Apply to join the ENABLE-2 consortium

Open Call for new antibiotic programmes

ENABLE-2 is accepting Expressions of Interest (EOIs) from researchers at publicly-funded universities and research institutes throughout Europe.

There are two entry levels:

ENABLE-2 Hit to Lead programme

• Novel Hit compounds with wild-type whole cell antibacterial activity and the potential for development as direct-acting antibiotics for systemic use.

ENABLE-2 Incubator – Hit validation

• Novel compounds with some documented whole cell antibacterial activity against any species or strain (including efflux-deficient or hyperpermeable strains), with a MIC of at least 32 µg/mL, or
• Novel compounds with only documented bacterial target activity.
• Potential for development as direct-acting antibiotics for systemic use.
• Not previously reported to have antibacterial activity.
• Antimicrobial peptides with only membrane perturbation activity are not eligible.
• Novel natural products are eligible.

EOI templates

Contact ENABLE-2