Katja Petzold research group

Our research group is interested in understanding how RNAs change their structures in order to perform function.

Structural Biophysics of RNA

Until recently, only snapshots of molecules could be observed, hiding their mode of operation. We employ Nuclear Magnetic Resonance (NMR), and other biophysical techniques, to investigate the molecular mechanism of RNA function. When function of these molecular machines becomes apparent, it also provides a variety of unique new drug targets. The lab develops methods in NMR and RNA biochemistry to address these questions. Current projects include viral, bacterial and eukaryotic regulatory RNAs, e.g. microRNAs, ribosomal RNAs or RNA from HBV.

Group members

Research leader: Katja Petzold

Group members: Henry Annecke, Katja Bekcic, Rubin Dasgupta, Ting Huang, Vivek Junghare, Eleni Kapidou, David Kosek, Magdalena Riad, Joanna Sajkowska-Kozielewicz, Christian Steinmetzger

Publications

Efficient 3′-pairing renders microRNA targeting less sensitive to mRNA seed accessibility

Kosek, David M; Banijamali, Elnaz; Becker, Walter; Petzold, Katja et al.

Part of Nucleic Acids Research, p. 11162-11177, 2023
- DOI for Efficient 3′-pairing renders microRNA targeting less sensitive to mRNA seed accessibility
- Download full text (pdf) of Efficient 3′-pairing renders microRNA targeting less sensitive to mRNA seed accessibility
Mass Spectrometry of RNA-Binding Proteins during Liquid-Liquid Phase Separation Reveals Distinct Assembly Mechanisms and Droplet Architectures

Sahin, Cagla; Motso, Aikaterini; Gu, Xinyu; Feyrer, Hannes et al.

Part of Journal of the American Chemical Society, p. 10659-10668, 2023
- DOI for Mass Spectrometry of RNA-Binding Proteins during Liquid-Liquid Phase Separation Reveals Distinct Assembly Mechanisms and Droplet Architectures
- Download full text (pdf) of Mass Spectrometry of RNA-Binding Proteins during Liquid-Liquid Phase Separation Reveals Distinct Assembly Mechanisms and Droplet Architectures
NanoBiT‐ and NanoBiT/BRET‐based assays allow the analysis of binding kinetics of Wnt‐3a to endogenous Frizzled 7 in a colorectal cancer model

Grätz, Lukas; Sajkowska‐Kozielewicz, Joanna J.; Wesslowski, Janine; Kinsolving, Julia et al.

Part of British Journal of Pharmacology, 2023
- DOI for NanoBiT‐ and NanoBiT/BRET‐based assays allow the analysis of binding kinetics of Wnt‐3a to endogenous Frizzled 7 in a colorectal cancer model
RNA:RNA interaction in ternary complexes resolved by chemical probing

Banijamali, Elnaz; Baronti, Lorenzo; Becker, Walter; Sajkowska-Kozielewicz, Joanna J. et al.

Part of RNA, p. 317-329, 2022
- DOI for RNA:RNA interaction in ternary complexes resolved by chemical probing
- Download full text (pdf) of RNA:RNA interaction in ternary complexes resolved by chemical probing
More publications