Biophysical Chemistry
Syllabus, Master's level, 1KB468
- Code
- 1KB468
- Education cycle
- Second cycle
- Main field(s) of study and in-depth level
- Chemistry A1N
- Grading system
- Fail (U), Pass (3), Pass with credit (4), Pass with distinction (5)
- Finalised by
- The Faculty Board of Science and Technology, 8 March 2012
- Responsible department
- Department of Chemistry - BMC
Entry requirements
120 credits including 60 credits in chemistry including 15 credits in biochemistry.
Learning outcomes
After successful completion of the course, the participant should have the ability to:
- Account for the different interactions that are important for the formation of structures in biological systems and for how thermodynamic parameters can be measured.
- Account for basic concepts within statistical thermodynamics and apply this to biological systems, macromolecules in solution, conformational equilibria, membrane equilibria, ligand binding and cooperativity.
- Account for structures and functions of biological membranes, as well as model systems and relevant methods for the study of these structures and functions.
- Explain and apply methods for the determination of functional molecular mass of biological macromolecules in solution as well as determination of equilibrium - and rate constants for macromolecule-ligand interactions.
- Account for and apply spectroscopic methods for the study of structures and functions in biological systems
Content
The structure of biological macromolecules. Statistical thermodynamics especially applied on biological systems, macromolecules in solution, conformational equilibria, membrane equilibria, ligand binding and cooperativity. Microcalorimetry. Methods to study equilibrium and speed for association-dissociation processes. Membrane proteins and membrane transport. Spectroscopic methods: UV-Vis and fluorescence, EPR, ESR and NMR related to biochemistry. Physical methods for studies of the interaction between biological macromolecules. Transport processes with relevance in biological systems and experimental biochemistry. Determination of functional molecular mass in solution using scattering methods and sedimentation
Instruction
The teaching is given as lectures, lessons, seminars, laboratory sessions and projects with presentations. Communication training and profile according to chosen specialisation integrated with other course parts.
Assessment
Written tests are organised at the end of the course and/or during the course and correspond to 6 credits. The laboratory sessions correspond to 4 .