Physiologically based biopharmaceutics modeling for subcutaneous drug administration

Research scientist: Ilse Dubbelboer, Researcher
Principal Investigator: Assoc. Prof. Erik Sjögren, Department of Pharmaceutical Biosciences, Uppsala University

Scientific and industrial context. The subcutaneous route of administration is important for current and future biologics. In addition to being the only option for parenteral self-administration, this route also presents many advantages such as the achievement of prolonged release and the possibility for administration of a wide range of formulations. Still, from a drug development perspective, readily available tools for translation of in vitro and pre-clinical data to clinical performance is still lacking.

Aim. To develop a physiologically based biopharmaceutics model for subcutaneous administration based on the interrelationships between physiology, the pharmacologically active substance and the drug delivery system.

Outcome. A freely accessible physiologically based biopharmaceutics model for subcutaneous drug administration.