Staffan Johansson research group

Adhesinon-dependent cell signaling

Adhesion of cells to specific proteins in the extracellular matrix contributes to the organization of tissues. In addition, it provides the cells with information about the composition and mechanical properties of the surrounding environment, which is important for their migration, differentiation, and proliferation. As the main adhesion and migration receptors of cells, integrins are potential targets for regulation of several adhesion-dependent processes of clinical relevance, such as wound healing, thrombus formation, leukocyte recruitment to inflammatory sites, and tumor metastasis. Our work is focused on integrin signals involved in cell cycle regulation, in particular cytokinesis and centrosome functions.