Zhen Zhang

Zhen Zhang's sensors detect bacteria responding to antibiotics as an electrical signal, with no microscope, stain or camera involved. That makes the test fast, small and cheap enough to potentially run at the point of care.

Professor

Department of Electrical Engineering at Uppsala University

zhen.zhang@angstrom.uu.se

Zhen's profile site

Cecilia's research group site

Research focus and interests

  • Silicon based nanoelectronics and nanosensors to investigate cellular heterogeneity and molecular heterogeneity, single-cell metabolic profiling, rapid antibiotic susceptibility tests

Research expertise and methodologies

  • Silicon nanodevice and nanofabrication technology
  • Microfluidics integration
  • Silicon nanosensors for supersensitive ion detection

Ongoing research projects

  1. Silicon sensor chip based rapid electrical antibiotic susceptibility tests
  2. Silicon sensor chip-microfluidics integration for real-time single-cell metabolic profiling with high-throughput

Key Publications

  1. Xu Z., Nolan V.C., Yu Y., Muir P., Koskiniemi S., Zhang Z. (2026) A lab-on-a-silicon-chip platform for all-electrical antibiotic susceptibility tests with a sample-to-results time within 20 minutes. Science Advances. https://doi.org/10.1126/sciadv.aeb2880
  2. Xu Z., Yu Y., Solomon P., Zhang Z. (2025) Integration of AC bias-stabilized SiNRFETs with microscale Ag/AgCl pseudo-reference electrodes for lab-on-chip biosensing applications. Sensors and Actuators B: Chemical. https://doi.org/10.1016/j.snb.2025.138000
  3. Xu X., Chen S., Yu Y., Virtanen P., Wu J., Hu Q., Koskiniemi S., Zhang Z. (2022) All-electrical antibiotic susceptibility testing within 30 minutes using silicon nano transistors. Sensors and Actuators B: Chemical. https://doi.org/10.1016/j.snb.2022.131458

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