Verónica Rendo – Targeting brain tumour evolution and treatment resistance

Our research group aims to uncover the mechanisms by which brain tumour cells evolve and become resistant to treatment. Our goal is to translate these findings into therapeutic strategies that more effectively and specifically kill cancer cells.

Despite decades of research, brain tumours remain one of the most lethal cancer types. The greatest challenge is that no curative treatment exists, and all patients eventually develop resistance against the limited amount of treatment options available.

Our lab aims to study the genetic and cell plasticity mechanisms that enable malignant brain tumour cells to develop, grow, and become resistant to treatment. To this end, we leverage cutting-edge genomic, functional genetics and computational approaches to explore these translational questions in clinical samples and preclinical models, which include patient-derived cell lines, organoids, and mouse xenografts.

Our overall goal is to identify and validate novel therapeutic strategies that extend the life of patients diagnosed with a malignant brain tumour.

Schematic figure of the different methods functional genomics, sequencing, drug screeeing and data analysis are used to study genetics changes in cultivated cells and patient samples, to understand the development of brain tumours and theraot resistance.

Overview of our lab’s research.

Read more about or research

More information is also available at www.rendolab.org

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