Katja Petzold research group

Our research group is interested in understanding how RNAs change their structures in order to perform function.

Structural Biophysics of RNA

Until recently, only snapshots of molecules could be observed, hiding their mode of operation. We employ Nuclear Magnetic Resonance (NMR), and other biophysical techniques, to investigate the molecular mechanism of RNA function. When function of these molecular machines becomes apparent, it also provides a variety of unique new drug targets. The lab develops methods in NMR and RNA biochemistry to address these questions. Current projects include viral, bacterial and eukaryotic regulatory RNAs, e.g. microRNAs, ribosomal RNAs or RNA from HBV.

SciLifeLab

Chemical Mechanisms of Life

Group members

Research leader: Katja Petzold

Group members: Henry Annecke, Katja Bekcic, Rubin Dasgupta, Vivek Junghare, Magdalena Riad, Saskia Rughöft, Joanna Sajkowska-Kozielewicz, Christian Steinmetzger

Publications

Elucidating microRNA-34a organisation within human Argonaute-2 by dynamic nuclear polarisation-enhanced magic angle spinning NMR

Dasgupta, Rubin; Becker, Walter; Petzold, Katja

Part of Nucleic Acids Research, p. 11995-12004, 2024
- DOI for Elucidating microRNA-34a organisation within human Argonaute-2 by dynamic nuclear polarisation-enhanced magic angle spinning NMR
- Download full text (pdf) of Elucidating microRNA-34a organisation within human Argonaute-2 by dynamic nuclear polarisation-enhanced magic angle spinning NMR
Investigating Interaction Dynamics of an Enantioselective Peptide‐Catalyzed Acylation Reaction

Brauser, Matthias; Petzold, Katja; Thiele, Christina M.

Part of Angewandte Chemie International Edition, 2024
- DOI for Investigating Interaction Dynamics of an Enantioselective Peptide‐Catalyzed Acylation Reaction
Efficient 3′-pairing renders microRNA targeting less sensitive to mRNA seed accessibility

Kosek, David M; Banijamali, Elnaz; Becker, Walter; Petzold, Katja et al.

Part of Nucleic Acids Research, p. 11162-11177, 2023
- DOI for Efficient 3′-pairing renders microRNA targeting less sensitive to mRNA seed accessibility
- Download full text (pdf) of Efficient 3′-pairing renders microRNA targeting less sensitive to mRNA seed accessibility
Mass Spectrometry of RNA-Binding Proteins during Liquid-Liquid Phase Separation Reveals Distinct Assembly Mechanisms and Droplet Architectures

Sahin, Cagla; Motso, Aikaterini; Gu, Xinyu; Feyrer, Hannes et al.

Part of Journal of the American Chemical Society, p. 10659-10668, 2023
- DOI for Mass Spectrometry of RNA-Binding Proteins during Liquid-Liquid Phase Separation Reveals Distinct Assembly Mechanisms and Droplet Architectures
- Download full text (pdf) of Mass Spectrometry of RNA-Binding Proteins during Liquid-Liquid Phase Separation Reveals Distinct Assembly Mechanisms and Droplet Architectures
NanoBiT‐ and NanoBiT/BRET‐based assays allow the analysis of binding kinetics of Wnt‐3a to endogenous Frizzled 7 in a colorectal cancer model

Grätz, Lukas; Sajkowska‐Kozielewicz, Joanna J.; Wesslowski, Janine; Kinsolving, Julia et al.

Part of British Journal of Pharmacology, 2023
- DOI for NanoBiT‐ and NanoBiT/BRET‐based assays allow the analysis of binding kinetics of Wnt‐3a to endogenous Frizzled 7 in a colorectal cancer model
More publications