A preclinical study on the influence of linkers in [⁶⁸Ga]Ga-NOTA-X-RM26 radiotracers for PET imaging of GRPR expression

Olaniran Håkansson, Esther; Zelepukin, Ivan V.; Obeid, Karim; Bitzios, Athanasios et al.

Part of EJNMMI Research, 2025

• DOI for A preclinical study on the influence of linkers in [⁶⁸Ga]Ga-NOTA-X-RM26 radiotracers for PET imaging of GRPR expression
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Designed Ankyrin Repeat Protein-Mediated Peptide Nucleic Acid-Based Pretargeting: A Proof-of-Principle Study

Oroujeni, Maryam; Westerlund, Kristina; Papalanis, Eleftherios; van Deventer, Alexander et al.

Part of Journal of Nuclear Medicine, p. 1105-1111, 2025

• DOI for Designed Ankyrin Repeat Protein-Mediated Peptide Nucleic Acid-Based Pretargeting: A Proof-of-Principle Study

Evaluation of maSSS/maSES-PEG2-RM26 for their potential therapeutic use after labeling with Re-188. Could their [^99mTc]Tc-labeled counterparts be used to estimate dosimetry?

Kanellopoulos, Panagiotis; Yu, Quanyi; Abouzayed, Abouzayed; Bezverkhniaia, Ekaterina et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2025

• DOI for Evaluation of maSSS/maSES-PEG2-RM26 for their potential therapeutic use after labeling with Re-188. Could their [^99mTc]Tc-labeled counterparts be used to estimate dosimetry?
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First-in-human experience with GRPR antagonist [⁶⁸Ga]Ga-NOTA-PEG₂-RM26 in prostate and breast cancer patients using PET/CT

Bjareback, Annie; Jonmarker, Olof; Tzortzakakis, Antonios; Jussing, Emma et al.

Part of EJNMMI Research, 2025

• DOI for First-in-human experience with GRPR antagonist [⁶⁸Ga]Ga-NOTA-PEG₂-RM26 in prostate and breast cancer patients using PET/CT
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Impact of Radiometal Chelates on In Vivo Visualization of Immune Checkpoint Protein Using Radiolabeled Affibody Molecules

Tolmachev, Vladimir M.; Papalanis, Eleftherios; Bezverkhniaia, Ekaterina A.; Rosly, Alia Hani et al.

Part of ACS Pharmacology & Translational Science, p. 706-717, 2025

• DOI for Impact of Radiometal Chelates on In Vivo Visualization of Immune Checkpoint Protein Using Radiolabeled Affibody Molecules
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Improving GRPR-targeting peptides for radiotheranostics application: insights from chelator modifications and α-methyl-L tryptophan substitution.

Obeid, Karim; Bezverkhniaia, Ekaterina; Tolmachev, Vladimir M.; Orlova, Anna et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2025

• DOI for Improving GRPR-targeting peptides for radiotheranostics application: insights from chelator modifications and α-methyl-L tryptophan substitution.
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Insulin-regulated aminopeptidase inhibitor C9 restores cellular activity in methadone-damaged primary cell cultures

Stam, Frida; Lind, Sara Florén; Nylander, Erik; Olaniran Håkansson, Esther et al.

Part of Neuroscience Letters, 2025

• DOI for Insulin-regulated aminopeptidase inhibitor C9 restores cellular activity in methadone-damaged primary cell cultures
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Linker modifications in radiolabeled RM26-based antagonists to gastrin-releasing peptide receptor (GRPR) improved tracers' pharmacokinetics

Bezverkhniaia, Ekaterina; Abouzayed, Ayman; Kanellopoulos, Panagiotis; Tolmachev, Vladimir M. et al.

Part of European Journal of Pharmaceutical Sciences, 2025

• DOI for Linker modifications in radiolabeled RM26-based antagonists to gastrin-releasing peptide receptor (GRPR) improved tracers' pharmacokinetics
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Phase I Clinical Study with the GRPR-Antagonist [^99mTc]Tc-DB8 for SPECT Imaging of Prostate Cancer: Does the Injected Peptide Mass Make a Difference?

Orlova, Anna; Rybina, Anastasia; Medvedeva, Anna; Zelchan, Roman et al.

Part of Pharmaceutics, 2025

• DOI for Phase I Clinical Study with the GRPR-Antagonist [^99mTc]Tc-DB8 for SPECT Imaging of Prostate Cancer: Does the Injected Peptide Mass Make a Difference?
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Reduction of negative charge in mercaptoacetyl-based chelators influences the biodistribution of prostate-specific membrane antigen-targeting pseudopeptides labeled with technetium-99m

Bezverkhniaia, Ekaterina; Kanellopoulos, Panagiotis; Rosenström, Ulrika; Tolmachev, Vladimir M. et al.

Part of ACS Pharmacology & Translational Science, p. 3600-3612, 2025

• DOI for Reduction of negative charge in mercaptoacetyl-based chelators influences the biodistribution of prostate-specific membrane antigen-targeting pseudopeptides labeled with technetium-99m
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RM2 and DB15 analogues bearing [¹⁷⁷Lu]Lu-DOTAGA via different linkers, as radiotherapeutics: a head-to-head comparative study

Kanellopoulos, Panagiotis; Bitzios, Athanasios; Zelepukin, Ivan; Bezverkhniaia, Ekaterina et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2025

• DOI for RM2 and DB15 analogues bearing [¹⁷⁷Lu]Lu-DOTAGA via different linkers, as radiotherapeutics: a head-to-head comparative study
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Single-Photon Emission Computer Tomography Imaging of Prostate-Specific Membrane Antigen (PSMA) Expression in Prostate Cancer Patients Using a Novel Peptide-Based Probe [^99mTc]Tc-BQ0413 with Picomolar Affinity to PSMA: A Phase I/II Clinical Study

Medvedeva, Anna; Chernov, Vladimir; Larkina, Maria; Rybina, Anastasiya et al.

Part of ACS Pharmacology & Translational Science, p. 736-747, 2025

• DOI for Single-Photon Emission Computer Tomography Imaging of Prostate-Specific Membrane Antigen (PSMA) Expression in Prostate Cancer Patients Using a Novel Peptide-Based Probe [^99mTc]Tc-BQ0413 with Picomolar Affinity to PSMA: A Phase I/II Clinical Study
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Smart Engineering of Complex Structural Tissue Constructs in 3D Bioprinting Via Photoinduced Nanoparticle-Mediated Spheroid Elimination

Iliasov, Artem; Baranova, Arina; Tikhonowski, Gleb; Koudan, Elizaveta et al.

Part of Biomedical Materials & Devices, 2025

• DOI for Smart Engineering of Complex Structural Tissue Constructs in 3D Bioprinting Via Photoinduced Nanoparticle-Mediated Spheroid Elimination

Synthesis and preclinical evaluation of gastrin releasing peptide receptor antagonist [¹⁸F]MeTz-PEG2-RM26 for positron emission tomography

Kanellopoulos, Panagiotis; Lundmark, Fanny; Abouzayed, Ayman; Balestri, Lorenzo Jacopo Ilic et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2025

• DOI for Synthesis and preclinical evaluation of gastrin releasing peptide receptor antagonist [¹⁸F]MeTz-PEG2-RM26 for positron emission tomography
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The effects of insulin-regulated aminopeptidase inhibition with HA08 on recognition memory acquisition and spatial working memory under reversed circadian conditions in male rats

Stam, Frida; Lind, Sara Florén; Zelleroth, Sofia; Badrd'din, Sally et al.

Part of IBRO Neuroscience Reports, p. 854-861, 2025

• DOI for The effects of insulin-regulated aminopeptidase inhibition with HA08 on recognition memory acquisition and spatial working memory under reversed circadian conditions in male rats
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The Impact of the Injected Mass of the Gastrin-Releasing Peptide Receptor Antagonist on Uptake in Breast Cancer: Lessons from a Phase I Trial of [99mTc]Tc-DB8

Bragina, Olga; Chernov, Vladimir; Larkina, Mariia; Varvashenya, Ruslan et al.

Part of Pharmaceutics, 2025

• DOI for The Impact of the Injected Mass of the Gastrin-Releasing Peptide Receptor Antagonist on Uptake in Breast Cancer: Lessons from a Phase I Trial of [99mTc]Tc-DB8
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Affibody-Drug Conjugates Targeting the Human Epidermal Growth Factor Receptor-3 Demonstrate Therapeutic Efficacy in Mice Bearing Low Expressing Xenografts

Zhang, Jie; Rinne, Sara S.; Yin, Wen; Leitao, Charles Dahlsson et al.

Part of ACS Pharmacology & Translational Science, p. 3228-3240, 2024

• DOI for Affibody-Drug Conjugates Targeting the Human Epidermal Growth Factor Receptor-3 Demonstrate Therapeutic Efficacy in Mice Bearing Low Expressing Xenografts
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Boron Nanoparticle-Enhanced Proton Therapy: Molecular Mechanisms of Tumor Cell Sensitization

Popov, Anton L.; Kolmanovich, Danil D.; Chukavin, Nikita N.; Zelepukin, Ivan V. et al.

Part of Molecules, 2024

• DOI for Boron Nanoparticle-Enhanced Proton Therapy: Molecular Mechanisms of Tumor Cell Sensitization
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Comparative Preclinical Evaluation of HYNIC-Modified Designed Ankyrin Repeat Proteins G3 for the ^99mTc-Based Imaging of HER2-Expressing Malignant Tumors

Larkina, Maria; Varvashenya, Ruslan; Yuldasheva, Feruza; Plotnikov, Evgenii et al.

Part of Molecular Pharmaceutics, p. 1919-1932, 2024

• DOI for Comparative Preclinical Evaluation of HYNIC-Modified Designed Ankyrin Repeat Proteins G3 for the ^99mTc-Based Imaging of HER2-Expressing Malignant Tumors

Comparison of approaches for increasing affinity of affibody molecules for imaging of B7-H3: dimerization and affinity maturation

Oroujeni, Maryam; Carlqvist, Matilda; Ryer, Eva; Orlova, Anna et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2024

• DOI for Comparison of approaches for increasing affinity of affibody molecules for imaging of B7-H3: dimerization and affinity maturation
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Den senaste utvecklingen av radionuklidbaserade teranostiska medel inriktad mot PSMA vid prostatacancer

Kahoori, Sahar

2024

Evaluation of a novel ¹⁷⁷Lu-labelled therapeutic Affibody molecule with a deimmunized ABD domain and improved biodistribution profile

Liu, Yongsheng; Oroujeni, Maryam; Liao, Yunqi; Vorobyeva, Anzhelika et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 4038-4048, 2024

• DOI for Evaluation of a novel ¹⁷⁷Lu-labelled therapeutic Affibody molecule with a deimmunized ABD domain and improved biodistribution profile
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Evaluation of ABD-Linked RM26 Conjugates for GRPR-Targeted Drug Delivery

Nagy, Abel; Abouzayed, Ayman; Kanellopoulos, Panagiotis; Landmark, Fredrika et al.

Part of ACS Omega, p. 36122-36133, 2024

• DOI for Evaluation of ABD-Linked RM26 Conjugates for GRPR-Targeted Drug Delivery
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GRPR-Antagonists Carrying DOTAGA-Chelator via Positively Charged Linkers: Perspectives for Prostate Cancer Theranostics

Obeid, Karim; Kanellopoulos, Panagiotis; Abouzayed, Ayman; Mattsson, Adam et al.

Part of Pharmaceutics, 2024

• DOI for GRPR-Antagonists Carrying DOTAGA-Chelator via Positively Charged Linkers: Perspectives for Prostate Cancer Theranostics
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Half-life extension via ABD-fusion leads to higher tumor uptake of an affibody-drug conjugate compared to PAS- and XTENylation.

Zhang, Jie; Bodenko, Vitalina; Larkina, Maria; Bezverkhniaia, Ekaterina et al.

Part of Journal of Controlled Release, p. 468-478, 2024

• DOI for Half-life extension via ABD-fusion leads to higher tumor uptake of an affibody-drug conjugate compared to PAS- and XTENylation.
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Influence of Molecular Design on the Tumor Targeting and Biodistribution of PSMA-Binding Tracers Labeled with Technetium-99m

Bezverkhniaia, Ekaterina; Kanellopoulos, Panagiotis; Rosenström, Ulrika; Tolmachev, Vladimir et al.

Part of International Journal of Molecular Sciences, 2024

• DOI for Influence of Molecular Design on the Tumor Targeting and Biodistribution of PSMA-Binding Tracers Labeled with Technetium-99m
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Laser-Synthesized Germanium Nanoparticles as Biodegradable Material for Near-Infrared Photoacoustic Imaging and Cancer Phototherapy

Belyaev, Iaroslav B.; Zelepukin, Ivan V.; Kotelnikova, Polina A.; Tikhonowski, Gleb V. et al.

Part of Advanced Science, 2024

• DOI for Laser-Synthesized Germanium Nanoparticles as Biodegradable Material for Near-Infrared Photoacoustic Imaging and Cancer Phototherapy
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Laser-synthesized plasmonic HfN-based nanoparticles as a novel multifunctional agent for photothermal therapy

Pastukhov, A. I.; Savinov, M. S.; Zelepukin, Ivan V.; Babkova, J. S. et al.

Part of Nanoscale, p. 17893-17907, 2024

• DOI for Laser-synthesized plasmonic HfN-based nanoparticles as a novel multifunctional agent for photothermal therapy
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Modification of contact lenses via metal-organic frameworks for glaucoma treatment

Yaremenko, Alexey V.; Melikov, Roman O.; Pechnikova, Nadezhda A.; Belyaev, Iaroslav B. et al.

Part of Aggregate, 2024

• DOI for Modification of contact lenses via metal-organic frameworks for glaucoma treatment
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MPS blockade with liposomes controls pharmacokinetics of nanoparticles in a size-dependent manner

Belyaev, Iaroslav B.; Mirkasymov, Aziz B.; Rodionov, Vladislav, I; Babkova, Julia S. et al.

Part of Biomedical Materials, 2024

• DOI for MPS blockade with liposomes controls pharmacokinetics of nanoparticles in a size-dependent manner
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Phase I Clinical Evaluation of Designed Ankyrin Repeat Protein [^99mTc]Tc(CO)₃-(HE)₃-Ec1 for Visualization of EpCAM-Expressing Lung Cancer

Zelchan, Roman; Chernov, Vladimir; Medvedeva, Anna; Rybina, Anastasia et al.

Part of Cancers, 2024

• DOI for Phase I Clinical Evaluation of Designed Ankyrin Repeat Protein [^99mTc]Tc(CO)₃-(HE)₃-Ec1 for Visualization of EpCAM-Expressing Lung Cancer
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Preclinical Evaluation of HER2-Targeting DARPin G3: Impact of Albumin-Binding Domain (ABD) Fusion

Deyev, Sergey M.; Oroujeni, Maryam; Garousi, Javad; Graeslund, Torbjoern et al.

Part of International Journal of Molecular Sciences, 2024

• DOI for Preclinical Evaluation of HER2-Targeting DARPin G3: Impact of Albumin-Binding Domain (ABD) Fusion
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Preclinical evaluation of new GRPR-antagonists with improved metabolic stability for radiotheranostic use in oncology

Kanellopoulos, Panagiotis; Mattsson, Adam; Abouzayed, Ayman; Obeid, Karim et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2024

• DOI for Preclinical evaluation of new GRPR-antagonists with improved metabolic stability for radiotheranostic use in oncology
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Rediscovery of mononuclear phagocyte system blockade for nanoparticle drug delivery

Zelepukin, Ivan V.; Shevchenko, Konstantin G.; Deyev, Sergey M.

Part of Perspectives, 2024

• DOI for Rediscovery of mononuclear phagocyte system blockade for nanoparticle drug delivery
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Shorter Peptide Nucleic Acid Probes Improve Affibody-Mediated Peptide Nucleic Acid-Based Pretargeting

Westerlund, Kristina; Oroujeni, Maryam; Gestin, Maxime; Clinton, Jacob et al.

Part of ACS Pharmacology & Translational Science, p. 1595-1611, 2024

• DOI for Shorter Peptide Nucleic Acid Probes Improve Affibody-Mediated Peptide Nucleic Acid-Based Pretargeting
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Synthesis and Preclinical Evaluation of Urea-Based Prostate-Specific Membrane Antigen-Targeted Conjugates Labeled with ¹⁷⁷Lu

Machulkin, Aleksei E.; Petrov, Stanislav A.; Bodenko, Vitalina; Larkina, Mariia S. et al.

Part of ACS Pharmacology & Translational Science, p. 1457-1473, 2024

• DOI for Synthesis and Preclinical Evaluation of Urea-Based Prostate-Specific Membrane Antigen-Targeted Conjugates Labeled with ¹⁷⁷Lu

Two Novel [⁶⁸Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar¹¹]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer

Kanellopoulos, Panagiotis; Bezverkhniaia, Ekaterina; Abouzayed, Ayman; Rosenström, Ulrika et al.

Part of ACS Omega, p. 18608-18616, 2024

• DOI for Two Novel [⁶⁸Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar¹¹]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer
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¹⁷⁷Lu-labeled PSMA targeting therapeutic with optimized linker for treatment of disseminated prostate cancer; evaluation of biodistribution and dosimetry

Abouzayed, Ayman; Seitova, Kamila; Lundmark, Fanny; Bodenko, Vitalina et al.

Part of Frontiers in Oncology, 2023

• DOI for ¹⁷⁷Lu-labeled PSMA targeting therapeutic with optimized linker for treatment of disseminated prostate cancer; evaluation of biodistribution and dosimetry
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Co-injection of anti-HER2 antibody Trastuzumab does not increase efficacy of [Lu-177]Lu-PSMA-617 therapy in an animal model of prostate cancer

Abouzayed, Ayman; Zedan, Wahed; Altai, Mohamed; Strand, Joanna et al.

Part of American Journal of Nuclear Medicine and Molecular Imaging, p. 107-+, 2023

Comparison of HER2-targeted affibody conjugates loaded with auristatin-and maytansine-derived drugs

Yin, Wen; Xu, Tianqi; Ding, Haozhong; Zhang, Jie et al.

Part of Journal of Controlled Release, p. 515-527, 2023

• DOI for Comparison of HER2-targeted affibody conjugates loaded with auristatin-and maytansine-derived drugs

Conditionally activated affibody-based prodrug targeting EGFR demonstrates improved tumour selectivity

Leitao, Charles Dahlsson; Borras, Anna Mestre; Xu, Tianqi; Oroujeni, Maryam et al.

Part of Journal of Controlled Release, p. 185-195, 2023

• DOI for Conditionally activated affibody-based prodrug targeting EGFR demonstrates improved tumour selectivity

Development of a PNA-drug conjugate for pretargeted delivery of cytotoxic drugs

Haraldsson, Astrid

2023

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Feasibility of Co-Targeting HER3 and EpCAM Using Seribantumab and DARPin-Toxin Fusion in a Pancreatic Cancer Xenograft Model

Xu, Tianqi; Schulga, Alexey; Konovalova, Elena; Rinne, Sara S. et al.

Part of International Journal of Molecular Sciences, 2023

• DOI for Feasibility of Co-Targeting HER3 and EpCAM Using Seribantumab and DARPin-Toxin Fusion in a Pancreatic Cancer Xenograft Model
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Phase I Trial of [Tc-99m]Tc-maSSS-PEG(2)-RM26, a Bombesin Analogue Antagonistic to Gastrin-Releasing Peptide Receptors (GRPRs), for SPECT Imaging of GRPR Expression in Malignant Tumors

Chernov, Vladimir; Rybina, Anastasiya; Zelchan, Roman; Medvedeva, Anna et al.

Part of Cancers, 2023

• DOI for Phase I Trial of [Tc-99m]Tc-maSSS-PEG(2)-RM26, a Bombesin Analogue Antagonistic to Gastrin-Releasing Peptide Receptors (GRPRs), for SPECT Imaging of GRPR Expression in Malignant Tumors
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Preclinical Characterisation of PSMA/GRPR-Targeting Heterodimer [Ga-68]Ga-BQ7812 for PET Diagnostic Imaging of Prostate Cancer: A Step towards Clinical Translation

Lundmark, Fanny; Abouzayed, Ayman; Rinne, Sara S.; Timofeev, Vasiliy et al.

Part of Cancers, 2023

• DOI for Preclinical Characterisation of PSMA/GRPR-Targeting Heterodimer [Ga-68]Ga-BQ7812 for PET Diagnostic Imaging of Prostate Cancer: A Step towards Clinical Translation
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Preclinical Evaluation of a Novel High-Affinity Radioligand [^99mTc]Tc-BQ0413 Targeting Prostate-Specific Membrane Antigen (PSMA)

Bezverkhniaia, Ekaterina; Kanellopoulos, Panagiotis; Abouzayed, Ayman; Larkina, Mariia et al.

Part of International Journal of Molecular Sciences, 2023

• DOI for Preclinical Evaluation of a Novel High-Affinity Radioligand [^99mTc]Tc-BQ0413 Targeting Prostate-Specific Membrane Antigen (PSMA)
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Preclinical evaluation of novel therapeutical GRPR-targeting antagonists labeled with ¹¹¹In

Mattsson, Adam

2023

Radionuclide Therapy of HER2-Expressing Xenografts Using [Lu-177]Lu-ABY-027 Affibody Molecule Alone and in Combination with Trastuzumab

Liu, Yongsheng; Xu, Tianqi; Vorobyeva, Anzhelika; Loftenius, Annika et al.

Part of Cancers, 2023

• DOI for Radionuclide Therapy of HER2-Expressing Xenografts Using [Lu-177]Lu-ABY-027 Affibody Molecule Alone and in Combination with Trastuzumab
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Synthesis, I-123-Radiolabeling Optimization, and Initial Preclinical Evaluation of Novel Urea-Based PSMA Inhibitors with a Tributylstannyl Prosthetic Group in Their Structures

Hasnowo, Lutfi A.; Larkina, Maria S.; Plotnikov, Evgenii; Bodenko, Vitalina et al.

Part of International Journal of Molecular Sciences, 2023

• DOI for Synthesis, I-123-Radiolabeling Optimization, and Initial Preclinical Evaluation of Novel Urea-Based PSMA Inhibitors with a Tributylstannyl Prosthetic Group in Their Structures
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The GRPR Antagonist [^99mTc]Tc-maSSS-PEG₂-RM26 towards Phase I Clinical Trial: Kit Preparation, Characterization and Toxicity

Abouzayed, Ayman; Borin, Jesper; Lundmark, Fanny; Rybina, Anastasiya et al.

Part of Diagnostics, 2023

• DOI for The GRPR Antagonist [^99mTc]Tc-maSSS-PEG₂-RM26 towards Phase I Clinical Trial: Kit Preparation, Characterization and Toxicity
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