Enhanced spray-dried formulations of inhaled drugs
Providing a solid scientific understanding of important aspects of spray-dried formulations of inhaled drugs that ultimately will enable enhanced spray-dried formulations to be developed.
Details
- Funder: Vinnova
Research Scientist: Mayura Talwelkar Shimpi, PhD
Principal Investigator: Professor Göran Frenning, Department of Pharmaceutical Biosciences, Uppsala University
Scientific and industrial context. Spray drying is a flexible singe-step technique for the preparation of micron-sized particles suitable for inhalation. With adequate processing parameters and excipients, spray drying is gentle enough to retain the biological activity of peptides, oligonucleotides and other biologics. Spray-dried particles can be used in carrier-free formulations, potentially enabling higher doses of active pharmaceutical ingredients (APIs) to be delivered to the lung.
Aim. To provide a solid scientific understanding of important aspects of spray-dried formulations of inhaled drugs that ultimately will enable enhanced spray-dried formulations to be developed. Of particular interest is to investigate the potential of “novel” excipients for achieving physiochemical stability of a range of API modalities, including small molecules and large biologic molecules.