Publications

Smad7 palmitoylation by the S-acyltransferase zDHHC17 enhances its inhibitory effect on TGF-β/Smad signaling

Voytyuk, Oleksandr; Ohata, Yae; Moustakas, Aristidis; ten Dijke, Peter et al.

Part of Journal of Biological Chemistry, 2024

• DOI for Smad7 palmitoylation by the S-acyltransferase zDHHC17 enhances its inhibitory effect on TGF-β/Smad signaling
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Special issue: TGF-β and epithelial-mesenchymal transition in cancer

ten Dijke, Peter; Miyazono, Kohei; Heldin, Carl-Henrik; Moustakas, Aristidis

Part of Seminars in Cancer Biology, p. 1-3, 2024

• DOI for Special issue: TGF-β and epithelial-mesenchymal transition in cancer

ΔNp63 bookmarks and creates an accessible epigenetic environment for TGFβ-induced cancer cell stemness and invasiveness

Vasilaki, Eleftheria; Bai, Yu; Ali, Mohamad Moustafa; Sundqvist, Anders et al.

Part of Cell Communication and Signaling, 2024

• DOI for ΔNp63 bookmarks and creates an accessible epigenetic environment for TGFβ-induced cancer cell stemness and invasiveness
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Hyaluronan-Induced CD44-iASPP Interaction Affects Fibroblast Migration and Survival

Lin, Chun-Yu; Basu, Kaustuv; Ruusala, Aino; Kozlova, Inna et al.

Part of Cancers, 2023

• DOI for Hyaluronan-Induced CD44-iASPP Interaction Affects Fibroblast Migration and Survival
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SUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferation

Wang, Kehuan; Papadopoulos, Natalia; Hamidi, Anahita; Lennartsson, Johan et al.

Part of BMC Molecular and Cell Biology, 2023

• DOI for SUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferation
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The E3 Ubiquitin Ligase TRIM21 Regulates Basal Levels of PDGFRβ

Sarri, Niki; Papadopoulos, Natalia; Lennartsson, Johan; Heldin, Carl-Henrik

Part of International Journal of Molecular Sciences, 2023

• DOI for The E3 Ubiquitin Ligase TRIM21 Regulates Basal Levels of PDGFRβ
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The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition

Tzavlaki, Kalliopi; Ohata, Yae; Morén, Anita; Watanabe, Yukihide et al.

Part of Journal of Cellular Physiology, p. 790-812, 2023

• DOI for The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition
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The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion

Gélabert, Caroline; Papoutsoglou, Panagiotis; Cancela Golan, Irene; Ahlström, Eric et al.

Part of Cell Communication and Signaling, 2023

• DOI for The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion
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CD44 Depletion in Glioblastoma Cells Suppresses Growth and Stemness and Induces Senescence

Kolliopoulos, Constantinos; Ali, Mohamad Moustafa; Castillejo-Lopez, Casimiro; Heldin, Carl-Henrik et al.

Part of Cancers, 2022

• DOI for CD44 Depletion in Glioblastoma Cells Suppresses Growth and Stemness and Induces Senescence
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Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFR beta and affect PDGF-BB-induced STAT3 signalling

Sarri, Niki; Wang, Kehuan; Tsioumpekou, Maria; Castillejo-Lopez, Casimiro et al.

Part of Cellular and Molecular Life Sciences (CMLS), 2022

• DOI for Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFR beta and affect PDGF-BB-induced STAT3 signalling
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Identification of a Small Molecule Inhibitor of Hyaluronan Synthesis, DDIT, Targeting Breast Cancer Cells

Karalis, Theodoros; Shiau, Andrew K. K.; Gahman, Timothy C. C.; Skandalis, Spyros S. S. et al.

Part of Cancers, 2022

• DOI for Identification of a Small Molecule Inhibitor of Hyaluronan Synthesis, DDIT, Targeting Breast Cancer Cells
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Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells

Tsirigoti, Chrysoula; Ali, Mohamad Moustafa; Maturi, Varun; Heldin, Carl-Henrik et al.

Part of Cell Death and Disease, 2022

• DOI for Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells
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PRRX1 induced by BMP signaling decreases tumorigenesis by epigenetically regulating glioma-initiating cell properties via DNA methyltransferase 3A

Tanabe, Ryo; Miyazono, Kohei; Todo, Tomoki; Saito, Nobuhito et al.

Part of Molecular Oncology, p. 269-288, 2022

• DOI for PRRX1 induced by BMP signaling decreases tumorigenesis by epigenetically regulating glioma-initiating cell properties via DNA methyltransferase 3A
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TGF beta selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition

Tsubakihara, Yutaro; Ohata, Yae; Okita, Yukari; Younis, Shady et al.

Part of Molecular Oncology, p. 2330-2354, 2022

• DOI for TGF beta selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition
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The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma

Caja, Laia; Dadras, Mahsa Shahidi; Mezheyeuski, Artur; Mendes Rodrigues-Junior, Dorival et al.

Part of Journal of Cellular Physiology, p. 743-762, 2022

• DOI for The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma
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The type II TGF-β receptor phosphorylates Tyr ¹⁸² in the type I receptor to activate downstream Src signaling

Yakymovych, Ihor; Yakymovych, Mariya; Hamidi, Anahita; Landström, Maréne et al.

Part of Science Signaling, 2022

• DOI for The type II TGF-β receptor phosphorylates Tyr ¹⁸² in the type I receptor to activate downstream Src signaling
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The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells

Song, Jie; Zhou, Yang; Yakymovych, Ihor; Schmidt, Alexej et al.

Part of EBioMedicine, 2022

• DOI for The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells
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BMP2-induction of FN14 promotes protumorigenic signaling in gynecologic cancer cells

Fukuda, Tomohiko; Fukuda, Risa; Koinuma, Daizo; Moustakas, Aristidis et al.

Part of Cellular Signalling, 2021

• DOI for BMP2-induction of FN14 promotes protumorigenic signaling in gynecologic cancer cells

The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor beta signaling

Papoutsoglou, Panagiotis; Rodrigues Junior, Dorival Mendes; Morén, Anita; Bergman, Andrew et al.

Part of Oncogene, p. 3748-3765, 2021

• DOI for The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor beta signaling
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The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma

Dadras, Mahsa Shahidi; Caja, Laia; Mezheyeuski, Artur; Liu, Sijia et al.

Part of Cell Death and Disease, 2021

• DOI for The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma
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TRAF4/6 Is Needed for CD44 Cleavage and Migration via RAC1 Activation

Kolliopoulos, Constantinos; Chatzopoulos, Athanasios; Skandalis, Spyros S.; Heldin, Carl-Henrik et al.

Part of Cancers, 2021

• DOI for TRAF4/6 Is Needed for CD44 Cleavage and Migration via RAC1 Activation
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Tumor Promoting Effect of BMP Signaling in Endometrial Cancer

Fukuda, Tomohiko; Fukuda, Risa; Miyazono, Kohei; Heldin, Carl-Henrik

Part of International Journal of Molecular Sciences, 2021

• DOI for Tumor Promoting Effect of BMP Signaling in Endometrial Cancer
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BMP signaling is a therapeutic target in ovarian cancer

Fukuda, Tomohiko; Fukuda, Risa; Tanabe, Ryo; Koinuma, Daizo et al.

Part of Cell Death Discovery, 2020

• DOI for BMP signaling is a therapeutic target in ovarian cancer
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Bone morphogenetic protein receptors: Structure, function and targeting by selective small molecule kinase inhibitors

Sanchez-Duffhues, Gonzalo; Williams, Eleanor; Goumans, Marie-Jose; Heldin, Carl-Henrik et al.

Part of Bone, 2020

• DOI for Bone morphogenetic protein receptors: Structure, function and targeting by selective small molecule kinase inhibitors
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Involvement of hyaluronan and CD44 in cancer and viral infections

Heldin, Paraskevi; Kolliopoulos, Constantinos; Lin, Chun-Yu; Heldin, Carl-Henrik

Part of Cellular Signalling, 2020

• DOI for Involvement of hyaluronan and CD44 in cancer and viral infections

Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis

Zhang, Yanyu; Cedervall, Jessica; Hamidi, Anahita; Herre, Melanie et al.

Part of Cancer Research, p. 3345-3358, 2020

• DOI for Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis

Smad7 Enhances TGF-beta-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells

Thakur, Noopur; Hamidi, Anahita; Song, Jie; Itoh, Susumu et al.

Part of iScience, 2020

• DOI for Smad7 Enhances TGF-beta-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells
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Smad7 Enhances TGF-b-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells

Thakur, Noopur; Hamidi, Anahita; Song, Jie; Itoh, Susumu et al.

Part of iScience, 2020

Specific targeting of PDGFR beta in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression

Tsioumpekou, Maria; Cunha, Sara I.; Ma, Haisha; Åhgren, Aive et al.

Part of Theranostics, p. 1122-1135, 2020

• DOI for Specific targeting of PDGFR beta in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression
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Structure-based discovery of novel small molecule inhibitors of platelet-derived growth factor-B

Zarei, Omid; Sarri, Niki; Dastmalchi, Siavoush; Zokai, Fateme et al.

Part of Bioorganic chemistry (Print), 2020

• DOI for Structure-based discovery of novel small molecule inhibitors of platelet-derived growth factor-B

TGF beta and EGF signaling orchestrates the AP-1-and p63 transcriptional regulation of breast cancer invasiveness

Sundqvist, Anders; Vasilaki, Eleftheria; Voytyuk, Oleksandr; Bai, Yu et al.

Part of Oncogene, p. 4436-4449, 2020

• DOI for TGF beta and EGF signaling orchestrates the AP-1-and p63 transcriptional regulation of breast cancer invasiveness
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Dual specificity phosphatase (DUSP)-4 is induced by platelet-derived growth factor -BB in an Erk1/2-, STAT3- and p53-dependent manner

Yin, Runting; Eger, Glenda; Sarri, Niki; Rorsman, Charlotte et al.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 469-474, 2019

• DOI for Dual specificity phosphatase (DUSP)-4 is induced by platelet-derived growth factor -BB in an Erk1/2-, STAT3- and p53-dependent manner

Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGFβ-induced EMT in breast cancer

Kolliopoulos, Constantinos; Lin, Chun-Yu; Heldin, Carl-Henrik; Moustakas, Aristidis et al.

Part of Matrix Biology, p. 29-45, 2019

• DOI for Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGFβ-induced EMT in breast cancer

High levels of serum hyaluronan is an early predictor of dengue warning signs and perturbs vascular integrity

Lin, Chun-Yu; Kolliopoulos, Constantinos; Huang, Chung-Hao; Tenhunen, Jyrki et al.

Part of EBioMedicine, p. 425-441, 2019

• DOI for High levels of serum hyaluronan is an early predictor of dengue warning signs and perturbs vascular integrity
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JNK-Dependent cJun Phosphorylation Mitigates TGF beta- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses

Sundqvist, Anders; Voytyuk, Olexandr; Hamdi, Mohamed; Popeijus, Herman E. et al.

Part of CELLS, 2019

• DOI for JNK-Dependent cJun Phosphorylation Mitigates TGF beta- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses
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LXR alpha limits TGF beta-dependent hepatocellular carcinoma associated fibroblast differentiation

Morén, Anita; Bellomo, Claudia; Tsubakihara, Yutaro; Kardassis, Dimitris et al.

Part of Oncogenesis, 2019

• DOI for LXR alpha limits TGF beta-dependent hepatocellular carcinoma associated fibroblast differentiation
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The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension

Morikawa, Masato; Mitani, Yoshihide; Holmborn, Katarina; Kato, Taichi et al.

Part of Science Signaling, 2019

• DOI for The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension

The TGFB2-AS1 lncRNA regulates TGFβ signaling by modulating corepressor activity

Papoutsoglou, Panagiotis; Tsubakihara, Yutaro; Caja, Laia; Pallis, Paris et al.

Part of Cell Reports, p. 3182-319800000000000, 2019

• DOI for The TGFB2-AS1 lncRNA regulates TGFβ signaling by modulating corepressor activity
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Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output

Kolliopoulos, Constantinos; Raja, Erna; Razmara, Masoud; Heldin, Paraskevi et al.

Part of Journal of Biological Chemistry, p. 4119-4136, 2019

• DOI for Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output
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Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells

Maturi, Varun; Morén, Anita; Enroth, Stefan; Heldin, Carl-Henrik et al.

Part of Molecular Oncology, p. 1153-1174, 2018

• DOI for Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells
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Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells

Maturi, Varun; Enroth, Stefan; Heldin, Carl-Henrik; Moustakas, Aristidis

Part of Journal of Cellular Physiology, p. 7113-7127, 2018

• DOI for Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells
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Intracellular trafficking of transforming growth factor beta receptors

Yakymovych, Ihor; Yakymovych, Mariya; Heldin, Carl-Henrik

Part of Acta biochimica et biophysica Sinica, p. 3-11, 2018

• DOI for Intracellular trafficking of transforming growth factor beta receptors

Involvement of platelet-derived growth factor ligands and receptors in tumorigenesis

Heldin, Carl-Henrik; Lennartsson, Johan; Westermark, Bengt

Part of Journal of Internal Medicine, p. 16-44, 2018

• DOI for Involvement of platelet-derived growth factor ligands and receptors in tumorigenesis

JUNB governs a feed-forward network of TGF beta signaling that aggravates breast cancer invasion

Sundqvist, Anders; Morikawa, Masato; Ren, Jiang; Vasilaki, Eleftheria et al.

Part of Nucleic Acids Research, p. 1180-1195, 2018

• DOI for JUNB governs a feed-forward network of TGF beta signaling that aggravates breast cancer invasion
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PDGFR beta translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1

Papadopoulos, Natalia; Lennartsson, Johan; Heldin, Carl-Henrik

Part of Journal of Cell Biology, p. 1701-1717, 2018

• DOI for PDGFR beta translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1

Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma

Bellomo, Claudia; Caja, Laia; Fabregat, Isabel; Mikulits, Wolfgang et al.

Part of Cell Death and Differentiation, p. 885-903, 2018

• DOI for Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma
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Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells

Caja, Laia; Tzavlaki, Kalliopi; Dadras, Mahsa Shahidi; Tan, E-Jean et al.

Part of Oncogene, p. 2515-2531, 2018

• DOI for Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells
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Targeting PDGF-mediated recruitment of pericytes blocks vascular mimicry and tumor growth

Thijssen, Victor L. J. L.; Paulis, Yvette W. J.; Nowak-Sliwinska, Patrycja; Deumelandt, Katrin L. et al.

Part of Journal of Pathology, p. 447-458, 2018

• DOI for Targeting PDGF-mediated recruitment of pericytes blocks vascular mimicry and tumor growth

The protein kinase SIK downregulates the polarity protein Par3

Vanlandewijck, Michael; Dadras, Mahsa Shahidi; Lomnytska, Marta; Mahzabin, Tanzila et al.

Part of Oncotarget, p. 5716-5735, 2018

• DOI for The protein kinase SIK downregulates the polarity protein Par3

The role of deubiquitinating enzyme USP17, hyaluronan synthase 2, and hyaluronan in non-small-cell lung cancer oncogenic transformation

Mehic, Merima, Sr.; de Sa, Vanessa Karen, Sr.; Hebestreit, Sandra; Heldin, Paraskevi et al.

Part of Clinical Cancer Research, p. 96-96, 2018

• DOI for The role of deubiquitinating enzyme USP17, hyaluronan synthase 2, and hyaluronan in non-small-cell lung cancer oncogenic transformation