Publications

Mild-to-moderate psoriasis is associated with subclinical inflammation in the duodenum and a tendency of disturbed intestinal barrier

Lundquist, Patrik; Hagforsen, Eva; Wagner, Michael; Alimohammadi, Mohammad et al.

Part of Biochimica et Biophysica Acta - Molecular Basis of Disease, 2025

• DOI for Mild-to-moderate psoriasis is associated with subclinical inflammation in the duodenum and a tendency of disturbed intestinal barrier
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A two-step activation mechanism enables mast cells to differentiate their response between extracellular and invasive enterobacterial infection

von Beek, Christopher; Fahlgren, Anna; Geiser, Petra; Di Martino, Maria Letizia et al.

Part of Nature Communications, 2024

• DOI for A two-step activation mechanism enables mast cells to differentiate their response between extracellular and invasive enterobacterial infection
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Blockade of endolysosomal acidification suppresses TLR3-mediated proinflammatory signaling in airway epithelial cells

Pejler, Gunnar; Zhao, Xinran O.; Fagerström, Ella; Paivandy, Aida

Part of Journal of Allergy and Clinical Immunology, p. 940-951, 2024

• DOI for Blockade of endolysosomal acidification suppresses TLR3-mediated proinflammatory signaling in airway epithelial cells
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Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4⁺ and CD8⁺ T Cells, and Skin Mast Cells by Quantitative Transcriptomics

Akula, Srinivas; Alvarado-Vazquez, Abigail; Mendez Enriquez, Erika Haide; Bal, Gürkan et al.

Part of International Journal of Molecular Sciences, 2024

• DOI for Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4⁺ and CD8⁺ T Cells, and Skin Mast Cells by Quantitative Transcriptomics
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Mast cell chymase suppresses functional parameters in primary human airway smooth muscle cells

Zhao, Xinran O.; Melo, Fabio Rabelo; Sommerhoff, Christian P.; Paivandy, Aida et al.

Part of Allergy. European Journal of Allergy and Clinical Immunology, p. 2524-2527, 2024

• DOI for Mast cell chymase suppresses functional parameters in primary human airway smooth muscle cells
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Mast Cells are Dependent on Glucose Transporter 1 (GLUT1) and GLUT3 for IgE-mediated Activation

Grujic, Mirjana; Alim, Md Abdul; Hellman, Lars; Peterson, Magnus et al.

Part of Inflammation, p. 1820-1836, 2024

• DOI for Mast Cells are Dependent on Glucose Transporter 1 (GLUT1) and GLUT3 for IgE-mediated Activation
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Absence of changes in the milk microbiota during Escherichia coli endotoxin induced experimental bovine mastitis

Dahlberg, Josef; Johnzon, Carl-Fredrik; Sun, Li; Pejler, Gunnar et al.

Part of Veterinary research (Print), 2023

• DOI for Absence of changes in the milk microbiota during Escherichia coli endotoxin induced experimental bovine mastitis
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Chymase Inhibition Resolves and Prevents Deep Vein Thrombosis Without Increasing Bleeding Time in the Mouse Model

Lapointe, Catherine; Vincent, Laurence; Giguere, Hugo; Auger-Messier, Mannix et al.

Part of Journal of the American Heart Association, 2023

• DOI for Chymase Inhibition Resolves and Prevents Deep Vein Thrombosis Without Increasing Bleeding Time in the Mouse Model
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Heparin and heparin proteoglycan-mimetics activate platelets via PEAR1 and PI3K beta

Kardeby, Caroline; Evans, Alice; Campos, Joana; Al-Wahaibi, Afraa Moosa et al.

Part of Journal of Thrombosis and Haemostasis, p. 101-116, 2023

• DOI for Heparin and heparin proteoglycan-mimetics activate platelets via PEAR1 and PI3K beta
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Monensin induces secretory granule-mediated cell death in eosinophils

Vraila, Marianthi; Asp, Elin; Melo, Fabio R.; Grujic, Mirjana et al.

Part of Journal of Allergy and Clinical Immunology, 2023

• DOI for Monensin induces secretory granule-mediated cell death in eosinophils
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Nafamostat has anti-asthmatic effects associated with suppressed pro-inflammatory gene expression, eosinophil infiltration and airway hyperreactivity

Allam, Venkata; Waern, Ida; Taha, Sowsan; Akula, Srinivas et al.

Part of Frontiers in Immunology, 2023

• DOI for Nafamostat has anti-asthmatic effects associated with suppressed pro-inflammatory gene expression, eosinophil infiltration and airway hyperreactivity
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Obesity Is Associated with Distorted Proteoglycan Expression in Adipose Tissue

Meen, Astri J.; Doncheva, Atanaska I.; Boettcher, Yvonne; Dankel, Simon N. et al.

Part of International Journal of Molecular Sciences, 2023

• DOI for Obesity Is Associated with Distorted Proteoglycan Expression in Adipose Tissue
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Phenotypic Switch and Growth of Melanoma Spheroids in the Presence of Mast Cells: Potential Impact of Nutrient-starvation Effects

Grujic, Mirjana; Nguyen, Thanh; Héchard, Tifaine; Wang, Helen et al.

Part of Anticancer Research, p. 1415-1426, 2023

• DOI for Phenotypic Switch and Growth of Melanoma Spheroids in the Presence of Mast Cells: Potential Impact of Nutrient-starvation Effects
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Tendon pain: what are the mechanisms behind it?

Ackermann, Paul W.; Alim, Md Abdul; Pejler, Gunnar; Peterson, Magnus

Part of Scandinavian Journal of Pain, p. 14-24, 2023

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Therapeutic administration of mouse mast cell protease 6 improves functional recovery after traumatic spinal cord injury in mice by promoting remyelination and reducing glial scar formation

Vangansewinkel, Tim; Lemmens, Stefanie; Tiane, Assia; Geurts, Nathalie et al.

Part of The FASEB Journal, 2023

• DOI for Therapeutic administration of mouse mast cell protease 6 improves functional recovery after traumatic spinal cord injury in mice by promoting remyelination and reducing glial scar formation
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Differential expression of enzymes in thymidylate biosynthesis in zebrafish at different developmental stages: implications for dtymk mutation-caused neurodegenerative disorders

Frisk, Junmei Hu; Orn, Stefan; Pejler, Gunnar; Eriksson, Staffan et al.

Part of BMC Neuroscience, 2022

• DOI for Differential expression of enzymes in thymidylate biosynthesis in zebrafish at different developmental stages: implications for dtymk mutation-caused neurodegenerative disorders
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Heavy metal tolerance of Mesorhizobium delmotii thymidylate kinase

Hu Frisk, Junmei; Pejler, Gunnar; Eriksson, Staffan; Wang, Liya

Part of Nucleosides, Nucleotides & Nucleic Acids, p. 1305-1317, 2022

• DOI for Heavy metal tolerance of Mesorhizobium delmotii thymidylate kinase
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Mast cell chymase affects the functional properties of primary human airway fibroblasts: Implications for asthma

Zhao, Xinran; Lampinen, Maria; Rollman, Ola; Sommerhoff, Christian P et al.

Part of Journal of Allergy and Clinical Immunology, p. 718-727, 2022

• DOI for Mast cell chymase affects the functional properties of primary human airway fibroblasts: Implications for asthma
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Mast cell chymase has a negative impact on human osteoblasts

Lind, Thomas; Melo, Fabio R.; Gustafson, Ann-Marie; Sundqvist, Anders et al.

Part of Matrix Biology, p. 1-19, 2022

• DOI for Mast cell chymase has a negative impact on human osteoblasts
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Mast cell chymase regulates extracellular matrix remodeling-related events in primary human small airway epithelial cells

Zhao, xinzh765; Sommerhoff, Christian P.; Paivandy, Aida; Pejler, Gunnar

Part of Journal of Allergy and Clinical Immunology, p. 1534-1544, 2022

• DOI for Mast cell chymase regulates extracellular matrix remodeling-related events in primary human small airway epithelial cells
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Mast cell tryptase potentiates neutrophil extracellular trap formation

Pejler, Gunnar; Alanazi, Sultan; Grujic, Mirjana; Adler, Jeremy et al.

Part of Journal of Innate Immunity, p. 433-446, 2022

• DOI for Mast cell tryptase potentiates neutrophil extracellular trap formation
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Mefloquine causes selective mast cell apoptosis in cutaneous mastocytosis lesions by a secretory granule-mediated pathway

Lampinen, Maria; Hagforsen, Eva; Weström, Simone; Bergström, Anna et al.

Part of Experimental dermatology, p. 1729-1740, 2022

• DOI for Mefloquine causes selective mast cell apoptosis in cutaneous mastocytosis lesions by a secretory granule-mediated pathway
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Monensin inhibits mast cell mediated airway contractions in human and guinea pig asthma models

Liu, Jielu; Nie, Mu; Dong, Caijuan; Säfholm, Jesper et al.

Part of Scientific Reports, 2022

• DOI for Monensin inhibits mast cell mediated airway contractions in human and guinea pig asthma models
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Neutrophil extracellular traps promote cancer-associated inflammation and myocardial stress.

Cedervall, Jessica; Herre, Melanie; Dragomir, Anca; Rabelo-Melo, F et al.

Part of Oncoimmunology, 2022

• DOI for Neutrophil extracellular traps promote cancer-associated inflammation and myocardial stress.
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Quantitative In-Depth Transcriptome Analysis Implicates Peritoneal Macrophages as Important Players in the Complement and Coagulation Systems

Paivandy, Aida; Akula, Srinivas; Lara, Sandra; Fu, Zhirong et al.

Part of International Journal of Molecular Sciences, 2022

• DOI for Quantitative In-Depth Transcriptome Analysis Implicates Peritoneal Macrophages as Important Players in the Complement and Coagulation Systems
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Serglycin Is Involved in Adipose Tissue Inflammation in Obesity

Doncheva, Atanaska, I; Norheim, Frode A.; Hjorth, Marit; Grujic, Mirjana et al.

Part of Journal of Immunology, p. 121-132, 2022

• DOI for Serglycin Is Involved in Adipose Tissue Inflammation in Obesity

Structural and functional analysis of human thymidylate kinase isoforms

Frisk, Junmei Hu; Pejler, Gunnar; Eriksson, Staffan; Wang, Liya

Part of Nucleosides, Nucleotides & Nucleic Acids, p. 321-332, 2022

• DOI for Structural and functional analysis of human thymidylate kinase isoforms
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The ingenious mast cell: Contemporary insights into mast cell behavior and function

Dahlin, Joakim S.; Maurer, Marcus; Metcalfe, Dean D.; Pejler, Gunnar et al.

Part of Allergy. European Journal of Allergy and Clinical Immunology, p. 83-99, 2022

• DOI for The ingenious mast cell: Contemporary insights into mast cell behavior and function
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Treatment of chronic airway diseases using nutraceuticals: Mechanistic insight

Allam, Venkata; Chellappan, Dinesh Kumar; Jha, Niraj Kumar; Shastri, Madhur D. et al.

Part of Critical reviews in food science and nutrition, p. 7576-7590, 2022

• DOI for Treatment of chronic airway diseases using nutraceuticals: Mechanistic insight

Tryptase reference values in a Swedish middle-aged general population and association with diabetes mellitus

Vitte, Joana; Sjölander, Anders; Rydell, Niclas; Molin, Magnus et al.

Part of Clinical and Experimental Allergy, p. 1330-1333, 2022

• DOI for Tryptase reference values in a Swedish middle-aged general population and association with diabetes mellitus
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Biochemical Characterizations of Human TMPK Mutations Identified in Patients with Severe Microcephaly: Single Amino Acid Substitutions Impair Dimerization and Abolish Their Catalytic Activity

Frisk, Junmei Hu; Vanoevelen, Jo M.; Bierau, Jorgen; Pejler, Gunnar et al.

Part of ACS Omega, p. 33943-33952, 2021

• DOI for Biochemical Characterizations of Human TMPK Mutations Identified in Patients with Severe Microcephaly: Single Amino Acid Substitutions Impair Dimerization and Abolish Their Catalytic Activity
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Dynamin inhibition causes context-dependent cell death of leukemia and lymphoma cells

von Beek, Christopher; Alriksson, Linnéa; Palle, Josefine; Gustafson, Ann-Marie et al.

Part of PLOS ONE, 2021

• DOI for Dynamin inhibition causes context-dependent cell death of leukemia and lymphoma cells
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Glutamate triggers the expression of functional ionotropic and metabotropic glutamate receptors in mast cells

Alim, Abdul; Grujic, Mirjana; Ackerman, Paul W; Kristiansson, Per et al.

Part of Cellular & Molecular Immunology, p. 2383-2392, 2021

• DOI for Glutamate triggers the expression of functional ionotropic and metabotropic glutamate receptors in mast cells
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Mast Cell Degranulation Increases Mouse Mast Cell Protease 4-Dependent Vasopressor Responses to Big Endothelin-1 But Not Angiotensin I

Vincent, Laurence; Lapointe, Catherine; Lo, Modou; Gagnon, Hugo et al.

Part of Journal of Pharmacology and Experimental Therapeutics, p. 213-221, 2021

• DOI for Mast Cell Degranulation Increases Mouse Mast Cell Protease 4-Dependent Vasopressor Responses to Big Endothelin-1 But Not Angiotensin I

Monensin induces selective mast cell apoptosis through a secretory granule-mediated pathway.

Maccarana, Marco; Liu, Jielu; Lampinen, Maria; Rollman, Ola et al.

Part of Allergy. European Journal of Allergy and Clinical Immunology, 2021

• DOI for Monensin induces selective mast cell apoptosis through a secretory granule-mediated pathway.
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Novel Strategies to Target Mast Cells in Disease

Paivandy, Aida; Pejler, Gunnar

Part of Journal of Innate Immunity, p. 131-147, 2021

• DOI for Novel Strategies to Target Mast Cells in Disease
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Platelet α-granule cargo packaging and release are affected by the luminal proteoglycan, serglycin

Chanzu, Harry; Lykins, Joshua; Wigna-Kumar, Subershan; Joshi, Smita et al.

Part of Journal of Thrombosis and Haemostasis, p. 1082-1095, 2021

• DOI for Platelet α-granule cargo packaging and release are affected by the luminal proteoglycan, serglycin

Tryptase Regulates the Epigenetic Modification of Core Histones in Mast Cell Leukemia Cells

Alanazi, Sultan; Melo, Fabio Rabelo; Pejler, Gunnar

Part of Frontiers in Immunology, 2021

• DOI for Tryptase Regulates the Epigenetic Modification of Core Histones in Mast Cell Leukemia Cells
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DNA demethylation regulates gene expression in IgE-activated mouse mast cells.

Paivandy, Aida; Grujic, Mirjana; Rafati, Nima; Pejler, Gunnar

Part of Allergy. European Journal of Allergy and Clinical Immunology, p. 1776-1780, 2020

• DOI for DNA demethylation regulates gene expression in IgE-activated mouse mast cells.
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Do Mast Cells Have a Role in Tendon Healing and Inflammation?

Alim, Abdul; Peterson, Magnus; Pejler, Gunnar

Part of Cells, 2020

• DOI for Do Mast Cells Have a Role in Tendon Healing and Inflammation?
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Histone Methyltransferase Inhibition Has a Cytotoxic Impact on Transformed Mast Cells: Implications for Mastocytosis

Alanazi, Sultan; Melo, Fabio R.; Pejler, Gunnar

Part of Anticancer Research, p. 2525-2536, 2020

• DOI for Histone Methyltransferase Inhibition Has a Cytotoxic Impact on Transformed Mast Cells: Implications for Mastocytosis

How Relevant Are Bone Marrow-Derived Mast Cells (BMMCs) as Models for Tissue Mast Cells?: A Comparative Transcriptome Analysis of BMMCs and Peritoneal Mast Cells

Akula, Srinivas; Paivandy, Aida; Fu, Zhirong; Thorpe, Michael et al.

Part of Cells, 2020

• DOI for How Relevant Are Bone Marrow-Derived Mast Cells (BMMCs) as Models for Tissue Mast Cells?: A Comparative Transcriptome Analysis of BMMCs and Peritoneal Mast Cells
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Identification of a novel thymidylate kinase activity.

Frisk, Junmei Hu; Eriksson, Staffan; Pejler, Gunnar; Wang, Liya

Part of Nucleosides, Nucleotides & Nucleic Acids, p. 1359-1368, 2020

• DOI for Identification of a novel thymidylate kinase activity.

Mast cell chymase protects against acute ischemic kidney injury by limiting neutrophil hyperactivation and recruitment

Madjene, Lydia Celia; Danelli, Luca; Dahdah, Albert; Vibhushan, Shamila et al.

Part of Kidney International, p. 516-527, 2020

• DOI for Mast cell chymase protects against acute ischemic kidney injury by limiting neutrophil hyperactivation and recruitment

Mast Cell β-Tryptase Is Enzymatically Stabilized by DNA

Alanazi, Sultan; Grujic, Mirjana; Lampinen, Maria; Rollman, Ola et al.

Part of International Journal of Molecular Sciences, 2020

• DOI for Mast Cell β-Tryptase Is Enzymatically Stabilized by DNA
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Mouse connective tissue mast cell proteases tryptase and carboxypeptidase A3 play protective roles in itch induced by endothelin-1

Magnúsdóttir, Elín Ingibjörg; Grujic, Mirjana; Bergman, Jessica; Pejler, Gunnar et al.

Part of Journal of Neuroinflammation, 2020

• DOI for Mouse connective tissue mast cell proteases tryptase and carboxypeptidase A3 play protective roles in itch induced by endothelin-1
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Novel aspects of mast cell and basophil function: Highlights from the 9th meeting of the European Mast Cell and Basophil Research Network (EMBRN)-A Marcus Wallenberg Symposium

Hallgren, Jenny; Hellman, Lars; Maurer, Marcus; Nilsson, Gunnar P. et al.

Part of Allergy. European Journal of Allergy and Clinical Immunology, p. 707-708, 2020

• DOI for Novel aspects of mast cell and basophil function: Highlights from the 9th meeting of the European Mast Cell and Basophil Research Network (EMBRN)-A Marcus Wallenberg Symposium
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Novel Insight into the in vivo Function of Mast Cell Chymase: Lessons from Knockouts and Inhibitors

Pejler, Gunnar

Part of Journal of Innate Immunity, p. 357-372, 2020

• DOI for Novel Insight into the in vivo Function of Mast Cell Chymase: Lessons from Knockouts and Inhibitors
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Protective role of mouse mast cell tryptase Mcpt6 in melanoma.

Grujic, Mirjana; Hellman, Lars; Gustafson, Ann-Marie; Akula, Srinivas et al.

Part of Pigment Cell & Melanoma Research, p. 579-590, 2020

• DOI for Protective role of mouse mast cell tryptase Mcpt6 in melanoma.

Quantitative In-Depth Analysis of the Mouse Mast Cell Transcriptome Reveals Organ-Specific Mast Cell Heterogeneity

Akula, Srinivas; Paivandy, Aida; Fu, Zhirong; Thorpe, Michael et al.

Part of CELLS, 2020

• DOI for Quantitative In-Depth Analysis of the Mouse Mast Cell Transcriptome Reveals Organ-Specific Mast Cell Heterogeneity
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