Chemical Molecular Design
Syllabus, Master's level, 1KB453
- Code
- 1KB453
- Education cycle
- Second cycle
- Main field(s) of study and in-depth level
- Chemistry A1N
- Grading system
- Fail (U), Pass (3), Pass with credit (4), Pass with distinction (5)
- Finalised by
- The Faculty Board of Science and Technology, 26 April 2011
- Responsible department
- Department of Chemistry - BMC
Entry requirements
120 credits in Science including 60 credits Chemistry, or equivalent.
Learning outcomes
After successful completion of the course, the participant should have the ability to:
- consider the complexity that is needed in a molecule to solve a particular scientific problem
- evaluate cost - benefit relationships in the design and synthesis of organic molecules
- describe and discuss design scaffolds for molecular recognition of small and biomacromolecular targets
- plan design and chemical modification of proteins
- describe and discuss common properties and principles of organometallic and organocatalysts, enzymes and engineered enzymes
- plan the preparation of simple artificial enzymes
Content
Design of molecules for the detection of bio-macromolecules: Small organic molecules for the recognition of proteins, their surface or active centre. Recognition of domains and complexes.
Studies and comparison of different types of molecular recognition; small vs small (exemplified by organometallic and organocatalysts), small vs large (exemplified by natural and artificial enzymes), large vs large (exemplified by protein-protein interactions).
Design of molecules that inhibit the interaction between bio-macromolecules: inhibition of protein-protein interactions, inhibition of interactions of nucleic acids. Design of catalysts: Organometallic catalysis and organocatalysis. Reengineering of enzymes, design of new enzymes. Design of multifunction molecules: biosensors.
The student shall in group projects identify suitable structures and plan their synthesis and evaluation.
Instruction
Lectures, theoretical exercises, literature searches, and projects. Training in oral and written reports. Participation in exercises and projects is mandatory.
Assessment
Written exam at the end of the course. The exercises as well as the theoretical work must be passed in order for the student to pass the whole course. Division of points: Written exam 7 credits, mandatory exercises and their reports 3 credits. The final grade is a weighted combination of the individual grades.