Theranostics

Novel radionuclide imaging methods for molecular profiling of prostate cancer
Molecular imaging may improve treatment of prostate cancer by better staging, personalising management and evaluation of therapy response. Our approach to visualization of prostate cancer is radionuclide targeting of the prostate tumour markers.
Publications
Part of ACS Pharmacology & Translational Science, p. 3228-3240, 2024
- DOI for Affibody-Drug Conjugates Targeting the Human Epidermal Growth Factor Receptor-3 Demonstrate Therapeutic Efficacy in Mice Bearing Low Expressing Xenografts
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Boron Nanoparticle-Enhanced Proton Therapy: Molecular Mechanisms of Tumor Cell Sensitization
Part of Molecules, 2024
- DOI for Boron Nanoparticle-Enhanced Proton Therapy: Molecular Mechanisms of Tumor Cell Sensitization
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Part of Molecular Pharmaceutics, p. 1919-1932, 2024
Part of EJNMMI Radiopharmacy and Chemistry, 2024
- DOI for Comparison of approaches for increasing affinity of affibody molecules for imaging of B7-H3: dimerization and affinity maturation
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2024
Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 4038-4048, 2024
- DOI for Evaluation of a novel 177Lu-labelled therapeutic Affibody molecule with a deimmunized ABD domain and improved biodistribution profile
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Evaluation of ABD-Linked RM26 Conjugates for GRPR-Targeted Drug Delivery
Part of ACS Omega, p. 36122-36133, 2024
- DOI for Evaluation of ABD-Linked RM26 Conjugates for GRPR-Targeted Drug Delivery
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Part of Pharmaceutics, 2024
- DOI for GRPR-Antagonists Carrying DOTAGA-Chelator via Positively Charged Linkers: Perspectives for Prostate Cancer Theranostics
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Part of Journal of Controlled Release, p. 468-478, 2024
- DOI for Half-life extension via ABD-fusion leads to higher tumor uptake of an affibody-drug conjugate compared to PAS- and XTENylation.
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Part of International Journal of Molecular Sciences, 2024
- DOI for Influence of Molecular Design on the Tumor Targeting and Biodistribution of PSMA-Binding Tracers Labeled with Technetium-99m
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Part of Advanced Science, 2024
- DOI for Laser-Synthesized Germanium Nanoparticles as Biodegradable Material for Near-Infrared Photoacoustic Imaging and Cancer Phototherapy
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Part of Nanoscale, p. 17893-17907, 2024
- DOI for Laser-synthesized plasmonic HfN-based nanoparticles as a novel multifunctional agent for photothermal therapy
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Modification of contact lenses via metal-organic frameworks for glaucoma treatment
Part of Aggregate, 2024
- DOI for Modification of contact lenses via metal-organic frameworks for glaucoma treatment
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MPS blockade with liposomes controls pharmacokinetics of nanoparticles in a size-dependent manner
Part of Biomedical Materials, 2024
- DOI for MPS blockade with liposomes controls pharmacokinetics of nanoparticles in a size-dependent manner
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Part of Cancers, 2024
- DOI for Phase I Clinical Evaluation of Designed Ankyrin Repeat Protein [99mTc]Tc(CO)3-(HE)3-Ec1 for Visualization of EpCAM-Expressing Lung Cancer
- Download full text (pdf) of Phase I Clinical Evaluation of Designed Ankyrin Repeat Protein [99mTc]Tc(CO)3-(HE)3-Ec1 for Visualization of EpCAM-Expressing Lung Cancer
Preclinical Evaluation of HER2-Targeting DARPin G3: Impact of Albumin-Binding Domain (ABD) Fusion
Part of International Journal of Molecular Sciences, 2024
- DOI for Preclinical Evaluation of HER2-Targeting DARPin G3: Impact of Albumin-Binding Domain (ABD) Fusion
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Part of EJNMMI Radiopharmacy and Chemistry, 2024
- DOI for Preclinical evaluation of new GRPR-antagonists with improved metabolic stability for radiotheranostic use in oncology
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Rediscovery of mononuclear phagocyte system blockade for nanoparticle drug delivery
Part of Perspectives, 2024
- DOI for Rediscovery of mononuclear phagocyte system blockade for nanoparticle drug delivery
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Part of ACS Pharmacology & Translational Science, p. 1595-1611, 2024
- DOI for Shorter Peptide Nucleic Acid Probes Improve Affibody-Mediated Peptide Nucleic Acid-Based Pretargeting
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Part of ACS Pharmacology & Translational Science, p. 1457-1473, 2024
Part of ACS Omega, p. 18608-18616, 2024
- DOI for Two Novel [68Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar11]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer
- Download full text (pdf) of Two Novel [68Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar11]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer
Part of Frontiers in Oncology, 2023
- DOI for 177Lu-labeled PSMA targeting therapeutic with optimized linker for treatment of disseminated prostate cancer; evaluation of biodistribution and dosimetry
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Part of American Journal of Nuclear Medicine and Molecular Imaging, p. 107-+, 2023
Comparison of HER2-targeted affibody conjugates loaded with auristatin-and maytansine-derived drugs
Part of Journal of Controlled Release, p. 515-527, 2023
Part of Journal of Controlled Release, p. 185-195, 2023
Development of a PNA-drug conjugate for pretargeted delivery of cytotoxic drugs
2023
Part of International Journal of Molecular Sciences, 2023
- DOI for Feasibility of Co-Targeting HER3 and EpCAM Using Seribantumab and DARPin-Toxin Fusion in a Pancreatic Cancer Xenograft Model
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Part of Cancers, 2023
- DOI for Phase I Trial of [Tc-99m]Tc-maSSS-PEG(2)-RM26, a Bombesin Analogue Antagonistic to Gastrin-Releasing Peptide Receptors (GRPRs), for SPECT Imaging of GRPR Expression in Malignant Tumors
- Download full text (pdf) of Phase I Trial of [Tc-99m]Tc-maSSS-PEG(2)-RM26, a Bombesin Analogue Antagonistic to Gastrin-Releasing Peptide Receptors (GRPRs), for SPECT Imaging of GRPR Expression in Malignant Tumors
Part of Cancers, 2023
- DOI for Preclinical Characterisation of PSMA/GRPR-Targeting Heterodimer [Ga-68]Ga-BQ7812 for PET Diagnostic Imaging of Prostate Cancer: A Step towards Clinical Translation
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Part of International Journal of Molecular Sciences, 2023
- DOI for Preclinical Evaluation of a Novel High-Affinity Radioligand [99mTc]Tc-BQ0413 Targeting Prostate-Specific Membrane Antigen (PSMA)
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Preclinical evaluation of novel therapeutical GRPR-targeting antagonists labeled with 111In
2023
Part of Cancers, 2023
- DOI for Radionuclide Therapy of HER2-Expressing Xenografts Using [Lu-177]Lu-ABY-027 Affibody Molecule Alone and in Combination with Trastuzumab
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Part of International Journal of Molecular Sciences, 2023
- DOI for Synthesis, I-123-Radiolabeling Optimization, and Initial Preclinical Evaluation of Novel Urea-Based PSMA Inhibitors with a Tributylstannyl Prosthetic Group in Their Structures
- Download full text (pdf) of Synthesis, I-123-Radiolabeling Optimization, and Initial Preclinical Evaluation of Novel Urea-Based PSMA Inhibitors with a Tributylstannyl Prosthetic Group in Their Structures
Part of Diagnostics, 2023
- DOI for The GRPR Antagonist [99mTc]Tc-maSSS-PEG2-RM26 towards Phase I Clinical Trial: Kit Preparation, Characterization and Toxicity
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Part of Oncology Letters, 2023
- DOI for Visualization of epithelial cell adhesion molecule-expressing renal cell carcinoma xenografts using designed ankyrin repeat protein Ec1 labelled with Tc-99m and I-125
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Part of Pharmaceutics, 2022
- DOI for Biologic Evaluation of a Heterodimeric HER2-Albumin Targeted Affibody Molecule Produced by Chemo-Enzymatic Peptide Synthesis
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Design, Synthesis, and Evaluation of Linker-Optimised PSMA-Targeting Radioligands
Part of Pharmaceutics, 2022
- DOI for Design, Synthesis, and Evaluation of Linker-Optimised PSMA-Targeting Radioligands
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Part of International Journal of Molecular Sciences, 2022
- DOI for Direct In Vivo Comparison of 99mTc-Labeled Scaffold Proteins, DARPin G3 and ADAPT6, for Visualization of HER2 Expression and Monitoring of Early Response for Trastuzumab Therapy
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Part of Pharmaceutics, 2022
- DOI for Effect of Inter-Domain Linker Composition on Biodistribution of ABD-Fused Affibody-Drug Conjugates Targeting HER2
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Part of Pharmaceutics, 2022
- DOI for Experimental Therapy of HER2-Expressing Xenografts Using the Second-Generation HER2-Targeting Affibody Molecule 188Re-ZHER2:41071
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In vitro characterization of affibody molecules intended for therapy of EGFR-expressing cancer
2022
PET-CT imaging of pulmonary inflammation using [Ga-68]Ga-DOTA-TATE
Part of EJNMMI Research, 2022
- DOI for PET-CT imaging of pulmonary inflammation using [Ga-68]Ga-DOTA-TATE
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Part of Journal of Nuclear Medicine, p. 528-535, 2022
Part of Pharmaceutics, 2022
- DOI for Preclinical Evaluation of a New Format of Ga-68- and In-111-Labeled Affibody Molecule Z(IGF-1R:4551) for the Visualization of IGF-1R Expression in Malignant Tumors Using PET and SPECT
- Download full text (pdf) of Preclinical Evaluation of a New Format of Ga-68- and In-111-Labeled Affibody Molecule Z(IGF-1R:4551) for the Visualization of IGF-1R Expression in Malignant Tumors Using PET and SPECT
Part of Biomedicines, 2022
- DOI for Targeting Tumor Cells Overexpressing the Human Epidermal Growth Factor Receptor 3 with Potent Drug Conjugates Based on Affibody Molecules
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The Performance of FDA-Approved PET Imaging Agents in the Detection of Prostate Cancer
Part of Biomedicines, 2022
- DOI for The Performance of FDA-Approved PET Imaging Agents in the Detection of Prostate Cancer
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A method of drug delivery to tumors based on rapidly biodegradable drug-loaded containers
Part of APPLIED MATERIALS TODAY, 2021
Part of Pharmaceutics, 2021
- DOI for Affibody-Derived Drug Conjugates Targeting HER2: Effect of Drug Load on Cytotoxicity and Biodistribution
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Part of Pharmaceutics, 2021
- DOI for Comparative Preclinical Evaluation of HER2-Targeting ABD-Fused Affibody® Molecules 177Lu-ABY-271 and 177Lu-ABY-027: Impact of DOTA Position on ABD Domain
- Download full text (pdf) of Comparative Preclinical Evaluation of HER2-Targeting ABD-Fused Affibody® Molecules 177Lu-ABY-271 and 177Lu-ABY-027: Impact of DOTA Position on ABD Domain
Part of Cancers, 2021
- DOI for Drug Conjugates Based on a Monovalent Affibody Targeting Vector Can Efficiently Eradicate HER2 Positive Human Tumors in an Experimental Mouse Model
- Download full text (pdf) of Drug Conjugates Based on a Monovalent Affibody Targeting Vector Can Efficiently Eradicate HER2 Positive Human Tumors in an Experimental Mouse Model
- More publications
Theranostics
Molecular imaging of prostate cancer
Development of radioactive tracers for prostate cancer.

Molecular Imaging
Molecular imaging makes it possible to study biochemical mechanisms and response to treatments in living species.

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Selected publications
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Our recent publications
- Zhang, Jie; Rinne, Sara S.; Yin, Wen et al., 2024
- Popov, Anton L.; Kolmanovich, Danil D.; Chukavin, Nikita N. et al., 2024
- Larkina, Maria; Varvashenya, Ruslan; Yuldasheva, Feruza et al., 2024
Meet our alumni
Read more about alumni from the Theranostics group.
