Diarmaid Hughes

Repurposing zidovudine and 5-fluoro-2′-deoxyuridine as antibiotic drugs made possible by synergy with both trimethoprim and the mitochondrial toxicity–reducing agent uridine

Levenfors, Jolanta J.; Bjerketorp, Joakim; Guss, Bengt; Nord, Christina et al.

Part of Journal of Antimicrobial Chemotherapy, p. 509-517, 2024

• DOI for Repurposing zidovudine and 5-fluoro-2′-deoxyuridine as antibiotic drugs made possible by synergy with both trimethoprim and the mitochondrial toxicity–reducing agent uridine
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Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria

Huseby, Douglas L.; Cao, Sha; Zamaratski, Edouard; Sooriyaarachchi, Sanjeewani et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2024

• DOI for Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria
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Model-informed drug development for antimicrobials: translational pharmacokinetic-pharmacodynamic modelling of apramycin to facilitate prediction of efficacious dose in complicated urinary tract infections

Hernández-Lozano, Irene; Aranzana-Climent, Vincent; Cao, Sha; Matias, Carina et al.

Part of Journal of Antimicrobial Chemotherapy, 2024

• DOI for Model-informed drug development for antimicrobials: translational pharmacokinetic-pharmacodynamic modelling of apramycin to facilitate prediction of efficacious dose in complicated urinary tract infections
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Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors

Benediktsdottir, Andrea; Sooriyaarachchi, Sanjeewani; Cao, Sha; Ottosson, Nina E. et al.

Part of European Journal of Medicinal Chemistry, 2024

• DOI for Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors
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Apramycin efficacy against carbapenem- and aminoglycoside-resistant Escherichia coli and Klebsiella pneumoniae in murine bloodstream infection models

Frimodt-Møller, Niels; Hansen, Jon U.; Plattner, Michel; Huseby, Douglas L. et al.

Part of International Journal of Antimicrobial Agents, 2024

• DOI for Apramycin efficacy against carbapenem- and aminoglycoside-resistant Escherichia coli and Klebsiella pneumoniae in murine bloodstream infection models
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Repurposing zidovudine and 5-fluoro-2′-deoxyuridine as antibiotic drugs made possible by synergy with both trimethoprim and the mitochondrial toxicity–reducing agent uridine

Levenfors, Jolanta J.; Bjerketorp, Joakim; Guss, Bengt; Nord, Christina et al.

Part of Journal of Antimicrobial Chemotherapy, p. 509-517, 2024

• DOI for Repurposing zidovudine and 5-fluoro-2′-deoxyuridine as antibiotic drugs made possible by synergy with both trimethoprim and the mitochondrial toxicity–reducing agent uridine
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Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria

Huseby, Douglas L.; Cao, Sha; Zamaratski, Edouard; Sooriyaarachchi, Sanjeewani et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2024

• DOI for Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria
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Model-informed drug development for antimicrobials: translational pharmacokinetic-pharmacodynamic modelling of apramycin to facilitate prediction of efficacious dose in complicated urinary tract infections

Hernández-Lozano, Irene; Aranzana-Climent, Vincent; Cao, Sha; Matias, Carina et al.

Part of Journal of Antimicrobial Chemotherapy, 2024

• DOI for Model-informed drug development for antimicrobials: translational pharmacokinetic-pharmacodynamic modelling of apramycin to facilitate prediction of efficacious dose in complicated urinary tract infections
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Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors

Benediktsdottir, Andrea; Sooriyaarachchi, Sanjeewani; Cao, Sha; Ottosson, Nina E. et al.

Part of European Journal of Medicinal Chemistry, 2024

• DOI for Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors
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Apramycin efficacy against carbapenem- and aminoglycoside-resistant Escherichia coli and Klebsiella pneumoniae in murine bloodstream infection models

Frimodt-Møller, Niels; Hansen, Jon U.; Plattner, Michel; Huseby, Douglas L. et al.

Part of International Journal of Antimicrobial Agents, 2024

• DOI for Apramycin efficacy against carbapenem- and aminoglycoside-resistant Escherichia coli and Klebsiella pneumoniae in murine bloodstream infection models
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Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model

Zhao, Chenyan; Kristoffersson, Anders N.; Khan, David D.; Lagerbäck, Pernilla et al.

Part of Scientific Reports, 2024

• DOI for Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model
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Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa

Cotman, Andrej Emanuel; Durcik, Martina; Tiz, Davide Benedetto; Fulgheri, Federica et al.

Part of Journal of Medicinal Chemistry, p. 1380-1425, 2023

• DOI for Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa
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New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus

Durcik, Martina; Cotman, Andrej Emanuel; Toplak, Zan; Mozina, Stefan et al.

Part of Journal of Medicinal Chemistry, p. 3968-3994, 2023

• DOI for New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus
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Evolution of Bacterial Interspecies Hybrids with Enlarged Chromosomes

Bartke, Katrin; Huseby, Douglas L; Brandis, Gerrit; Hughes, Diarmaid

Part of Genome Biology and Evolution, 2022

• DOI for Evolution of Bacterial Interspecies Hybrids with Enlarged Chromosomes
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Positive Selection during Niche Adaptation Results in Large-Scale and Irreversible Rearrangement of Chromosomal Gene Order in Bacteria

Cao, Sha; Brandis, Gerrit; Huseby, Douglas L; Hughes, Diarmaid

Part of Molecular biology and evolution, 2022

• DOI for Positive Selection during Niche Adaptation Results in Large-Scale and Irreversible Rearrangement of Chromosomal Gene Order in Bacteria
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Expert workshop summary: Advancing toward a standardized murine model to evaluate treatments for antimicrobial resistance lung infections

Arrazuria, Rakel; Kerscher, Bernhard; Huber, Karen E.; Hoover, Jennifer L. et al.

Part of Frontiers in Microbiology, 2022

• DOI for Expert workshop summary: Advancing toward a standardized murine model to evaluate treatments for antimicrobial resistance lung infections
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Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)

Lu, Lu; Åkerbladh, Linda; Ahmad, Shabbir; Konda, Vivek et al.

Part of ACS - Infectious Diseases, p. 482-498, 2022

• DOI for Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)
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Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia

Aranzana-Climent, Vincent; Hughes, Diarmaid; Cao, Sha; Tomczak, Magdalena et al.

Part of Clinical Microbiology and Infection, p. 1367-1374, 2022

• DOI for Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia
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Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli

Praski Alzrigat, Lisa; Huseby, Douglas L.; Brandis, Gerrit; Hughes, Diarmaid

Part of Journal of Antimicrobial Chemotherapy, p. 77-83, 2021

• DOI for Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli
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Phenotypic and genetic barriers to establishment of horizontally transferred genes encoding ribosomal protection proteins

Yadav, Kavita; Garoff, Linnea; Huseby, Douglas L; Hughes, Diarmaid

Part of Journal of Antimicrobial Chemotherapy, p. 1441-1447, 2021

• DOI for Phenotypic and genetic barriers to establishment of horizontally transferred genes encoding ribosomal protection proteins

Genetic Architecture and Fitness of Bacterial Interspecies Hybrids

Bartke, Katrin; Garoff, Linnéa; Huseby, Douglas L; Brandis, Gerrit et al.

Part of Molecular biology and evolution, p. 1472-1481, 2021

• DOI for Genetic Architecture and Fitness of Bacterial Interspecies Hybrids
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Chromosomal Location Determines the Rate of Intrachromosomal Homologous Recombination in Salmonella

Garmendia, Eva; Brandis, Gerrit; Guy, Lionel; Cao, Sha et al.

Part of mBio, 2021

• DOI for Chromosomal Location Determines the Rate of Intrachromosomal Homologous Recombination in Salmonella
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ENABLE: an engine for European antibacterial drug discovery and development

Olliver, Marie; Griestop, Laura; Hughes, Diarmaid; Belfrage, Anna Karin et al.

Part of Nature reviews. Drug discovery, p. 407-408, 2021

• DOI for ENABLE: an engine for European antibacterial drug discovery and development

Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation

Benediktsdottir, Andrea; Lu, Lu; Cao, Sha; Zamaratski, Edouard et al.

Part of European Journal of Medicinal Chemistry, 2021

• DOI for Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation
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Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin

Sou, Tomás; Hansen, Jon; Liepinsh, Edgars; Backlund, Maria et al.

Part of Clinical Pharmacology and Therapeutics, p. 1063-1073, 2021

• DOI for Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin
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Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice

Becker, Katja; Aranzana-Climent, Vincent; Cao, Sha; Nilsson, Anna et al.

Part of Clinical Microbiology and Infection, p. 1315-1321, 2021

• DOI for Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice
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Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis

Becker, Katja; Cao, Sha; Nilsson, Anna; Erlandsson, Maria et al.

Part of EBioMedicine, 2021

• DOI for Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis
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Evaluating the potential efficacy and limitations of a phage for joint antibiotic and phage therapy of Staphylococcus aureus infections

Berryhill, Brandon A.; Huseby, Douglas L; McCall, Ingrid C.; Hughes, Diarmaid et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2021

• DOI for Evaluating the potential efficacy and limitations of a phage for joint antibiotic and phage therapy of Staphylococcus aureus infections
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Expression of the qepA1 gene is induced under antibiotic exposure

Brandis, Gerrit; Gockel, Jonas; Garoff, Linnéa; Guy, Lionel et al.

Part of Journal of Antimicrobial Chemotherapy, p. 1433-1440, 2021

• DOI for Expression of the qepA1 gene is induced under antibiotic exposure
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Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response

Brandis, Gerrit; Granström, Susanna; Leber, Anna T.; Bartke, Katrin et al.

Part of Journal of Antimicrobial Chemotherapy, p. 606-615, 2021

• DOI for Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response
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Isopedopeptins A-H: Cationic Cyclic Lipodepsipeptides from Pedobacter cryoconitis UP508 Targeting WHO Top-Priority Carbapenem-Resistant Bacteria

Nord, Christina; Bjerketorp, Joakim; Levenfors, Jolanta J.; Cao, Sha et al.

Part of ACS Chemical Biology, p. 2937-2944, 2020

• DOI for Isopedopeptins A-H: Cationic Cyclic Lipodepsipeptides from Pedobacter cryoconitis UP508 Targeting WHO Top-Priority Carbapenem-Resistant Bacteria
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The SNAP hypothesis: Chromosomal rearrangements could emerge from positive Selection during Niche Adaptation

Brandis, Gerrit; Hughes, Diarmaid

Part of PLOS Genetics, 2020

• DOI for The SNAP hypothesis: Chromosomal rearrangements could emerge from positive Selection during Niche Adaptation
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Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli

Garoff, Linnéa; Pietsch, Franziska; Huseby, Douglas L; Lilja, Tua et al.

Part of Molecular biology and evolution, p. 1637-1646, 2020

• DOI for Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli
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Synthesis of New N-Acyl-1,2,3-triazole Chalcones and Determination of Their Antibacterial Activity

Odin, I. S.; Cao, Sha; Hughes, Diarmaid; Zamaratskii, E. V. et al.

Part of Doklady. Chemistry, p. 89-92, 2020

• DOI for Synthesis of New N-Acyl-1,2,3-triazole Chalcones and Determination of Their Antibacterial Activity

Structure-activity relationship studies on the inhibition of the bacterial translation of novel Odilorhabdins analogues

Loza, Einars; Sarciaux, Matthieu; Ikaunieks, Martins; Katkevics, Martins et al.

Part of Bioorganic & Medicinal Chemistry, 2020

• DOI for Structure-activity relationship studies on the inhibition of the bacterial translation of novel Odilorhabdins analogues

Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene

Huseby, Douglas L; Brandis, Gerrit; Praski Alzrigat, Lisa; Hughes, Diarmaid

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 3185-3191, 2020

• DOI for Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene
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Measuring Homologous Recombination Rates between Chromosomal Locations in Salmonella

Brandis, Gerrit; Cao, Sha; Hughes, Diarmaid

Part of Bio-protocol, 2019

• DOI for Measuring Homologous Recombination Rates between Chromosomal Locations in Salmonella

Operon Concatenation Is an Ancient Feature That Restricts the Potential to Rearrange Bacterial Chromosomes

Brandis, Gerrit; Cao, Sha; Hughes, Diarmaid

Part of Molecular biology and evolution, p. 1990-2000, 2019

• DOI for Operon Concatenation Is an Ancient Feature That Restricts the Potential to Rearrange Bacterial Chromosomes
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In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii

Juhas, Mario; Widlake, Emma; Teo, Jeanette; Huseby, Douglas L et al.

Part of Journal of Antimicrobial Chemotherapy, p. 944-952, 2019

• DOI for In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii
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Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site

Pantel, Lucile; Florin, Tanja; Dobosz-Bartoszek, Malgorzata; Racine, Emilie et al.

Part of Molecular Cell, p. 83-94, 2018

• DOI for Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site

Co-evolution with recombination affects the stability of mobile genetic element insertions within gene families of Salmonella

Brandis, Gerrit; Cao, Sha; Hughes, Diarmaid

Part of Molecular Microbiology, p. 697-710, 2018

• DOI for Co-evolution with recombination affects the stability of mobile genetic element insertions within gene families of Salmonella
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Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase

Szałaj, Natalia; Lu, Lu; Benediktsdottir, Andrea; Zamaratski, Edouard et al.

Part of European Journal of Medicinal Chemistry, p. 1346-1360, 2018

• DOI for Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase

Muramyl Endopeptidase Spr Contributes to Intrinsic Vancomycin Resistance in Salmonella enterica Serovar Typhimurium

Vestö, Kim; Huseby, Douglas L; Snygg, Lina; Wang, Helen et al.

Part of Frontiers in Microbiology, 2018

• DOI for Muramyl Endopeptidase Spr Contributes to Intrinsic Vancomycin Resistance in Salmonella enterica Serovar Typhimurium
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Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB.

Brandis, Gerrit; Hughes, Diarmaid

Part of Scientific Reports, 2018

• DOI for Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB.
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Increased expression of Qnr is sufficient to confer clinical resistance to ciprofloxacin in Escherichia coli

Garoff, Linnéa; Yadav, Kavita; Hughes, Diarmaid

Part of Journal of Antimicrobial Chemotherapy, p. 348-352, 2018

• DOI for Increased expression of Qnr is sufficient to confer clinical resistance to ciprofloxacin in Escherichia coli
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Methods to determine mutational trajectories after experimental evolution of antibiotic resistance.

Huseby, Douglas L; Hughes, Diarmaid

Part of Methods in Molecular Biology, p. 95-103, 2018

• DOI for Methods to determine mutational trajectories after experimental evolution of antibiotic resistance.

Effect of aminoacyl-tRNA synthetase mutations on susceptibility to ciprofloxacin in Escherichia coli

Garoff, Linnéa; Huseby, Douglas L; Praski Alzrigat, Lisa; Hughes, Diarmaid

Part of Journal of Antimicrobial Chemotherapy, p. 3285-3292, 2018

• DOI for Effect of aminoacyl-tRNA synthetase mutations on susceptibility to ciprofloxacin in Escherichia coli
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Transcriptional Regulation Buffers Gene Dosage Effects on a Highly Expressed Operon in Salmonella

Garmendia, Eva; Brandis, Gerrit; Hughes, Diarmaid

Part of mBio, 2018

• DOI for Transcriptional Regulation Buffers Gene Dosage Effects on a Highly Expressed Operon in Salmonella
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Imidazopyrazinones (IPYs): Non-Quinolone Bacterial Topoisomerase Inhibitors Showing Partial Cross-Resistance with Quinolones

Jeannot, Frédéric; Taillier, Thomas; Despeyroux, Pierre; Renard, Stéphane et al.

Part of Journal of Medicinal Chemistry, p. 3565-3581, 2018

• DOI for Imidazopyrazinones (IPYs): Non-Quinolone Bacterial Topoisomerase Inhibitors Showing Partial Cross-Resistance with Quinolones

Predicting mutant selection in competition experiments with ciprofloxacin-exposed Escherichia coli

Khan, David; Lagerbäck, Pernilla; Malmberg, Christer; Kristoffersson, Anders et al.

Part of International Journal of Antimicrobial Agents, p. 399-406, 2018

• DOI for Predicting mutant selection in competition experiments with ciprofloxacin-exposed Escherichia coli

The processive kinetics of gene conversion in bacteria

Paulsson, Johan; El Karoui, Meriem; Lindell, Monica; Hughes, Diarmaid

Part of Molecular Microbiology, p. 752-760, 2017

• DOI for The processive kinetics of gene conversion in bacteria
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Mutation supply and relative fitness shape the genotypes of ciprofloxacin-resistant Escherichia coli

Huseby, Douglas L.; Pietsch, Franziska; Brandis, Gerrit; Garoff, Linnéa et al.

Part of Molecular biology and evolution, p. 1029-1039, 2017

• DOI for Mutation supply and relative fitness shape the genotypes of ciprofloxacin-resistant Escherichia coli
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Early-Life Human Microbiota Associated With Childhood Allergy Promotes the T Helper 17 Axis in Mice

Petursdottir, Dagbjort H.; Nordlander, Sofia; Qazi, Khaleda Rahman; Carvalho-Queiroz, Claudia et al.

Part of Frontiers in Immunology, 2017

• DOI for Early-Life Human Microbiota Associated With Childhood Allergy Promotes the T Helper 17 Axis in Mice
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Selection and Transmission of Antibiotic-Resistant Bacteria

Andersson, Dan I; Hughes, Diarmaid

Part of Microbiology Spectrum, 2017

• DOI for Selection and Transmission of Antibiotic-Resistant Bacteria

Ciprofloxacin selects for RNA polymerase mutations with pleiotropic antibiotic resistance effects

Pietsch, Franziska; Bergman, Jessica M.; Brandis, Gerrit; Marcusson, Linda L. et al.

Part of Journal of Antimicrobial Chemotherapy, p. 75-84, 2017

• DOI for Ciprofloxacin selects for RNA polymerase mutations with pleiotropic antibiotic resistance effects

Can a pharmacokinetic/pharmacodynamic (PKPD) model be predictive across bacterial densities and strains?: External evaluation of a PKPD model describing longitudinal in vitro data

Nielsen, Elisabet I.; Khan, David D.; Cao, Sha; Lustig, Ulrika et al.

Part of Journal of Antimicrobial Chemotherapy, p. 3108-3116, 2017

• DOI for Can a pharmacokinetic/pharmacodynamic (PKPD) model be predictive across bacterial densities and strains?: External evaluation of a PKPD model describing longitudinal in vitro data

Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)

De Rosa, Maria; Lu, Lu; Zamaratski, Edouard; Szałaj, Natalia et al.

Part of Bioorganic & Medicinal Chemistry, p. 897-911, 2017

• DOI for Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)
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Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli: Multiple Antibiotic-Resistance, Gram-Negative Bacteria, Multidrug Efflux Pump, Urinary-Tract-Infections, Fluoroquinolone Resistance, Quinolone Resistance, Mechanisms, Expression, Sequence, Soxs

Praski Alzrigat, Lisa; Huseby, Douglas L; Brandis, Gerrit; Hughes, Diarmaid

Part of Journal of Antimicrobial Chemotherapy, p. 3016-3024, 2017

• DOI for Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli: Multiple Antibiotic-Resistance, Gram-Negative Bacteria, Multidrug Efflux Pump, Urinary-Tract-Infections, Fluoroquinolone Resistance, Quinolone Resistance, Mechanisms, Expression, Sequence, Soxs
• Download full text (pdf) of Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli: Multiple Antibiotic-Resistance, Gram-Negative Bacteria, Multidrug Efflux Pump, Urinary-Tract-Infections, Fluoroquinolone Resistance, Quinolone Resistance, Mechanisms, Expression, Sequence, Soxs

Having your cake and eating it - Staphylococcus aureus small colony variants can evolve faster growth rate without losing their antibiotic resistance

Brandis, Gerrit; Cao, Sha; Huseby, Douglas L.; Hughes, Diarmaid

Part of MICROBIAL CELL, p. 275-277, 2017

• DOI for Having your cake and eating it - Staphylococcus aureus small colony variants can evolve faster growth rate without losing their antibiotic resistance
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Functional Constraints on Replacing an Essential Gene with Its Ancient and Modern Homologs

Kacar, Betül; Garmendia, Eva; Tuncbag, Nurcan; Andersson, Dan I et al.

Part of mBio, 2017

• DOI for Functional Constraints on Replacing an Essential Gene with Its Ancient and Modern Homologs

Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureus

Cao, Sha; Huseby, Douglas L; Brandis, Gerrit; Hughes, Diarmaid

Part of mBio, 2017

• DOI for Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureus
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Bacterial pathogens, antibiotics and antibiotic resistance: Editorial

Banin, Ehud; Hughes, Diarmaid; Kuipers, Oscar P.

Part of FEMS Microbiology Reviews, p. 450-452, 2017

• DOI for Bacterial pathogens, antibiotics and antibiotic resistance: Editorial

The Selective Advantage of Synonymous Codon Usage Bias in Salmonella

Brandis, Gerrit; Hughes, Diarmaid

Part of PLOS Genetics, 2016

• DOI for The Selective Advantage of Synonymous Codon Usage Bias in Salmonella
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Evidence for the critical role of a secondary site rpoB mutation in the compensatory evolution and successful transmission of an MDR tuberculosis outbreak strain

Meftahi, Nedra; Namouchi, Amine; Mhenni, Besma; Brandis, Gerrit et al.

Part of Journal of Antimicrobial Chemotherapy, p. 324-332, 2016

• DOI for Evidence for the critical role of a secondary site rpoB mutation in the compensatory evolution and successful transmission of an MDR tuberculosis outbreak strain

Autoregulation of the tufB operon in Salmonella

Brandis, Gerrit; Bergman, Jessica M.; Hughes, Diarmaid

Part of Molecular Microbiology, p. 1004-1016, 2016

• DOI for Autoregulation of the tufB operon in Salmonella

Discovery and structure-activity relationships of a novel isothiazolone class of bacterial type II topoisomerase inhibitors

Cooper, Ian R.; McCarroll, Andrew J.; McGarry, David; Kirkham, James et al.

Part of Bioorganic & Medicinal Chemistry Letters, p. 4179-4183, 2016

• DOI for Discovery and structure-activity relationships of a novel isothiazolone class of bacterial type II topoisomerase inhibitors

Genetics: Location affects sporulation

Lazazzera, Beth A; Hughes, Diarmaid

Part of Nature, p. 42-43, 2015

• DOI for Genetics: Location affects sporulation

Comprehensive phenotypic characterization of rifampicin resistance mutations in Salmonella provides insight into the evolution of resistance in Mycobacterium tuberculosis

Brandis, Gerrit; Pietsch, Franziska; Alemayehu, Rahel; Hughes, Diarmaid

Part of Journal of Antimicrobial Chemotherapy, p. 680-685, 2015

• DOI for Comprehensive phenotypic characterization of rifampicin resistance mutations in Salmonella provides insight into the evolution of resistance in Mycobacterium tuberculosis

A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants

Khan, David D.; Lagerbäck, Pernilla; Cao, Sha; Lustig, Ulrika et al.

Part of Journal of Antimicrobial Chemotherapy, p. 3051-3060, 2015

• DOI for A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants

Turnover of mRNAs is one of the essential functions of RNase E

Larsson Hammarlöf, Disa; Bergman, Jessica M.; Garmendia, Eva; Hughes, Diarmaid

Part of Molecular Microbiology, p. 34-45, 2015

• DOI for Turnover of mRNAs is one of the essential functions of RNase E

Acetate availability and utilization supports the growth of mutant sub-populations on aging bacterial colonies

Bergman, Jessica M; Wrande, Marie; Hughes, Diarmaid

Part of PLOS ONE, 2014

• DOI for Acetate availability and utilization supports the growth of mutant sub-populations on aging bacterial colonies
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Reducing ppGpp Level Rescues an Extreme Growth Defect Caused by Mutant EF-Tu

Bergman, Jessica; Hammarlöf, Disa L; Hughes, Diarmaid

Part of PLOS ONE, 2014

• DOI for Reducing ppGpp Level Rescues an Extreme Growth Defect Caused by Mutant EF-Tu
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Mutant prevention concentrations of pradofloxacin for susceptible and mutant strains of Escherichia coli with reduced fluoroquinolone susceptibility

Marcusson, Linda L.; Lindgren, Patricia Komp; Olofsson, Sara K.; Hughes, Diarmaid et al.

Part of International Journal of Antimicrobial Agents, p. 354-357, 2014

• DOI for Mutant prevention concentrations of pradofloxacin for susceptible and mutant strains of Escherichia coli with reduced fluoroquinolone susceptibility

Cell-wall-inhibiting antibiotic combinations with activity against multidrug-resistant Klebsiella pneumoniae and Escherichia coli

Hickman, Rachel A.; Hughes, Diarmaid; Cars, Thomas; Malmberg, Christer et al.

Part of Clinical Microbiology and Infection, 2014

• DOI for Cell-wall-inhibiting antibiotic combinations with activity against multidrug-resistant Klebsiella pneumoniae and Escherichia coli

Genetic characterization of compensatory evolution in strains carrying rpoB Ser531Leu, the rifampicin resistance mutation most frequently found in clinical isolates

Brandis, Gerrit; Hughes, Diarmaid

Part of Journal of Antimicrobial Chemotherapy, p. 2493-2497, 2013

• DOI for Genetic characterization of compensatory evolution in strains carrying rpoB Ser531Leu, the rifampicin resistance mutation most frequently found in clinical isolates

Fitness-compensatory mutations in rifampicin-resistant RNA polymerase

Brandis, Gerrit; Wrande, Marie; Liljas, Lars; Hughes, Diarmaid

Part of Molecular Microbiology, p. 142-151, 2012

• DOI for Fitness-compensatory mutations in rifampicin-resistant RNA polymerase

Genome-Wide Detection of Spontaneous Chromosomal Rearrangements in Bacteria

Sun, Song; Ke, Rongqin; Hughes, Diarmaid; Nilsson, Mats et al.

Part of PLOS ONE, 2012

• DOI for Genome-Wide Detection of Spontaneous Chromosomal Rearrangements in Bacteria
• Download full text (pdf) of Genome-Wide Detection of Spontaneous Chromosomal Rearrangements in Bacteria

Fitness cost: a bacteriological explanation for the demise of the first international methicillin-resistant Staphylococcus aureus epidemic

Nielsen, Karen L.; Pedersen, Thomas M.; Udekwu, Klas I.; Petersen, Andreas et al.

Part of Journal of Antimicrobial Chemotherapy, p. 1325-1332, 2012

• DOI for Fitness cost: a bacteriological explanation for the demise of the first international methicillin-resistant Staphylococcus aureus epidemic

Selection of resistance at lethal and non-lethal antibiotic concentrations

Hughes, Diarmaid; Andersson, Dan I

Part of Current Opinion in Microbiology, p. 555-560, 2012

• DOI for Selection of resistance at lethal and non-lethal antibiotic concentrations

Evolution of antibiotic resistance at non-lethal drug concentrations.

Andersson, Dan I; Hughes, Diarmaid

Part of Drug resistance updates, p. 162-172, 2012

• DOI for Evolution of antibiotic resistance at non-lethal drug concentrations.

Selection of Resistant Bacteria at Very Low Antibiotic Concentrations

Gullberg, Erik; Cao, Sha; Berg, Otto G.; Ilbäck, Carolina et al.

Part of PLoS pathogens, 2011

• DOI for Selection of Resistant Bacteria at Very Low Antibiotic Concentrations

Genetic Complexity of Fusidic Acid-Resistant Small Colony Variants (SCV) in Staphylococcus aureus

Lannergård, Jonas; Cao, Sha; Norström, Tobias; Delgado, Alejandro et al.

Part of PLOS ONE, 2011

• DOI for Genetic Complexity of Fusidic Acid-Resistant Small Colony Variants (SCV) in Staphylococcus aureus

Intra- and Extracellular Activities of Dicloxacillin and Linezolid against a Clinical Staphylococcus aureus Strain with a Small-Colony-Variant Phenotype in an In Vitro Model of THP-1 Macrophages and an In Vivo Mouse Peritonitis Model

Sandberg, Anne; Lemaire, Sandrine; Van Bambeke, Françoise; Tulkens, Paul M. et al.

Part of Antimicrobial Agents and Chemotherapy, p. 1443-1452, 2011

• DOI for Intra- and Extracellular Activities of Dicloxacillin and Linezolid against a Clinical Staphylococcus aureus Strain with a Small-Colony-Variant Phenotype in an In Vitro Model of THP-1 Macrophages and an In Vivo Mouse Peritonitis Model

Can phylogenetic type predict resistance development?

Nazir, Humera; Cao, Sha; Hasan, Fariha; Hughes, Diarmaid

Part of Journal of Antimicrobial Chemotherapy, p. 778-787, 2011

• DOI for Can phylogenetic type predict resistance development?

Temperature-sensitive mutants of RNase E in Salmonella enterica

Hammarlöf, Disa L.; Liljas, Lars; Hughes, Diarmaid

Part of Journal of Bacteriology, p. 6639-6650, 2011

• DOI for Temperature-sensitive mutants of RNase E in Salmonella enterica

Can phylogenetic type predict resistance development?

Nazir, Humera; Cao, Sha; Hasan, Fariha; Hughes, Diarmaid

Part of Journal of Antimicrobial Chemotherapy, p. 778-787, 2011

• DOI for Can phylogenetic type predict resistance development?

Effect of the translesion DNA polymerases, endonucleases and RpoS on mutation rates in Salmonella typhimurium

Koskiniemi, Sanna; Hughes, Diarmaid; Andersson, Dan I

Part of Genetics, p. 783-795, 2010

• DOI for Effect of the translesion DNA polymerases, endonucleases and RpoS on mutation rates in Salmonella typhimurium

Genetic Determinants of Resistance to Fusidic Acid among Clinical Bacteremia Isolates of Staphylococcus aureus

Lannergård, Jonas; Norström, Tobias; Hughes, Diarmaid

Part of Antimicrobial Agents and Chemotherapy, p. 2059-2065, 2009

• DOI for Genetic Determinants of Resistance to Fusidic Acid among Clinical Bacteremia Isolates of Staphylococcus aureus

Interplay in the Selection of Fluoroquinolone Resistance and Bacterial Fitness

Marcusson, Linda L; Frimodt-Møller, Niels; Hughes, Diarmaid

Part of PLoS Pathogens, 2009

• DOI for Interplay in the Selection of Fluoroquinolone Resistance and Bacterial Fitness

Identification of the Genetic Basis for Clinical Menadione-Auxotrophic Small-Colony Variant Isolates of Staphylococcus aureus

Lannergård, Jonas; von Eiff, Christof; Sander, Gunnar; Cordes, Tina et al.

Part of Antimicrobial Agents and Chemotherapy, p. 4017-4022, 2008

• DOI for Identification of the Genetic Basis for Clinical Menadione-Auxotrophic Small-Colony Variant Isolates of Staphylococcus aureus

Accumulation of mutants in "aging" bacterial colonies is due to growth under selection, not stress-induced mutagenesis

Wrande, Marie; Roth, John R.; Hughes, Diarmaid

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 11863-11868, 2008

• DOI for Accumulation of mutants in "aging" bacterial colonies is due to growth under selection, not stress-induced mutagenesis

Mutants of the RNA-processing enzyme RNase E reverse the extreme slow-growth phenotype caused by a mutant translation factor EF-Tu

Hammarlöf, Disa L; Hughes, Diarmaid

Part of Molecular Microbiology, p. 1194-1209, 2008

• DOI for Mutants of the RNA-processing enzyme RNase E reverse the extreme slow-growth phenotype caused by a mutant translation factor EF-Tu

Dose-related selection of fluoroquinolone-resistant Escherichia coli

Olofsson, Sara K; Marcusson, Linda L.; Strömbäck, Ann; Hughes, Diarmaid et al.

Part of Journal of Antimicrobial Chemotherapy, p. 795-801, 2007

• DOI for Dose-related selection of fluoroquinolone-resistant Escherichia coli

Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus

Norström, Tobias; Lannergård, Jonas; Hughes, Diarmaid

Part of Antimicrobial Agents and Chemotherapy, p. 4438-4446, 2007

• DOI for Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus

Selection of ciprofloxacin resistance in Escherichia coli in an in vitro kinetic model: relation between drug exposure and mutant prevention concentration

Olofsson, Sara K; Marcusson, Linda L; Komp Lindgren, Patricia; Hughes, Diarmaid et al.

Part of Journal of Antimicrobial Chemotherapy, p. 1116-1121, 2006

• DOI for Selection of ciprofloxacin resistance in Escherichia coli in an in vitro kinetic model: relation between drug exposure and mutant prevention concentration

Weak mutators can drive the evolution of fluoroquinolone resistance in Escherichia coli

Örlén, Hanna; Hughes, Diarmaid

Part of Antimicrobial Agents and Chemotherapy, p. 3454-3456, 2006

• DOI for Weak mutators can drive the evolution of fluoroquinolone resistance in Escherichia coli

Biological cost of single and multiple norfloxacin resistance mutations in Escherichia coli implicated in urinary tract infections

Komp Lindgren, Patricia; Marcusson, Linda L; Sandvang, Dorthe; Fridmodt-Møller, Niels et al.

Part of Antimicrobial Agents and Chemotherapy, p. 2343-2351, 2005

• DOI for Biological cost of single and multiple norfloxacin resistance mutations in Escherichia coli implicated in urinary tract infections

Establishment of a superficial skin infection model in mice by using Staphylococcus aureus and Streptococcus pyogenes

Kugelberg, Elisabeth; Norström, Tobias; Petersen, Thomas K; Duvold, Tore et al.

Part of Antimicrobial Agents and Chemotherapy, p. 3435-3441, 2005

• DOI for Establishment of a superficial skin infection model in mice by using Staphylococcus aureus and Streptococcus pyogenes

Mutant prevention concentrations of ciprofloxacin for urinary tract infection isolates of Escherichia coli

Marcusson, Linda L; Olofsson, Sara K; Komp Lindgren, Patricia; Cars, Otto et al.

Part of Journal of Antimicrobial Chemotherapy, p. 938-943, 2005

• DOI for Mutant prevention concentrations of ciprofloxacin for urinary tract infection isolates of Escherichia coli

Hyper-susceptibility of a fusidic acid-resistant mutant of Salmonella to different classes of antibiotics

Macvanin, Mirjana; Hughes, Diarmaid

Part of FEMS Microbiology Letters, p. 215-220, 2005

• DOI for Hyper-susceptibility of a fusidic acid-resistant mutant of Salmonella to different classes of antibiotics

Fusidic acid-resistant mutants of Salmonella enterica serovar typhimurium have low levels of heme and a reduced rate of respiration and are sensitive to oxidative stress

Macvanin, Mirjana; Ballagi, Andras; Hughes, Diarmaid

Part of Antimicrobial Agents and Chemotherapy, p. 3877-3883, 2004

• DOI for Fusidic acid-resistant mutants of Salmonella enterica serovar typhimurium have low levels of heme and a reduced rate of respiration and are sensitive to oxidative stress

Evidence against reciprocal recombination as the basis for tuf gene conversion in Salmonella enterica serovar Typhimurium

Arwidsson, Ola; Hughes, Diarmaid

Part of Journal of Molecular Biology, p. 463-467, 2004

• DOI for Evidence against reciprocal recombination as the basis for tuf gene conversion in Salmonella enterica serovar Typhimurium

Fusidic acid-resistant mutants of Salmonella enterica serovar Typhimurium with low fitness in vivo are defective in RpoS induction

Macvanin, Mirjana; Björkman, Johanna; Eriksson, Sofia; Rhen, Mikael et al.

Part of Antimicrobial Agents and Chemotherapy, p. 3743-3749, 2003

• DOI for Fusidic acid-resistant mutants of Salmonella enterica serovar Typhimurium with low fitness in vivo are defective in RpoS induction

Mutation Rate and Evolution of Fluoroquinolone Resistance in Escherichia coli Isolates from Patients with Urinary tract infections

Komp Lindgren, Patricia; Karlsson, Åsa; Hughes, Diarmaid

Part of Antimicrobial Agents and Chemotherapy, p. 3222-3232, 2003

• DOI for Mutation Rate and Evolution of Fluoroquinolone Resistance in Escherichia coli Isolates from Patients with Urinary tract infections

Biological cost and compensatory evolution in fusidic acid-resistant Staphylococcus aureus

Nagaev, Ivan; Björkman, Johanna; Andersson, Dan I; Hughes, Diarmaid

Part of Molecular Microbiology, p. 433-439, 2001

• DOI for Biological cost and compensatory evolution in fusidic acid-resistant Staphylococcus aureus

Fusidic acid-resistant EF-G perturbs the accumulation of ppGpp

Macvanin, Mirjana; Johanson, Urban; Ehrenberg, Måns; Hughes, Diarmaid

Part of Molecular Microbiology, p. 98-107, 2000

• DOI for Fusidic acid-resistant EF-G perturbs the accumulation of ppGpp

Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site

Laurberg, M; Kristensen, O; Martemyanov, K; Gudkov, A.T et al.

Part of Journal of Molecular Biology, p. 593-603, 2000

• DOI for Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site

Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance

Björkman, J; Nagaev, I; Berg, O G; Hughes, Diarmaid et al.

Part of Science, p. 1479-1482, 2000

• DOI for Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance

Co-evolution of the tuf genes links gene conversion with the generation of chromosomal inversions

Hughes, Diarmaid

Part of Journal of Molecular Biology, p. 355-364, 2000

• DOI for Co-evolution of the tuf genes links gene conversion with the generation of chromosomal inversions

Novel ribosomal mutations affecting translational accuracy, antibiotic resistance and virulence of Salmonella typhimurium

Björkman, Johanna; Samuelsson, Patrik; Andersson, Dan I; Hughes, Diarmaid

Part of Molecular Microbiology, p. 53-58, 1999

• DOI for Novel ribosomal mutations affecting translational accuracy, antibiotic resistance and virulence of Salmonella typhimurium

Virulence of antibiotic-resistant Salmonella typhimurium

Bjorkman, J; Hughes, Diarmaid; Andersson, DI

Part of PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, p. 3949-3953, 1998

Carbon starvation of Salmonella typhimurium does not cause a general increase of mutation rates

Hughes, Diarmaid; Andersson, DI

Part of JOURNAL OF BACTERIOLOGY, p. 6688-6691, 1997

Homologous recombination between the tuf genes of Salmonella typhimurium

Abdulkarim, Farhad; Hughes, Diarmaid

Part of Journal of Molecular Biology, p. 506-522, 1996

• DOI for Homologous recombination between the tuf genes of Salmonella typhimurium

Muller's ratchet decreases fitness of a DNA-based microbe

Andersson, Dan I; Hughes, Diarmaid

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 906-907, 1996

Mutants of EF-Tu defective in binding aminoacyl-tRNA

Abdulkarim, Farhad; Ehrenberg, Måns; Hughes, Diarmaid

Part of FEBS Letters, p. 297-303, 1996

• DOI for Mutants of EF-Tu defective in binding aminoacyl-tRNA

The dynamic structure of EF-G studied by fusidic acid resistance and internal revertants

Johanson, U; AEvarsson, A; Liljas, A; Hughes, Diarmaid

Part of JOURNAL OF MOLECULAR BIOLOGY, p. 420-432, 1996

A new mutation in 16S rRNA of Escherichia coli conferring spectinomycin resistance

Johanson, Urban; Hughes, Diarmaid

Part of Nucleic Acids Research, p. 464-466, 1995

Fusidic acid-resistant mutants define three regions in elongation factor G of Salmonella typhimurium

Johanson, Urban; Hughes, Diarmaid

Part of Gene, p. 55-59, 1994

• DOI for Fusidic acid-resistant mutants define three regions in elongation factor G of Salmonella typhimurium

Mutations to kirromycin resistance occur in the interface of domains I and III of EF-Tu.GTP

Abdulkarim, Farhad; Liljas, Lars; Hughes, Diarmaid

Part of FEBS Letters, p. 118-122, 1994

• DOI for Mutations to kirromycin resistance occur in the interface of domains I and III of EF-Tu.GTP

Growth and translation elongation rate are sensitive to the concentration of EF-Tu

Tubulekas, Ioannis; Hughes, Diarmaid

Part of Molecular Microbiology, p. 761-770, 1993

• DOI for Growth and translation elongation rate are sensitive to the concentration of EF-Tu

Suppression of rpsL phenotypes by tuf mutations reveals a unique relationship between translation elongation and growth rate

Tubulekas, Ioannis; Hughes, Diarmaid

Part of Molecular Microbiology, p. 275-284, 1993

• DOI for Suppression of rpsL phenotypes by tuf mutations reveals a unique relationship between translation elongation and growth rate

A single amino acid substitution in elongation factor Tu disrupts interaction between the ternary complex and the ribosome

Tubulekas, I; Hughes, Diarmaid

Part of Journal of Bacteriology, p. 240-250, 1993

Comparison of the complete sequence of the str operon in Salmonella typhimurium and Escherichia coli

Johanson, Urban; Hughes, Diarmaid

Part of Gene, p. 93-98, 1992

• DOI for Comparison of the complete sequence of the str operon in Salmonella typhimurium and Escherichia coli

Mutant ribosomes can generate dominant kirromycin resistance

Tubulekas, Ioannis; Buckingham, Richard H.; Hughes, Diarmaid

Part of Journal of Bacteriology, p. 3635-3643, 1991

Error-prone EF-Tu reduces in vivo enzyme activity and cellular growth rate

Hughes, Diarmaid

Part of Molecular Microbiology, p. 623-630, 1991

The nucleotide sequence of rpsL and its flanking regions in Salmonella typhimurium

Hughes, Diarmaid; Buckingham, RH

Part of Gene, p. 123-124, 1991

• DOI for The nucleotide sequence of rpsL and its flanking regions in Salmonella typhimurium

Missense substitutions lethal to essential functions of EF-Tu

Abdulkarim, Farhad; Tuohy, TMF; Buckingham, RH; Hughes, Diarmaid

Part of Biochimie, p. 1457-1464, 1991

• DOI for Missense substitutions lethal to essential functions of EF-Tu

Both genes for EF-Tu in Salmonella typhimurium are individually dispensible for growth

Hughes, Diarmaid

Part of Journal of Molecular Biology, p. 41-51, 1990

• DOI for Both genes for EF-Tu in Salmonella typhimurium are individually dispensible for growth

Overproduction of release factor reduces spontaneous frameshifting and frameshift suppression by mutant elongation factor Tu

Rydén Aulin, Monica; Hughes, Diarmaid

Part of Journal of Bacteriology, p. 6721-6726, 1990

The role of EF-Tu and other translation components in determining translocation step size

Tuohy, TMF; Thompson, S; Gesteland, R; Hughes, Diarmaid et al.

Part of Biochimica et Biophysica Acta, Gene Structure and Expression, p. 274-278, 1990

• DOI for The role of EF-Tu and other translation components in determining translocation step size

Variability of murine bacterial pneumonia models used to evaluate antimicrobial agents

Arrazuria, Rakel; Kerscher, Bernhard; Huber, Karen E.; Hoover, Jennifer L. et al.

Part of Frontiers in Microbiology, 2022

• DOI for Variability of murine bacterial pneumonia models used to evaluate antimicrobial agents
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Evolutionary Trajectories to Antibiotic Resistance

Hughes, Diarmaid; Andersson, Dan I

Part of Annual Review of Microbiology, p. 579-596, 2017

• DOI for Evolutionary Trajectories to Antibiotic Resistance

Environmental and genetic modulation of the phenotypic expression of antibiotic resistance

Hughes, Diarmaid; Andersson, Dan I

Part of FEMS Microbiology Reviews, p. 374-391, 2017

• DOI for Environmental and genetic modulation of the phenotypic expression of antibiotic resistance

Using the power of genetic suppressors to probe the essential functions of RNase E

Hughes, Diarmaid

Part of Current Genetics, p. 53-57, 2016

• DOI for Using the power of genetic suppressors to probe the essential functions of RNase E

Mechanisms and consequences of bacterial resistance to antimicrobial peptides

Andersson, Dan I.; Hughes, Diarmaid; Kubicek-Sutherland, Jessica Z.

Part of Drug resistance updates, p. 43-57, 2016

• DOI for Mechanisms and consequences of bacterial resistance to antimicrobial peptides
• Download full text (pdf) of Mechanisms and consequences of bacterial resistance to antimicrobial peptides

Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms

Hughes, Diarmaid; Andersson, Dan I.

Part of Nature reviews genetics, p. 459-471, 2015

• DOI for Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms

Selection and Evolution of Resistance to Antimicrobial Drugs

Hughes, Diarmaid

Part of IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, p. 521-529, 2014

• DOI for Selection and Evolution of Resistance to Antimicrobial Drugs

Microbiological effects of sublethal levels of antibiotics

Andersson, Dan I.; Hughes, Diarmaid

Part of Nature Reviews Microbiology, p. 465-478, 2014

• DOI for Microbiological effects of sublethal levels of antibiotics

Discovery and preclinical development of new antibiotics

Hughes, Diarmaid; Karlén, Anders

Part of Upsala Journal of Medical Sciences, p. 162-169, 2014

• DOI for Discovery and preclinical development of new antibiotics

Rifampicin Resistance: Fitness Costs and the Significance of Compensatory Evolution

Hughes, Diarmaid; Brandis, Gerrit

Part of Antibiotics, p. 206-216, 2013

• DOI for Rifampicin Resistance: Fitness Costs and the Significance of Compensatory Evolution
• Download full text (pdf) of Rifampicin Resistance: Fitness Costs and the Significance of Compensatory Evolution

The origin of mutants under selection: Interactions of mutation, growth and selection

Andersson, Dan I.; Hughes, Diarmaid; Roth, John R

Part of EcoSal Plus, 2011

• DOI for The origin of mutants under selection: Interactions of mutation, growth and selection

Persistence of antibiotic resistance in bacterial populations

Andersson, Dan I.; Hughes, Diarmaid

Part of FEMS Microbiology Reviews, p. 901-911, 2011

• DOI for Persistence of antibiotic resistance in bacterial populations

Biological roles of translesion synthesis DNA polymerases in eubacteria

Andersson, Dan I.; Koskiniemi, Sanna; Hughes, Diarmaid

Part of Molecular Microbiology, p. 540-548, 2010

• DOI for Biological roles of translesion synthesis DNA polymerases in eubacteria

Antibiotic resistance and its cost: is it possible to reverse resistance?

Andersson, Dan I.; Hughes, Diarmaid

Part of Nature Reviews Microbiology, p. 260-271, 2010

• DOI for Antibiotic resistance and its cost: is it possible to reverse resistance?

Gene amplification and adaptive evolution in bacteria

Andersson, Dan I.; Hughes, Diarmaid

Part of Annual Review of Genetics, p. 167-195, 2009

• DOI for Gene amplification and adaptive evolution in bacteria

Exploiting genomics, genetics and chemistry to combat antibiotic resistance

Hughes, Diarmaid

Part of Nature reviews genetics, p. 432-441, 2003

• DOI for Exploiting genomics, genetics and chemistry to combat antibiotic resistance

The physiological cost of antibiotic resistance

Macvanin, Mirjana; Hughes, Diarmaid

Part of Recent research developments in microbiology, p. 607-629, 2003

Evaluating genome dynamics: the constraints on rearrangements within bacterial genomes

Hughes, Diarmaid

Part of Genome Biology, p. 6.1-6.8, 2000

• DOI for Evaluating genome dynamics: the constraints on rearrangements within bacterial genomes

Antibiotikaresistens här för att stanna?

Andersson, D.I; Björkman, Johanna; Hughes, Diarmaid

Part of Läkartidningen, p. 3940-3944, 1998

tRNA-ribosome interactions

Ehrenberg, Måns; Bilgin, Neş’e; Dincbas, Vildan; Karimi, Reza et al.

Part of Biochemistry and Cell Biology, p. 1049-1054, 1995

Ternary complex-ribosome interaction: its influence on protein synthesis and on growth rate

Hughes, Diarmaid; Tubulekas, I

Part of Biochemical Society Transactions, p. 851-857, 1993

Antibiotic Development and Resistance

Hughes, Diarmaid; Andersson, Dan I

Taylor and Francis Publishers, London and New York, 2001

Elongation Factors: Translation

Hughes, Diarmaid

Part of Reference Module in Life Sciences, Elsevier, 2017

• DOI for Elongation Factors: Translation

Adventures with mutation and selection in beehive and cow country

Hughes, Diarmaid; Andersson, Dan I

Part of The Lure of Bacterial Genetics, p. 245-253, ASM Press, 2010

Measurements of heme levels and respiration rate in Salmonella enterica serovar typhimurium

Hughes, Diarmaid; Macvanin, Mirjana

Part of Antibiotic Resistance Protocols, p. 105-112, Humana Press, 2010

• DOI for Measurements of heme levels and respiration rate in Salmonella enterica serovar typhimurium

Assays of sensitivity of antibiotic-resistant bacteria to hydrogen peroxide and measurement of catalase activity

Macvanin, Mirjana; Hughes, Diarmaid

Part of Antibiotic Resistance Protocols, p. 95-103, Humana Press, 2010

• DOI for Assays of sensitivity of antibiotic-resistant bacteria to hydrogen peroxide and measurement of catalase activity

Effects of antibiotic resistance on bacterial fitness, virulence and transmission

Andersson, Dan I.; Hughes, Diarmaid

Part of Evolutionary biology of bacterial and fungal pathogens, p. 307-318, ASM Press, 2008

Comparative genomics and the development of novel antimicrobials

Hughes, Diarmaid

Part of Comparative genomics: basic and applied research, p. 177-192, CRC Press, Taylor and Francis Group, Boca Raton, FL, USA, 2008

• DOI for Comparative genomics and the development of novel antimicrobials

Biological consequences for bacteria of homologous recombination

Hughes, Diarmaid; Norström, Tobias

Part of The Dynamic Bacterial Genome, p. 351-384, Cambridge University Press, New York, USA, 2005

• DOI for Biological consequences for bacteria of homologous recombination

Target alterations mediating antibiotic resistance

Hughes, Diarmaid; Andersson, Dan I

Part of Antibiotic Development and Resistance, p. 23-36, Taylor and Francis Publishers, London and New York, 2001

Impact of homologous recombination and gene conversion on genomic organisation and stability

Hughes, Diarmaid

Part of Organization of the prokaryotic genome, p. 109-128, American Society for Microbiology, Washington, USA, 1999

Limitations of translational accuracy

Kurland, CG; Hughes, Diarmaid; Ehrenberg, M.

Part of Escherichia coli and Salmonella, p. 979-1004, ASM Press, Washington DC, USA, 1996

Co-evolution protects the tuf genes from inactivation by mobile genetic elements

Brandis, Gerrit; Hughes, Diarmaid

A large chromosomal inversion causes the formation of an unstable tufA/B hybrid operon

Brandis, Gerrit; Hughes, Diarmaid

High-level intrinsic suppression of a frameshift mutation in an essential gene

Huseby, Douglas L.; Praski-Alzrigat, Lisa; Brandis, Gerrit; Hughes, Diarmaid

Antibiotikaresistens: är den reversibel?

Andersson, Dan; Björkman, Johanna; Hughes, Diarmaid

Part of Smittskydd: Smittskyddsinstitutets tidskrift, p. 3-5, 1998