Mechanistic in-silico modeling of colonic drug absorption and the predictive performance of extended-release formulations
To identify and address gaps in GastroPlus®, GI-Sim, and Simcyp® software packages for predicting colon absorption and extended-release formulations, and to enhance the colon model in GI-Sim.
Details
- Funder: Vinnova
Research scientist: Harshad Sunil Jadhav, PhD Student
Principal investigator: Professor Christel Bergström, Department of Pharmacy, Uppsala University
Aim: To identify and address gaps in GastroPlus®, GI-Sim, and Simcyp® software packages for predicting colon absorption and extended-release formulations, and to enhance the colon model in GI-Sim.
Outcome: To incorporate physiologically relevant parameters to refine prediction methodologies, aiming to improve the accuracy and reliability of these software tools in biopharmaceutics modeling.
Samarbetsparter
AstraZeneca AB
Project members
Project leader: Christel Bergström
Co-investigators: Harshad Sunil Jadhav, PhD Student, Department of Pharmacy / AstraZeneca