Sebastian Barg

Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction

Yeh, Yu-Te; Sona, Chandan; Yan, Xin; Li, Yunxiao et al.

Part of Nature Communications, 2023

• DOI for Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction
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SEC14-like condensate phase transitions at plasma membranes regulate root growth in Arabidopsis

Liu, Chen; Mentzelopoulou, Andriani; Papagavriil, Fotini; Ramachandran, Prashanth et al.

Part of PLoS biology, 2023

• DOI for SEC14-like condensate phase transitions at plasma membranes regulate root growth in Arabidopsis
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Local PI(4,5)P₂ signaling inhibits fusion pore expansion during exocytosis

Omar-Hmeadi, Muhmmad; Gucek, Alenka; Barg, Sebastian

Part of Cell Reports, 2023

• DOI for Local PI(4,5)P₂ signaling inhibits fusion pore expansion during exocytosis
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The β-cell primary cilium is an autonomous Ca²⁺ compartment for paracrine GABA signaling

Sanchez, Gonzalo; Incedal, Tugce Ceren; Prada, Juan; O'Callaghan, Paul et al.

Part of Journal of Cell Biology, 2023

• DOI for The β-cell primary cilium is an autonomous Ca²⁺ compartment for paracrine GABA signaling
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Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

Balboa, Diego; Barsby, Tom; Lithovius, Väinö; Saarimäki-Vire, Jonna et al.

Part of Nature Biotechnology, p. 1042-1055, 2022

• DOI for Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.
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Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets

Golec, Ewelina; Ekstrom, Alexander; Noga, Maciej; Omar-Hmeadi, Muhmmad et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2022

• DOI for Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets
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In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis

Petrenko, Volodymyr; Gandasi, Nikhil; Sage, Daniel; Tengholm, Anders et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 2484-2495, 2020

• DOI for In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis
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Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.

Omar-Hmeadi, Muhmmad; Lund, Per-Eric; Gandasi, Nikhil; Tengholm, Anders et al.

Part of Nature Communications, 2020

• DOI for Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.
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The Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 is Essential for Proinsulin Handling

Mojtaba Ghiasi, Seyed; Dahlby, Tina; Hede Andersen, Caroline; Haataja, Leena et al.

Part of Diabetes, p. 747-760, 2019

• DOI for The Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 is Essential for Proinsulin Handling

Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis

Gucek, Alenka; Gandasi, Nikhil R; Omar-Hmeadi, Muhmmad; Bakke, Marit et al.

Part of eLIFE, 2019

• DOI for Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis
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Glucose-Dependent Granule Docking Limits Insulin Secretion and Is Decreased in Human Type 2 Diabetes

Gandasi, Nikhil R; Yin, Peng; Omar-Hmeadi, Muhmmad; Ottosson Laakso, Emilia et al.

Part of Cell Metabolism, p. 470-478, 2018

• DOI for Glucose-Dependent Granule Docking Limits Insulin Secretion and Is Decreased in Human Type 2 Diabetes

PtdIns(4,5)P₂ is not required for secretory granule docking

Omar-Hmeadi, Muhmmad; Gandasi, Nikhil R; Barg, Sebastian

Part of Traffic, p. 436-445, 2018

• DOI for PtdIns(4,5)P₂ is not required for secretory granule docking

Functional Characterization of Native, High-Affinity GABA_A Receptors in Human Pancreatic β Cells

Korol, Sergiy V; Jin, Zhe; Jin, Yang; Bhandage, Amol K. et al.

Part of EBioMedicine, 2018

• DOI for Functional Characterization of Native, High-Affinity GABA_A Receptors in Human Pancreatic β Cells
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Syntaxin clusters at secretory granules in a munc18-bound conformation

Yin, Peng; Gandasi, Nikhil R.; Arora, Swati; Omar-Hmeadi, Muhmmad et al.

Part of Molecular Biology of the Cell, p. 2700-2708, 2018

• DOI for Syntaxin clusters at secretory granules in a munc18-bound conformation
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MiR-335 overexpression impairs insulin secretion through defective priming of insulin vesicles

Salunkhe, Vishal A.; Ofori, Jones K.; Gandasi, Nikhil R; Salo, Sofia A. et al.

Part of Physiological Reports, 2017

• DOI for MiR-335 overexpression impairs insulin secretion through defective priming of insulin vesicles
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Ca²⁺ channel clustering with insulin-containing granules is disturbed in type 2 diabetes

Gandasi, Nikhil R.; Yin, Peng; Riz, Michela; Chibalina, Margarita V et al.

Part of Journal of Clinical Investigation, p. 2353-2364, 2017

• DOI for Ca²⁺ channel clustering with insulin-containing granules is disturbed in type 2 diabetes
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Plasma membrane PI(4,5)P-2 is critical for secretory granule exocytosis

Omar-Hmeadi, Muhmmad; Gandasi, Nikhil R.; Barg, Sebastian

Part of Molecular Biology of the Cell, p. 3727-3727, 2017

• DOI for Plasma membrane PI(4,5)P-2 is critical for secretory granule exocytosis

Recruitment of Epac2A to Insulin Granule Docking Sites Regulates Priming for Exocytosis

Alenkvist, Ida; Gandasi, Nikhil R; Barg, Sebastian; Tengholm, Anders

Part of Diabetes, p. 2610-2622, 2017

• DOI for Recruitment of Epac2A to Insulin Granule Docking Sites Regulates Priming for Exocytosis

How Kiss-and-Run Can Make Us Sick: SOX4 Puts a Break on the Pore

Barg, Sebastian; Gucek, Alenka

Part of Diabetes, p. 1791-1793, 2016

• DOI for How Kiss-and-Run Can Make Us Sick: SOX4 Puts a Break on the Pore

Plasma Membrane Phosphatidylinositol 4,5-Bisphosphate Regulates Ca2+-Influx and Insulin Secretion from Pancreatic beta Cells

Xie, Beichen; Nguyen, Phuoc My; Gucek, Alenka; Thonig, Antje et al.

Part of CELL CHEMICAL BIOLOGY, p. 816-826, 2016

• DOI for Plasma Membrane Phosphatidylinositol 4,5-Bisphosphate Regulates Ca2+-Influx and Insulin Secretion from Pancreatic beta Cells

Statistical Frailty Modeling for Quantitative Analysis of Exocytotic Events Recorded by Live Cell Imaging: Rapid Release of Insulin-Containing Granules Is Impaired in Human Diabetic beta-cells

Cortese, Giuliana; Gandasi, Nikhil R.; Barg, Sebastian; Pedersen, Morten Gram

Part of PLOS ONE, 2016

• DOI for Statistical Frailty Modeling for Quantitative Analysis of Exocytotic Events Recorded by Live Cell Imaging: Rapid Release of Insulin-Containing Granules Is Impaired in Human Diabetic beta-cells
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Quantitative Imaging of the Exocytosis Machinery Assembly

Gandasi, Nikhil R.; Barg, Sebastian

Part of Biophysical Journal, 2015

MiR-335 regulates exocytotic proteins and affects glucose-stimulated insulin secretion through decreased Ca2+-dependent exocytosis in beta cells

Salunkhe, V. A.; Ofori, J.; Gandasi, Nikhil R.; Salo, S. A. et al.

Part of Diabetologia, 2015

G-protein coupled receptor dynamics in insulin secreting cells

Kay, Emma I.; Barg, Sebastian

Part of Diabetologia, 2015

Survey of Red Fluorescence Proteins as Markers for Secretory Granule Exocytosis

Gandasi, Nikhil R.; Vesto, Kim; Helou, Maria; Yin, Peng et al.

Part of PLOS ONE, 2015

• DOI for Survey of Red Fluorescence Proteins as Markers for Secretory Granule Exocytosis
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The Complement Inhibitor CD59 Regulates Insulin Secretion by Modulating Exocytotic Events

Krus, Ulrika; King, Ben C; Nagaraj, Vini; Gandasi, Nikhil R et al.

Part of Cell Metabolism, p. 883-890, 2014

• DOI for The Complement Inhibitor CD59 Regulates Insulin Secretion by Modulating Exocytotic Events

CD59 is required for pancreatic beta cell insulin exocytosis

Krus, Ulrika; King, Benjamin C.; Nagaraj, Vini; Gandasi, Nikhil et al.

Part of Molecular Immunology, p. 279-279, 2014

Contact-induced clustering of syntaxin and munc18 docks secretory granules at the exocytosis site

Gandasi, Nikhil R; Barg, Sebastian

Part of Nature Communications, 2014

• DOI for Contact-induced clustering of syntaxin and munc18 docks secretory granules at the exocytosis site

Aberrant association between vascular endothelial growth factor receptor-2 and VE-cadherin in response to vascular endothelial growth factor-a in Shb-deficient lung endothelial cells

Zang, Guangxiang; Christoffersson, Gustaf; Tian, Geng; Harun-Or-Rashid, Mohammad et al.

Part of Cellular Signalling, p. 85-92, 2013

• DOI for Aberrant association between vascular endothelial growth factor receptor-2 and VE-cadherin in response to vascular endothelial growth factor-a in Shb-deficient lung endothelial cells
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In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in alpha-Cells

Jin, Yang; Korol, Sergiy V; Jin, Zhe; Barg, Sebastian et al.

Part of PLOS ONE, 2013

• DOI for In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in alpha-Cells
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PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice

Iglesias, José; Barg, Sebastian; Vallois, David; Lahiri, Shawon et al.

Part of Journal of Clinical Investigation, p. 4105-4117, 2012

• DOI for PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice

Multivesicular exocytosis in rat pancreatic beta cells

Hoppa, M B; Jones, E; Karanauskaite, J; Ramracheya, R et al.

Part of Diabetologia, p. 1001-1012, 2012

• DOI for Multivesicular exocytosis in rat pancreatic beta cells

Single secretory granules of live cells recruit syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in large copy numbers

Knowles, M. K.; Barg, Sebastian; Wan, L.; Midorikawa, M. et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 20810-20815, 2010

• DOI for Single secretory granules of live cells recruit syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in large copy numbers

Syntaxin clusters assemble reversibly at sites of secretory granules in live cells

Barg, Sebastian; Knowles, M. K.; Chen, X.; Midorikawa, M. et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 20804-20809, 2010

• DOI for Syntaxin clusters assemble reversibly at sites of secretory granules in live cells

Defective secretion of islet hormones in chromogranin-B deficient mice

Obermüller, Stefanie; Calegari, Federico; King, Angus; Lindqvist, Anders et al.

Part of PLOS ONE, 2010

• DOI for Defective secretion of islet hormones in chromogranin-B deficient mice

Quantitative analysis of t-SNARE and Ca2+-channel clusters near secretory granules

Barg, Sebastian; Gandasi, Nikhil

Part of Diabetologia, 2010

• DOI for Quantitative analysis of t-SNARE and Ca2+-channel clusters near secretory granules

cAMP Mediators of Pulsatile Insulin Secretion from Glucose-stimulated Single β-Cells

Idevall Hagren, Olof; Barg, Sebastian; Gylfe, Erik; Tengholm, Anders

Part of Journal of Biological Chemistry, p. 23005-23016, 2010

• DOI for cAMP Mediators of Pulsatile Insulin Secretion from Glucose-stimulated Single β-Cells

TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells

da Silva Xavier, Gabriela; Loder, Merewyn K; McDonald, Angela; Tarasov, Andrei I et al.

Part of Diabetes, p. 894-905, 2009

• DOI for TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells

High extracellular glucose inhibits exocytosis through disruption of syntaxin 1A-containing lipid rafts

Somanath, Sangeeta; Barg, Sebastian; Marshall, Catriona; Silwood, Christopher J et al.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 241-246, 2009

• DOI for High extracellular glucose inhibits exocytosis through disruption of syntaxin 1A-containing lipid rafts

Impaired glucose homeostasis in Shb-/- mice

Åkerblom, Björn; Barg, Sebastian; Calounova, Gabriela; Mokhtari, Dariush et al.

Part of Journal of Endocrinology, p. 271-279, 2009

• DOI for Impaired glucose homeostasis in Shb-/- mice

Compensatory endocytosis in chromaffin cells

Barg, Sebastian; Machado, Jose David

Part of Acta Physiologica, p. 195-201, 2008

• DOI for Compensatory endocytosis in chromaffin cells

Release of the styryl dyes from single synaptic vesicles in hippocampal neurons.

Chen, Xi; Barg, Sebastian; Almers, Wolfhard

Part of The Journal of neuroscience : the official journal of the Society for Neuroscience, p. 1894-1903, 2008

• DOI for Release of the styryl dyes from single synaptic vesicles in hippocampal neurons.
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Granule docking and cargo release in pancreatic β-cells

Barg, Sebastian; Lindqvist, Anders; Obermüller, Stefanie

Part of Biochemical Society Transactions, p. 294-299, 2008

• DOI for Granule docking and cargo release in pancreatic β-cells

Selective nucleotide-release from dense-core granules in insulin-secreting cells

Obermüller, Stefanie; Lindqvist, Anders; Karanauskaite, Jovita; Galvanovskis, Juris et al.

Part of Journal of Cell Science, p. 4271-82, 2005

• DOI for Selective nucleotide-release from dense-core granules in insulin-secreting cells
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Membrane phosphoinositides control insulin secretion through their effects on ATP-sensitive K+ channel activity.

Lin, Chia-Wei; Yan, Feifei; Shimamura, Satoko; Barg, Sebastian et al.

Part of Diabetes, p. 2852-8, 2005

Large dense-core vesicle exocytosis in pancreatic beta-cells monitored by capacitance measurements.

Kanno, Takahiro; Ma, Xiasong; Barg, Sebastian; Eliasson, Lena et al.

Part of Methods, p. 302-11, 2004

• DOI for Large dense-core vesicle exocytosis in pancreatic beta-cells monitored by capacitance measurements.

Insulin secretion: a high-affinity Ca2+ sensor after all?

Barg, Sebastian; Rorsman, Patrik

Part of The Journal of General Physiology, p. 623-5, 2004

• DOI for Insulin secretion: a high-affinity Ca2+ sensor after all?

SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells.

Eliasson, Lena; Ma, Xiaosong; Renström, Erik; Barg, Sebastian et al.

Part of The Journal of General Physiology, p. 181-97, 2003

Mechanisms of exocytosis in insulin-secreting B-cells and glucagon-secreting A-cells.

Barg, Sebastian

Part of Pharmacology and Toxicology, p. 3-13, 2003

Delay between fusion pore opening and peptide release from large dense-core vesicles in neuroendocrine cells

Barg, Sebastian; Olofsson, Charlotta S; Schriever-Abeln, Jenny; Wendt, Anna et al.

Part of Neuron, p. 287-299, 2002

• DOI for Delay between fusion pore opening and peptide release from large dense-core vesicles in neuroendocrine cells