Research news
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New biomarkers for detecting cancer
Biomarkers in the blood could be used for the early detection of colorectal cancer, lung cancer and ovarian cancer. A new study from IGP shows that the performance of such biomarkers is comparable to or better than established tests and could be developed for clinical use. Läs mer -
Different paediatric brain tumours originate from the same type of cell
Researchers at IGP have discovered that severe brain tumours in children that appear to be completely different actually arise from the same type of cell. This cell type can give rise to tumours in the pineal gland, the retina and the cerebellum. The discovery that these tumours are related may make it possible to treat them in similar ways. Läs mer -
Immunostimulatory gene therapy has been evaluated for patients with malignant melanoma
A new clinical study shows promising results from treatment with immunostimulatory gene therapy in combination with checkpoint inhibitors for patients with malignant melanoma. The study has been published in the scientific journal Nature Communications. Läs mer -
IGP research “Best Basic Investigation” in Journal of Nuclear Medicine
A research team at IGP has had their latest study selected as Best Basic Investigation and overall Featured Article of the Month in the highly ranked Journal of Nuclear Medicine. The work demonstrates a strong therapeutic potential of a new targeted radiopharmaceutical for cancer treatment. Läs mer -
Genetic changes associated with relapse of mantle cell lymphoma
A new study from IGP shows how mantle cell lymphoma changes over time and that new genetic risks arise in cases of relapse. In addition, the genetic changes are affected by the treatment the patient has received. The results show that it is important to perform genetic analyses in cases of relapse and to consider treatments that have less impact on genetic risk. Läs mer -
Unique treatment strategy beneficial for metastatic testicular cancer
A study from IGP shows that carefully selected patients with metastatic testicular cancer benefit from early treatment with high doses of chemotherapy combined with stem cell transplantation. Läs mer -
New protocol for studying blood vessels
In a new publication from IGP, the researchers present a protocol for generating cells that can be used experimentally to study neurovascular communication. The protocol opens new avenues for modelling vascular biology and developing treatments for blood vessel diseases. Läs mer -
More advanced analyses of archived patient samples with new assay
A research team at IGP has developed a breakthrough method that allows scientists to study archived tissue samples from patients. The method unlocks the powerful resource stored in the archived specimens for studying disease progression in cancer. Läs mer -
New technology may enable precision treatment of paediatric brain tumours
The malignant paediatric brain tumour medulloblastoma is driven by proteins deep within the cancer cells, for which there are sometimes no effective drugs available. Researchers at IGP have identified a new genetic technique that enables targeting of tumour cells with elevated levels of such proteins. The technique could be used to eliminate cells responsible for tumour relapse. The hope is to develop an effective drug against recurrence of this disease within a few years. Läs mer -
Breast cancer risk varies between different hormonal contraceptives
Some common hormonal contraceptives are linked to a slightly higher risk of breast cancer than others. This is shown by a new Swedish study from Uppsala University, in which researchers followed more than two million women and teenage girls in Sweden to identify how different hormonal contraceptives affect the risk of breast cancer. Läs mer -
Unravelling the complexities of colon aging
A cellular and spatial atlas of the mouse colon has provided insight into how the cells and tissues of the intestine are affected by ageing. The international research study, recently published in the scientific journal Nature Biotechnology, may contribute to increased knowledge about diseases and conditions in older people. Läs mer -
New possibility to prevent injury after kidney transplantation
A research group at IGP, headed by Bo Nilsson, has developed a novel drug which in preclinical trials was shown to mitigate organ injuries following kidney transplantation. The study was recently published in American Journal of Transplantation. Läs mer -
More effective treatment method for mantle cell lymphoma
A new treatment option for patients with the complex tumour disease mantle cell lymphoma provides longer time to relapse and fewer side effects. This is shown in a new research study from Lund and Uppsala Universities. The results are so promising that the new treatment option has already been implemented in the recently published guidelines from the European Society for Medical Oncology. Läs mer -
Reprogramming the epigenetic code affects growth and survival of tumour cells in multiple myeloma
In the cancer type multiple myeloma, the malignant cells differ significantly from normal cells regarding the layer of chemical “tags” on DNA and proteins that control whether genes are turned on or off. These “tags” affect growth and survival of the tumour cells and could be utilised for developing new treatment strategies against multiple myeloma. This is shown in a recent study from IGP published in the journal Scientific Reports. Läs mer -
New antibody-based strategy shows promise in preventing kidney damage and fibrosis
A collaborative study led by researchers at IGP, Karolinska Institutet, and Northwestern University, reveals a promising new therapeutic strategy to protect the kidneys from progressive damage and fibrosis, conditions that underlie chronic kidney disease. The findings were recently published in the Journal of Clinical Investigation. Läs mer -
Newly discovered chemical compound suggests potential treatment of childhood cancer
Researchers at IGP have identified a molecule that could be used as a new treatment strategy for the pediatric cancer types neuroblastoma and medulloblastoma. This is shown in a recent paper published in the journal Cell Death and Disease. Läs mer -
Discovery indicates new treatment options against glioblastoma
Glioblastoma is one of the most aggressive brain tumour types. Researchers at IGP have now discovered that a specific enzyme – NDST1 – has a key role in how tumour cells behave Läs mer -
Key genes controlling brain tumour spread identified
An international research team led from IGP has identified new mechanisms behind how the aggressive brain tumour glioblastoma spreads in the brain. Targeting the identified connection between the tumour invasion routes and the tumour cell states could be a potential new treatment strategy. Läs mer -
Drug combination shows promising anti-tumour effects on blood cancer cells
Researchers at IGP have identified a promising therapeutic approach for the challenging blood cancer multiple myeloma. In a new preclinical study, they demonstrate that a dual treatment with drugs that inhibit epigenetic regulation reduces tumour growth and induces cancer cell death. Läs mer -
Cultured nerve tissue can be used in ALS studies
With the aid of a 3D printer, researchers at Uppsala University have succeeded in creating a model that resembles human nerve tissue. The model, which can be cultured from the patient’s own cells, makes it possible to test new drug treatments in a lab environment. Läs mer