Chemical Molecular Design

10 credits

Syllabus, Master's level, 1KB453

A revised version of the syllabus is available.
Education cycle
Second cycle
Main field(s) of study and in-depth level
Chemistry A1N
Grading system
Fail (U), Pass (3), Pass with credit (4), Pass with distinction (5)
Finalised by
The Faculty Board of Science and Technology, 26 April 2011
Responsible department
Department of Chemistry - BMC

Entry requirements

120 credits in Science including 60 credits Chemistry, or equivalent.

Learning outcomes

After successful completion of the course, the participant should have the ability to:

  • consider the complexity that is needed in a molecule to solve a particular scientific problem
  • evaluate cost - benefit relationships in the design and synthesis of organic molecules
  • describe and discuss design scaffolds for molecular recognition of small and biomacromolecular targets
  • plan design and chemical modification of proteins
  • describe and discuss common properties and principles of organometallic and organocatalysts, enzymes and engineered enzymes
  • plan the preparation of simple artificial enzymes


Design of molecules for the detection of bio-macromolecules: Small organic molecules for the recognition of proteins, their surface or active centre. Recognition of domains and complexes.

Studies and comparison of different types of molecular recognition; small vs small (exemplified by organometallic and organocatalysts), small vs large (exemplified by natural and artificial enzymes), large vs large (exemplified by protein-protein interactions).

Design of molecules that inhibit the interaction between bio-macromolecules: inhibition of protein-protein interactions, inhibition of interactions of nucleic acids. Design of catalysts: Organometallic catalysis and organocatalysis. Reengineering of enzymes, design of new enzymes. Design of multifunction molecules: biosensors.

The student shall in group projects identify suitable structures and plan their synthesis and evaluation.


Lectures, theoretical exercises, literature searches, and projects. Training in oral and written reports. Participation in exercises and projects is mandatory.


Written exam at the end of the course. The exercises as well as the theoretical work must be passed in order for the student to pass the whole course. Division of points: Written exam 7 credits, mandatory exercises and their reports 3 credits. The final grade is a weighted combination of the individual grades.