Patrick Micke's publications

Ageing promotes metastasis via activation of the integrated stress response

Patel, Angana A. H.; Dzanan, Jozefina J.; Ali, Kevin X.; Eklund, Ella A. et al.

Part of Nature, 2026

• DOI for Ageing promotes metastasis via activation of the integrated stress response
• Download full text (pdf) of Ageing promotes metastasis via activation of the integrated stress response

An Intelligent Differential Capacitive Bioelectronic Sensing System for Reliable Microfluidic Reagent Delivery in Automated Pathology

Kabashkin, Igor; Krainukovs, Aleksandrs; Pasicniks, Dmitrijs; Gercevs, Ivans et al.

Part of Electronics, 2026

• DOI for An Intelligent Differential Capacitive Bioelectronic Sensing System for Reliable Microfluidic Reagent Delivery in Automated Pathology
• Download full text (pdf) of An Intelligent Differential Capacitive Bioelectronic Sensing System for Reliable Microfluidic Reagent Delivery in Automated Pathology

Composite proteomic and metabolomic plasma biomarkers for detection of colorectal, lung and ovarian cancers

Åkerrén Ögren, Jim; Ekström, Joakim; Rameika, Natallia; Torell, Emma et al.

Part of Molecular Cancer, 2026

• DOI for Composite proteomic and metabolomic plasma biomarkers for detection of colorectal, lung and ovarian cancers
• Download full text (pdf) of Composite proteomic and metabolomic plasma biomarkers for detection of colorectal, lung and ovarian cancers

Design of a Modular Cyber-Physical Architecture for Multiplex Histological Staining

Kabashkin, Igor; Krainukovs, Aleksandrs; Pasicniks, Dmitrijs; Gercevs, Ivans et al.

Part of Applied Sciences, 2026

• DOI for Design of a Modular Cyber-Physical Architecture for Multiplex Histological Staining
• Download full text (pdf) of Design of a Modular Cyber-Physical Architecture for Multiplex Histological Staining

In situ mapping of activated PDGFRβ defines a prognostic discrepancy between histological subtypes of NSCLC

Lindberg, Amanda; Hellberg, Louise; Grandon, Anaïs; Yu, Hui et al.

Part of Cell Communication and Signaling, 2026

• DOI for In situ mapping of activated PDGFRβ defines a prognostic discrepancy between histological subtypes of NSCLC
• Download full text (pdf) of In situ mapping of activated PDGFRβ defines a prognostic discrepancy between histological subtypes of NSCLC

Incremental prognostic value of immune cell densities beyond clinical parameters in non-small cell lung cancer

Nordling, Love; Backman, Max; Mezheyeuski, Artur; Lindblad, Joakim et al.

Part of Lung Cancer, 2026

• DOI for Incremental prognostic value of immune cell densities beyond clinical parameters in non-small cell lung cancer
• Download full text (pdf) of Incremental prognostic value of immune cell densities beyond clinical parameters in non-small cell lung cancer

Left behind but not left alone: Excluded cell populations in the non-small cell lung cancer stroma predict superior long-term overall survival

Marwitz, Sebastian; Brunnstrom, Hans; Gulyas, Miklos; Botling, Johan et al.

Part of European Journal of Cancer, 2026

• DOI for Left behind but not left alone: Excluded cell populations in the non-small cell lung cancer stroma predict superior long-term overall survival

Spatially resolved T cell receptor diversity mapping uncovers of the cancer immune microenvironment

Magoulopoulou, Anastasia; Chatzinikolaou, Maria; Metousis, Andreas; Hu, Taobo et al.

Part of eBioMedicine, 2026

• DOI for Spatially resolved T cell receptor diversity mapping uncovers of the cancer immune microenvironment
• Download full text (pdf) of Spatially resolved T cell receptor diversity mapping uncovers of the cancer immune microenvironment

Vascular leakage in non-small cell lung cancer is associated with immune evasion and poor response to immunotherapy

Nwadozi, Emmanuel; Strell, Carina; Nordling, Sofia; Lindberg, Amanda et al.

Part of Cancer Letters, 2026

• DOI for Vascular leakage in non-small cell lung cancer is associated with immune evasion and poor response to immunotherapy
• Download full text (pdf) of Vascular leakage in non-small cell lung cancer is associated with immune evasion and poor response to immunotherapy

Gene expression-based identification of prognostic markers in lung adenocarcinoma

Salomonsson, Annette; Ehinger, Daniel; Jonsson, Mats; Botling, Johan et al.

Part of PLOS ONE, 2025

• DOI for Gene expression-based identification of prognostic markers in lung adenocarcinoma
• Download full text (pdf) of Gene expression-based identification of prognostic markers in lung adenocarcinoma

In situ detection of PD1–PD-L1 interactions as a functional predictor for response to immune checkpoint inhibition in NSCLC

Lindberg, Amanda; Muhl, Lars; Yu, Hui; Hellberg, Louise et al.

Part of Journal of Thoracic Oncology, p. 625-640, 2025

• DOI for In situ detection of PD1–PD-L1 interactions as a functional predictor for response to immune checkpoint inhibition in NSCLC
• Download full text (pdf) of In situ detection of PD1–PD-L1 interactions as a functional predictor for response to immune checkpoint inhibition in NSCLC

Predictors of survival and recurrence patterns following definitive chemoradiotherapy in stage III non-small cell lung cancer: a retrospective cohort study

Broström, Erika; Isaksson, Johan; Xanthoulis, Panagiotis; Börjesson, Rebecka et al.

Part of Translational Lung Cancer Research, p. 1972-1985, 2025

• DOI for Predictors of survival and recurrence patterns following definitive chemoradiotherapy in stage III non-small cell lung cancer: a retrospective cohort study
• Download full text (pdf) of Predictors of survival and recurrence patterns following definitive chemoradiotherapy in stage III non-small cell lung cancer: a retrospective cohort study

Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma

Biswas, Dhruva; Liu, Yun-Hsin; Herrero, Javier; Wu, Yin et al.

Part of Nature Cancer, p. 86-101, 2025

• DOI for Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma
• Download full text (pdf) of Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma

scFFPE-ATAC enables high-throughput single cell chromatin accessibility profiling in formalin-fixed paraffin-embedded samples

Yadav, Ram Prakash; Xing, Pengwei; Zhao, Miao; Hollander, Peter et al.

Part of Nature Communications, 2025

• DOI for scFFPE-ATAC enables high-throughput single cell chromatin accessibility profiling in formalin-fixed paraffin-embedded samples
• Download full text (pdf) of scFFPE-ATAC enables high-throughput single cell chromatin accessibility profiling in formalin-fixed paraffin-embedded samples

Spatial distribution of tertiary lymphoid structures in the molecular and clinical context of non-small cell lung cancer.

Elfving, Hedvig; Yu, Hui; Kassete Fessehatsio, Kaleab; Brunnström, Hans et al.

Part of Cellular Oncology, p. 801-808, 2025

• DOI for Spatial distribution of tertiary lymphoid structures in the molecular and clinical context of non-small cell lung cancer.
• Download full text (pdf) of Spatial distribution of tertiary lymphoid structures in the molecular and clinical context of non-small cell lung cancer.

Spatial TCR clonality and clonal expansion in the in situ microenvironment of non-small cell lung cancer

Yu, Hui; Magoulopoulou, Anastasia; Amini, Rose-Marie; Chatzinikolaou, Maria Paraskevi et al.

Part of Journal for ImmunoTherapy of Cancer, 2025

• DOI for Spatial TCR clonality and clonal expansion in the in situ microenvironment of non-small cell lung cancer
• Download full text (pdf) of Spatial TCR clonality and clonal expansion in the in situ microenvironment of non-small cell lung cancer

The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma

Ohata, Yae; Ali, Mohamad M.; Tsubakihara, Yutaro; Itoh, Yuka et al.

Part of Cell Death and Differentiation, p. 1915-1929, 2025

• DOI for The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma
• Download full text (pdf) of The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma

Tumoral pSMAD2 as a prognostic biomarker in early-stage breast cancer: insights from the randomized SweBCG91RT trial

Tullberg, Axel Stenmark; Thurfjell, Viktoria; Kovacs, Aniko; Micke, Patrick et al.

Part of Breast Cancer Research and Treatment, p. 499-509, 2025

• DOI for Tumoral pSMAD2 as a prognostic biomarker in early-stage breast cancer: insights from the randomized SweBCG91RT trial
• Download full text (pdf) of Tumoral pSMAD2 as a prognostic biomarker in early-stage breast cancer: insights from the randomized SweBCG91RT trial

Unlocking novel T cell-based immunotherapy for hepatocellular carcinoma through neoantigen-driven T cell receptor isolation

Maravelia, Panagiota; Yao, Haidong; Cai, Curtis; Silva, Daniela Nascimento et al.

Part of Gut, p. 1125-1136, 2025

• DOI for Unlocking novel T cell-based immunotherapy for hepatocellular carcinoma through neoantigen-driven T cell receptor isolation
• Download full text (pdf) of Unlocking novel T cell-based immunotherapy for hepatocellular carcinoma through neoantigen-driven T cell receptor isolation

Diagnostic gastrointestinal markers in primary lung cancer and pulmonary metastases

Malmros, Karina; Lindholm, Andreas; Vidarsdottir, Halla; Jirström, Karin et al.

Part of Virchows Archiv, p. 347-357, 2024

• DOI for Diagnostic gastrointestinal markers in primary lung cancer and pulmonary metastases
• Download full text (pdf) of Diagnostic gastrointestinal markers in primary lung cancer and pulmonary metastases

Distinct microRNA Signature and Suppression of ZFP36L1 Define ASCL1-Positive Lung Adenocarcinoma

Enokido, Takayoshi; Horie, Masafumi; Yoshino, Seiko; Suzuki, Hiroshi I. et al.

Part of Molecular Cancer Research, p. 29-40, 2024

• DOI for Distinct microRNA Signature and Suppression of ZFP36L1 Define ASCL1-Positive Lung Adenocarcinoma

The histological growth patterns in liver metastases from colorectal cancer display differences in lymphoid, myeloid, and mesenchymal cells

Garcia-Vicien, Gemma; Ruiz, Nuria; Micke, Patrick; Ruffinelli, Jose Carlos et al.

Part of MEDCOMM, 2024

• DOI for The histological growth patterns in liver metastases from colorectal cancer display differences in lymphoid, myeloid, and mesenchymal cells
• Download full text (pdf) of The histological growth patterns in liver metastases from colorectal cancer display differences in lymphoid, myeloid, and mesenchymal cells

Tumor Heterogeneity Confounds Lymphocyte Metrics in Diagnostic Lung Cancer Biopsies

Elfving, Hedvig; Thurfjell, Viktoria; Mattsson, Johanna Sofia Margareta; Backman, Max et al.

Part of Archives of Pathology & Laboratory Medicine, 2024

• DOI for Tumor Heterogeneity Confounds Lymphocyte Metrics in Diagnostic Lung Cancer Biopsies
• Download full text (pdf) of Tumor Heterogeneity Confounds Lymphocyte Metrics in Diagnostic Lung Cancer Biopsies

Use of beta-blockers in patients with ductal carcinoma in situ and risk of invasive breast cancer recurrence: a Swedish retrospective cohort study

Strell, Carina; Smith, Daniel Robert; Valachis, Antonis; Woldeyesus, Hellen et al.

Part of Breast Cancer Research and Treatment, p. 293-299, 2024

• DOI for Use of beta-blockers in patients with ductal carcinoma in situ and risk of invasive breast cancer recurrence: a Swedish retrospective cohort study
• Download full text (pdf) of Use of beta-blockers in patients with ductal carcinoma in situ and risk of invasive breast cancer recurrence: a Swedish retrospective cohort study

An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers

Mezheyeuski, Artur; Backman, Max; Mattsson, Johanna Sofia Margareta; Martin-Bernabe, Alfonso et al.

Part of eBioMedicine, 2023

• DOI for An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers
• Download full text (pdf) of An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers

Expression of cancer-testis antigens in the immune microenvironment of non-small cell lung cancer

Hikmet Noraddin, Feria; Rassy, Marc; Backman, Max; Méar, Loren et al.

Part of Molecular Oncology, p. 2603-2617, 2023

• DOI for Expression of cancer-testis antigens in the immune microenvironment of non-small cell lung cancer
• Download full text (pdf) of Expression of cancer-testis antigens in the immune microenvironment of non-small cell lung cancer

Fibroblast subsets in non-small cell lung cancer: Associations with survival, mutations, and immune features

Pellinen, Teijo; Paavolainen, Lassi; Martín-Bernabé, Alfonso; Papatella Araujo, Renata et al.

Part of Journal of the National Cancer Institute, p. 71-82, 2023

• DOI for Fibroblast subsets in non-small cell lung cancer: Associations with survival, mutations, and immune features
• Download full text (pdf) of Fibroblast subsets in non-small cell lung cancer: Associations with survival, mutations, and immune features

Matched Analyses of Brain Metastases versus Primary Non-Small Cell Lung Cancer Reveal a Unique microRNA Signature

Tsakonas, Georgios; Koulouris, Andreas; Kazmierczak, Dominika; Botling, Johan et al.

Part of International Journal of Molecular Sciences, 2023

• DOI for Matched Analyses of Brain Metastases versus Primary Non-Small Cell Lung Cancer Reveal a Unique microRNA Signature
• Download full text (pdf) of Matched Analyses of Brain Metastases versus Primary Non-Small Cell Lung Cancer Reveal a Unique microRNA Signature

Phenotypic characterization of spatial immune infiltration niches in non-small cell lung cancer

Gerdtsson, Anna Sandström; Knulst, Mattis; Botling, Johan; Mezheyeuski, Artur et al.

Part of Oncoimmunology, 2023

• DOI for Phenotypic characterization of spatial immune infiltration niches in non-small cell lung cancer
• Download full text (pdf) of Phenotypic characterization of spatial immune infiltration niches in non-small cell lung cancer

Spatial immunophenotyping of the tumour microenvironment in non-small cell lung cancer

Backman, Max; Strell, Carina; Lindberg, Amanda; Mattsson, Johanna S. M. et al.

Part of European Journal of Cancer, p. 40-52, 2023

• DOI for Spatial immunophenotyping of the tumour microenvironment in non-small cell lung cancer
• Download full text (pdf) of Spatial immunophenotyping of the tumour microenvironment in non-small cell lung cancer

A Novel Pancreatic Cancer Mini-tumor Model to Study Desmoplasia and Myofibroblastic Cancer-Associated Fibroblast Differentiation

Harryvan, T.J.; Hawinkels, L.J.A.C.; Inderson, A.; van Hooft, J.E. et al.

Part of Gastro Hep Advances, p. 678-681, 2022

• DOI for A Novel Pancreatic Cancer Mini-tumor Model to Study Desmoplasia and Myofibroblastic Cancer-Associated Fibroblast Differentiation
• Download full text (pdf) of A Novel Pancreatic Cancer Mini-tumor Model to Study Desmoplasia and Myofibroblastic Cancer-Associated Fibroblast Differentiation

Comparison of ROS1-rearrangement detection methods in a cohort of surgically resected non-small cell lung carcinomas

Thurfjell, Viktoria; Micke, Patrick; Yu, Hui; Krupar, Rosemarie et al.

Part of Translational Lung Cancer Research, p. 2477-2494, 2022

• DOI for Comparison of ROS1-rearrangement detection methods in a cohort of surgically resected non-small cell lung carcinomas
• Download full text (pdf) of Comparison of ROS1-rearrangement detection methods in a cohort of surgically resected non-small cell lung carcinomas

Difficulties in diagnostics of lung tumours in biopsies: an interpathologist concordance study evaluating the international diagnostic guidelines

Ericson Lindquist, Kajsa; Ciornei, Cristina; Westbom-Fremer, Sofia; Gudinaviciene, Inga et al.

Part of Journal of Clinical Pathology, p. 302-309, 2022

• DOI for Difficulties in diagnostics of lung tumours in biopsies: an interpathologist concordance study evaluating the international diagnostic guidelines
• Download full text 1 (pdf) of Difficulties in diagnostics of lung tumours in biopsies: an interpathologist concordance study evaluating the international diagnostic guidelines
• Download full text 2 (pdf) of Difficulties in diagnostics of lung tumours in biopsies: an interpathologist concordance study evaluating the international diagnostic guidelines

Expression of cartilage oligomeric matrix protein in periampullary adenocarcinoma is associated with pancreatobiliary-type morphology, higher levels of fibrosis and immune cell exclusion

Papadakos, Konstantinos S.; Lundgren, Sebastian; Gialeli, Chrysostomi; Micke, Patrick et al.

Part of Oncoimmunology, 2022

• DOI for Expression of cartilage oligomeric matrix protein in periampullary adenocarcinoma is associated with pancreatobiliary-type morphology, higher levels of fibrosis and immune cell exclusion
• Download full text (pdf) of Expression of cartilage oligomeric matrix protein in periampullary adenocarcinoma is associated with pancreatobiliary-type morphology, higher levels of fibrosis and immune cell exclusion

Highly elevated systemic inflammation is a strong independent predictor of early mortality in advanced non-small cell lung cancer

Isaksson, Johan; Wennström, Leo; Brandén, Eva; Koyi, Hirsh et al.

Part of Cancer Treatment and Research Communications, 2022

• DOI for Highly elevated systemic inflammation is a strong independent predictor of early mortality in advanced non-small cell lung cancer
• Download full text (pdf) of Highly elevated systemic inflammation is a strong independent predictor of early mortality in advanced non-small cell lung cancer

Prognostic Significance of the Loss of Heterozygosity of KRAS in Early-Stage Lung Adenocarcinoma

Khadse, Anand; Haakensen, Vilde D.; Silwal-Pandit, Laxmi; Hamfjord, Julian et al.

Part of Frontiers in Oncology, 2022

• DOI for Prognostic Significance of the Loss of Heterozygosity of KRAS in Early-Stage Lung Adenocarcinoma
• Download full text (pdf) of Prognostic Significance of the Loss of Heterozygosity of KRAS in Early-Stage Lung Adenocarcinoma

Spatial Immunology in Liver Metastases from Colorectal Carcinoma according to the Histologic Growth Pattern

Garcia-Vicien, Gemma; Mezheyeuski, Artur; Micke, Patrick; Ruiz, Nuria et al.

Part of Cancers, 2022

• DOI for Spatial Immunology in Liver Metastases from Colorectal Carcinoma according to the Histologic Growth Pattern
• Download full text (pdf) of Spatial Immunology in Liver Metastases from Colorectal Carcinoma according to the Histologic Growth Pattern

Tumour-infiltrating lymphocytes add prognostic information for patients with low-risk DCIS: findings from the SweDCIS randomised radiotherapy trial

Schiza, Aglaia; Thurfjell, Viktoria; Stenmark Tullberg, Axel; Olofsson, Helena et al.

Part of European Journal of Cancer, p. 128-137, 2022

• DOI for Tumour-infiltrating lymphocytes add prognostic information for patients with low-risk DCIS: findings from the SweDCIS randomised radiotherapy trial
• Download full text (pdf) of Tumour-infiltrating lymphocytes add prognostic information for patients with low-risk DCIS: findings from the SweDCIS randomised radiotherapy trial

An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation

Sabatier, Pierre; Beusch, Christian M.; Saei, Amir A.; Aoun, Mike et al.

Part of Nature Communications, 2021

• DOI for An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation
• Download full text (pdf) of An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation

Evaluation of NTRK immunohistochemistry as a screening method for NTRK gene fusion detection in non-small cell lung cancer

Elfving, Hedvig; Broström, Erika; Moens, Lotte N.J.; Almlöf, Jonas et al.

Part of Lung Cancer, p. 53-59, 2021

• DOI for Evaluation of NTRK immunohistochemistry as a screening method for NTRK gene fusion detection in non-small cell lung cancer

FGFR1 overexpression in non-small cell lung cancer is mediated by genetic and epigenetic mechanisms and is a determinant of FGFR1 inhibitor response

Bogatyrova, Olga; Mattsson, Johanna S M; Ross, Edith M.; Sanderson, Michael P. et al.

Part of European Journal of Cancer, p. 136-149, 2021

• DOI for FGFR1 overexpression in non-small cell lung cancer is mediated by genetic and epigenetic mechanisms and is a determinant of FGFR1 inhibitor response
• Download full text (pdf) of FGFR1 overexpression in non-small cell lung cancer is mediated by genetic and epigenetic mechanisms and is a determinant of FGFR1 inhibitor response

High Density of NRF2 Expression in Malignant Cells Is Associated with Increased Risk of CNS Metastasis in Early-Stage NSCLC

Tsakonas, Georgios; Martin-Bernabe, Alfonso; Rounis, Konstantinos; Moreno-Ruiz, Pablo et al.

Part of Cancers, 2021

• DOI for High Density of NRF2 Expression in Malignant Cells Is Associated with Increased Risk of CNS Metastasis in Early-Stage NSCLC
• Download full text (pdf) of High Density of NRF2 Expression in Malignant Cells Is Associated with Increased Risk of CNS Metastasis in Early-Stage NSCLC

Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene

Doffe, Flora; Carbonnier, Vincent; Tissier, Manon; Leroy, Bernard et al.

Part of Cell Death and Differentiation, p. 1477-1492, 2021

• DOI for Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene
• Download full text (pdf) of Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene

Infiltration of NK and plasma cells is associated with a distinct immune subset in non‐small cell lung cancer

Backman, Max; La Fleur, Linnea; Kurppa, Pinja; Djureinovic, Dijana et al.

Part of Journal of Pathology, p. 243-256, 2021

• DOI for Infiltration of NK and plasma cells is associated with a distinct immune subset in non‐small cell lung cancer
• Download full text (pdf) of Infiltration of NK and plasma cells is associated with a distinct immune subset in non‐small cell lung cancer

PD-L1 amplification is associated with an immune cell rich phenotype in squamous cell cancer of the lung

Goldmann, Torsten; Marwitz, Sebastian; Nitschkowski, Dorte; Krupar, Rosemarie et al.

Part of Cancer Immunology and Immunotherapy, p. 2577-2587, 2021

• DOI for PD-L1 amplification is associated with an immune cell rich phenotype in squamous cell cancer of the lung
• Download full text (pdf) of PD-L1 amplification is associated with an immune cell rich phenotype in squamous cell cancer of the lung

Plasma Proteome Fingerprints Reveal Distinctiveness and Clinical Outcome of SARS-CoV-2 Infection

Bauer, Wolfgang; Weber, Marcus; Diehl-Wiesenecker, Eva; Galtung, Noa et al.

Part of Viruses, 2021

• DOI for Plasma Proteome Fingerprints Reveal Distinctiveness and Clinical Outcome of SARS-CoV-2 Infection
• Download full text (pdf) of Plasma Proteome Fingerprints Reveal Distinctiveness and Clinical Outcome of SARS-CoV-2 Infection

Plasma Proteomic Analysis in Non-Small Cell Lung Cancer Patients Treated with PD-1/PD-L1 Blockade

Eltahir, Mohamed; Isaksson, Johan; Mattsson, Johanna Sofia Margareta; Karre, Klas et al.

Part of Cancers, 2021

• DOI for Plasma Proteomic Analysis in Non-Small Cell Lung Cancer Patients Treated with PD-1/PD-L1 Blockade
• Download full text (pdf) of Plasma Proteomic Analysis in Non-Small Cell Lung Cancer Patients Treated with PD-1/PD-L1 Blockade

Programmed Cell Death Ligand 1 Expression in Resected Non-Small Cell Lung Cancer

Yu, Hui; Brustugun, Odd Terje; Ekman, Simon; Botling, Johan et al.

Part of Clinical Lung Cancer, p. 555-562, 2021

• DOI for Programmed Cell Death Ligand 1 Expression in Resected Non-Small Cell Lung Cancer

Stromal FAP is an independent poor prognosis marker in non-small cell lung adenocarcinoma and associated with p53 mutation

Moreno-Ruiz, Pablo; Corvigno, Sara; te Grootenhuis, Nienke C.; La Fleur, Linnéa et al.

Part of Lung Cancer, p. 10-19, 2021

• DOI for Stromal FAP is an independent poor prognosis marker in non-small cell lung adenocarcinoma and associated with p53 mutation
• Download full text (pdf) of Stromal FAP is an independent poor prognosis marker in non-small cell lung adenocarcinoma and associated with p53 mutation

Targeting hepatocyte growth factor in epithelial-stromal interactions in an in vitro experimental model of human periodontitis

Yamaguchi, Yoko; Saito, Akira; Horie, Masafumi; Aoki, Akira et al.

Part of Odontology, p. 912-920, 2021

• DOI for Targeting hepatocyte growth factor in epithelial-stromal interactions in an in vitro experimental model of human periodontitis
• Download full text (pdf) of Targeting hepatocyte growth factor in epithelial-stromal interactions in an in vitro experimental model of human periodontitis

Targeting MARCO and IL-37R on immunosuppressive macrophages in lung cancer blocks regulatory T cells and supports cytotoxic lymphocyte function

La Fleur, Linnea; Botling, Johan; He, Fei; Pelicano, Catarina et al.

Part of Cancer Research, p. 956-967, 2021

• DOI for Targeting MARCO and IL-37R on immunosuppressive macrophages in lung cancer blocks regulatory T cells and supports cytotoxic lymphocyte function

TGF-beta-mediated epithelial-mesenchymal transition and tumor-promoting effects in CMT64 cells are reflected in the transcriptomic signature of human lung adenocarcinoma

Miyashita, Naoya; Enokido, Takayoshi; Horie, Masafumi; Fukuda, Kensuke et al.

Part of Scientific Reports, 2021

• DOI for TGF-beta-mediated epithelial-mesenchymal transition and tumor-promoting effects in CMT64 cells are reflected in the transcriptomic signature of human lung adenocarcinoma
• Download full text (pdf) of TGF-beta-mediated epithelial-mesenchymal transition and tumor-promoting effects in CMT64 cells are reflected in the transcriptomic signature of human lung adenocarcinoma

The Immune Landscape of Colorectal Cancer

Mezheyeuski, Artur; Micke, Patrick; Martin-Bernabe, Alfonso; Backman, Max et al.

Part of Cancers, 2021

• DOI for The Immune Landscape of Colorectal Cancer
• Download full text (pdf) of The Immune Landscape of Colorectal Cancer

The prognostic impact of the tumour stroma fraction: A machine learning-based analysis in 16 human solid tumour types

Micke, Patrick; Strell, Carina; Mattsson, Johanna Sofia Margareta; Martin-Bernabe, Alfonso et al.

Part of eBioMedicine, 2021

• DOI for The prognostic impact of the tumour stroma fraction: A machine learning-based analysis in 16 human solid tumour types
• Download full text (pdf) of The prognostic impact of the tumour stroma fraction: A machine learning-based analysis in 16 human solid tumour types

An immune gene expression signature distinguishes central nervous system metastases from primary tumours in non-small-cell lung cancer

Tsakonas, Georgios; Lewensohn, Rolf; Botling, Johan; Ortiz-Villalon, Cristian et al.

Part of European Journal of Cancer, p. 24-34, 2020

• DOI for An immune gene expression signature distinguishes central nervous system metastases from primary tumours in non-small-cell lung cancer
• Download full text (pdf) of An immune gene expression signature distinguishes central nervous system metastases from primary tumours in non-small-cell lung cancer

ASCL1 promotes tumor progression through cell-autonomous signaling and immune modulation in a subset of lung adenocarcinoma

Miyashita, Naoya; Horie, Masafumi; Mikami, Yu; Urushiyama, Hirokazu et al.

Part of Cancer Letters, p. 121-132, 2020

• DOI for ASCL1 promotes tumor progression through cell-autonomous signaling and immune modulation in a subset of lung adenocarcinoma

Comprehensive analysis of RNA binding motif protein 3 (RBM3) in non-small cell lung cancer

Salomonsson, Annette; Micke, Patrick; Mattsson, Johanna S M; La Fleur, Linnéa et al.

Part of Cancer Medicine, p. 5609-5619, 2020

• DOI for Comprehensive analysis of RNA binding motif protein 3 (RBM3) in non-small cell lung cancer
• Download full text (pdf) of Comprehensive analysis of RNA binding motif protein 3 (RBM3) in non-small cell lung cancer

Diagnostic Value of Insulinoma-Associated Protein 1 (INSM1) and Comparison With Established Neuroendocrine Markers in Pulmonary Cancers: A Comprehensive Study and Review of the Literature

Staaf, Johan; Tran, Lena; Söderlund, Linnea; Nodin, Björn et al.

Part of Archives of Pathology & Laboratory Medicine, p. 1075-1085, 2020

• DOI for Diagnostic Value of Insulinoma-Associated Protein 1 (INSM1) and Comparison With Established Neuroendocrine Markers in Pulmonary Cancers: A Comprehensive Study and Review of the Literature

PD-L1 expression in gastroenteropancreatic neuroendocrine neoplasms grade 3

Ali, Abir Salwa; Langer, Seppo W.; Federspiel, Birgitte; Hjortland, Geir Olav et al.

Part of PLOS ONE, 2020

• DOI for PD-L1 expression in gastroenteropancreatic neuroendocrine neoplasms grade 3
• Download full text (pdf) of PD-L1 expression in gastroenteropancreatic neuroendocrine neoplasms grade 3

Platelet-derived growth factor receptor β activation and regulation in murine myelofibrosis

Kramer, Frederike; Dernedde, Jens; Mezheyeuski, Artur; Tauber, Rudolf et al.

Part of Haematologica, p. 2083-2094, 2020

• DOI for Platelet-derived growth factor receptor β activation and regulation in murine myelofibrosis
• Download full text (pdf) of Platelet-derived growth factor receptor β activation and regulation in murine myelofibrosis

Quantitative, qualitative and spatial analysis of lymphocyte infiltration in periampullary and pancreatic adenocarcinoma

Lundgren, Sebastian; Elebro, Jacob; Heby, Margareta; Nodin, Björn et al.

Part of International Journal of Cancer, p. 3461-3473, 2020

• DOI for Quantitative, qualitative and spatial analysis of lymphocyte infiltration in periampullary and pancreatic adenocarcinoma
• Download full text (pdf) of Quantitative, qualitative and spatial analysis of lymphocyte infiltration in periampullary and pancreatic adenocarcinoma

The Novel Anti-cMet Antibody seeMet 12 Potentiates Sorafenib Therapy and Radiotherapy in a Colorectal Cancer Model

Spiegelberg, Diana; Lundgren Mortensen, Anja Charlotte; Palupi, Kartika Dyah; Micke, Patrick et al.

Part of Frontiers in Oncology, 2020

• DOI for The Novel Anti-cMet Antibody seeMet 12 Potentiates Sorafenib Therapy and Radiotherapy in a Colorectal Cancer Model
• Download full text (pdf) of The Novel Anti-cMet Antibody seeMet 12 Potentiates Sorafenib Therapy and Radiotherapy in a Colorectal Cancer Model

The protein expression profile of ACE2 in human tissues

Noraddin, Feria Hikmet; Méar, Loren; Edvinsson, Åsa; Micke, Patrick et al.

Part of Molecular Systems Biology, 2020

• DOI for The protein expression profile of ACE2 in human tissues

Topographical Distribution and Spatial Interactions of Innate and Semi-Innate Immune Cells in Pancreatic and Other Periampullary Adenocarcinoma

Lundgren, Sebastian; Micke, Patrick; Elebro, Jacob; Heby, Margareta et al.

Part of Frontiers in Immunology, 2020

• DOI for Topographical Distribution and Spatial Interactions of Innate and Semi-Innate Immune Cells in Pancreatic and Other Periampullary Adenocarcinoma
• Download full text (pdf) of Topographical Distribution and Spatial Interactions of Innate and Semi-Innate Immune Cells in Pancreatic and Other Periampullary Adenocarcinoma

A clonal expression biomarker associates with lung cancer mortality

Biswas, Dhruva; Birkbak, Nicolai J.; Rosenthal, Rachel; Hiley, Crispin T. et al.

Part of Nature Medicine, p. 1540-1548, 2019

• DOI for A clonal expression biomarker associates with lung cancer mortality

A combined gene expression tool for parallel histological prediction and gene fusion detection in non-small cell lung cancer

Karlsson, Anna; Cirenajwis, Helena; Ericson-Lindquist, Kajsa; Brunnström, Hans et al.

Part of Scientific Reports, 2019

• DOI for A combined gene expression tool for parallel histological prediction and gene fusion detection in non-small cell lung cancer
• Download full text (pdf) of A combined gene expression tool for parallel histological prediction and gene fusion detection in non-small cell lung cancer

Cancer stemness, intratumoral heterogeneity, and immune response across cancers

Miranda, Alex; Hamilton, Phineas T.; Zhang, Allen W.; Pattnaik, Swetansu et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 9020-9029, 2019

• DOI for Cancer stemness, intratumoral heterogeneity, and immune response across cancers

c-MET as a biomarker in patients with surgically resected non-small cell lung cancer

Tsakonas, Georgios; Botling, Johan; Micke, Patrick; Rivard, Chris et al.

Part of Lung Cancer, p. 69-74, 2019

• DOI for c-MET as a biomarker in patients with surgically resected non-small cell lung cancer

Immunohistochemical profiles in primary lung cancers and epithelial pulmonary metastases

Vidarsdottir, Halla; Tran, Lena; Nodin, Björn; Jirström, Karin et al.

Part of Human Pathology, p. 221-230, 2019

• DOI for Immunohistochemical profiles in primary lung cancers and epithelial pulmonary metastases

LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer

Cadenas, Cristina; Vosbeck, Sonja; Edlund, Karolina; Grgas, Katharina et al.

Part of International Journal of Cancer, p. 901-915, 2019

• DOI for LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer
• Download full text (pdf) of LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer

Mucin staining is of limited value in addition to basic immunohistochemical analyses in the diagnostics of non-small cell lung cancer

Micke, Patrick; Botling, Johan; Mattsson, Johanna Sofia Margareta; Planck, Maria et al.

Part of Scientific Reports, 2019

• DOI for Mucin staining is of limited value in addition to basic immunohistochemical analyses in the diagnostics of non-small cell lung cancer
• Download full text (pdf) of Mucin staining is of limited value in addition to basic immunohistochemical analyses in the diagnostics of non-small cell lung cancer

Multiplex plasma protein profiling identifies novel markers to discriminate patients with adenocarcinoma of the lung

Djureinovic, Dijana; Pontén, Victor; Landelius, Per; Al Sayegh, Sahar et al.

Part of BMC Cancer, 2019

• DOI for Multiplex plasma protein profiling identifies novel markers to discriminate patients with adenocarcinoma of the lung
• Download full text (pdf) of Multiplex plasma protein profiling identifies novel markers to discriminate patients with adenocarcinoma of the lung

Mutation patterns in a population-based non-small cell lung cancer cohort and prognostic impact of concomitant mutations in KRAS and TP53 or STK11

La Fleur, Linnea; Falk-Sörqvist, Elin; Smeds, Patrik; Berglund, Anders et al.

Part of Lung Cancer, p. 50-58, 2019

• DOI for Mutation patterns in a population-based non-small cell lung cancer cohort and prognostic impact of concomitant mutations in KRAS and TP53 or STK11
• Download full text (pdf) of Mutation patterns in a population-based non-small cell lung cancer cohort and prognostic impact of concomitant mutations in KRAS and TP53 or STK11

NK- and T-cell subsets in malignant mesothelioma patients: Baseline pattern and changes in the context of anti-CTLA-4 therapy

Sottile, Rosa; Tannazi, Milad; Johansson, Maria H.; Cristiani, Costanza Maria et al.

Part of International Journal of Cancer, p. 2238-2248, 2019

• DOI for NK- and T-cell subsets in malignant mesothelioma patients: Baseline pattern and changes in the context of anti-CTLA-4 therapy

Prognostic Impact of Tumor Cell Programmed Death Ligand 1 Expression and Immune Cell Infiltration in NSCLC

Edlund, Karolina; Madjar, Katrin; Mattsson, Johanna Sofia Margareta; Djureinovic, Dijana et al.

Part of Journal of Thoracic Oncology, p. 628-640, 2019

• DOI for Prognostic Impact of Tumor Cell Programmed Death Ligand 1 Expression and Immune Cell Infiltration in NSCLC
• Download full text (pdf) of Prognostic Impact of Tumor Cell Programmed Death Ligand 1 Expression and Immune Cell Infiltration in NSCLC

Programmed Cell Death Ligand 1 Immunohistochemistry: A Concordance Study Between Surgical Specimen, Biopsy, and Tissue Microarray

Elfving, Hedvig; Mattsson, Johanna Sofia Margareta; Lindskog, Cecilia; Backman, Max et al.

Part of Clinical Lung Cancer, p. 258-2620, 2019

• DOI for Programmed Cell Death Ligand 1 Immunohistochemistry: A Concordance Study Between Surgical Specimen, Biopsy, and Tissue Microarray

Real-world prevalence of programmed death ligand 1 expression in locally advanced or metastatic non small-cell lung cancer: The global, multicenter EXPRESS study

Dietel, M.; Savelov, N.; Salanova, R.; Micke, Patrick et al.

Part of Lung Cancer, p. 174-179, 2019

• DOI for Real-world prevalence of programmed death ligand 1 expression in locally advanced or metastatic non small-cell lung cancer: The global, multicenter EXPRESS study

30O Real-world prevalence of PD-L1 expression in locally advanced or metastatic non-small cell lung cancer (NSCLC): The global, multicentre EXPRESS study

Dietel, M.; Savelov, N.; Salanova, R.; Micke, Patrick et al.

Part of Journal of Thoracic Oncology, 2018

• DOI for 30O Real-world prevalence of PD-L1 expression in locally advanced or metastatic non-small cell lung cancer (NSCLC): The global, multicentre EXPRESS study

An Integrative Analysis of Transcriptome and Epigenome Features of ASCL1-Positive Lung Adenocarcinomas

Miyashita, Naoya; Horie, Masafumi; Suzuki, Hiroshi I.; Yoshihara, Masahito et al.

Part of Journal of Thoracic Oncology, p. 1676-1691, 2018

• DOI for An Integrative Analysis of Transcriptome and Epigenome Features of ASCL1-Positive Lung Adenocarcinomas

An integrative transcriptome analysis reveals a functional role for thyroid transcription factor-1 in small cell lung cancer

Horie, Masafumi; Miyashita, Naoya; Mattsson, Johanna Sofia Margareta; Mikami, Yu et al.

Part of Journal of Pathology, p. 154-165, 2018

• DOI for An integrative transcriptome analysis reveals a functional role for thyroid transcription factor-1 in small cell lung cancer

Comparison of Three Different TTF-1 Clones in Resected Primary Lung Cancer and Epithelial Pulmonary Metastase

Vidarsdottir, Halla; Tran, Lena; Nodin, Björn; Jirström, Karin et al.

Part of American Journal of Clinical Pathology, p. 533-544, 2018

• DOI for Comparison of Three Different TTF-1 Clones in Resected Primary Lung Cancer and Epithelial Pulmonary Metastase

COX-2 expression and effects of celecoxib in addition to standard chemotherapy in advanced non-small cell lung cancer.

Gulyas, Miklos; Mattsson, Johanna Sofia Margareta; Lindgren, Andrea; Ek, Lars et al.

Part of Acta Oncologica, p. 244-250, 2018

• DOI for COX-2 expression and effects of celecoxib in addition to standard chemotherapy in advanced non-small cell lung cancer.

Detection of autoantibodies against cancer-testis antigens in non-small cell lung cancer

Djureinovic, Dijana; Dodig-Crnkovic, Tea; Hellström, Cecilia; Holgersson, Georg et al.

Part of Lung Cancer, p. 157-163, 2018

• DOI for Detection of autoantibodies against cancer-testis antigens in non-small cell lung cancer

Digital multiplex immunofluorescence analysis identifies immune profiles in the tumor stroma associated with clinical outcome

Mezheyeuski, Artur; Bergsland, Christian; Backman, Max; Sjöblom, Tobias et al.

Part of CANCER IMMUNOLOGY RESEARCH, 2018

• DOI for Digital multiplex immunofluorescence analysis identifies immune profiles in the tumor stroma associated with clinical outcome

Digital pathology 2.0: a deep learning image analysis tool to identify lung cancer in human tissue samples

Micke, Patrick; Björk, L.; Backman, M.; Elfving, H. et al.

Part of Virchows Archiv, 2018

Expression of scavenger receptor MARCO defines a targetable tumor-associated macrophage subset in non-small cell lung cancer

La Fleur, Linnea; Boura, Vanessa F.; Alexeyenko, Andrey; Berglund, Anders et al.

Part of International Journal of Cancer, p. 1741-1752, 2018

• DOI for Expression of scavenger receptor MARCO defines a targetable tumor-associated macrophage subset in non-small cell lung cancer

LMO7 and LIMCH1 interact with LRIG proteins in lung cancer, with prognostic implications for early-stage disease

Karlsson, Terese; Kvarnbrink, Samuel; Holmlund, Camilla; Botling, Johan et al.

Part of Lung Cancer, p. 174-184, 2018

• DOI for LMO7 and LIMCH1 interact with LRIG proteins in lung cancer, with prognostic implications for early-stage disease

Multispectral imaging for quantitative and compartment-specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients

Mezheyeuski, Artur; Bergsland, Christian Holst; Backman, Max; Djureinovic, Dijana et al.

Part of Journal of Pathology, p. 421-431, 2018

• DOI for Multispectral imaging for quantitative and compartment-specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients

Radionuclide Therapy of HER2-Expressing Human Xenografts Using Affibody-Based Peptide Nucleic Acid-Mediated Pretargeting: In Vivo Proof of Principle

Westerlund, Kristina; Altai, Mohamed; Mitran, Bogdan; Konijnenberg, Mark et al.

Part of Journal of Nuclear Medicine, p. 1092-1098, 2018

• DOI for Radionuclide Therapy of HER2-Expressing Human Xenografts Using Affibody-Based Peptide Nucleic Acid-Mediated Pretargeting: In Vivo Proof of Principle

Real-World Prevalence of PD-L1 Expression in Advanced NoneSmall-Cell Lung Cancer: The Global, Multicenter EXPRESS Study

Salanova, R.; Dietel, M.; Savelov, N.; Micke, Patrick et al.

Part of Journal of Thoracic Oncology, 2018

The Heidelberg compact electron beam ion traps

Micke, Patrick; Kühn, S; Buchauer, L; Harries, J R et al.

Part of Review of Scientific Instruments, 2018

• DOI for The Heidelberg compact electron beam ion traps

The Role of TGF- Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis

Saito, Akira; Horie, Masafumi; Micke, Patrick; Nagase, Takahide

Part of International Journal of Molecular Sciences, 2018

• DOI for The Role of TGF- Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis
• Download full text (pdf) of The Role of TGF- Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis

A pathology atlas of the human cancer transcriptome

Uhlen, Mathias; Zhang, Cheng; Lee, Sunjae; Sjöstedt, Evelina et al.

Part of Science, 2017

• DOI for A pathology atlas of the human cancer transcriptome

Antitumoral effect and reduced systemic toxicity in mice after intra-tumoral injection of an in vivo solidifying calcium sulfate formulation with docetaxel

Sandelin, Martin; Gruden, S.; Räsänen, Veera; Micke, Patrick et al.

Part of Annals of Oncology, 2017

• DOI for Antitumoral effect and reduced systemic toxicity in mice after intra-tumoral injection of an in vivo solidifying calcium sulfate formulation with docetaxel

Antitumoral effect and reduced systemic toxicity in mice after intra-tumoral injection of an in vivo solidifying calcium sulfate formulation with docetaxel

Grudén, Stefan; Sandelin, Martin; Rasanen, Veera; Micke, Patrick et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 186-193, 2017

• DOI for Antitumoral effect and reduced systemic toxicity in mice after intra-tumoral injection of an in vivo solidifying calcium sulfate formulation with docetaxel
• Download full text (pdf) of Antitumoral effect and reduced systemic toxicity in mice after intra-tumoral injection of an in vivo solidifying calcium sulfate formulation with docetaxel

Establishing Reflex NGS Testing in NSCLC in a Regional Network of County Hospitals in Central Sweden

Isaksson, Johan; Willen, Linda; La Fleur, Linnea; Mindus, Stephanie et al.

Part of Journal of Thoracic Oncology, 2017

• DOI for Establishing Reflex NGS Testing in NSCLC in a Regional Network of County Hospitals in Central Sweden

Gene Expression Profiling of Large Cell Lung Cancer Links Transcriptional Phenotypes to the New Histological WHO 2015 Classification

Karlsson, Anna; Brunnström, Hans; Micke, Patrick; Veerla, Srinivas et al.

Part of Journal of Thoracic Oncology, p. 1257-1267, 2017

• DOI for Gene Expression Profiling of Large Cell Lung Cancer Links Transcriptional Phenotypes to the New Histological WHO 2015 Classification
• Download full text (pdf) of Gene Expression Profiling of Large Cell Lung Cancer Links Transcriptional Phenotypes to the New Histological WHO 2015 Classification

Integrative analysis of genome-wide gene copy number changes and gene expression in non-small cell lung cancer

Jabs, Verena; Edlund, Karolina; Koenig, Helena; Grinberg, Marianna et al.

Part of PLOS ONE, 2017

• DOI for Integrative analysis of genome-wide gene copy number changes and gene expression in non-small cell lung cancer
• Download full text (pdf) of Integrative analysis of genome-wide gene copy number changes and gene expression in non-small cell lung cancer

Integrative CAGE and DNA Methylation Profiling Identify Epigenetically Regulated Genes in NSCLC

Horie, Masafumi; Kaczkowski, Bogumil; Ohshima, Mitsuhiro; Matsuzaki, Hirotaka et al.

Part of Molecular Cancer Research, p. 1354-1365, 2017

• DOI for Integrative CAGE and DNA Methylation Profiling Identify Epigenetically Regulated Genes in NSCLC

Mutation Profiling by Targeted Next Generation Sequencing of an Unselected NSCLC Cohort

La Fleur, Linnea; Falk-Sörqvist, Elin; Smeds, Patrik; Sundström, Magnus et al.

Part of Journal of Thoracic Oncology, 2017

• DOI for Mutation Profiling by Targeted Next Generation Sequencing of an Unselected NSCLC Cohort