Paraskevi Heldin research group

We aim to investigate the molecular mechanisms that lead to excessive hyaluronan accumulation in certain tumors and infections, resulting in the over-activity of CD44 signaling. Such knowledge is crucial for better management of metastasis and infections.

Targeting hyaluronan-CD44 signaling in cancer and infection

During tumor progression, cell surface molecules such as CD44 function as microenvironmental sensors functioning as metastasis suppressors or promoters in a cellular context. Our research focus on the growth factor-mediated induced hyaluronan-CD44 signaling during inflammation, cancer and infection. We found that increased hyaluronan synthase 2 (HAS2)-synthesized hyaluronan activated CD44 signaling during Dengue virus infection-induced inflammation, disrupting endothelial integrity. Increased serum hyaluronan levels are an early predictor of warning signs for severe dengue virus infection. In certain tumors, such as gliomas, a CD44/hyaluronan feedback circuit drives tumor progression, and is related to the expression of PDGF and PDGF receptor family members.

Group members

Research leader: Paraskevi Heldin

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