Research news
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CAR-T cells can arm bystander T cells with CAR molecules via trogocytosis
Engineered immune cells called CAR-T cells are used in the treatment of cancer. Researchers from IGP have now discovered that CAR molecules can be transferred from the CAR-T cells to other T cells in the tumour microenvironment. The researchers also pinpoint how this transfer is regulated, which may be used to improve the efficacy of CAR-T cell therapy. The study has been published in the journal Science Immunology. Läs mer -
New method to stratify lung cancer patients for immunotherapy
Researchers at IGP have developed a new way of predicting which lung cancer patients are more likely to benefit from immunotherapy. The method could eventually be used to stratify patients before choosing a treatment. Läs mer -
Route of entry for Semliki Forest virus into the brain revealed
In a recent study, researchers from Uppsala University show that the Semliki Forest virus enters the central nervous system by first entering the cerebrospinal fluid and then binding to a specific cell type before penetrating deeper into the brain. This finding can potentially be used to develop the Semliki Forest virus as an agent for treating brain cancer. The study has been published in the journal Nature Communications. Läs mer -
Potential treatment strategy for brain vascular disease
Blocking a specific immune cell response can reduce blood vessel lesions and blood clots in the disease Cerebral Cavernous Malformation, and potentially be used as a new treatment strategy. This is shown in a study from Uppsala University where the researchers have studied the mechanisms behind the disease in mice and in patient samples. Läs mer -
Different menopausal hormone treatments pose different risks
Researchers at IGP have analysed the effects of seven different hormone treatments for menopausal symptoms, and the risk of blood clots, stroke and heart attack. The risks differed depending on the active substance and how the medicine is taken. The study involved around one million women aged 50–58 and is the largest and most comprehensive study of currently prescribed hormonal substances in the world. Läs mer -
Genetic variation enhances cancer drug sensitivity
By exploiting the genetic variation in cancer cells, an already approved cancer drug demonstrated enhanced effects against cancer cells in specific patient groups. This is shown in a recent study from IGP, published in the journal eBiomedicine. The findings suggest a potential for more individually tailored and more effective cancer therapies. Läs mer -
How tumour cells change shape – new method could improve cancer treatment
Researchers at IGP have developed an advanced computational model that can reveal how tumour cells ‘think’ when they change shape. This opens up new possibilities for treating severe brain tumours such as glioblastoma and medulloblastoma. Läs mer -
Newly discovered gene involved in response to cancer immunotherapy
Researchers at IGP have identified a gene that influences the efficacy of immunotherapy for the cancer type neuroblastoma. This is shown in a study performed in collaboration with research groups in Sweden, Spain and Germany and recently published in Journal of Clinical Investigation. Läs mer -
Promising treatment for rectal cancer
A new treatment for locally advanced rectal cancer shows favourable results in that surgery can sometimes be avoided completely. It also reduces the risk of recurrence. The method has been confirmed as effective in a comprehensive study conducted at IGP and published in eClinicalMedicine. Läs mer -
Genetic signatures provide prognostic information in colorectal cancer
Using a unique collection of genetic and clinical data for colorectal cancer, researchers at IGP revealed genetic new alterations and developed of a new molecular classifier of tumour variants. The finding could lead to improved possibilities for individualised therapies. This is shown in study recently published in the journal Nature. Läs mer -
Lymphoma patients at high risk of infections after diagnosis
Every year, around 100 people are affected by mantle cell lymphoma. A study from IGP shows that these patients are more vulnerable to other diseases and that the risk of infection for this type of patient should therefore be carefully evaluated. The results of have been published in the journal Hemasphere. Läs mer -
Modified cold virus could provide new weapon against cancer
Injections with a genetically modified virus have shown promise against pancreatic cancer in a new study conducted by researchers at IGP, Baylor College of Medicine in Houston, Texas, and Lokon Pharma. In almost all patients, the tumours shrank. Läs mer -
Achilles’ heel for immunotherapy identified in triple-negative breast cancer
In a recent study published in the journal Nature Communications, researchers from IGP show that the gene NEDD8 affects the capacity of cancer cells to develop resistance against immunotherapy. The findings could be used to develop more effective immunotherapies for the cancer form triple-negative breast cancer. Läs mer -
Lower survival for women than men with germ cell tumours
Women who suffer from the ovarian cancer known as germ cell tumours have a worse prognosis than men with the corresponding tumours, i.e. testicular cancer. After five years with the disease, 98 per cent of men were alive, but survival for women was only 85 per cent. This is shown in a new study from IGP and Uppsala University Hospital published in the journal Journal of Internal Medicine. Läs mer -
Quiescent cancer cells potential target for colorectal cancer therapy
For patients with colorectal cancer the tumour often recurs since quiescent cancer cells can escape therapy and start growing again. In a study from IGP, the researchers have discovered a protein that identifies such quiescent cancer cells. This could improve the possibilities to eliminate also these cells and ultimately lead to more effective therapy. Läs mer -
Patients with precursor stage of malignant melanoma show better survival than people in general
Malignant melanoma is the cancer type that shows the largest increase in Sweden. A study from IGP shows that patients with a precursor stage of malignant melanoma have a significantly better survival than the population in general, despite an increased risk of being diagnosed with malignant melanoma. The results have been published in the journal eClinicalMedicine/The Lancet. Läs mer