Estefanía Echeverri

Spinal implants have been successfully used to treat various conditions; however, the release of ions and particles from these materials raises safety concerns. In this project, our focus is on understanding the biological impact of wear debris and corrosion particles from spinal implants on the human body.

Our research aims to investigate the initial response triggered by these particles within periprosthetic tissues, primarily driven by inflammatory cells such as fibroblasts and macrophages. Through comprehensive studies, we seek to uncover how these cells respond to corrosion products derived from novel materials and alloys intended for spinal implants.

Moreover, given the close interaction between orthopedic implants and bone tissue, we consider it essential to assess the response of relevant bone cells. Special attention is given to evaluating the osteogenic potential of these materials, providing insight into their ability to support bone regeneration and integration.

Recognizing the critical proximity of spinal implants to the central nervous system, our project aims to evaluate the neural tissue response to ions and particles released from implants. This includes the response of glial cells, such as microglia and astrocytes, to provide insights into their potential detrimental effects and help assess the safety of spinal implants.

By drawing on interdisciplinary expertise and employing advanced methodologies, our research seeks to advance the understanding of spinal implant biocompatibility and safety. Ultimately, our findings hold promise for improving the design and clinical application of spinal implants, ensuring optimal patient outcomes and quality of life.