Publications

Mast Cell Chymase and Human Lung Fibroblast Interaction: Mechanisms and Implications for Asthma

Pejler, Gunnar; Paivandy, Aida; Melo, Fabio R.; Allam, Venkata et al.

Part of Inflammation, 2026

• DOI for Mast Cell Chymase and Human Lung Fibroblast Interaction: Mechanisms and Implications for Asthma
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Mast cell proteases and their significance in physiology, pathology, and therapeutic approaches

Derakhshani, Afshin; Mahajan, Leela; Lesack, Kyle; Saranjam, Navid et al.

Part of Pharmacological Reviews, 2026

• DOI for Mast cell proteases and their significance in physiology, pathology, and therapeutic approaches
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Serglycin modulates inflammation and metabolism in macrophages

Porteymour, Shirin; Das Sajib, Saikat; von Hofsten, Susannah; Doncheva, Atanaska I. et al.

Part of iScience, 2026

• DOI for Serglycin modulates inflammation and metabolism in macrophages
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Trifluoperazine causes mast cell apoptosis through a secretory granule-mediated pathway

Vraila, Marianthi; Frisk, Jun Mei Hu; Mayavannan, Animamalar; Grujic, Mirjana et al.

Part of Cell Death Discovery, 2026

• DOI for Trifluoperazine causes mast cell apoptosis through a secretory granule-mediated pathway
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Mast Cell Phenotypic Heterogeneity Impacts the Interplay with Pathogenic Salmonella Typhimurium Bacteria

von Beek, Christopher; Prensa, Grisna I.; Andersson, Julia H. M.; Pejler, Gunnar et al.

Part of European Journal of Immunology, 2025

• DOI for Mast Cell Phenotypic Heterogeneity Impacts the Interplay with Pathogenic Salmonella Typhimurium Bacteria
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Mast cell tryptase induces nuclear remodelling and reduced growth in breast cancer cells

Pano, Filip; Bub, Laura; Parrine, Debora; Paivandy, Aida et al.

Part of Cell Death Discovery, 2025

• DOI for Mast cell tryptase induces nuclear remodelling and reduced growth in breast cancer cells
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Melanoma cells suppress mast cell function via a melanin-dependent mechanism

Melo, Fabio R.; Nyman, Lea; Österman Menander, Ida; Grujic, Mirjana et al.

Part of The FEBS Journal, p. 6075-6099, 2025

• DOI for Melanoma cells suppress mast cell function via a melanin-dependent mechanism
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Mild-to-moderate psoriasis is associated with subclinical inflammation in the duodenum and a tendency of disturbed intestinal barrier

Lundquist, Patrik; Hagforsen, Eva; Wagner, Michael; Alimohammadi, Mohammad et al.

Part of Biochimica et Biophysica Acta - Molecular Basis of Disease, 2025

• DOI for Mild-to-moderate psoriasis is associated with subclinical inflammation in the duodenum and a tendency of disturbed intestinal barrier
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Monensin Suppresses Multiple Features of House Dust Mite-Induced Experimental Asthma in Mice

Allam, Venkata; Akula, Srinivas; Waern, Ida; Taha, Sowsan et al.

Part of Inflammation, p. 806-819, 2025

• DOI for Monensin Suppresses Multiple Features of House Dust Mite-Induced Experimental Asthma in Mice
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Targeting carboxypeptidase A/B activity with the phosphinic inhibitor C28 reduces the asthmatic response in a mouse model of house dust mite-induced asthma

Allam, Venkata Sita Rama Raju; Montpeyó, David; Beau, Fabrice; Taha, Sowsan et al.

Part of Inflammation Research, 2025

• DOI for Targeting carboxypeptidase A/B activity with the phosphinic inhibitor C28 reduces the asthmatic response in a mouse model of house dust mite-induced asthma
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Targeting of the IL-5 pathway in severe asthma reduces mast cell progenitors

Alvarado-Vazquez, Perla Abigail; Méndez-Enriquez, Erika; Salomonsson, Maya; Kopac, Peter et al.

Part of Journal of Allergy and Clinical Immunology, p. 1310-1320, 2025

• DOI for Targeting of the IL-5 pathway in severe asthma reduces mast cell progenitors
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A two-step activation mechanism enables mast cells to differentiate their response between extracellular and invasive enterobacterial infection

von Beek, Christopher; Fahlgren, Anna; Geiser, Petra; Di Martino, Maria Letizia et al.

Part of Nature Communications, 2024

• DOI for A two-step activation mechanism enables mast cells to differentiate their response between extracellular and invasive enterobacterial infection
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Blockade of endolysosomal acidification suppresses TLR3-mediated proinflammatory signaling in airway epithelial cells

Pejler, Gunnar; Zhao, Xinran O.; Fagerström, Ella; Paivandy, Aida

Part of Journal of Allergy and Clinical Immunology, p. 940-951, 2024

• DOI for Blockade of endolysosomal acidification suppresses TLR3-mediated proinflammatory signaling in airway epithelial cells
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Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4⁺ and CD8⁺ T Cells, and Skin Mast Cells by Quantitative Transcriptomics

Akula, Srinivas; Alvarado-Vazquez, Abigail; Mendez Enriquez, Erika Haide; Bal, Gürkan et al.

Part of International Journal of Molecular Sciences, 2024

• DOI for Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4⁺ and CD8⁺ T Cells, and Skin Mast Cells by Quantitative Transcriptomics
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Mast cell chymase suppresses functional parameters in primary human airway smooth muscle cells

Zhao, Xinran O.; Melo, Fabio Rabelo; Sommerhoff, Christian P.; Paivandy, Aida et al.

Part of Allergy. European Journal of Allergy and Clinical Immunology, p. 2524-2527, 2024

• DOI for Mast cell chymase suppresses functional parameters in primary human airway smooth muscle cells
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Mast Cells are Dependent on Glucose Transporter 1 (GLUT1) and GLUT3 for IgE-mediated Activation

Grujic, Mirjana; Alim, Md Abdul; Hellman, Lars; Peterson, Magnus et al.

Part of Inflammation, p. 1820-1836, 2024

• DOI for Mast Cells are Dependent on Glucose Transporter 1 (GLUT1) and GLUT3 for IgE-mediated Activation
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Absence of changes in the milk microbiota during Escherichia coli endotoxin induced experimental bovine mastitis

Dahlberg, Josef; Johnzon, Carl-Fredrik; Sun, Li; Pejler, Gunnar et al.

Part of Veterinary research (Print), 2023

• DOI for Absence of changes in the milk microbiota during Escherichia coli endotoxin induced experimental bovine mastitis
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Chymase Inhibition Resolves and Prevents Deep Vein Thrombosis Without Increasing Bleeding Time in the Mouse Model

Lapointe, Catherine; Vincent, Laurence; Giguere, Hugo; Auger-Messier, Mannix et al.

Part of Journal of the American Heart Association, 2023

• DOI for Chymase Inhibition Resolves and Prevents Deep Vein Thrombosis Without Increasing Bleeding Time in the Mouse Model
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Heparin and heparin proteoglycan-mimetics activate platelets via PEAR1 and PI3K beta

Kardeby, Caroline; Evans, Alice; Campos, Joana; Al-Wahaibi, Afraa Moosa et al.

Part of Journal of Thrombosis and Haemostasis, p. 101-116, 2023

• DOI for Heparin and heparin proteoglycan-mimetics activate platelets via PEAR1 and PI3K beta
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Monensin induces secretory granule-mediated cell death in eosinophils

Vraila, Marianthi; Asp, Elin; Melo, Fabio R.; Grujic, Mirjana et al.

Part of Journal of Allergy and Clinical Immunology, 2023

• DOI for Monensin induces secretory granule-mediated cell death in eosinophils
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Nafamostat has anti-asthmatic effects associated with suppressed pro-inflammatory gene expression, eosinophil infiltration and airway hyperreactivity

Allam, Venkata; Waern, Ida; Taha, Sowsan; Akula, Srinivas et al.

Part of Frontiers in Immunology, 2023

• DOI for Nafamostat has anti-asthmatic effects associated with suppressed pro-inflammatory gene expression, eosinophil infiltration and airway hyperreactivity
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Obesity Is Associated with Distorted Proteoglycan Expression in Adipose Tissue

Meen, Astri J.; Doncheva, Atanaska I.; Boettcher, Yvonne; Dankel, Simon N. et al.

Part of International Journal of Molecular Sciences, 2023

• DOI for Obesity Is Associated with Distorted Proteoglycan Expression in Adipose Tissue
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Phenotypic Switch and Growth of Melanoma Spheroids in the Presence of Mast Cells: Potential Impact of Nutrient-starvation Effects

Grujic, Mirjana; Nguyen, Thanh; Héchard, Tifaine; Wang, Helen et al.

Part of Anticancer Research, p. 1415-1426, 2023

• DOI for Phenotypic Switch and Growth of Melanoma Spheroids in the Presence of Mast Cells: Potential Impact of Nutrient-starvation Effects
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Tendon pain: what are the mechanisms behind it?

Ackermann, Paul W.; Alim, Md Abdul; Pejler, Gunnar; Peterson, Magnus

Part of Scandinavian Journal of Pain, p. 14-24, 2023

• DOI for Tendon pain: what are the mechanisms behind it?
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Therapeutic administration of mouse mast cell protease 6 improves functional recovery after traumatic spinal cord injury in mice by promoting remyelination and reducing glial scar formation

Vangansewinkel, Tim; Lemmens, Stefanie; Tiane, Assia; Geurts, Nathalie et al.

Part of The FASEB Journal, 2023

• DOI for Therapeutic administration of mouse mast cell protease 6 improves functional recovery after traumatic spinal cord injury in mice by promoting remyelination and reducing glial scar formation
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Differential expression of enzymes in thymidylate biosynthesis in zebrafish at different developmental stages: implications for dtymk mutation-caused neurodegenerative disorders

Frisk, Junmei Hu; Orn, Stefan; Pejler, Gunnar; Eriksson, Staffan et al.

Part of BMC Neuroscience, 2022

• DOI for Differential expression of enzymes in thymidylate biosynthesis in zebrafish at different developmental stages: implications for dtymk mutation-caused neurodegenerative disorders
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Heavy metal tolerance of Mesorhizobium delmotii thymidylate kinase

Hu Frisk, Junmei; Pejler, Gunnar; Eriksson, Staffan; Wang, Liya

Part of Nucleosides, Nucleotides & Nucleic Acids, p. 1305-1317, 2022

• DOI for Heavy metal tolerance of Mesorhizobium delmotii thymidylate kinase
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Mast cell chymase affects the functional properties of primary human airway fibroblasts: Implications for asthma

Zhao, Xinran; Lampinen, Maria; Rollman, Ola; Sommerhoff, Christian P et al.

Part of Journal of Allergy and Clinical Immunology, p. 718-727, 2022

• DOI for Mast cell chymase affects the functional properties of primary human airway fibroblasts: Implications for asthma
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Mast cell chymase has a negative impact on human osteoblasts

Lind, Thomas; Melo, Fabio R.; Gustafson, Ann-Marie; Sundqvist, Anders et al.

Part of Matrix Biology, p. 1-19, 2022

• DOI for Mast cell chymase has a negative impact on human osteoblasts
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Mast cell chymase regulates extracellular matrix remodeling-related events in primary human small airway epithelial cells

Zhao, xinzh765; Sommerhoff, Christian P.; Paivandy, Aida; Pejler, Gunnar

Part of Journal of Allergy and Clinical Immunology, p. 1534-1544, 2022

• DOI for Mast cell chymase regulates extracellular matrix remodeling-related events in primary human small airway epithelial cells
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Mast cell tryptase potentiates neutrophil extracellular trap formation

Pejler, Gunnar; Alanazi, Sultan; Grujic, Mirjana; Adler, Jeremy et al.

Part of Journal of Innate Immunity, p. 433-446, 2022

• DOI for Mast cell tryptase potentiates neutrophil extracellular trap formation
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Mefloquine causes selective mast cell apoptosis in cutaneous mastocytosis lesions by a secretory granule-mediated pathway

Lampinen, Maria; Hagforsen, Eva; Weström, Simone; Bergström, Anna et al.

Part of Experimental dermatology, p. 1729-1740, 2022

• DOI for Mefloquine causes selective mast cell apoptosis in cutaneous mastocytosis lesions by a secretory granule-mediated pathway
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Monensin induces selective mast cell apoptosis through a secretory granule-mediated pathway.

Maccarana, Marco; Liu, Jielu; Lampinen, Maria; Rollman, Ola et al.

Part of Allergy. European Journal of Allergy and Clinical Immunology, p. 1025-1028, 2022

• DOI for Monensin induces selective mast cell apoptosis through a secretory granule-mediated pathway.
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Monensin inhibits mast cell mediated airway contractions in human and guinea pig asthma models

Liu, Jielu; Nie, Mu; Dong, Caijuan; Säfholm, Jesper et al.

Part of Scientific Reports, 2022

• DOI for Monensin inhibits mast cell mediated airway contractions in human and guinea pig asthma models
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Neutrophil extracellular traps promote cancer-associated inflammation and myocardial stress.

Cedervall, Jessica; Herre, Melanie; Dragomir, Anca; Rabelo-Melo, F et al.

Part of Oncoimmunology, 2022

• DOI for Neutrophil extracellular traps promote cancer-associated inflammation and myocardial stress.
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Quantitative In-Depth Transcriptome Analysis Implicates Peritoneal Macrophages as Important Players in the Complement and Coagulation Systems

Paivandy, Aida; Akula, Srinivas; Lara, Sandra; Fu, Zhirong et al.

Part of International Journal of Molecular Sciences, 2022

• DOI for Quantitative In-Depth Transcriptome Analysis Implicates Peritoneal Macrophages as Important Players in the Complement and Coagulation Systems
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Serglycin Is Involved in Adipose Tissue Inflammation in Obesity

Doncheva, Atanaska, I; Norheim, Frode A.; Hjorth, Marit; Grujic, Mirjana et al.

Part of Journal of Immunology, p. 121-132, 2022

• DOI for Serglycin Is Involved in Adipose Tissue Inflammation in Obesity

Structural and functional analysis of human thymidylate kinase isoforms

Frisk, Junmei Hu; Pejler, Gunnar; Eriksson, Staffan; Wang, Liya

Part of Nucleosides, Nucleotides & Nucleic Acids, p. 321-332, 2022

• DOI for Structural and functional analysis of human thymidylate kinase isoforms
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The ingenious mast cell: Contemporary insights into mast cell behavior and function

Dahlin, Joakim S.; Maurer, Marcus; Metcalfe, Dean D.; Pejler, Gunnar et al.

Part of Allergy. European Journal of Allergy and Clinical Immunology, p. 83-99, 2022

• DOI for The ingenious mast cell: Contemporary insights into mast cell behavior and function
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Treatment of chronic airway diseases using nutraceuticals: Mechanistic insight

Allam, Venkata; Chellappan, Dinesh Kumar; Jha, Niraj Kumar; Shastri, Madhur D. et al.

Part of Critical reviews in food science and nutrition, p. 7576-7590, 2022

• DOI for Treatment of chronic airway diseases using nutraceuticals: Mechanistic insight

Tryptase reference values in a Swedish middle-aged general population and association with diabetes mellitus

Vitte, Joana; Sjölander, Anders; Rydell, Niclas; Molin, Magnus et al.

Part of Clinical and Experimental Allergy, p. 1330-1333, 2022

• DOI for Tryptase reference values in a Swedish middle-aged general population and association with diabetes mellitus
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Biochemical Characterizations of Human TMPK Mutations Identified in Patients with Severe Microcephaly: Single Amino Acid Substitutions Impair Dimerization and Abolish Their Catalytic Activity

Frisk, Junmei Hu; Vanoevelen, Jo M.; Bierau, Jorgen; Pejler, Gunnar et al.

Part of ACS Omega, p. 33943-33952, 2021

• DOI for Biochemical Characterizations of Human TMPK Mutations Identified in Patients with Severe Microcephaly: Single Amino Acid Substitutions Impair Dimerization and Abolish Their Catalytic Activity
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Dynamin inhibition causes context-dependent cell death of leukemia and lymphoma cells

von Beek, Christopher; Alriksson, Linnéa; Palle, Josefine; Gustafson, Ann-Marie et al.

Part of PLOS ONE, 2021

• DOI for Dynamin inhibition causes context-dependent cell death of leukemia and lymphoma cells
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Glutamate triggers the expression of functional ionotropic and metabotropic glutamate receptors in mast cells

Alim, Abdul; Grujic, Mirjana; Ackerman, Paul W; Kristiansson, Per et al.

Part of Cellular & Molecular Immunology, p. 2383-2392, 2021

• DOI for Glutamate triggers the expression of functional ionotropic and metabotropic glutamate receptors in mast cells
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Mast Cell Degranulation Increases Mouse Mast Cell Protease 4-Dependent Vasopressor Responses to Big Endothelin-1 But Not Angiotensin I

Vincent, Laurence; Lapointe, Catherine; Lo, Modou; Gagnon, Hugo et al.

Part of Journal of Pharmacology and Experimental Therapeutics, p. 213-221, 2021

• DOI for Mast Cell Degranulation Increases Mouse Mast Cell Protease 4-Dependent Vasopressor Responses to Big Endothelin-1 But Not Angiotensin I

Novel Strategies to Target Mast Cells in Disease

Paivandy, Aida; Pejler, Gunnar

Part of Journal of Innate Immunity, p. 131-147, 2021

• DOI for Novel Strategies to Target Mast Cells in Disease
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Platelet α-granule cargo packaging and release are affected by the luminal proteoglycan, serglycin

Chanzu, Harry; Lykins, Joshua; Wigna-Kumar, Subershan; Joshi, Smita et al.

Part of Journal of Thrombosis and Haemostasis, p. 1082-1095, 2021

• DOI for Platelet α-granule cargo packaging and release are affected by the luminal proteoglycan, serglycin

Tryptase Regulates the Epigenetic Modification of Core Histones in Mast Cell Leukemia Cells

Alanazi, Sultan; Melo, Fabio Rabelo; Pejler, Gunnar

Part of Frontiers in Immunology, 2021

• DOI for Tryptase Regulates the Epigenetic Modification of Core Histones in Mast Cell Leukemia Cells
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DNA demethylation regulates gene expression in IgE-activated mouse mast cells.

Paivandy, Aida; Grujic, Mirjana; Rafati, Nima; Pejler, Gunnar

Part of Allergy. European Journal of Allergy and Clinical Immunology, p. 1776-1780, 2020

• DOI for DNA demethylation regulates gene expression in IgE-activated mouse mast cells.
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Do Mast Cells Have a Role in Tendon Healing and Inflammation?

Alim, Abdul; Peterson, Magnus; Pejler, Gunnar

Part of Cells, 2020

• DOI for Do Mast Cells Have a Role in Tendon Healing and Inflammation?
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