Our current publications

Column coupling for chiral LC-MS separation resolves triacylglycerol enantiomers and regioisomers in complex samples without flow recycling

Nilsson, Jenny M.; Balgoma, David; Stephansson, Edvin Dedering; Landström, Sofia et al.

Part of Talanta, 2027

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• DOI for Column coupling for chiral LC-MS separation resolves triacylglycerol enantiomers and regioisomers in complex samples without flow recycling
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[⁶⁸Ga]Ga-NOTA-ATH001 positron emission tomography as a general tool for non-invasive detection of platelet derived growth factor receptor beta in mesenchymal cells

Mitran, Bogdan; Eriksson, Olof

Part of Nuclear Medicine and Biology, 2026

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• DOI for [⁶⁸Ga]Ga-NOTA-ATH001 positron emission tomography as a general tool for non-invasive detection of platelet derived growth factor receptor beta in mesenchymal cells
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A novel ¹⁸F-labelled tetrazine ester prosthetic group for improved radiolabelling and in vivo stability of proteins and peptides

Lechi, Francesco; Odell, Luke R.; Wegrzyniak, Olivia; Balestri, Lorenzo et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2026

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• DOI for A novel ¹⁸F-labelled tetrazine ester prosthetic group for improved radiolabelling and in vivo stability of proteins and peptides
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A Separation Buffers Platform Set to Facilitate CZE Charge Heterogeneity Method Development for Monoclonal Antibodies

Baxter, Joanne; Waltham, Kevin; Fitton, Lori; Sänger-van de Griend, Cari

Part of Electrophoresis, p. 420-434, 2026

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• DOI for A Separation Buffers Platform Set to Facilitate CZE Charge Heterogeneity Method Development for Monoclonal Antibodies

Aggregation behavior of sodium caprate under different pH, concentration, and intestinal fluid conditions: a coarse-grained molecular dynamics study comparing Martini 2 and Martini 3

Akter, Shahina; Bergström, L. Magnus; Hansson, Per; Hossain, Shakhawath et al.

Part of Physical Chemistry, Chemical Physics - PCCP, p. 13514-13525, 2026

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• DOI for Aggregation behavior of sodium caprate under different pH, concentration, and intestinal fluid conditions: a coarse-grained molecular dynamics study comparing Martini 2 and Martini 3
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Ascending single-dose study of the safety, pharmacokinetics, and pharmacodynamics of CSTI-500, a novel monoamine triple reuptake inhibitor, first-in-human

Appel, Lieuwe; Risinger, Robert; Wall, Anders; Murck, Harald et al.

Part of Psychopharmacology, p. 565-580, 2026

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• DOI for Ascending single-dose study of the safety, pharmacokinetics, and pharmacodynamics of CSTI-500, a novel monoamine triple reuptake inhibitor, first-in-human
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Barettin, a Nonopioid, Nonhallucinogenic Marine Natural Product with Antihyperalgesic Properties Mediated by 5HT2A Inverse Agonism

Seekins, Caleb A.; Okine, Michael; Forrest, Emily G.; Chavez, Timothy et al.

Part of Journal of Natural Products, p. 1298-1308, 2026

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• DOI for Barettin, a Nonopioid, Nonhallucinogenic Marine Natural Product with Antihyperalgesic Properties Mediated by 5HT2A Inverse Agonism
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Barettin Suppresses Pancreatic Ductal Adenocarcinoma Proliferation via Topoisomerase IIα Inhibition

Seekins, Caleb A.; Archuleta, Monique R.; Evans, Alexandria E.; Podgorski, Julia et al.

Part of Marine Drugs, 2026

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• DOI for Barettin Suppresses Pancreatic Ductal Adenocarcinoma Proliferation via Topoisomerase IIα Inhibition
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Brain interstitial fluid pharmacokinetics and therapeutic effect of a BBB penetrating amyloid beta antibody measured by microdialysis

Wik, Elin; Dahlén, Amelia; Julku, Ulrika; Xiong, Mengfei et al.

Part of Neurotherapeutics, 2026

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• DOI for Brain interstitial fluid pharmacokinetics and therapeutic effect of a BBB penetrating amyloid beta antibody measured by microdialysis
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Combining bacterial display and protein language models to engineer a CD69-binding affibody for molecular imaging of immune activation

Olsson, Hugo; Westerberg, Cornelia; Persson, Jonas; Löfstrand, Lina et al.

Part of Protein Engineering Design & Selection, 2026

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• DOI for Combining bacterial display and protein language models to engineer a CD69-binding affibody for molecular imaging of immune activation
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Comparative LCMS2 Analysis of Synthetic Ether- and Ester-Linked Polyacids Refines Structural Boundaries for Small Molecules in Dissolved Organic Matter

Flygare, Agnes D.; Moodie, Lindon W. K.; Hawkes, Jeffrey A.; Craig, Alexander J.

Part of Environmental Science and Technology, p. 13427-13436, 2026

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• DOI for Comparative LCMS2 Analysis of Synthetic Ether- and Ester-Linked Polyacids Refines Structural Boundaries for Small Molecules in Dissolved Organic Matter
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Differences in Plasma Exposure of Cannabidiol and Cannabidiolic Acid Following Oral Administration to Horses

Ekstrand, Carl; Michanek, Peter; Hernlund, Elin; Gehring, Ronette et al.

Part of Journal of Veterinary Pharmacology and Therapeutics, p. 22-32, 2026

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• DOI for Differences in Plasma Exposure of Cannabidiol and Cannabidiolic Acid Following Oral Administration to Horses
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Diffusion of Affibody molecules in extracellular matrix mimetic hydrogels and the effect of albumin binding

Parlow, Julia; Sandegren, Anna; Güler, Rezan; Karlberg, Ida et al.

Part of International Journal of Biological Macromolecules, 2026

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• DOI for Diffusion of Affibody molecules in extracellular matrix mimetic hydrogels and the effect of albumin binding
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Efficient ⁶⁸Ga Labeling of a B7-H3-Targeting Affibody Molecule via Acyclic Tris(hydroxypyridinone) Chelator: Effects on Biodistribution in a Preclinical Model

Tolmachev, Vladimir; Herlina, Amelinda Janice; Papalanis, Eleftherios; Bezverkhniaia, Ekaterina A. et al.

Part of International Journal of Molecular Sciences, 2026

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• DOI for Efficient ⁶⁸Ga Labeling of a B7-H3-Targeting Affibody Molecule via Acyclic Tris(hydroxypyridinone) Chelator: Effects on Biodistribution in a Preclinical Model
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Electrochemical Cascade N-Acylation and C-H Halogenation of Azaindoles

Ponra, Sudipta; Peter, Zoé; Sheikh, Mohammad Waris; Eriksson, Lars et al.

Part of ChemElectroChem, 2026

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• DOI for Electrochemical Cascade N-Acylation and C-H Halogenation of Azaindoles
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Engineering a conditionally active cetuximab prodrug via affibody-based paratope masking

Mestre Borras, Anna; Mehari, Hanna; Bitzios, Athanasios; Zelepukin, Ivan et al.

Part of Journal of Biological Engineering, 2026

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• DOI for Engineering a conditionally active cetuximab prodrug via affibody-based paratope masking
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Enhancing depression management in older cancer patients: the pharmacist's role

Jadhari, Rojita; Pathak, Nabin; Dhungana, Shreya; Acharya, Ajaya et al.

Part of European journal of hospital pharmacy. Science and practice, p. 197-198, 2026

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• DOI for Enhancing depression management in older cancer patients: the pharmacist's role

Exploring the theranostic potential of two metabolically stable GRPR-targeting peptides labelled with Ga-68 for PET imaging

Obeid, Karim; Bezverkhniaia, Ekaterina; Tolmachev, Vladimir M.; Orlova, Anna et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2026

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• DOI for Exploring the theranostic potential of two metabolically stable GRPR-targeting peptides labelled with Ga-68 for PET imaging
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Extracellular vesicle secretome from mesenchymal stromal cells prevents post-ischemic heart failure by targeting cardiac fibrosis

Grinnemo, Karl-Henrik; Braesch-Andersen, Ken; Wedin, Johan; Velica, Anna et al.

Part of Cell Stem Cell, p. 1324-1338, 2026

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• DOI for Extracellular vesicle secretome from mesenchymal stromal cells prevents post-ischemic heart failure by targeting cardiac fibrosis
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From virtual screening to selective angiotensin II type 2 receptor ligands: discovery of a novel scaffold

Patel, Jayendra Z.; Sandberg, Lars; Wannberg, Johan; Söderström, Marcus et al.

Part of Results in Chemistry, 2026

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• DOI for From virtual screening to selective angiotensin II type 2 receptor ligands: discovery of a novel scaffold
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Heterocyclic scaffold-fused dimethoxy-dibenzocyclooctynes for photoactivatable click chemistry

Larsson, N. Alfred; Jo, Taegeun; Bremberg, Ulf; Crespi, Stefano et al.

Part of Organic and biomolecular chemistry, p. 120-126, 2026

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• DOI for Heterocyclic scaffold-fused dimethoxy-dibenzocyclooctynes for photoactivatable click chemistry
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Identification of ZFTA as a Novel KLHL20 Substrate and Mechanistic Insights Into Fuzzy Binding of Disordered Peptides via Biosensor Analysis and Computational Modelling

Myers, Nadine; Whittaker, Joanna; Cadot, Marie Elodie Helene; Varga, Julia K. et al.

Part of ChemBioChem, 2026

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• DOI for Identification of ZFTA as a Novel KLHL20 Substrate and Mechanistic Insights Into Fuzzy Binding of Disordered Peptides via Biosensor Analysis and Computational Modelling
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Improvement of Peak Integration in Capillary Electrophoresis: Reference Data Set No. 1

Krompholz, Marlon; Blanc, Timothy; Lu, Huixin; Christensen, Patricia et al.

Part of Electrophoresis, p. 276-294, 2026

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• DOI for Improvement of Peak Integration in Capillary Electrophoresis: Reference Data Set No. 1
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In vivo imaging of the innate immune system in the pancreas in new-onset and long-standing type 1 diabetes

Anvari, Ebrahim; Zhang, Hongchao; Hill, Henrik; Guarienti Missima, Nathalia et al.

Part of Diabetes, obesity and metabolism, p. 4876-4883, 2026

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• DOI for In vivo imaging of the innate immune system in the pancreas in new-onset and long-standing type 1 diabetes
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Increased affinity by dimerization of radiolabeled Affibody molecule ATH001 targeting PDGFRβ

Abouzayed, Ayman; Olsson, Hugo; Papadopoulos, Natalia; Mitran, Bogdan et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2026

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• DOI for Increased affinity by dimerization of radiolabeled Affibody molecule ATH001 targeting PDGFRβ
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Independent origins of spicules reconcile paleontological and molecular evidence of sponge evolutionary history

Rossi, Maria Eleonora; Keating, Joseph N.; Kenny, Nathan J.; Giacomelli, Mattia et al.

Part of Science Advances, 2026

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• DOI for Independent origins of spicules reconcile paleontological and molecular evidence of sponge evolutionary history
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Inhibition of PERK signaling suppresses tumor progression and blocks GP73-GRP78-dependent stromal activation in hepatocellular carcinoma

Khaled, Jaafar; Kopsida, Maria; Serafín, Tania Payo; Sennefelt Nyman, Sofi et al.

Part of Neoplasia, p. 101329-101329, 2026

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• DOI for Inhibition of PERK signaling suppresses tumor progression and blocks GP73-GRP78-dependent stromal activation in hepatocellular carcinoma

Late-stage defluorinative functionalization: synthesis of thio-amides and heterocycles from trifluoromethylarenes

Söderström, Marcus; Olaniran Håkansson, Esther; Odell, Luke R.

Part of Organic Chemistry Frontiers, p. 1275-1280, 2026

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• DOI for Late-stage defluorinative functionalization: synthesis of thio-amides and heterocycles from trifluoromethylarenes
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Low-dose testosterone administration and oestrogen synthase availability in the female brain: A pilot study

Dubol, Manon; Jonasson, My; Takahashi, Kayo; Wikström, Johan et al.

Part of Journal of neuroendocrinology, 2026

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• DOI for Low-dose testosterone administration and oestrogen synthase availability in the female brain: A pilot study
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New high affinity AT2 receptor ligands comprising a 2-methyl substituted phenylthiophene scaffold

Gising, Johan; Wannberg, Johan; Isaksson, Rebecka; Sallander, Jessica et al.

Part of Bioorganic & Medicinal Chemistry, 2026

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• DOI for New high affinity AT2 receptor ligands comprising a 2-methyl substituted phenylthiophene scaffold
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Novel approaches for PET imaging of endometriosis

Zhang, Hongchao; Eriksson, Olof; Olovsson, Matts; Wilson, Viola et al.

Part of Nuclear Medicine and Biology, 2026

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• DOI for Novel approaches for PET imaging of endometriosis
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One-Pot Amidation/C―H Halogenation by an Efficient Electrochemical Cascade

Ponra, Sudipta; Sitdikov, Ruzal; Aman, Hasil; Calis, Alyssio et al.

Part of Angewandte Chemie International Edition, 2026

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• DOI for One-Pot Amidation/C―H Halogenation by an Efficient Electrochemical Cascade
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Optimizing T cell responses of targeted peptide antigen delivery by modulating antigen processing through amino acid exchange

Laurén, Ida; Kostakis, Alexandros; Lord, Martin; Björklund, Elvira et al.

Part of International Journal of Biological Macromolecules, 2026

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• DOI for Optimizing T cell responses of targeted peptide antigen delivery by modulating antigen processing through amino acid exchange
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Positron Emission Tomography imaging of tumor necrosis factor in lung injury

Wegrzyniak, Olivia; Han, Huayi; Eriksson, Olof

Part of Upsala Journal of Medical Sciences, 2026

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• DOI for Positron Emission Tomography imaging of tumor necrosis factor in lung injury
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Preclinical Evaluation of a ¹⁷⁷Lu-Labeled Gastrin-Releasing Peptide Receptor Antagonist and Prostate Cancer Treatment with Monotherapy and in Combination with Everolimus

Kumar, Naveen; Bilinska, Adrianna; Menéndez, Elena; Läppchen, Tilman et al.

Part of ACS Pharmacology & Translational Science, p. 59-68, 2026

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• DOI for Preclinical Evaluation of a ¹⁷⁷Lu-Labeled Gastrin-Releasing Peptide Receptor Antagonist and Prostate Cancer Treatment with Monotherapy and in Combination with Everolimus
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Preclinical evaluation of an antibody-based companion diagnostic for CD44v6 expressing cancer

Oroujeni, Maryam; Selvaraju, Ram Kumar; Persson, Helena; Dahllund, Leif et al.

Part of Nuclear medicine communications, p. 401-410, 2026

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• DOI for Preclinical evaluation of an antibody-based companion diagnostic for CD44v6 expressing cancer
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Preclinical Validation of [¹⁷⁷Lu]Lu-AKIR001, a CD44v6-Targeted Radiotherapeutic Entering First-in-Human Trials

Mortensen, Anja C. L.; Mohajershojai, Tabassom; Gustafsson, Amanda; Berglund, Hanna et al.

Part of Journal of Nuclear Medicine, p. 269-275, 2026

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• DOI for Preclinical Validation of [¹⁷⁷Lu]Lu-AKIR001, a CD44v6-Targeted Radiotherapeutic Entering First-in-Human Trials
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Pretargeted 177Lu/225Ac combination therapy of colorectal cancer

Rinne, Sara S.; Salehi, Niloufar; Vaughn, Brett A.; Vargas, Daniela Burnes et al.

Part of Theranostics, p. 5898-5910, 2026

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• DOI for Pretargeted 177Lu/225Ac combination therapy of colorectal cancer
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Profiling of 5-hydroxymethylcytosine in blood reveals preferential enrichment at exon-intron junctions and predictive value for Parkinson's disease

Antczak, Philipp; Brandt, Peter; Radosavljevic, Lav; Svenningsson, Per et al.

Part of npj Parkinson's Disease, 2026

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• DOI for Profiling of 5-hydroxymethylcytosine in blood reveals preferential enrichment at exon-intron junctions and predictive value for Parkinson's disease
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Revealing the Morphology of Small Multilamellar Lipid Nanoparticles (SMLPs) made by In-Vial Homogenization

Akcesme, Sevda; Schmager, Stefanie; Al-Tikriti, Yassir; Gedda, Lars et al.

Part of European Journal of Pharmaceutical Sciences, 2026

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• DOI for Revealing the Morphology of Small Multilamellar Lipid Nanoparticles (SMLPs) made by In-Vial Homogenization
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Rules for Dibenzocyclooctadiene Conformational Dynamics

Robertson, Luke; Xu, Wen; Brieskorn, Louisa; Chaitoglou, Iro et al.

Part of Journal of Natural Products, p. 528-538, 2026

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• DOI for Rules for Dibenzocyclooctadiene Conformational Dynamics
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Self-assembly of a therapeutic peptide surfactant: A small-angle X-ray study

Brunzell, Ellen; Sigfridsson, Kalle; Bergström, Magnus

Part of Langmuir, p. 6471-6478, 2026

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• DOI for Self-assembly of a therapeutic peptide surfactant: A small-angle X-ray study
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Structural determination of self-assembled aggregates formed by a therapeutic cyclical peptide and an ionic surfactant in aqueous solution

Brunzell, Ellen; Kim Högström, Yumi; López Hernández, Marcos; Skov Pedersen, Jan et al.

Part of Journal of Colloid and Interface Science, 2026

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• DOI for Structural determination of self-assembled aggregates formed by a therapeutic cyclical peptide and an ionic surfactant in aqueous solution
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Systematic optimization of gel-free capillary zone electrophoresis for phosphodiester oligonucleotide separations at acidic pH

Haglöf, Jakob; Regnell, Julia; Sänger-van de Griend, Cari

Part of Analytica Chimica Acta, 2026

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• DOI for Systematic optimization of gel-free capillary zone electrophoresis for phosphodiester oligonucleotide separations at acidic pH
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The Use of Glycine-Containing Peptide-Based Chelators for Labeling with 99mTc Improves the Imaging Properties of EpCAM-Targeting Designed Ankyrin Repeat Ec1

Deyev, Sergey; Fominykh, Anastasia; Varvashenya, Ruslan; Yanovich, Gleb et al.

Part of Molecular Pharmaceutics, p. 2469-2480, 2026

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• DOI for The Use of Glycine-Containing Peptide-Based Chelators for Labeling with 99mTc Improves the Imaging Properties of EpCAM-Targeting Designed Ankyrin Repeat Ec1

Toward generalizable predictive models for DNA-encoded libraries

Poongavanam, Vasanthanathan; Turunen, S Pauliina; Sandberg, Kristian; Yngve, Ulrika et al.

Part of Drug Discovery Today, 2026

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• DOI for Toward generalizable predictive models for DNA-encoded libraries
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Tumour accumulation of anti-carcinoembryonic antigen affibody-albumin-binding domain fusion depends on domains' order

Papalanis, Eleftherios; Li, Ruonan; Oroujeni, Maryam; Zhang, Jie et al.

Part of International Journal of Biological Macromolecules, 2026

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• DOI for Tumour accumulation of anti-carcinoembryonic antigen affibody-albumin-binding domain fusion depends on domains' order
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A comprehensive mechanistic investigation of factors affecting intestinal absorption and bioavailability of two PROTACs in rats

Niessen, Janis; Arendt, Nathalie; Sjöblom, Markus; Dubbelboer, Ilse R. et al.

Part of European journal of pharmaceutics and biopharmaceutics, 2025

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• DOI for A comprehensive mechanistic investigation of factors affecting intestinal absorption and bioavailability of two PROTACs in rats
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A Diastereoselective Mizoroki-Heck Reaction for Synthesis of Spirooxindole-Based Nonnatural Amino Acids Using a Boc-Protected Amine Chiral Auxiliary

Lindman, Jens; Puthiyaparambath, Sharathna; Gising, Johan; Odell, Luke R. et al.

Part of Synlett, p. 2009-2013, 2025

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• DOI for A Diastereoselective Mizoroki-Heck Reaction for Synthesis of Spirooxindole-Based Nonnatural Amino Acids Using a Boc-Protected Amine Chiral Auxiliary
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A Multicomponent aza-Prins Strategy for the Diastereoselective Synthesis of Piperidine-Fused Dihydroquinazolinones

Dybeck, Lovisa; Baudoin, Morgane; Odell, Luke R.

Part of European Journal of Organic Chemistry, 2025

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• DOI for A Multicomponent aza-Prins Strategy for the Diastereoselective Synthesis of Piperidine-Fused Dihydroquinazolinones
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