Paraskevi Heldin

A biological guide to glycosaminoglycans: current perspectives and pending questions

Ricard-Blum, Sylvie; Vives, Romain R.; Schaefer, Liliana; Goette, Martin et al.

Part of The FEBS Journal, p. 3331-3366, 2024

• DOI for A biological guide to glycosaminoglycans: current perspectives and pending questions
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Hyaluronan-Induced CD44-iASPP Interaction Affects Fibroblast Migration and Survival

Lin, Chun-Yu; Basu, Kaustuv; Ruusala, Aino; Kozlova, Inna et al.

Part of Cancers, 2023

• DOI for Hyaluronan-Induced CD44-iASPP Interaction Affects Fibroblast Migration and Survival
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CD44 Depletion in Glioblastoma Cells Suppresses Growth and Stemness and Induces Senescence

Kolliopoulos, Constantinos; Ali, Mohamad Moustafa; Castillejo-Lopez, Casimiro; Heldin, Carl-Henrik et al.

Part of Cancers, 2022

• DOI for CD44 Depletion in Glioblastoma Cells Suppresses Growth and Stemness and Induces Senescence
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Identification of a Small Molecule Inhibitor of Hyaluronan Synthesis, DDIT, Targeting Breast Cancer Cells

Karalis, Theodoros; Shiau, Andrew K. K.; Gahman, Timothy C. C.; Skandalis, Spyros S. S. et al.

Part of Cancers, 2022

• DOI for Identification of a Small Molecule Inhibitor of Hyaluronan Synthesis, DDIT, Targeting Breast Cancer Cells
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The natural antisense transcript HAS2-AS1 regulates breast cancer cells aggressiveness independently from hyaluronan metabolism

Parnigoni, Arianna; Caon, Ilaria; Teo, Wei Xuan; Hua, San Hue et al.

Part of Matrix Biology, p. 140-161, 2022

• DOI for The natural antisense transcript HAS2-AS1 regulates breast cancer cells aggressiveness independently from hyaluronan metabolism

Hyaluronan-Induced CD44-iASPP Interaction Affects Fibroblast Migration and Survival

Lin, Chun-Yu; Basu, Kaustuv; Ruusala, Aino; Kozlova, Inna et al.

Part of Cancers, 2023

• DOI for Hyaluronan-Induced CD44-iASPP Interaction Affects Fibroblast Migration and Survival
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CD44 Depletion in Glioblastoma Cells Suppresses Growth and Stemness and Induces Senescence

Kolliopoulos, Constantinos; Ali, Mohamad Moustafa; Castillejo-Lopez, Casimiro; Heldin, Carl-Henrik et al.

Part of Cancers, 2022

• DOI for CD44 Depletion in Glioblastoma Cells Suppresses Growth and Stemness and Induces Senescence
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Identification of a Small Molecule Inhibitor of Hyaluronan Synthesis, DDIT, Targeting Breast Cancer Cells

Karalis, Theodoros; Shiau, Andrew K. K.; Gahman, Timothy C. C.; Skandalis, Spyros S. S. et al.

Part of Cancers, 2022

• DOI for Identification of a Small Molecule Inhibitor of Hyaluronan Synthesis, DDIT, Targeting Breast Cancer Cells
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The natural antisense transcript HAS2-AS1 regulates breast cancer cells aggressiveness independently from hyaluronan metabolism

Parnigoni, Arianna; Caon, Ilaria; Teo, Wei Xuan; Hua, San Hue et al.

Part of Matrix Biology, p. 140-161, 2022

• DOI for The natural antisense transcript HAS2-AS1 regulates breast cancer cells aggressiveness independently from hyaluronan metabolism

Hyaluronan nanoscale clustering and Hyaluronan synthase 2 expression are linked to the invasion of child fibroblasts and infantile fibrosarcoma in vitro and in vivo

Tonge, Joseph J.; Notley, Scott; Dunning, Mark J.; Lopez-Guajardo, Ana et al.

Part of Scientific Reports, 2022

• DOI for Hyaluronan nanoscale clustering and Hyaluronan synthase 2 expression are linked to the invasion of child fibroblasts and infantile fibrosarcoma in vitro and in vivo
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TRAF4/6 Is Needed for CD44 Cleavage and Migration via RAC1 Activation

Kolliopoulos, Constantinos; Chatzopoulos, Athanasios; Skandalis, Spyros S.; Heldin, Carl-Henrik et al.

Part of Cancers, 2021

• DOI for TRAF4/6 Is Needed for CD44 Cleavage and Migration via RAC1 Activation
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Plasma hyaluronan, hyaluronidase activity and endogenous hyaluronidase inhibition in sepsis: an experimental and clinical cohort study

van der Heijden, Jaap; Kolliopoulos, Constantinos; Skorup, Paul; Sallisalmi, Marko et al.

Part of Intensive Care Medicine Experimental, 2021

• DOI for Plasma hyaluronan, hyaluronidase activity and endogenous hyaluronidase inhibition in sepsis: an experimental and clinical cohort study
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Plasma Hyaluronan Decreases During ICU Stay in COVID-19 Survivors but Not inNon-Survivor: A Retrospective Cohort Study

van der Heijden, Jaap; Kolliopoulos, Constantinos; Stattin, Karl; Lipcsey, Miklos et al.

Part of Biomarkers Journal, 2021

Involvement of hyaluronan and CD44 in cancer and viral infections

Heldin, Paraskevi; Kolliopoulos, Constantinos; Lin, Chun-Yu; Heldin, Carl-Henrik

Part of Cellular Signalling, 2020

• DOI for Involvement of hyaluronan and CD44 in cancer and viral infections

Tumor-suppressive functions of 4-MU on breast cancer cells of different ER status: Regulation of hyaluronan/HAS2/CD44 and specific matrix effectors

Karalis, Theodoros T.; Heldin, Paraskevi; Vynios, Demitrios H.; Neill, Thomas et al.

Part of Matrix Biology, p. 118-138, 2019

• DOI for Tumor-suppressive functions of 4-MU on breast cancer cells of different ER status: Regulation of hyaluronan/HAS2/CD44 and specific matrix effectors

Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGFβ-induced EMT in breast cancer

Kolliopoulos, Constantinos; Lin, Chun-Yu; Heldin, Carl-Henrik; Moustakas, Aristidis et al.

Part of Matrix Biology, p. 29-45, 2019

• DOI for Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGFβ-induced EMT in breast cancer

High levels of serum hyaluronan is an early predictor of dengue warning signs and perturbs vascular integrity

Lin, Chun-Yu; Kolliopoulos, Constantinos; Huang, Chung-Hao; Tenhunen, Jyrki et al.

Part of EBioMedicine, p. 425-441, 2019

• DOI for High levels of serum hyaluronan is an early predictor of dengue warning signs and perturbs vascular integrity
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Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output

Kolliopoulos, Constantinos; Raja, Erna; Razmara, Masoud; Heldin, Paraskevi et al.

Part of Journal of Biological Chemistry, p. 4119-4136, 2019

• DOI for Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output
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Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2)

Melero-Fernandez de Mera, R. M.; Arasu, U. T.; Karna, R.; Oikari, S. et al.

Part of Matrix Biology, p. 85-103, 2019

• DOI for Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2)

Regulation of hyaluronan biosynthesis and clinical impact of excessive hyaluronan production

Heldin, Paraskevi; Lin, Chun-Yu; Kolliopoulos, Constantinos; Chen, Yen-Hsu et al.

Part of Matrix Biology, p. 100-117, 2019

• DOI for Regulation of hyaluronan biosynthesis and clinical impact of excessive hyaluronan production

The role of deubiquitinating enzyme USP17, hyaluronan synthase 2, and hyaluronan in non-small-cell lung cancer oncogenic transformation

Mehic, Merima; de Sa, Vanessa Karen; Hebestreit, Sandra; Heldin, Paraskevi et al.

Part of Clinical Cancer Research, p. 96-96, 2018

• DOI for The role of deubiquitinating enzyme USP17, hyaluronan synthase 2, and hyaluronan in non-small-cell lung cancer oncogenic transformation

The deubiquitinating enzymes USP4 and USP17 target hyaluronan synthase 2 and differentially affect its function

Mehić, Merima; de Sa, Vanessa Karen; Hebestreit, Sandra; Heldin, Carl-Henrik et al.

Part of Oncogenesis, 2017

• DOI for The deubiquitinating enzymes USP4 and USP17 target hyaluronan synthase 2 and differentially affect its function
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Fluorescence Resonance Energy Transfer (FRET) and Proximity Ligation Assays Reveal Functionally Relevant Homo-and Heteromeric Complexes among Hyaluronan Synthases HAS1, HAS2, and HAS3

Bart, Genevieve; Vico, Nuria Ortega; Hassinen, Antti; Pujol, Francois M. et al.

Part of Journal of Biological Chemistry, p. 11479-11490, 2015

• DOI for Fluorescence Resonance Energy Transfer (FRET) and Proximity Ligation Assays Reveal Functionally Relevant Homo-and Heteromeric Complexes among Hyaluronan Synthases HAS1, HAS2, and HAS3

Platelet-derived Growth Factor beta-Receptor, Transforming Growth Factor beta Type I Receptor, and CD44 Protein Modulate Each Other's Signaling and Stability

Porsch, Helena; Mehic, Merima; Olofsson, Berit; Heldin, Paraskevi et al.

Part of Journal of Biological Chemistry, p. 19747-19757, 2014

• DOI for Platelet-derived Growth Factor beta-Receptor, Transforming Growth Factor beta Type I Receptor, and CD44 Protein Modulate Each Other's Signaling and Stability

Preface

Simpson, Melanie A; Heldin, Paraskevi

Part of Advances in Cancer Research, 2014

• DOI for Preface

Proteoglycans/Glycosaminoglycans: from basic research to clinical practice

Tzanakakis, George; Kovalszky, Ilona; Heldin, Paraskevi; Nikitovic, Dragana

Part of BioMed Research International, 2014

• DOI for Proteoglycans/Glycosaminoglycans: from basic research to clinical practice
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Deregulation of hyaluronan synthesis, degradation and binding promotes breast cancer

Heldin, Paraskevi; Basu, Kaustuv; Olofsson, Berit; Porsch, Helena et al.

Part of Journal of Biochemistry (Tokyo), p. 395-408, 2013

• DOI for Deregulation of hyaluronan synthesis, degradation and binding promotes breast cancer

Efficient TGF beta-induced epithelial-mesenchymal transition depends on hyaluronan synthase HAS2

Porsch, Helena; Bernert, Berit; Mehić, Merima; Theocharis, A D et al.

Part of Oncogene, p. 4355-4365, 2013

• DOI for Efficient TGF beta-induced epithelial-mesenchymal transition depends on hyaluronan synthase HAS2

IQGAP1 regulates hyaluronan-mediated fibroblast motility and proliferation

Kozlova, Inna; Ruusala, Aino; Voytyuk, Oleksandr; Skandalis, Spyros S et al.

Part of Cellular Signalling, p. 1856-1862, 2012

• DOI for IQGAP1 regulates hyaluronan-mediated fibroblast motility and proliferation

Hyaluronan production regulation from porcine hyalocyte cell line by cytokines

Nishitsuka, Koichi; Kashiwagi, Yoshiko; Tojo, Naoki; Kanno, Chikako et al.

Part of Experimental Eye Research, p. 539-545, 2007

• DOI for Hyaluronan production regulation from porcine hyalocyte cell line by cytokines

Hyaluronan accumulation in thyroid tissue: evidence for contributions from epithelial cells and fibroblasts

Gianoukakis, Andrew G.; Jennings, Timothy A.; King, Chris S.; Sheehan, Christine E. et al.

Part of Endocrinology, p. 54-62, 2007

• DOI for Hyaluronan accumulation in thyroid tissue: evidence for contributions from epithelial cells and fibroblasts

Inhibition of Platelet-derived Growth Factor-BB-induced Receptor Activation and Fibroblast Migration by Hyaluronan Activation of CD44

Li, Lingli; Heldin, Carl-Henrik; Heldin, Paraskevi

Part of Journal of Biological Chemistry, p. 26512-26519, 2006

• DOI for Inhibition of Platelet-derived Growth Factor-BB-induced Receptor Activation and Fibroblast Migration by Hyaluronan Activation of CD44

Hyaluronan fragments induce endothelial cell differentiation in a CD44- and CXCL1/GRO1-dependent manner

Takahashi, Yoshinori; Li, Lingli; Kamiryo, Masaru; Asteriou, Trias et al.

Part of Journal of Biological Chemistry, p. 24195-24204, 2005

• DOI for Hyaluronan fragments induce endothelial cell differentiation in a CD44- and CXCL1/GRO1-dependent manner

Hyaluronan fragments induce endothelial cell differentiation in a CD44- and CXCL1/GRO1-dependent manner.

Takahashi, Yoshinori; Li, Lingli; Kamiryo, Masaru; Asteriou, Trias et al.

Part of J Biol Chem, 2005

Hyaluronan and its binding proteins in the epithelium and intraluminal fluid of the bovine oviduct

Bergqvist, Ann-Sofi; Yokoo, Masaki; Heldin, Paraskevi; Frendin, Jan et al.

Part of Zygote (Cambridge. Print), p. 207-218, 2005

• DOI for Hyaluronan and its binding proteins in the epithelium and intraluminal fluid of the bovine oviduct

Phase I and Pharmacokinetic Evaluation of Intravenous Hyaluronic Acid in Combination with Doxorubicin or 5-Fluorouracil

Rosenthal, Mark A; Gibbs, Peter; Brown, Tracey J; Wong, Shirley et al.

Part of Chemotherapy, p. 132-141, 2005

• DOI for Phase I and Pharmacokinetic Evaluation of Intravenous Hyaluronic Acid in Combination with Doxorubicin or 5-Fluorouracil

Antisense-mediated suppression of hyaluronan synthase 2 inhibits the tumorigenesis and progression of breast cancer

Udabage, Lishanthi; Brownlee, Gary R.; Waltham, Mark; Blick, Tony et al.

Part of Cancer Research, p. 6139-6150, 2005

• DOI for Antisense-mediated suppression of hyaluronan synthase 2 inhibits the tumorigenesis and progression of breast cancer

Hyaluronan synthase in trabecular meshwork cells.

Usui, T.; Nakajima, F.; Ideta, R.; Kaji, Y. et al.

Part of Br J Ophthalmol, p. 357-60, 2003

Expression of hyaluronan synthase 2 or hyaluronidase 1 differentially affect the growth rate of transplantable colon carcinoma cell tumors.

Jacobson, Annica; Rahmanian, Mehdi; Rubin, Kristofer; Heldin, Paraskevi

Part of Int J Cancer, p. 212, 2002

Testicular hyaluronidase induces tubular structures of endothelial cells grown in three-dimensional collagen gel through a CD44-mediated mechanism.

Rahmanian, Mehdi; Heldin, Paraskevi

Part of Int J Cancer, p. 601, 2002

Improvement of rat liver graft function after storage in University ofWisconsin solution containing testicular hyaluronidase.

Papanikolaou, Vassilios; Vrochides, Dionisios; Gakis, Dimitrios; Patsiaoura, Kalliopi et al.

Part of Liver Transpl, p. 1028, 2002

Hgf/sf induces mesothelial cell migration and proliferation by autocrineand paracrine pathways.

Warn, Richard; Harvey, Pascale; Warn, Alba; Foley-Comer, Adam et al.

Part of Exp Cell Res, p. 258, 2001

Hyaluronan production increases the malignant properties of mesotheliomacells.

Li, Y; Heldin, Paraskevi

Part of Br J Cancer, p. 600, 2001

Stimulatory effects of pleural fluids from mesothelioma patients on CD44 expression, hyaluronan production and cell proliferation in primary cultures of normal mesothelial and transformed cells

Teder, P; Versnel, M A; Heldin, P

Part of Int J Cancer, p. 393-398, 1996

Characterization of the mechanism involved in bleomycin-induced increased hyaluronan production in rat lung

Teder, P; Nettelbladt, O; Heldin, P

Part of Am. J. Respir. Cell Mol. Biol., p. 181-189, 1995

A biological guide to glycosaminoglycans: current perspectives and pending questions

Ricard-Blum, Sylvie; Vives, Romain R.; Schaefer, Liliana; Goette, Martin et al.

Part of The FEBS Journal, p. 3331-3366, 2024

• DOI for A biological guide to glycosaminoglycans: current perspectives and pending questions
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Intracellular hyaluronan: Importance for cellular functions

Skandalis, Spyros S.; Karalis, Theodoros; Heldin, Paraskevi

Part of Seminars in Cancer Biology, p. 20-30, 2020

• DOI for Intracellular hyaluronan: Importance for cellular functions

HAS2 and CD44 in Breast Tumorigenesis

Heldin, Paraskevi; Basu, Kaustuv; Kozlova, Inna; Porsch, Helena

Part of Hyaluronan Signaling and Turnover, p. 211-229, Elsevier, 2014

• DOI for HAS2 and CD44 in Breast Tumorigenesis

Advances in Cancer Research: Hyaluronan Signaling And Turnover, Volume One Hundred And Twenty Three, Preface

Simpson, Melanie A.; Heldin, Paraskevi

Part of Hyaluronan Signaling and Turnover, p. 15-16, Elsevier, 2014