Jennifer Meadows research group

Comparative genomics to dissect complex disease
Comparative genomics involves the evaluation of genome homology, composition, organization and function, both within and across the species border. Through these analyses we can identify regions of genomic sequence that are conserved and constrained. These can be used as signposts for functional regions of the genome, including non-coding regulatory elements hidden to current high throughput scans, or elements yet to be identified in species with less resources than human or mouse. Our research team leverages these constrained signposts to aid in the dissection and functional characterisation of those natural genetic variants that contribute to heritable complex disease.
In combination with our national and international collaborators, we are an interdisciplinary team with expertise in molecular and population genetics, genome sequencing, bioinformatics, immunology and neurobiology.
Research Focus
We are currently investigating the molecular genetics of:
(1) Perturbations of the immune system: autoinflammatory disease (AID) and ankylosing spondylitis (AS).
(2) Canine brain neural networks: how does our best friend’s brain function in comparison to ours.
Research funding is provided by the Swedish Research Council, FORMAS.
Group members
Publications
An endothelial regulatory module links blood pressure regulation with elite athletic performance
Part of PLOS Genetics, 2024
- DOI for An endothelial regulatory module links blood pressure regulation with elite athletic performance
- Download full text (pdf) of An endothelial regulatory module links blood pressure regulation with elite athletic performance
Characterization of Nuclear Mitochondrial Insertions in Canine Genome Assemblies
Part of Genes, 2024
- DOI for Characterization of Nuclear Mitochondrial Insertions in Canine Genome Assemblies
- Download full text (pdf) of Characterization of Nuclear Mitochondrial Insertions in Canine Genome Assemblies
Effect of an endothelial regulatory module on plasma proteomics in exercising horses
Part of Comparative Biochemistry and Physiology - Part D, 2024
Part of RMD Open, 2024
- DOI for The HLA region in ANCA-associated vasculitis: characterisation of genetic associations in a Scandinavian patient population
- Download full text (pdf) of The HLA region in ANCA-associated vasculitis: characterisation of genetic associations in a Scandinavian patient population
Bayesian mixed model analysis uncovered 21 risk loci for chronic kidney disease in boxer dogs
Part of PLOS Genetics, 2023
- DOI for Bayesian mixed model analysis uncovered 21 risk loci for chronic kidney disease in boxer dogs
- Download full text (pdf) of Bayesian mixed model analysis uncovered 21 risk loci for chronic kidney disease in boxer dogs
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