håkan; Elgue, Graciela et al.

Part of Platelets, p. 318-327, 2006

• DOI for Effects on blood compatibility in vitro by combining a direct P2Y(12) receptor inhibitor and heparin coating of stents

p53 is involved in clearance of ionizing radiation-induced RAD51 foci in a human colon cancer cell line

Orre, Lukas M.; Stenerlöw, Bo; Dhar, Sumeer; Larsson, Rolf et al.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 1211-7, 2006

• DOI for p53 is involved in clearance of ionizing radiation-induced RAD51 foci in a human colon cancer cell line

Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model

Fryknäs, Mårten; Rickardson, Linda; Wickström, Malin; Dhar, Sumeer et al.

Part of Journal of Biomolecular Screening, p. 457-468, 2006

• DOI for Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model

CHS 828 kill tumour cells by inhibiting the nuclear factor-kappa B translocation but unlikely through down-regulation of proteasome

Hassan, Saadia B.; Lövborg, Henrik; Lindhagen, Elin; Karlsson, Mats O. et al.

Part of Anticancer Research, p. 4431-4436, 2006

Identification and evaluation of potential anti-cancer drugs on human neuroendocrine tumor cell lines

Larsson, Dhana E.; Lövborg, Henrik; Rickardson, Linda; Larsson, Rolf et al.

Part of Anticancer Research, p. 4125-4129, 2006

(+)-agelasine D: improved synthesis and evaluation of antibacterial and cytotoxic activities.

Vik, Anders; Hedner, Erik; Charnock, Colin; Samuelsen, Orjan et al.

Part of J Nat Prod, p. 381-6, 2006

Improved blood compatibility of a stent graft by combining heparin coating and abciximab.

Christensen, Kjeld; Larsson, Rolf; Emanuelsson, HÃ¥kan; Elgue, Graciela et al.

Part of Thromb Res, p. 245-53, 2005

Bioactive heparin immobilized onto microfluidic channels in poly(dimethylsiloxane) results in hydrophilic surface properties.

Thorslund, Sara; Sanchez, Javier; Larsson, Rolf; Nikolajeff, Fredrik et al.

Part of Colloids Surf B Biointerfaces, p. 240-7, 2005

Functionality and stability of heparin immobilized onto poly(dimethylsiloxane)

Thorslund, Sara; Sanchez, Javier; Larsson, Rolf; Nikolajeff, Fredrik et al.

Part of Colloids and Surfaces B, p. 76-81, 2005

• DOI for Functionality and stability of heparin immobilized onto poly(dimethylsiloxane)

Bioactive heparin immobilized onto microfluidic channels in poly(dimethylsiloxane) results in hydrophilic surface properties,

Thorslund, Sara; Sanchez, Javier; Larsson, Rolf; Nikolajeff, Fredrik et al.

Part of Colloids and Surfaces B: Biointerfaces, p. 106-113, 2005

In vitro activity of imatinib in cells from patients with adult acute lymphoblastic leukemia

Hallböök, Helene; Barbany, Gisela; Åleskog, Anna; Björnberg, Annelie et al.

Part of Anti-Cancer Drugs, p. 631-634, 2005

Translocation t(1;19) is related to low cellular drug resistance in childhood acute lymphoblastic leukaemia

Frost, B M; Forestier, E; Gustafsson, G; Nygren, Peter et al.

Part of Leukemia, p. 165-169, 2005

• DOI for Translocation t(1;19) is related to low cellular drug resistance in childhood acute lymphoblastic leukaemia

Predictive value of in vitro assessment of cytotoxic drug activity in advanced breast cancer.

Villman, Kenneth; Blomqvist, Carl; Larsson, Rolf; Nygren, Peter

Part of Anticancer Drugs, p. 609-15, 2005

In vitro activity of the flt3-inhibitor su5614 and standard cytotoxic agents in tumour cells from patients with wild type and mutated flt3 acute myeloid leukaemia.

Åleskog, Anna; Höglund, Martin; Pettersson, Jenny; Hermansson, Monica et al.

Part of Leuk Res, p. 1079-81, 2005

In vitro drug resistance in B cell chronic lymphocytic leukemia: a comparison with acute myelocytic and acute lymphocytic leukemia.

Åleskog, Anna; Larsson, Rolf; Höglund, Martin; Kristensen, Jörgen et al.

Part of Anticancer Drugs, p. 277-83, 2005

Screening for apoptosis--classical and emerging techniques.

Lövborg, Henrik; Gullbo, Joachim; Larsson, Rolf

Part of Anticancer Drugs, p. 593-9, 2005

Identification of molecular mechanisms for cellular drug resistance by combining drug activity and gene expression profiles

Rickardson, Linda; Fryknäs, Mårten; Dhar, Sumeer; Lövborg, Henrik et al.

Part of British Journal of Cancer, p. 483-492, 2005

Cellular drug sensitivity in MLL-rearranged childhood acute leukaemia is correlated to partner genes and cell lineage.

Palle, J; Frost, B M; Forestier, E; Gustafsson, G et al.

Part of Br J Haematol, p. 189-98, 2005

Pharmacokinetic-pharmacodynamic modelling of the schedule-dependent effect of the anti-cancer agent CHS 828 in a rat hollow fibre model.

Friberg, Lena E; Hassan, Saadia B; Lindhagen, Elin; Larsson, Rolf et al.

Part of Eur J Pharm Sci, p. 163-73, 2005

Translocation t(12;21) is related to in vitro cellular drug sensitivity to doxorubicin and etoposide in childhood acute lymphoblastic leukemia

Frost, Britt-Marie; Forestier, Erik; Gustafsson, Göran; Nygren, Peter et al.

Part of Blood, p. 2452-7, 2004

• DOI for Translocation t(12;21) is related to in vitro cellular drug sensitivity to doxorubicin and etoposide in childhood acute lymphoblastic leukemia

Pharmacodynamic differences between species exemplified by the novel anticancer agent CHS 828

Lindhagen, Elin; Vig-Hjarnaa, Pernille; Friberg, Lena E; Latini, Scilla et al.

Part of Drug development research, p. 218-226, 2004

• DOI for Pharmacodynamic differences between species exemplified by the novel anticancer agent CHS 828

Multiparametric evaluation of apoptosis: effects of standard cytotoxic agents and the cyanoguanidine CHS 828

Lövborg, Henrik; Nygren, Peter; Larsson, Rolf

Part of Molecular Cancer Therapeutics, p. 521-526, 2004

Cytotoxic cyclotides from Viola tricolor

Svangård, Erika; Göransson, Ulf; Hocaoglu, Zozan; Gullbo, Joachim et al.

Part of Journal of natural products (Print), p. 144-7, 2004

• DOI for Cytotoxic cyclotides from Viola tricolor

Antitumor efficacy and acute toxicity of the novel dipeptide melphalanyl-p-L-fluorophenylalanine ethyl ester (J1) in vivo.

Gullbo, Joachim; Lindhagen, Elin; Bashir-Hassan, Saadia; Tullberg, Marcus et al.

Part of Invest New Drugs, p. 411-20, 2004

Development and characterization of two human tumor sublines expressing high-grade resistance to the cyanoguadine CHS 828

Gullbo, Joachim; Lövborg, Henrik; Dhar, Sumeer; Lukinius, Agneta et al.

Part of Anti-Cancer Drugs, p. 45-54, 2004

VH gene mutation status and cellular drug resistance in chronic lymphocytic leukemia

Åleskog, Anna; Tobin, Gerard; Laurell, Anna; Thunberg, Ulf et al.

Part of Eur J Haematol, p. 407-411, 2004

Anticancer agent CHS 828 suppresses nuclear factor-kappa B activity in cancer cells through downregulation of IKK activity.

Olsen, Lone Stengelshøj; Hjarnaa, Pernille-Julia Vig; Latini, Scilla; Holm, Pernille Kaae et al.

Part of Int J Cancer, p. 198-205, 2004

Cytotoxicity and pharmacokinetics of cladribine metabolite, 2-chloroadenine in patients with leukemia.

Lindemalm, Synnöve; Liliemark, Jan; Juliusson, Gunnar; Larsson, Rolf et al.

Part of Cancer Lett, p. 171-7, 2004

Cytotoxic effect in vivo and in vitro of CHS 828 on human myeloma cell lines.

Hovstadius, Peter; Lindhagen, Elin; Hassan, Sadia; Nilsson, Kenneth et al.

Part of Anticancer Drugs, p. 63-70, 2004

Cytotoxic activity of a new paclitaxel formulation, Pacliex, in vitro and in vivo.

Hassan, Saadia; Dhar, Sumeer; Sandstrom, M; Arsenau, D et al.

Part of Cancer Chemother Pharmacol., 2004

Characterization of heparin surfaces using photoelectron spectroscopy and quartz crystal microbalance

Kristensen, E; Rensmo, H; Larsson, R; Siegbahn, H

Part of Biomaterials, p. 4153-4159, 2003

Antitumor activity of the novel melphalan containing tripeptide J3 (L-prolyl-melphalanyl-p-L-fluorophenylalanine ethyl ester): Comparison with its m-L-sarcolysin analogue P2

Gullbo, Joachim; Wallinder, Charlotta; Tullberg, Marcus; Lövborg, Henrik et al.

Part of Molecular Cancer Therapeutics, p. 1331-1339, 2003

Structure activity relationship for alkylating dipeptide nitrogen mustard derivatives

Gullbo, Joachim; Tullberg, Marcus; Våbeno, Jon; Ehrsson, Hans et al.

Part of Oncology Research, p. 113-132, 2003

Increased in vitro cellular drug resistance is related to poor outcome in high-risk childhood acute lymphoblastic leukaemia

Frost, Britt-Marie; Nygren, Peter; Gustafsson, G; Forestier, E et al.

Part of British Journal of Haematology, p. 376-385, 2003

• DOI for Increased in vitro cellular drug resistance is related to poor outcome in high-risk childhood acute lymphoblastic leukaemia

Small, novel proteins from the mistletoe Phoradendron tomentosum exhibit highly selective cytotoxicity to human breast cancer cells

Johansson, S.; Gullbo, Joachim; Lindholm, P.; Ek, B. et al.

Part of Cellular and Molecular Life Sciences (CMLS), p. 165-175, 2003

• DOI for Small, novel proteins from the mistletoe Phoradendron tomentosum exhibit highly selective cytotoxicity to human breast cancer cells

Overview of the clinical efficacy of investigational anticancer drugs.

Nygren, Peter; Larsson, Rolf

Part of J Intern Med., p. 46, 2003

Population pharmacokinetic modelling of unbound and total plasma concentrations of paclitaxel in cancer patients.

Henningsson, A; Sparreboom, A; Sandström, M; Freijs, A et al.

Part of Eur J Cancer., p. 1105, 2003

Antitumor activity of the alkylating oligopeptides J1(L-melphalanyl-p-L-fluorophenylalanine ethyl ester) and P2(L-prolyl-m-L-fluorophenylalanine ethyl ester):comparison with melphalan.

Gullbo, Joachim; Dhar, Sumeer; Luthman, K; Ehrsson, H et al.

Part of Anticancer Drugs., p. 617, 2003

Inhibition of thrombin abrogates the instant blood-mediated inflammatory reaction triggered by isolated human islets: possible application of the thrombin inhibitor melagatran in clinical islet transplantation.

Moberg, Lisa; Ekdahl, Kristina Nilsson; Elgue, Graciela; Larsson, Rolf et al.

Part of Diabetes, p. 1779-84, 2002

C3 adsorbed to a polymer surface can form an initiating alternative pathway convertase.

Andersson, Jonas; Nilsson Ekdahl, Kristina; Larsson, Rolf; Nilsson, Ulf R et al.

Part of J Immunol, p. 5786, 2002

Cell adhesion and tissue factor upregulation in oxygenators used during coronary artery bypass grafting are modified by the Corline Heparin Surface

Johnell, Matilda; Elgue, Graciela; Thelin, Stefan; Larsson, Rolf et al.

Part of Scandinavian Cardiovascular Journal, p. 351-357, 2002

• DOI for Cell adhesion and tissue factor upregulation in oxygenators used during coronary artery bypass grafting are modified by the Corline Heparin Surface

Coagulation, fibrinolysis and cell activation in patients and shed mediastinal blood during coronary artery bypass grafting using a new heparin-coated surface

Johnell, Matilda; Elgue, Graciela; Larsson, Rolf; Larsson, Anders et al.

Part of Journal of Thoracic and Cardiovascular Surgery, p. 321-332, 2002

• DOI for Coagulation, fibrinolysis and cell activation in patients and shed mediastinal blood during coronary artery bypass grafting using a new heparin-coated surface

Cyclotides: a novel type of cytotoxic agents

Lindholm, Petra; Göransson, Ulf; Johansson, Senia; Claeson, Per et al.

Part of Molecular Cancer Therapeutics, p. 365-369, 2002

In vitro activity of the novel cytotoxic agent CHS 828 in childhood acute leukemia

Frost, Britt-Marie; Lönnerholm, Gudmar; Nygren, Peter; Larsson, Rolf et al.

Part of Anti-Cancer Drugs, p. 735-742, 2002

Ligatoxin B, a new cytotoxic protein with a novel helix-turn-helix DNA-binding domain from the mistletoe Phoradendron liga

Li, Shi-Sheng; Gullbo, Joachim; Lindholm, Petra; Larsson, Rolf et al.

Part of Biochemical Journal, p. 405-13, 2002

• DOI for Ligatoxin B, a new cytotoxic protein with a novel helix-turn-helix DNA-binding domain from the mistletoe Phoradendron liga

A phase I study of CHS 828 in patients with solid tumor malignancy.

Hovstadius, Peter; Larsson, Rolf; Jonsson, Elin; Skov, T et al.

Part of Clin Cancer Res., p. 2843, 2002

In vitro evaluation of the efficacy of idarubicin in human tumour cells from patients with low-grade non-Hodgkin´s lymphoma.

Åleskog, Anna; Jonsson, Elin; Larsson, Rolf; Nygren, Peter et al.

Part of Br J Haematol, p. 563, 2002

Action of a novel anticancer agent, CHS 828, on mouse fibroblasts: increased sensitivity of cells lacking poly (ADP-Ribose) polymerase-1

Lövborg, Henrik; Wojciechowski, J; Larsson, Rolf; Wesierska-Gadek, J

Part of Cancer Res., p. 4206, 2002

DNA-dependent protein kinase in leukaemia cells and correlation with drug sensitivity.

Eriksson, A; Lewensohn, R; Larsson, Rolf; Nilsson, A

Part of Anticancer Res., p. 1787, 2002

Metabolic effects of the cytotoxic guanidino-containing drug CHS 828 in human U-937 lymphoma cells.

Ekelund, Sara; Larsson, Rolf; Nygren, Peter

Part of Anticancer Res, p. 2269, 2002

Interactions between the new cytotoxic drug CHS 828 and amiloride and mitomycin C in a human tumour cell line and in tumour cells from patients.

Ekelund, Sara; Persson, I; Larsson, Rolf; Nygren, Peter

Part of Chemotherapy, p. 196, 2002

Cytotoxic activity of a new lipid formulation of doxorubicin in cell lines and primary tumor cells.

Gullbo, Joachim; Arsenau, D; Grundmark, Birgitta; Alvfors, Carina et al.

Part of Anticancer Res, p. 4191, 2002

Assessment of drug activity and proliferation ex vivo for prediction ofoutcome in aggressive non-Hodgkin's lymphomas.

Ericsson, SM; Larsson, Rolf; Nygren, Peter; Sundstrom, C et al.

Part of Acta Oncol, p. 36, 2002

Selection of chemotherapy by ex vivo assessment of tumor sensitivity tocytotoxic drugs: results of a clinical trial.

Berglund, A; Glimelius, B; Bergh, J; Brodin, O et al.

Part of Med Oncol, p. 151, 2002

CHS 828 inhibits neuroblastoma growth in mice alone and in combination with antiangiogeneic drugs.

Svensson, Å; Bäckman, U; Jonsson, Elin; Larsson, Rolf et al.

Part of Pediatric Res, p. 607, 2002

Modulation of pyridyl cyanoguanidine (CHS 828) induced cytotoxicity by 3-aminobenzamide in U-937 GTB cells.

Lövborg, Henrik; Martinsson, Petra; Gullbo, Joachim; Ekelund, Sara et al.

Part of Biochem Pharmacol, p. 1491, 2002

The combination of the antitumoural pyridyl cyanoguanidine CHS 828 and etoposide in vitro from cytotoxic synergy to complete inhibition of apoptosis.

Martinsson, Petra; Ekelund, Sara; Nygren, Peter; Larsson, Rolf

Part of Br J Pharmacol, p. 568, 2002

Contact between a polymer and whole blood: sequence of events leading to thrombin generation.

Hong, Jaan; Larsson, Anders; Ekdahl, Kristina; Elgue, Graciela et al.

Part of J Lab Clin Med, p. 139, 2001

Binding of a model regulator of complement activation (RCA) to a biomaterial surface: surface-bound factor H inhibits complement activation.

Andersson, Jonas; Larsson, Rolf; Richter, Ralf; Nilsson Ekdahl, Kristina et al.

Part of Biomaterials, p. 2435, 2001

A new in vitro model for the study of pig-to human vascular hyperacute rejection.

Bennet, W; Wundberg, B; Elgue, Graciela; Larsson, Rolf et al.

Part of Xentotransplantation, p. 176, 2001

Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells

Johansson, Senia; Lindholm, Petra; Gullbo, Joachim; Larsson, Rolf et al.

Part of Anti-Cancer Drugs, p. 475-83, 2001

Temporal effects of the novel antitumour pyridyl cyanoguanidine CHS 828, on human lymphoma cells.

Martinsson, Petra; Liminga, Gunnar; Dhar, Sumeer; de la Torre, M et al.

Part of Eur J Cancer, p. 260, 2001

Cellular pharmacodynamics of the cytotoxic guanidino-containing drug CHS 828. Comparison with methylglyoxal-bis (guanylhydrazone).

Ekelund, Sara; Sjoholm, Å; Nygren, Peter; Binderup, L et al.

Part of Eur J Pharmacol, p. 39, 2001

Activity of CHS 828 in primary cultures of human hematological and solidtumors in vitro.

Åleskog, Anna; Bashir-Hassan, Saadai; Hovstadius, Peter; Kristensen, J et al.

Part of Anti-Cancer Drugs, p. 821, 2001

Model for time dependency of the cytotoxic effect of CHS 828 in vitro suggests two different mechanisms of action.

Hassan, Sadia; Jonsson, Elin; Larsson, Rolf; Karlsson, MO

Part of J Pharmacol Exp Ther, p. 1140, 2001

Characteristics of etoposide induced apoptopic cell death in the U-937 human lymphoma cell line.

Martinsson, Petra; Liminga, Gunnar; Nygren, Peter; Larsson, Rolf

Part of Anti-Cancer Drugs, p. 699, 2001

Guanidino-containing drugs in cancer chemotherapy: biochemical and clinical pharmacology.

Ekelund, Sara; Nygren, Peter; Larsson, Rolf

Part of Biochem Pharmacol, p. 1183, 2001

A hollow fiber model for in vitro studies of cytotoxic compounds: activityof the cyanoguanidine CHS 828.

Hassan, Saadia B; de la Torre, M; Nygren, Peter; Karlsson, MO et al.

Part of Anti-Cancer Drugs, p. 33, 2001

In vivo activity of CHS 828 on hollow-fibre cultures of primary humantumour cells from patients.

Jonsson, Elin; Friberg, LE; Karlsson, MO; Hassan, Saadia B et al.

Part of Cancer Lett, p. 193, 2001

Cell death with atypical features induced by the novel antitumoral drug CHS 828, in human U-937 GTB cells.

Martinsson, Petra; de la Torre, M; Binderup, L; Nygren, Peter et al.

Part of Eur J Pharmacol, p. 181, 2001

Evaluation of drug interactions in the established FEC regimen in primary cultures of tumour cells from patients

von Heideman, A; Sandström, M; Csoka, K; Tholander, Bengt et al.

Part of Annals of Oncology, p. 1301-1307, 2000

Antitumor effect of suramin analogues in human tumour cell lines and primary cultures of tumour cells

Dhar, Sumeer; Gullbo, Joachim; Csoka, Katalin; Eriksson, E et al.

Part of Eur J Cancer, p. 803, 2000

Cellular cytotoxic drug sensitivity in children with leukemia and Down´s syndrome: an explanation differences in clinical outcome?

Frost, BM; Gustafsson, G; Nygren, Peter; Larsson, Rolf et al.

Part of Leukemia, 2000

Early stimulation of acidification rate by novel cytotoxic pyridyl cyanoguanidines in human tumor cells: comparison with m-iodobenzylguanidine

Ekelund, Sara; Liminga, Gunnar; Bjorkling, F; Ottosen, E et al.

Part of Biochem Pharmacol, p. 839, 2000

Differential activity of topotecan, irinotecan and SN-38 in primary cultures of human tumor cells but not in cell lines.

Jonsson, Elin; Dhar, Sumeer; Jonsson, B; Nygren, Peter et al.

Part of Eur J Cancer, p. 2120, 2000

Determination of drug effect on tumor cells, host animal toxicity and drug pharmacokinetics in a hollow fiber model in rats.

Jonsson, Elin; Simonsen, LE; Hassan, Sadia; Freijs, A et al.

Part of Cancer Chemother Pharmacol, p. 493, 2000

Cyanoguanidine CHS 828 induces programmed cell death with apoptotic features in human breast cancer cells in vitro.

Hansen, CM; Hansen, D; Holm, PK; Larsson, Rolf et al.

Part of Anticancer Res., p. 4211, 2000

Apoptosis induced by calcein acetoxymethyl ester in the human histiocytic lymphoma cell line U-937 GTB.

Liminga, Gunnar; Martinsson, Petra; Jonsson, B; Nygren, Peter et al.

Part of Biochem Pharmacol, p. 1751, 2000

Melflufen: a peptidase-potentiated alkylating agent in clinical trials

Wickström, Malin; Nygren, Peter; Larsson, Rolf; Harmenberg, Johan et al.

Part of Oncotarget, p. 66641-66655, 2017

• DOI for Melflufen: a peptidase-potentiated alkylating agent in clinical trials
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Aminopeptidase N (CD13) as a target for cancer chemotherapy

Wickström, Malin; Larsson, Rolf; Nygren, Peter; Gullbo, Joachim

Part of Cancer Science, p. 501-508, 2011

• DOI for Aminopeptidase N (CD13) as a target for cancer chemotherapy

Hemocompatibility of Nanocellulose Polypyrrole Membranes Intended for Hemodialysis

Ferraz, Natalia; Carlsson, Daniel O; Hong, Jaan; Larsson, Rolf et al.

Part of 9th World Biomaterials Congress, June 1-5, 2012, Chengdu, China, 2012

Ex vivo activity of cytotoxic drugs and targeted agents in Small Intestinal NETs

Daskalakis, Kosmas; Norlén, Olov; Karakatsanis, Andreas; Hellman, Per et al.

Drug combination screening in multicellular tumor spheroids identifies synthetic lethalities in quiescent cancer cells

Senkowski, Wojciech; Nazir, Madiha; Gustafsson, Mats G; Nygren, Peter et al.

Paired glioblastoma cell cultures of the fluorescent bulk tumor and non-fluorescent tumor margin display differential phenotypes and cell states across patients

Neves, Inês; Lu, Xi; Maturi, Nagaprathyusha; Dang, Yonglong et al.