Publications

The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma

Ohata, Yae; Ali, Mohamad M.; Tsubakihara, Yutaro; Itoh, Yuka et al.

Part of Cell Death and Differentiation, p. 1915-1929, 2025

• DOI for The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma
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The TGF-β Family in Glioblastoma

Golan, Irene; Caja, Laia

Part of International Journal of Molecular Sciences, 2024

• DOI for The TGF-β Family in Glioblastoma
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Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation

Peleli, Maria; Antoniadou, Ivi; Mendes Rodrigues Junior, Dorival; Savvoulidou, Odysseia et al.

Part of Redox Biology, 2023

• DOI for Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation
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The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition

Tzavlaki, Kalliopi; Ohata, Yae; Morén, Anita; Watanabe, Yukihide et al.

Part of Journal of Cellular Physiology, p. 790-812, 2023

• DOI for The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition
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The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion

Gélabert, Caroline; Papoutsoglou, Panagiotis; Cancela Golan, Irene; Ahlström, Eric et al.

Part of Cell Communication and Signaling, 2023

• DOI for The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion
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Aporphine and isoquinoline derivatives block glioblastoma cell stemness and enhance temozolomide cytotoxicity

Mendes Rodrigues Junior, Dorival; Raminelli, Cristiano; Hassanie, Haifa; Trossini, Gustavo Henrique Goulart et al.

Part of Scientific Reports, p. 21113, 2022

• DOI for Aporphine and isoquinoline derivatives block glioblastoma cell stemness and enhance temozolomide cytotoxicity
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Editorial: Targeting intra- and extracellular signals contributing to cancer stemness and metastasis in aggressive cancers, Volume II.

Caja, Laia; Lonardo, Enza; Sancho, Patricia

Part of Frontiers in Pharmacology, 2022

• DOI for Editorial: Targeting intra- and extracellular signals contributing to cancer stemness and metastasis in aggressive cancers, Volume II.

Metabolic determinants of stemness in medulloblastoma

Martin-Rubio, Paula; Espiau-Romera, Pilar; Royo-Garcia, Alba; Caja, Laia et al.

Part of World Journal of Stem Cells, p. 587-598, 2022

• DOI for Metabolic determinants of stemness in medulloblastoma
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NOX4 regulates TGF beta-induced proliferation and self-renewal in glioblastoma stem cells

Garcia-Gomez, Pedro; Golan, Irene; Dadras, Mahsa Shahidi; Mezheyeuski, Artur et al.

Part of Molecular Oncology, p. 1891-1912, 2022

• DOI for NOX4 regulates TGF beta-induced proliferation and self-renewal in glioblastoma stem cells
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The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma

Caja, Laia; Dadras, Mahsa Shahidi; Mezheyeuski, Artur; Mendes Rodrigues-Junior, Dorival et al.

Part of Journal of Cellular Physiology, p. 743-762, 2022

• DOI for The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma
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Glucose and Amino Acid Metabolic Dependencies Linked to Stemness and Metastasis in Different Aggressive Cancer Types

Chisari, Andrea; Golan, Irene; Campisano, Sabrina; Gélabert, Caroline et al.

Part of Frontiers in Pharmacology, 2021

• DOI for Glucose and Amino Acid Metabolic Dependencies Linked to Stemness and Metastasis in Different Aggressive Cancer Types
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The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor beta signaling

Papoutsoglou, Panagiotis; Rodrigues Junior, Dorival Mendes; Morén, Anita; Bergman, Andrew et al.

Part of Oncogene, p. 3748-3765, 2021

• DOI for The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor beta signaling
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The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma

Dadras, Mahsa Shahidi; Caja, Laia; Mezheyeuski, Artur; Liu, Sijia et al.

Part of Cell Death and Disease, 2021

• DOI for The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma
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Downregulation of Epidermal Growth Factor Receptor in hepatocellular carcinoma facilitates Transforming Growth Factor-beta-induced epithelial to amoeboid transition

Lopez-Luque, Judit; Bertran, Esther; Crosas-Molist, Eva; Maiques, Oscar et al.

Part of Cancer Letters, p. 15-24, 2019

• DOI for Downregulation of Epidermal Growth Factor Receptor in hepatocellular carcinoma facilitates Transforming Growth Factor-beta-induced epithelial to amoeboid transition
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TANK-binding kinase 1 is a mediator of platelet-induced EMT in mammary carcinoma cells

Zhang, Yanyu; Valsala Madhavan Unnithan, Ragaseema; Hamidi, Anahita; Caja, Laia et al.

Part of The FASEB Journal, p. 7822-7832, 2019

• DOI for TANK-binding kinase 1 is a mediator of platelet-induced EMT in mammary carcinoma cells

The TGFB2-AS1 lncRNA regulates TGFβ signaling by modulating corepressor activity

Papoutsoglou, Panagiotis; Tsubakihara, Yutaro; Caja, Laia; Pallis, Paris et al.

Part of Cell Reports, p. 3182-319800000000000, 2019

• DOI for The TGFB2-AS1 lncRNA regulates TGFβ signaling by modulating corepressor activity
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Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma

Bellomo, Claudia; Caja, Laia; Fabregat, Isabel; Mikulits, Wolfgang et al.

Part of Cell Death and Differentiation, p. 885-903, 2018

• DOI for Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma
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Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells

Caja, Laia; Tzavlaki, Kalliopi; Dadras, Mahsa Shahidi; Tan, E-Jean et al.

Part of Oncogene, p. 2515-2531, 2018

• DOI for Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells
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TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer

Caja, Laia; Dituri, Francesco; Mancarella, Serena; Caballero-Diaz, Daniel et al.

Part of International Journal of Molecular Sciences, 2018

• DOI for TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer
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Transforming growth factor beta as regulator of cancer stemness and metastasis

Bellomo, Claudia; Caja, Laia; Moustakas, Aristidis

Part of British Journal of Cancer, p. 761-769, 2016

• DOI for Transforming growth factor beta as regulator of cancer stemness and metastasis
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Transforming growth factor beta and bone morphogenetic protein actions in brain tumors

Caja, Laia Puigsubira; Bellomo, Claudia; Moustakas, Aristidis

Part of FEBS Letters, p. 1588-1597, 2015

• DOI for Transforming growth factor beta and bone morphogenetic protein actions in brain tumors
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Vascular smooth muscle cell phenotypic changes in patients with Marfan syndrome

Crosas-Molist, Eva; Meirelles, Thayna; López-Luque, Judit; Serra-Peinado, Carla et al.

Part of Arteriosclerosis, Thrombosis and Vascular Biology, p. 960-972, 2015

• DOI for Vascular smooth muscle cell phenotypic changes in patients with Marfan syndrome

A trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitins

Pérez-Perarnau, Alba; Preciado, Sara; Palmeri, Claudia Mariela; Moncunill-Massaguer, Cristina et al.

Part of Angewandte Chemie International Edition, p. 10150-10154, 2014

• DOI for A trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitins

Caveolin-1 is required for TGF-β-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17

Moreno-Càceres, J; Caja, Laia; Mainez, J; Mayoral, R et al.

Part of Cell Death and Disease, 2014

• DOI for Caveolin-1 is required for TGF-β-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17

Overactivation of the TGF-β pathway confers a mesenchymal-like phenotype and CXCR4-dependent migratory properties to liver tumor cells

Bertran, Esther; Crosas-Molist, Eva; Sancho, Patricia; Caja, Laia et al.

Part of Hepatology, p. 2032-44, 2013

• DOI for Overactivation of the TGF-β pathway confers a mesenchymal-like phenotype and CXCR4-dependent migratory properties to liver tumor cells

The Epstein-Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteins

Coppotelli, Giuseppe; Mughal, Nouman; Callegari, Simone; Sompallae, Ramakrishna et al.

Part of Nucleic Acids Research, p. 2950-2962, 2013

• DOI for The Epstein-Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteins
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Context-dependent action of transforming growth factor β family members on normal and cancer stem cells

Caja, Laia; Kahata, Kaoru; Moustakas, Aristidis

Part of Current pharmaceutical design, p. 4072-4086, 2012

• DOI for Context-dependent action of transforming growth factor β family members on normal and cancer stem cells

Lack of amino acids in mouse hepatocytes in culture induces the selection of preneoplastic cells.

Chisari, Andrea N; Sancho, Patricia; Caja, Laia; Bertran, Esther et al.

Part of Cellular Signalling, p. 325-32, 2012

• DOI for Lack of amino acids in mouse hepatocytes in culture induces the selection of preneoplastic cells.

Protein-tyrosine phosphatase 1B (PTP1B) deficiency confers resistance to transforming growth factor-β (TGF-β)-induced suppressor effects in hepatocytes.

Ortiz, Conrad; Caja, Laia; Bertran, Esther; Gonzalez-Rodriguez, Águeda et al.

Part of Journal of Biological Chemistry, p. 15263-74, 2012

• DOI for Protein-tyrosine phosphatase 1B (PTP1B) deficiency confers resistance to transforming growth factor-β (TGF-β)-induced suppressor effects in hepatocytes.

Regulation of transcription factor Twist expression by the DNA architectural protein high mobility group A2 during epithelial-to-mesenchymal transition

Tan, E-Jean; Thuault, Sylvie; Caja, Laia; Carletti, Tea et al.

Part of Journal of Biological Chemistry, p. 7134-7145, 2012

• DOI for Regulation of transcription factor Twist expression by the DNA architectural protein high mobility group A2 during epithelial-to-mesenchymal transition

Sorafenib sensitizes hepatocellular carcinoma cells to physiological apoptotic stimuli.

Fernando, Joan; Sancho, Patricia; Fernández-Rodriguez, Conrado M; Lledó, José L et al.

Part of Journal of Cellular Physiology, p. 1319-25, 2012

• DOI for Sorafenib sensitizes hepatocellular carcinoma cells to physiological apoptotic stimuli.

Dissecting the effect of targeting the epidermal growth factor receptor on TGF-β-induced-apoptosis in human hepatocellular carcinoma cells.

Caja, Laia; Sancho, Patricia; Bertran, Esther; Fabregat, Isabel

Part of Journal of Hepatology, p. 351-358, 2011

• DOI for Dissecting the effect of targeting the epidermal growth factor receptor on TGF-β-induced-apoptosis in human hepatocellular carcinoma cells.

The transforming growth factor-beta (TGF-β) mediates acquisition of a mesenchymal stem cell-like phenotype in human liver cells.

Caja, Laia; Bertran, Esther; Campbell, Jean; Fausto, Nelson et al.

Part of Journal of Cellular Physiology, p. 1214-1223, 2011

• DOI for The transforming growth factor-beta (TGF-β) mediates acquisition of a mesenchymal stem cell-like phenotype in human liver cells.

The tyrphostin AG1478 inhibits proliferation and induces death of liver tumor cells through EGF receptor-dependent and independent mechanisms.

Caja, Laia; Sancho, Patricia; Bertran, Esther; Ortiz, Conrad et al.

Part of Biochemical pharmacology, p. 1583-1592, 2011

• DOI for The tyrphostin AG1478 inhibits proliferation and induces death of liver tumor cells through EGF receptor-dependent and independent mechanisms.

Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-{beta}-induced cell death through impairing up-regulation of the NADPH oxidase NOX4.

Caja, Laia; Sancho, Patricia; Bertran, Esther; Iglesias-Serret, Daniel et al.

Part of Cancer Research, p. 7595-7602, 2009

• DOI for Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-{beta}-induced cell death through impairing up-regulation of the NADPH oxidase NOX4.

Role of CXCR4/SDF-1 alpha in the migratory phenotype of hepatoma cells that have undergone epithelial-mesenchymal transition in response to the transforming growth factor-beta.

Bertran, Esther; Caja, Laia; Navarro, Estanis; Sancho, Patricia et al.

Part of Cellular Signalling, p. 1595-1606, 2009

• DOI for Role of CXCR4/SDF-1 alpha in the migratory phenotype of hepatoma cells that have undergone epithelial-mesenchymal transition in response to the transforming growth factor-beta.

The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms.

Sancho, Patricia; Bertran, Esther; Caja, Laia; Carmona-Cuenca, Irene et al.

Part of Biochimica et Biophysica Acta, p. 253-263, 2009

• DOI for The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms.

Inhibition of the EGF receptor blocks autocrine growth and increases the cytotoxic effects of doxorubicin in rat hepatoma cells: role of reactive oxygen species production and glutathione depletion

Ortiz, Conrad; Caja, Laia; Sancho, Patricia; Bertran, Esther et al.

Part of Biochemical pharmacology, p. 1935-1945, 2008

• DOI for Inhibition of the EGF receptor blocks autocrine growth and increases the cytotoxic effects of doxorubicin in rat hepatoma cells: role of reactive oxygen species production and glutathione depletion

Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity

Carmona-Cuenca, Irene; Roncero, César; Sancho, Patricia; Caja, Laia et al.

Part of Journal of Hepatology, p. 965-76, 2008

• DOI for Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity

Differential intracellular signalling induced by TGF-beta in rat adult hepatocytes and hepatoma cells: implications in liver carcinogenesis.

Caja, Laia; Ortiz, Conrad; Bertran, Esther; Murillo, Miguel M et al.

Part of Cellular Signalling, p. 683-94, 2007

• DOI for Differential intracellular signalling induced by TGF-beta in rat adult hepatocytes and hepatoma cells: implications in liver carcinogenesis.