Publications

The TGF-β Family in Glioblastoma

Golan, Irene; Caja, Laia

Part of International Journal of Molecular Sciences, 2024

• DOI for The TGF-β Family in Glioblastoma
• Download full text (pdf) of The TGF-β Family in Glioblastoma

Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation

Peleli, Maria; Antoniadou, Ivi; Mendes Rodrigues Junior, Dorival; Savvoulidou, Odysseia et al.

Part of Redox Biology, 2023

• DOI for Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation
• Download full text (pdf) of Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation

The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition

Tzavlaki, Kalliopi; Ohata, Yae; Morén, Anita; Watanabe, Yukihide et al.

Part of Journal of Cellular Physiology, p. 790-812, 2023

• DOI for The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition
• Download full text (pdf) of The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition

The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion

Gélabert, Caroline; Papoutsoglou, Panagiotis; Cancela Golan, Irene; Ahlström, Eric et al.

Part of Cell Communication and Signaling, 2023

• DOI for The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion
• Download full text (pdf) of The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion

Aporphine and isoquinoline derivatives block glioblastoma cell stemness and enhance temozolomide cytotoxicity

Mendes Rodrigues Junior, Dorival; Raminelli, Cristiano; Hassanie, Haifa; Trossini, Gustavo Henrique Goulart et al.

Part of Scientific Reports, p. 21113, 2022

• DOI for Aporphine and isoquinoline derivatives block glioblastoma cell stemness and enhance temozolomide cytotoxicity
• Download full text (pdf) of Aporphine and isoquinoline derivatives block glioblastoma cell stemness and enhance temozolomide cytotoxicity

Editorial: Targeting intra- and extracellular signals contributing to cancer stemness and metastasis in aggressive cancers, Volume II.

Caja, Laia; Lonardo, Enza; Sancho, Patricia

Part of Frontiers in Pharmacology, 2022

• DOI for Editorial: Targeting intra- and extracellular signals contributing to cancer stemness and metastasis in aggressive cancers, Volume II.

Metabolic determinants of stemness in medulloblastoma

Martin-Rubio, Paula; Espiau-Romera, Pilar; Royo-Garcia, Alba; Caja, Laia et al.

Part of World Journal of Stem Cells, p. 587-598, 2022

• DOI for Metabolic determinants of stemness in medulloblastoma
• Download full text (pdf) of Metabolic determinants of stemness in medulloblastoma

NOX4 regulates TGF beta-induced proliferation and self-renewal in glioblastoma stem cells

Garcia-Gomez, Pedro; Golan, Irene; Dadras, Mahsa Shahidi; Mezheyeuski, Artur et al.

Part of Molecular Oncology, p. 1891-1912, 2022

• DOI for NOX4 regulates TGF beta-induced proliferation and self-renewal in glioblastoma stem cells
• Download full text (pdf) of NOX4 regulates TGF beta-induced proliferation and self-renewal in glioblastoma stem cells

The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma

Caja, Laia; Dadras, Mahsa Shahidi; Mezheyeuski, Artur; Mendes Rodrigues-Junior, Dorival et al.

Part of Journal of Cellular Physiology, p. 743-762, 2022

• DOI for The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma
• Download full text (pdf) of The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma

Glucose and Amino Acid Metabolic Dependencies Linked to Stemness and Metastasis in Different Aggressive Cancer Types

Chisari, Andrea; Golan, Irene; Campisano, Sabrina; Gélabert, Caroline et al.

Part of Frontiers in Pharmacology, 2021

• DOI for Glucose and Amino Acid Metabolic Dependencies Linked to Stemness and Metastasis in Different Aggressive Cancer Types
• Download full text (pdf) of Glucose and Amino Acid Metabolic Dependencies Linked to Stemness and Metastasis in Different Aggressive Cancer Types

The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor beta signaling

Papoutsoglou, Panagiotis; Rodrigues Junior, Dorival Mendes; Morén, Anita; Bergman, Andrew et al.

Part of Oncogene, p. 3748-3765, 2021

• DOI for The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor beta signaling
• Download full text (pdf) of The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor beta signaling

The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma

Dadras, Mahsa Shahidi; Caja, Laia; Mezheyeuski, Artur; Liu, Sijia et al.

Part of Cell Death and Disease, 2021

• DOI for The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma
• Download full text (pdf) of The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma

Downregulation of Epidermal Growth Factor Receptor in hepatocellular carcinoma facilitates Transforming Growth Factor-beta-induced epithelial to amoeboid transition

Lopez-Luque, Judit; Bertran, Esther; Crosas-Molist, Eva; Maiques, Oscar et al.

Part of Cancer Letters, p. 15-24, 2019

• DOI for Downregulation of Epidermal Growth Factor Receptor in hepatocellular carcinoma facilitates Transforming Growth Factor-beta-induced epithelial to amoeboid transition
• Download full text (pdf) of Downregulation of Epidermal Growth Factor Receptor in hepatocellular carcinoma facilitates Transforming Growth Factor-beta-induced epithelial to amoeboid transition

TANK-binding kinase 1 is a mediator of platelet-induced EMT in mammary carcinoma cells

Zhang, Yanyu; Valsala Madhavan Unnithan, Ragaseema; Hamidi, Anahita; Caja, Laia et al.

Part of The FASEB Journal, p. 7822-7832, 2019

• DOI for TANK-binding kinase 1 is a mediator of platelet-induced EMT in mammary carcinoma cells

The TGFB2-AS1 lncRNA regulates TGFβ signaling by modulating corepressor activity

Papoutsoglou, Panagiotis; Tsubakihara, Yutaro; Caja, Laia; Pallis, Paris et al.

Part of Cell Reports, p. 3182-319800000000000, 2019

• DOI for The TGFB2-AS1 lncRNA regulates TGFβ signaling by modulating corepressor activity
• Download full text (pdf) of The TGFB2-AS1 lncRNA regulates TGFβ signaling by modulating corepressor activity

Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma

Bellomo, Claudia; Caja, Laia; Fabregat, Isabel; Mikulits, Wolfgang et al.

Part of Cell Death and Differentiation, p. 885-903, 2018

• DOI for Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma
• Download full text (pdf) of Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma

Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells

Caja, Laia; Tzavlaki, Kalliopi; Dadras, Mahsa Shahidi; Tan, E-Jean et al.

Part of Oncogene, p. 2515-2531, 2018

• DOI for Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells
• Download full text (pdf) of Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells

TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer

Caja, Laia; Dituri, Francesco; Mancarella, Serena; Caballero-Diaz, Daniel et al.

Part of International Journal of Molecular Sciences, 2018

• DOI for TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer
• Download full text (pdf) of TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer

Transforming growth factor beta as regulator of cancer stemness and metastasis

Bellomo, Claudia; Caja, Laia; Moustakas, Aristidis

Part of British Journal of Cancer, p. 761-769, 2016

• DOI for Transforming growth factor beta as regulator of cancer stemness and metastasis
• Download full text (pdf) of Transforming growth factor beta as regulator of cancer stemness and metastasis

Transforming growth factor beta and bone morphogenetic protein actions in brain tumors

Caja, Laia Puigsubira; Bellomo, Claudia; Moustakas, Aristidis

Part of FEBS Letters, p. 1588-1597, 2015

• DOI for Transforming growth factor beta and bone morphogenetic protein actions in brain tumors
• Download full text (pdf) of Transforming growth factor beta and bone morphogenetic protein actions in brain tumors

Vascular smooth muscle cell phenotypic changes in patients with Marfan syndrome

Crosas-Molist, Eva; Meirelles, Thayna; López-Luque, Judit; Serra-Peinado, Carla et al.

Part of Arteriosclerosis, Thrombosis and Vascular Biology, p. 960-972, 2015

• DOI for Vascular smooth muscle cell phenotypic changes in patients with Marfan syndrome

A trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitins

Pérez-Perarnau, Alba; Preciado, Sara; Palmeri, Claudia Mariela; Moncunill-Massaguer, Cristina et al.

Part of Angewandte Chemie International Edition, p. 10150-10154, 2014

• DOI for A trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitins

Caveolin-1 is required for TGF-β-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17

Moreno-Càceres, J; Caja, Laia; Mainez, J; Mayoral, R et al.

Part of Cell Death and Disease, 2014

• DOI for Caveolin-1 is required for TGF-β-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17

Overactivation of the TGF-β pathway confers a mesenchymal-like phenotype and CXCR4-dependent migratory properties to liver tumor cells

Bertran, Esther; Crosas-Molist, Eva; Sancho, Patricia; Caja, Laia et al.

Part of Hepatology, p. 2032-44, 2013

• DOI for Overactivation of the TGF-β pathway confers a mesenchymal-like phenotype and CXCR4-dependent migratory properties to liver tumor cells

The Epstein-Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteins

Coppotelli, Giuseppe; Mughal, Nouman; Callegari, Simone; Sompallae, Ramakrishna et al.

Part of Nucleic Acids Research, p. 2950-2962, 2013

• DOI for The Epstein-Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteins
• Download full text (pdf) of The Epstein-Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteins

Context-dependent action of transforming growth factor β family members on normal and cancer stem cells

Caja, Laia; Kahata, Kaoru; Moustakas, Aristidis

Part of Current pharmaceutical design, p. 4072-4086, 2012

• DOI for Context-dependent action of transforming growth factor β family members on normal and cancer stem cells

Lack of amino acids in mouse hepatocytes in culture induces the selection of preneoplastic cells.

Chisari, Andrea N; Sancho, Patricia; Caja, Laia; Bertran, Esther et al.

Part of Cellular Signalling, p. 325-32, 2012

• DOI for Lack of amino acids in mouse hepatocytes in culture induces the selection of preneoplastic cells.

Protein-tyrosine phosphatase 1B (PTP1B) deficiency confers resistance to transforming growth factor-β (TGF-β)-induced suppressor effects in hepatocytes.

Ortiz, Conrad; Caja, Laia; Bertran, Esther; Gonzalez-Rodriguez, Águeda et al.

Part of Journal of Biological Chemistry, p. 15263-74, 2012

• DOI for Protein-tyrosine phosphatase 1B (PTP1B) deficiency confers resistance to transforming growth factor-β (TGF-β)-induced suppressor effects in hepatocytes.

Regulation of transcription factor Twist expression by the DNA architectural protein high mobility group A2 during epithelial-to-mesenchymal transition

Tan, E-Jean; Thuault, Sylvie; Caja, Laia; Carletti, Tea et al.

Part of Journal of Biological Chemistry, p. 7134-7145, 2012

• DOI for Regulation of transcription factor Twist expression by the DNA architectural protein high mobility group A2 during epithelial-to-mesenchymal transition

Sorafenib sensitizes hepatocellular carcinoma cells to physiological apoptotic stimuli.

Fernando, Joan; Sancho, Patricia; Fernández-Rodriguez, Conrado M; Lledó, José L et al.

Part of Journal of Cellular Physiology, p. 1319-25, 2012

• DOI for Sorafenib sensitizes hepatocellular carcinoma cells to physiological apoptotic stimuli.

Dissecting the effect of targeting the epidermal growth factor receptor on TGF-β-induced-apoptosis in human hepatocellular carcinoma cells.

Caja, Laia; Sancho, Patricia; Bertran, Esther; Fabregat, Isabel

Part of Journal of Hepatology, p. 351-358, 2011

• DOI for Dissecting the effect of targeting the epidermal growth factor receptor on TGF-β-induced-apoptosis in human hepatocellular carcinoma cells.

The transforming growth factor-beta (TGF-β) mediates acquisition of a mesenchymal stem cell-like phenotype in human liver cells.

Caja, Laia; Bertran, Esther; Campbell, Jean; Fausto, Nelson et al.

Part of Journal of Cellular Physiology, p. 1214-1223, 2011

• DOI for The transforming growth factor-beta (TGF-β) mediates acquisition of a mesenchymal stem cell-like phenotype in human liver cells.

The tyrphostin AG1478 inhibits proliferation and induces death of liver tumor cells through EGF receptor-dependent and independent mechanisms.

Caja, Laia; Sancho, Patricia; Bertran, Esther; Ortiz, Conrad et al.

Part of Biochemical pharmacology, p. 1583-1592, 2011

• DOI for The tyrphostin AG1478 inhibits proliferation and induces death of liver tumor cells through EGF receptor-dependent and independent mechanisms.

Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-{beta}-induced cell death through impairing up-regulation of the NADPH oxidase NOX4.

Caja, Laia; Sancho, Patricia; Bertran, Esther; Iglesias-Serret, Daniel et al.

Part of Cancer Research, p. 7595-7602, 2009

• DOI for Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-{beta}-induced cell death through impairing up-regulation of the NADPH oxidase NOX4.

Role of CXCR4/SDF-1 alpha in the migratory phenotype of hepatoma cells that have undergone epithelial-mesenchymal transition in response to the transforming growth factor-beta.

Bertran, Esther; Caja, Laia; Navarro, Estanis; Sancho, Patricia et al.

Part of Cellular Signalling, p. 1595-1606, 2009

• DOI for Role of CXCR4/SDF-1 alpha in the migratory phenotype of hepatoma cells that have undergone epithelial-mesenchymal transition in response to the transforming growth factor-beta.

The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms.

Sancho, Patricia; Bertran, Esther; Caja, Laia; Carmona-Cuenca, Irene et al.

Part of Biochimica et Biophysica Acta, p. 253-263, 2009

• DOI for The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms.

Inhibition of the EGF receptor blocks autocrine growth and increases the cytotoxic effects of doxorubicin in rat hepatoma cells: role of reactive oxygen species production and glutathione depletion

Ortiz, Conrad; Caja, Laia; Sancho, Patricia; Bertran, Esther et al.

Part of Biochemical pharmacology, p. 1935-1945, 2008

• DOI for Inhibition of the EGF receptor blocks autocrine growth and increases the cytotoxic effects of doxorubicin in rat hepatoma cells: role of reactive oxygen species production and glutathione depletion

Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity

Carmona-Cuenca, Irene; Roncero, César; Sancho, Patricia; Caja, Laia et al.

Part of Journal of Hepatology, p. 965-76, 2008

• DOI for Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity

Differential intracellular signalling induced by TGF-beta in rat adult hepatocytes and hepatoma cells: implications in liver carcinogenesis.

Caja, Laia; Ortiz, Conrad; Bertran, Esther; Murillo, Miguel M et al.

Part of Cellular Signalling, p. 683-94, 2007

• DOI for Differential intracellular signalling induced by TGF-beta in rat adult hepatocytes and hepatoma cells: implications in liver carcinogenesis.