Publications

TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles

Mendes Rodrigues Junior, Dorival; Tsirigoti, Chrysoula; Psatha, Konstantina; Kletsas, Dimitris et al.

Part of Journal of Experimental & Clinical Cancer Research, 2025

• DOI for TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles
• Download full text (pdf) of TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles

PDGF-induced internalisation promotes proteolytic cleavage of PDGFRβ in mesenchymal cells

Rubin Sander, Marie; Tsiatsiou, Agni Karolina; Wang, Kehuan; Papadopoulos, Natalia et al.

Part of Growth Factors, p. 147-160, 2024

• DOI for PDGF-induced internalisation promotes proteolytic cleavage of PDGFRβ in mesenchymal cells
• Download full text (pdf) of PDGF-induced internalisation promotes proteolytic cleavage of PDGFRβ in mesenchymal cells

Smad7 palmitoylation by the S-acyltransferase zDHHC17 enhances its inhibitory effect on TGF-β/Smad signaling

Voytyuk, Oleksandr; Ohata, Yae; Moustakas, Aristidis; ten Dijke, Peter et al.

Part of Journal of Biological Chemistry, 2024

• DOI for Smad7 palmitoylation by the S-acyltransferase zDHHC17 enhances its inhibitory effect on TGF-β/Smad signaling
• Download full text (pdf) of Smad7 palmitoylation by the S-acyltransferase zDHHC17 enhances its inhibitory effect on TGF-β/Smad signaling

Special issue: frontiers in recent advances on cancer diagnosis and treatment

Westermark, Bengt; Heldin, Carl-Henrik

Part of Upsala Journal of Medical Sciences, 2024

• DOI for Special issue: frontiers in recent advances on cancer diagnosis and treatment
• Download full text (pdf) of Special issue: frontiers in recent advances on cancer diagnosis and treatment

Special issue: TGF-β and epithelial-mesenchymal transition in cancer

ten Dijke, Peter; Miyazono, Kohei; Heldin, Carl-Henrik; Moustakas, Aristidis

Part of Seminars in Cancer Biology, p. 1-3, 2024

• DOI for Special issue: TGF-β and epithelial-mesenchymal transition in cancer

ΔNp63 bookmarks and creates an accessible epigenetic environment for TGFβ-induced cancer cell stemness and invasiveness

Vasilaki, Eleftheria; Bai, Yu; Ali, Mohamad Moustafa; Sundqvist, Anders et al.

Part of Cell Communication and Signaling, 2024

• DOI for ΔNp63 bookmarks and creates an accessible epigenetic environment for TGFβ-induced cancer cell stemness and invasiveness
• Download full text (pdf) of ΔNp63 bookmarks and creates an accessible epigenetic environment for TGFβ-induced cancer cell stemness and invasiveness

Hyaluronan-Induced CD44-iASPP Interaction Affects Fibroblast Migration and Survival

Lin, Chun-Yu; Basu, Kaustuv; Ruusala, Aino; Kozlova, Inna et al.

Part of Cancers, 2023

• DOI for Hyaluronan-Induced CD44-iASPP Interaction Affects Fibroblast Migration and Survival
• Download full text (pdf) of Hyaluronan-Induced CD44-iASPP Interaction Affects Fibroblast Migration and Survival

SUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferation

Wang, Kehuan; Papadopoulos, Natalia; Hamidi, Anahita; Lennartsson, Johan et al.

Part of BMC Molecular and Cell Biology, 2023

• DOI for SUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferation
• Download full text (pdf) of SUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferation

The E3 Ubiquitin Ligase TRIM21 Regulates Basal Levels of PDGFRβ

Sarri, Niki; Papadopoulos, Natalia; Lennartsson, Johan; Heldin, Carl-Henrik

Part of International Journal of Molecular Sciences, 2023

• DOI for The E3 Ubiquitin Ligase TRIM21 Regulates Basal Levels of PDGFRβ
• Download full text (pdf) of The E3 Ubiquitin Ligase TRIM21 Regulates Basal Levels of PDGFRβ

The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition

Tzavlaki, Kalliopi; Ohata, Yae; Morén, Anita; Watanabe, Yukihide et al.

Part of Journal of Cellular Physiology, p. 790-812, 2023

• DOI for The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition
• Download full text (pdf) of The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition

The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion

Gélabert, Caroline; Papoutsoglou, Panagiotis; Cancela Golan, Irene; Ahlström, Eric et al.

Part of Cell Communication and Signaling, 2023

• DOI for The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion
• Download full text (pdf) of The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion

CD44 Depletion in Glioblastoma Cells Suppresses Growth and Stemness and Induces Senescence

Kolliopoulos, Constantinos; Ali, Mohamad Moustafa; Castillejo-Lopez, Casimiro; Heldin, Carl-Henrik et al.

Part of Cancers, 2022

• DOI for CD44 Depletion in Glioblastoma Cells Suppresses Growth and Stemness and Induces Senescence
• Download full text (pdf) of CD44 Depletion in Glioblastoma Cells Suppresses Growth and Stemness and Induces Senescence

Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFR beta and affect PDGF-BB-induced STAT3 signalling

Sarri, Niki; Wang, Kehuan; Tsioumpekou, Maria; Castillejo-Lopez, Casimiro et al.

Part of Cellular and Molecular Life Sciences (CMLS), 2022

• DOI for Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFR beta and affect PDGF-BB-induced STAT3 signalling
• Download full text (pdf) of Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFR beta and affect PDGF-BB-induced STAT3 signalling

Identification of a Small Molecule Inhibitor of Hyaluronan Synthesis, DDIT, Targeting Breast Cancer Cells

Karalis, Theodoros; Shiau, Andrew K. K.; Gahman, Timothy C. C.; Skandalis, Spyros S. S. et al.

Part of Cancers, 2022

• DOI for Identification of a Small Molecule Inhibitor of Hyaluronan Synthesis, DDIT, Targeting Breast Cancer Cells
• Download full text (pdf) of Identification of a Small Molecule Inhibitor of Hyaluronan Synthesis, DDIT, Targeting Breast Cancer Cells

Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells

Tsirigoti, Chrysoula; Ali, Mohamad Moustafa; Maturi, Varun; Heldin, Carl-Henrik et al.

Part of Cell Death and Disease, 2022

• DOI for Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells
• Download full text (pdf) of Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells

PRRX1 induced by BMP signaling decreases tumorigenesis by epigenetically regulating glioma-initiating cell properties via DNA methyltransferase 3A

Tanabe, Ryo; Miyazono, Kohei; Todo, Tomoki; Saito, Nobuhito et al.

Part of Molecular Oncology, p. 269-288, 2022

• DOI for PRRX1 induced by BMP signaling decreases tumorigenesis by epigenetically regulating glioma-initiating cell properties via DNA methyltransferase 3A
• Download full text (pdf) of PRRX1 induced by BMP signaling decreases tumorigenesis by epigenetically regulating glioma-initiating cell properties via DNA methyltransferase 3A

TGF beta selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition

Tsubakihara, Yutaro; Ohata, Yae; Okita, Yukari; Younis, Shady et al.

Part of Molecular Oncology, p. 2330-2354, 2022

• DOI for TGF beta selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition
• Download full text (pdf) of TGF beta selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition

The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma

Caja, Laia; Dadras, Mahsa Shahidi; Mezheyeuski, Artur; Mendes Rodrigues-Junior, Dorival et al.

Part of Journal of Cellular Physiology, p. 743-762, 2022

• DOI for The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma
• Download full text (pdf) of The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma

The type II TGF-β receptor phosphorylates Tyr ¹⁸² in the type I receptor to activate downstream Src signaling

Yakymovych, Ihor; Yakymovych, Mariya; Hamidi, Anahita; Landström, Maréne et al.

Part of Science Signaling, 2022

• DOI for The type II TGF-β receptor phosphorylates Tyr ¹⁸² in the type I receptor to activate downstream Src signaling
• Download full text (pdf) of The type II TGF-β receptor phosphorylates Tyr ¹⁸² in the type I receptor to activate downstream Src signaling

The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells

Song, Jie; Zhou, Yang; Yakymovych, Ihor; Schmidt, Alexej et al.

Part of EBioMedicine, 2022

• DOI for The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells
• Download full text (pdf) of The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells

BMP2-induction of FN14 promotes protumorigenic signaling in gynecologic cancer cells

Fukuda, Tomohiko; Fukuda, Risa; Koinuma, Daizo; Moustakas, Aristidis et al.

Part of Cellular Signalling, 2021

• DOI for BMP2-induction of FN14 promotes protumorigenic signaling in gynecologic cancer cells

The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor beta signaling

Papoutsoglou, Panagiotis; Rodrigues Junior, Dorival Mendes; Morén, Anita; Bergman, Andrew et al.

Part of Oncogene, p. 3748-3765, 2021

• DOI for The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor beta signaling
• Download full text (pdf) of The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor beta signaling

The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma

Dadras, Mahsa Shahidi; Caja, Laia; Mezheyeuski, Artur; Liu, Sijia et al.

Part of Cell Death and Disease, 2021

• DOI for The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma
• Download full text (pdf) of The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma

TRAF4/6 Is Needed for CD44 Cleavage and Migration via RAC1 Activation

Kolliopoulos, Constantinos; Chatzopoulos, Athanasios; Skandalis, Spyros S.; Heldin, Carl-Henrik et al.

Part of Cancers, 2021

• DOI for TRAF4/6 Is Needed for CD44 Cleavage and Migration via RAC1 Activation
• Download full text (pdf) of TRAF4/6 Is Needed for CD44 Cleavage and Migration via RAC1 Activation

Tumor Promoting Effect of BMP Signaling in Endometrial Cancer

Fukuda, Tomohiko; Fukuda, Risa; Miyazono, Kohei; Heldin, Carl-Henrik

Part of International Journal of Molecular Sciences, 2021

• DOI for Tumor Promoting Effect of BMP Signaling in Endometrial Cancer
• Download full text (pdf) of Tumor Promoting Effect of BMP Signaling in Endometrial Cancer

BMP signaling is a therapeutic target in ovarian cancer

Fukuda, Tomohiko; Fukuda, Risa; Tanabe, Ryo; Koinuma, Daizo et al.

Part of Cell Death Discovery, 2020

• DOI for BMP signaling is a therapeutic target in ovarian cancer
• Download full text (pdf) of BMP signaling is a therapeutic target in ovarian cancer

Bone morphogenetic protein receptors: Structure, function and targeting by selective small molecule kinase inhibitors

Sanchez-Duffhues, Gonzalo; Williams, Eleanor; Goumans, Marie-Jose; Heldin, Carl-Henrik et al.

Part of Bone, 2020

• DOI for Bone morphogenetic protein receptors: Structure, function and targeting by selective small molecule kinase inhibitors
• Download full text (pdf) of Bone morphogenetic protein receptors: Structure, function and targeting by selective small molecule kinase inhibitors

Involvement of hyaluronan and CD44 in cancer and viral infections

Heldin, Paraskevi; Kolliopoulos, Constantinos; Lin, Chun-Yu; Heldin, Carl-Henrik

Part of Cellular Signalling, 2020

• DOI for Involvement of hyaluronan and CD44 in cancer and viral infections

Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis

Zhang, Yanyu; Cedervall, Jessica; Hamidi, Anahita; Herre, Melanie et al.

Part of Cancer Research, p. 3345-3358, 2020

• DOI for Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis

Smad7 Enhances TGF-beta-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells

Thakur, Noopur; Hamidi, Anahita; Song, Jie; Itoh, Susumu et al.

Part of iScience, 2020

• DOI for Smad7 Enhances TGF-beta-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells
• Download full text (pdf) of Smad7 Enhances TGF-beta-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells

Smad7 Enhances TGF-b-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells

Thakur, Noopur; Hamidi, Anahita; Song, Jie; Itoh, Susumu et al.

Part of iScience, 2020

Specific targeting of PDGFR beta in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression

Tsioumpekou, Maria; Cunha, Sara I.; Ma, Haisha; Åhgren, Aive et al.

Part of Theranostics, p. 1122-1135, 2020

• DOI for Specific targeting of PDGFR beta in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression
• Download full text (pdf) of Specific targeting of PDGFR beta in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression

Structure-based discovery of novel small molecule inhibitors of platelet-derived growth factor-B

Zarei, Omid; Sarri, Niki; Dastmalchi, Siavoush; Zokai, Fateme et al.

Part of Bioorganic chemistry (Print), 2020

• DOI for Structure-based discovery of novel small molecule inhibitors of platelet-derived growth factor-B

TGF beta and EGF signaling orchestrates the AP-1-and p63 transcriptional regulation of breast cancer invasiveness

Sundqvist, Anders; Vasilaki, Eleftheria; Voytyuk, Oleksandr; Bai, Yu et al.

Part of Oncogene, p. 4436-4449, 2020

• DOI for TGF beta and EGF signaling orchestrates the AP-1-and p63 transcriptional regulation of breast cancer invasiveness
• Download full text (pdf) of TGF beta and EGF signaling orchestrates the AP-1-and p63 transcriptional regulation of breast cancer invasiveness

Dual specificity phosphatase (DUSP)-4 is induced by platelet-derived growth factor -BB in an Erk1/2-, STAT3- and p53-dependent manner

Yin, Runting; Eger, Glenda; Sarri, Niki; Rorsman, Charlotte et al.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 469-474, 2019

• DOI for Dual specificity phosphatase (DUSP)-4 is induced by platelet-derived growth factor -BB in an Erk1/2-, STAT3- and p53-dependent manner

Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGFβ-induced EMT in breast cancer

Kolliopoulos, Constantinos; Lin, Chun-Yu; Heldin, Carl-Henrik; Moustakas, Aristidis et al.

Part of Matrix Biology, p. 29-45, 2019

• DOI for Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGFβ-induced EMT in breast cancer

High levels of serum hyaluronan is an early predictor of dengue warning signs and perturbs vascular integrity

Lin, Chun-Yu; Kolliopoulos, Constantinos; Huang, Chung-Hao; Tenhunen, Jyrki et al.

Part of EBioMedicine, p. 425-441, 2019

• DOI for High levels of serum hyaluronan is an early predictor of dengue warning signs and perturbs vascular integrity
• Download full text (pdf) of High levels of serum hyaluronan is an early predictor of dengue warning signs and perturbs vascular integrity

JNK-Dependent cJun Phosphorylation Mitigates TGF beta- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses

Sundqvist, Anders; Voytyuk, Olexandr; Hamdi, Mohamed; Popeijus, Herman E. et al.

Part of CELLS, 2019

• DOI for JNK-Dependent cJun Phosphorylation Mitigates TGF beta- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses
• Download full text (pdf) of JNK-Dependent cJun Phosphorylation Mitigates TGF beta- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses

LXR alpha limits TGF beta-dependent hepatocellular carcinoma associated fibroblast differentiation

Morén, Anita; Bellomo, Claudia; Tsubakihara, Yutaro; Kardassis, Dimitris et al.

Part of Oncogenesis, 2019

• DOI for LXR alpha limits TGF beta-dependent hepatocellular carcinoma associated fibroblast differentiation
• Download full text (pdf) of LXR alpha limits TGF beta-dependent hepatocellular carcinoma associated fibroblast differentiation

The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension

Morikawa, Masato; Mitani, Yoshihide; Holmborn, Katarina; Kato, Taichi et al.

Part of Science Signaling, 2019

• DOI for The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension

The TGFB2-AS1 lncRNA regulates TGFβ signaling by modulating corepressor activity

Papoutsoglou, Panagiotis; Tsubakihara, Yutaro; Caja, Laia; Pallis, Paris et al.

Part of Cell Reports, p. 3182-319800000000000, 2019

• DOI for The TGFB2-AS1 lncRNA regulates TGFβ signaling by modulating corepressor activity
• Download full text (pdf) of The TGFB2-AS1 lncRNA regulates TGFβ signaling by modulating corepressor activity

Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output

Kolliopoulos, Constantinos; Raja, Erna; Razmara, Masoud; Heldin, Paraskevi et al.

Part of Journal of Biological Chemistry, p. 4119-4136, 2019

• DOI for Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output
• Download full text (pdf) of Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output

Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells

Maturi, Varun; Morén, Anita; Enroth, Stefan; Heldin, Carl-Henrik et al.

Part of Molecular Oncology, p. 1153-1174, 2018

• DOI for Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells
• Download full text (pdf) of Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells

Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells

Maturi, Varun; Enroth, Stefan; Heldin, Carl-Henrik; Moustakas, Aristidis

Part of Journal of Cellular Physiology, p. 7113-7127, 2018

• DOI for Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells
• Download full text (pdf) of Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells

Intracellular trafficking of transforming growth factor beta receptors

Yakymovych, Ihor; Yakymovych, Mariya; Heldin, Carl-Henrik

Part of Acta biochimica et biophysica Sinica, p. 3-11, 2018

• DOI for Intracellular trafficking of transforming growth factor beta receptors

Involvement of platelet-derived growth factor ligands and receptors in tumorigenesis

Heldin, Carl-Henrik; Lennartsson, Johan; Westermark, Bengt

Part of Journal of Internal Medicine, p. 16-44, 2018

• DOI for Involvement of platelet-derived growth factor ligands and receptors in tumorigenesis

JUNB governs a feed-forward network of TGF beta signaling that aggravates breast cancer invasion

Sundqvist, Anders; Morikawa, Masato; Ren, Jiang; Vasilaki, Eleftheria et al.

Part of Nucleic Acids Research, p. 1180-1195, 2018

• DOI for JUNB governs a feed-forward network of TGF beta signaling that aggravates breast cancer invasion
• Download full text (pdf) of JUNB governs a feed-forward network of TGF beta signaling that aggravates breast cancer invasion

PDGFR beta translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1

Papadopoulos, Natalia; Lennartsson, Johan; Heldin, Carl-Henrik

Part of Journal of Cell Biology, p. 1701-1717, 2018

• DOI for PDGFR beta translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1

Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma

Bellomo, Claudia; Caja, Laia; Fabregat, Isabel; Mikulits, Wolfgang et al.

Part of Cell Death and Differentiation, p. 885-903, 2018

• DOI for Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma
• Download full text (pdf) of Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma

Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells

Caja, Laia; Tzavlaki, Kalliopi; Dadras, Mahsa Shahidi; Tan, E-Jean et al.

Part of Oncogene, p. 2515-2531, 2018

• DOI for Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells
• Download full text (pdf) of Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells