Pharmaceutical cellbiology

Description

The research area consists of four PI:s that work on different aspects of cell biology; development of novel molecular biology tools (professor Ola Söderberg), investigation of the role of vitamin D and other steroids in cell function (senior lecturer Maria Norlin), analysis of cell signaling in tumors (professor Johan Lennartsson) and the oncoprotein Myc (senior professor Lars-Gunnar Larsson) The research environment joins researchers with different expertize around a common goal: to understand the cell biology in health and disease, and to employ this knowledge for improved diagnostics and therapy. The unit works in close collaboration around four main projects: Method development, Vitamin D, Cell signaling and Myc.

Cell signaling

Method development

The MYC Oncoprotein

Vitamin D

Giovanna Zinzalla's Research: Interplay between bHLHZip transcription factors and SWI/SNF complexes

Utvalda publikationer

Raykova D, Kermpatsou D, Malmqvist T, Harrison PJ, Rubin Sander M, Stiller C, Heldin J, Leino M, Ricardo S, Klemm A, David L, Spjuth O, Vemuri K, Dimberg A, Sundqvist A, Norlin M, Klaesson A, Kampf C & Söderberg O
“A method for Boolean Analysis of Protein Interactions at a Molecular Level”
Nature Communications, 2022, 13(1):4755

Wåhlén E, Olsson F, Söderberg O, Lennartsson J & Heldin J
”Differential impact on lipid raft depletion on platelet-derived growth factor (PDGF)-induced ERK1/2 MAP-kinase, SRC and AKT signaling”
Cell Signal, 2022, 96:110356

Olsson F, Sarri N, Papadopoulos N, Lennartsson J & Norlin M.
“Effects of 1a,25-dihydroxyvitamin D and tacalcitol on cell signaling and anchorage-independent growth in T98G and U251 glioblastoma cells”
Biochem Biophys Rep, 2022, Jul 31;31:101313

Tsioumpekou M, Cunha SI, Ma H, Åhgren A, Cedervall J, Olsson AK, Heldin CH & Lennartsson J
“Specific targeting of PDGFRb in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression”
Theranostics, 2020, 10(3):1122-1135

Yin R, Eger G, Sarri N, Rorsman C, Heldin CH & Lennartsson J
“Dual specificity phosphatase (DUSP)-4 is induced by platelet-derived growth factor-BB in an Erk1/2, STAT3- and p53-dependent manner”
Biochem Biophys Res Commun, 2019, 519(3):469-474

Leino M, Heldin J, Rubin Sander M, Kermpatsou D, Raykova D, Koos B & Söderberg O “Optimization of proximity-dependent initiation of hybridization chain reaction for improved performance”
Mol Syst Des Eng, 2019, 4: 1058-65

Heldin J, Sander M, Leino M, Thomsson S, Lennartsson J & Söderberg O
“Dynamin inhibitors impair platelet-derived growth factor b-receptor dimerization and signaling”
Exp Cell Res, 2019, 380(1): 69-79

Zainy A, Almokhtar M, Wikvall K, Ljunggren Ö, Ubhayasekera K, Bergquist J, Kibar P & Norlin M “Effects of glucocorticoids on vitamin D3- metabolizing 24-hydroxylase (CYP24A1) in Saos-2 cells and primary human osteoblasts”
Mol. Cell. Endocrinol, 2019, 496, 110525

Emanuelsson I, Almokhtar M, Wikvall K, Grönbladh A, Nylander E, Svensson AL, Fex Svenningsen Å & Norlin M
“Expression and regulation of CYP17A1 and 3β-hydroxysteroid dehydrogenase in cells of the nervous system: Potential effects of vitamin D on brain steroidogenesis.”
Neurochem Int, 2018, 113, 46-55

Klaesson A, Grannas K, Ebai T, Heldin J, Zieba A, Koos B, Leino M, Raykova D, Oelrich J, Arngården L, Söderberg O & Landegren U
“Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes”
Sci Rep, 2018, 8(1):5400

Doktorsavhandlingar

2009
Hanna Pettersson “Steroid-Metabolizing Cytochrome P450 (CYP) Enzymes in the Maintenance of Cholesterol and Sex Hormone Levels”
https://uu.diva-portal.org/smash/get/diva2:211308/FULLTEXT01.pdf

2010
Karl-Johan Leuchowius ” High Content Analysis of Proteins and Protein Interactions by Proximity Ligation”
http://uu.diva-portal.org/smash/get/diva2:301950/FULLTEXT01.pdf

Piotr Wardega,”Regulation of PDGFRb signaling”,
http://uu.diva-portal.org/smash/get/diva2:311700/FULLTEXT01.pdf

2011
Irene Weibrecht “Visualizing Interacting Biomolecules In Situ”
http://uu.diva-portal.org/smash/get/diva2:410507/FULLTEXT01.pdf

Johan Lundqvist “Enzymatic Regulation of Steroidogenesis and Nuclear Receptor Activation: Special Focus on Vitamin D and Sex Hormones”
https://uu.diva-portal.org/smash/get/diva2:413207/FULLTEXT01.pdf

2012
Agata Zieba “Application of Proximity Ligation Assay for Multidirectional Studies on Transforming Growth Factor Receptor-β Pathway”
http://uu.diva-portal.org/smash/get/diva2:513327/FULLTEXT01.pdf

2014
Carl-Magnus Clausson “Making Visible the Proximity Between Proteins”
http://uu.diva-portal.org/smash/get/diva2:695615/FULLTEXT01.pdf

2015
Karin Grannas “Improvements and Applications of in situ Proximity Ligation Assays” http://uu.diva-portal.org/smash/get/diva2:801280/FULLTEXT01.pdf

Haisha Ma, “Regulation of Platelet-Derived Growth Factor Receptor Signaling and its Targeting in Cancer Therapy”,
http://uu.diva-portal.org/smash/get/diva2:799179/FULLTEXT01.pdf

2016
Linda Arngården “Analysis of signaling pathway activity in single cells using the in situ Proximity Ligation Assay”
http://uu.diva-portal.org/smash/get/diva2:915351/FULLTEXT01.pdf

Glenda Eger, “Regulation and Function of MAP Kinases in PDGF Signaling”
http://uu.diva-portal.org/smash/get/diva2:953232/FULLTEXT01.pdf

2017
Ida Emanuelsson “Steroids and steroid-metabolizing enzymes in the nervous system: Special focus on cell survival and sex hormone synthesis”
https://uu.diva-portal.org/smash/get/diva2:1137536/FULLTEXT01.pdf

2018
Axel Klaesson “Development of DNA-based methods for analysis of protein interactions” http://uu.diva-portal.org/smash/get/diva2:1177746/FULLTEXT01.pdf

Mokhtar Almokhtar “Expression and regulation of steroid metabolizing enzymes in cells of the nervous and skeletal systems: Special focus on vitamin D metabolism”
https://uu.diva-portal.org/smash/get/diva2:1158259/FULLTEXT01.pdf

Ahmad Zayny “Vitamin D metabolism in osteoblast-like cells: effects of drugs on inactivation by CYP24A1”
https://uu.diva-portal.org/smash/get/diva2:1210514/SUMMARY01.pdf

2019
Maria Tsioumpekou, “Studies of PDGF receptor signaling in vitro and in vivo”
http://uu.diva-portal.org/smash/get/diva2:1285221/FULLTEXT01.pdf

Publications

Visualizing DNA single- and double-strand breaks in the Flash comet assay by DNA polymerase-assisted end-labelling

Bivehed, Erik; Hellman, Björn; Wenson, Leonie; Stenerlöw, Bo et al.

Part of Nucleic Acids Research, 2024
- DOI for Visualizing DNA single- and double-strand breaks in the Flash comet assay by DNA polymerase-assisted end-labelling
- Download full text (pdf) of Visualizing DNA single- and double-strand breaks in the Flash comet assay by DNA polymerase-assisted end-labelling
Cellular responses to silencing of PDIA3 (protein disulphide-isomerase A3): Effects on proliferation, migration, and genes in control of active vitamin D

Kermpatsou, Despoina; Olsson, Frida; Wåhlén, Erik; Söderberg, Ola et al.

Part of Journal of Steroid Biochemistry and Molecular Biology, 2024
- DOI for Cellular responses to silencing of PDIA3 (protein disulphide-isomerase A3): Effects on proliferation, migration, and genes in control of active vitamin D
- Download full text (pdf) of Cellular responses to silencing of PDIA3 (protein disulphide-isomerase A3): Effects on proliferation, migration, and genes in control of active vitamin D
Purification of DNA oligonucleotides to improve hybridization chain reaction performance

Leino, Mattias; Söderberg, Ola

Part of New Biotechnology, p. 33-40, 2023
- DOI for Purification of DNA oligonucleotides to improve hybridization chain reaction performance
- Download full text (pdf) of Purification of DNA oligonucleotides to improve hybridization chain reaction performance
The E3 Ubiquitin Ligase TRIM21 Regulates Basal Levels of PDGFRβ

Sarri, Niki; Papadopoulos, Natalia; Lennartsson, Johan; Heldin, Carl-Henrik

Part of International Journal of Molecular Sciences, 2023
- DOI for The E3 Ubiquitin Ligase TRIM21 Regulates Basal Levels of PDGFRβ
- Download full text (pdf) of The E3 Ubiquitin Ligase TRIM21 Regulates Basal Levels of PDGFRβ
Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs

Mihalič, Filip; Simonetti, Leandro; Giudice, Girolamo; Rubin Sander, Marie et al.

Part of Nature Communications, 2023
- DOI for Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs
- Download full text (pdf) of Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs
SUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferation

Wang, Kehuan; Papadopoulos, Natalia; Hamidi, Anahita; Lennartsson, Johan et al.

Part of BMC Molecular and Cell Biology, 2023
- DOI for SUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferation
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Activated EGFR and PDGFR internalize in separate vesicles and downstream AKT and ERK1/2 signaling are differentially impacted by cholesterol depletion

Wåhlén, Erik; Olsson, Frida; Raykova, Doroteya; Söderberg, Ola et al.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 195-201, 2023
- DOI for Activated EGFR and PDGFR internalize in separate vesicles and downstream AKT and ERK1/2 signaling are differentially impacted by cholesterol depletion
- Download full text (pdf) of Activated EGFR and PDGFR internalize in separate vesicles and downstream AKT and ERK1/2 signaling are differentially impacted by cholesterol depletion
A method for Boolean analysis of protein interactions at a molecular level

Raykova, Doroteya; Kermpatsou, Despoina; Malmqvist, Tony; Harrison, Philip J et al.

Part of Nature Communications, 2022
- DOI for A method for Boolean analysis of protein interactions at a molecular level
- Download full text (pdf) of A method for Boolean analysis of protein interactions at a molecular level
Effects of 1a,25-dihydroxyvitamin D-3 and tacalcitol on cell signaling and anchorage-independent growth in T98G and U251 glioblastoma cells

Olsson, Frida; Sarri, Niki; Papadopoulos, Natalia; Lennartsson, Johan et al.

Part of Biochemistry and Biophysics Reports, 2022
- DOI for Effects of 1a,25-dihydroxyvitamin D-3 and tacalcitol on cell signaling and anchorage-independent growth in T98G and U251 glioblastoma cells
- Download full text (pdf) of Effects of 1a,25-dihydroxyvitamin D-3 and tacalcitol on cell signaling and anchorage-independent growth in T98G and U251 glioblastoma cells
Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFR beta and affect PDGF-BB-induced STAT3 signalling

Sarri, Niki; Wang, Kehuan; Tsioumpekou, Maria; Castillejo-Lopez, Casimiro et al.

Part of Cellular and Molecular Life Sciences (CMLS), 2022
- DOI for Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFR beta and affect PDGF-BB-induced STAT3 signalling
- Download full text (pdf) of Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFR beta and affect PDGF-BB-induced STAT3 signalling
Differential impact of lipid raft depletion on platelet-derived growth factor (PDGF)-induced ERK1/2 MAP-kinase, SRC and AKT signaling

Wåhlén, Erik; Olsson, Frida; Söderberg, Ola; Lennartsson, Johan et al.

Part of Cellular Signalling, 2022
- DOI for Differential impact of lipid raft depletion on platelet-derived growth factor (PDGF)-induced ERK1/2 MAP-kinase, SRC and AKT signaling
- Download full text (pdf) of Differential impact of lipid raft depletion on platelet-derived growth factor (PDGF)-induced ERK1/2 MAP-kinase, SRC and AKT signaling
In Situ Rolling Circle Amplification Förster Resonance Energy Transfer (RCA-FRET) for Washing-Free Real-Time Single-Protein Imaging

Frances-Soriano, Laura; Leino, Mattias; Dos Santos, Marcelina Cardoso; Kovacs, Daniel et al.

Part of Analytical Chemistry, p. 1842-1850, 2021
- DOI for In Situ Rolling Circle Amplification Förster Resonance Energy Transfer (RCA-FRET) for Washing-Free Real-Time Single-Protein Imaging
Structure-based discovery of novel small molecule inhibitors of platelet-derived growth factor-B

Zarei, Omid; Sarri, Niki; Dastmalchi, Siavoush; Zokai, Fateme et al.

Part of Bioorganic chemistry (Print), 2020
- DOI for Structure-based discovery of novel small molecule inhibitors of platelet-derived growth factor-B
Flash-comet: Significantly improved speed and sensitivity of the comet assay through the introduction of lithium-based solutions and a more gentle lysis

Bivehed, Erik; Söderberg, Ola; Hellman, Björn

Part of Mutation research. Genetic toxicology and environmental mutagenesis, 2020
- DOI for Flash-comet: Significantly improved speed and sensitivity of the comet assay through the introduction of lithium-based solutions and a more gentle lysis
Specific targeting of PDGFR beta in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression

Tsioumpekou, Maria; Cunha, Sara I.; Ma, Haisha; Åhgren, Aive et al.

Part of Theranostics, p. 1122-1135, 2020
- DOI for Specific targeting of PDGFR beta in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression
- Download full text (pdf) of Specific targeting of PDGFR beta in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression
Effects of glucocorticoids on vitamin D₃-metabolizing 24-hydroxylase (CYP24A1) in Saos-2 cells and primary human osteoblasts

Zayny, Ahmad; Almokhtar, Mokhtar; Wikvall, Kjell; Ljunggren, Östen et al.

Part of Molecular and Cellular Endocrinology, 2019
- DOI for Effects of glucocorticoids on vitamin D₃-metabolizing 24-hydroxylase (CYP24A1) in Saos-2 cells and primary human osteoblasts
In situ quantification of individual mRNA transcripts in melanocytes discloses gene regulation of relevance to speciation

Wu, Chi-Chih; Klaesson, Axel; Buskas, Julia; Ranefall, Petter et al.

Part of Journal of Experimental Biology, 2019
- DOI for In situ quantification of individual mRNA transcripts in melanocytes discloses gene regulation of relevance to speciation
Dual specificity phosphatase (DUSP)-4 is induced by platelet-derived growth factor -BB in an Erk1/2-, STAT3- and p53-dependent manner

Yin, Runting; Eger, Glenda; Sarri, Niki; Rorsman, Charlotte et al.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 469-474, 2019
- DOI for Dual specificity phosphatase (DUSP)-4 is induced by platelet-derived growth factor -BB in an Erk1/2-, STAT3- and p53-dependent manner
Optimization of proximity-dependent initiation of hybridization chain reaction for improved performance

Leino, Mattias; Heldin, Johan; Rubin Sander, Marie; Kermpatsou, Despoina et al.

Part of Molecular Systems Design & Engineering, p. 1058-1065, 2019
- DOI for Optimization of proximity-dependent initiation of hybridization chain reaction for improved performance
- Download full text (pdf) of Optimization of proximity-dependent initiation of hybridization chain reaction for improved performance
Dynamin inhibitors impair platelet-derived growth factor beta-receptor dimerization and signaling

Heldin, Johan; Rubin Sander, Marie; Leino, Mattias; Thomsson, Sara et al.

Part of Experimental Cell Research, p. 69-79, 2019
- DOI for Dynamin inhibitors impair platelet-derived growth factor beta-receptor dimerization and signaling
- Download full text (pdf) of Dynamin inhibitors impair platelet-derived growth factor beta-receptor dimerization and signaling
PDGFR beta translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1

Papadopoulos, Natalia; Lennartsson, Johan; Heldin, Carl-Henrik

Part of Journal of Cell Biology, p. 1701-1717, 2018
- DOI for PDGFR beta translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1
Expression and regulation of CYP17A1 and 3β-hydroxysteroid dehydrogenase in cells of the nervous system: potential effects of vitamin D on brain steroidogenesis

Emanuelsson, Ida; Almokhtar, Mokhtar; Wikvall, Kjell; Gröndbladh, Alfhild et al.

Part of Neurochemistry International, p. 46-55, 2018
- DOI for Expression and regulation of CYP17A1 and 3β-hydroxysteroid dehydrogenase in cells of the nervous system: potential effects of vitamin D on brain steroidogenesis
Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes

Klaesson, Axel; Grannas, Karin; Ebai, Tonge; Heldin, Johan et al.

Part of Scientific Reports, 2018
- DOI for Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes
- Download full text (pdf) of Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes
Vitamin D Analogues Tacalcitol and Calcipotriol Inhibit Proliferation and Migration of T98G Human Glioblastoma Cells

Emanuelsson, Ida; Wikvall, Kjell; Friman, Tomas; Norlin, Maria

Part of Neuroscience, 2018
- DOI for Vitamin D Analogues Tacalcitol and Calcipotriol Inhibit Proliferation and Migration of T98G Human Glioblastoma Cells
Drug-mediated gene regulation of vitamin D₃ metabolism in primary human dermal fibroblasts

Norlin, Maria; Lundqvist, Johan; Ellfolk, Maria; Hellström Pigg, Maritta et al.

Part of Basic & Clinical Pharmacology & Toxicology, p. 59-63, 2017
- DOI for Drug-mediated gene regulation of vitamin D₃ metabolism in primary human dermal fibroblasts
Flow Cytometric Measurement of Blood Cells with BCR-ABL1 Fusion Protein in Chronic Myeloid Leukemia

Löf, Liza; Arngården, Linda; Olsson-Strömberg, Ulla; Siart, Benjamin et al.

Part of Scientific Reports, p. 1-9, 2017
- DOI for Flow Cytometric Measurement of Blood Cells with BCR-ABL1 Fusion Protein in Chronic Myeloid Leukemia
- Download full text (pdf) of Flow Cytometric Measurement of Blood Cells with BCR-ABL1 Fusion Protein in Chronic Myeloid Leukemia
Insufficient antibody validation challenges oestrogen receptor beta research

Andersson, Sandra; Sundberg, Mårten; Pristovsek, Nusa; Ibrahim, Ahmed et al.

Part of Nature Communications, 2017
- DOI for Insufficient antibody validation challenges oestrogen receptor beta research
- Download full text (pdf) of Insufficient antibody validation challenges oestrogen receptor beta research
Motor neuron-like NSC-34 cells as a new model for the study of vitamin D metabolism in the brain.

Almokhtar, Mokhtar; Wikvall, Kjell; Ubhayasekera, S. J. Kumari A.; Bergquist, Jonas et al.

Part of Journal of Steroid Biochemistry and Molecular Biology, p. 178-188, 2016
- DOI for Motor neuron-like NSC-34 cells as a new model for the study of vitamin D metabolism in the brain.
Effects of osteoporosis-inducing drugs on vitamin D-related gene transcription and mineralization in MG-63 and Saos-2 cells

Wegler, Christine; Wikvall, Kjell; Norlin, Maria

Part of Basic & Clinical Pharmacology & Toxicology, 2016
- DOI for Effects of osteoporosis-inducing drugs on vitamin D-related gene transcription and mineralization in MG-63 and Saos-2 cells
Estrogen-mediated regulation of steroid metabolism in rat glial cells; effects on neurosteroid levels via regulation of CYP7B1-mediated catalysis

Wicher, Grzegorz; Norlin, Maria

Part of Journal of Steroid Biochemistry and Molecular Biology, p. 21-27, 2015
- DOI for Estrogen-mediated regulation of steroid metabolism in rat glial cells; effects on neurosteroid levels via regulation of CYP7B1-mediated catalysis
Protective effects of 27-and 24-hydroxycholesterol against staurosporine-induced cell death in undifferentiated neuroblastoma SH-SY5Y cells

Emanuelsson, Ida; Norlin, Maria

Part of Neuroscience Letters, p. 44-48, 2012
- DOI for Protective effects of 27-and 24-hydroxycholesterol against staurosporine-induced cell death in undifferentiated neuroblastoma SH-SY5Y cells
Vitamin D-mediated regulation of CYP21A2 transcription – a novel mechanism for vitamin D action

Lundqvist, Johan; Wikvall, Kjell; Norlin, Maria

Part of Biochimica et Biophysica Acta - General Subjects, p. 1553-1559, 2012
- DOI for Vitamin D-mediated regulation of CYP21A2 transcription – a novel mechanism for vitamin D action
Effects of CYP7B1-related steroids on androgen receptor activation in different cell lines

Lundqvist, Johan; Norlin, Maria

Part of Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, p. 973-979, 2012
- DOI for Effects of CYP7B1-related steroids on androgen receptor activation in different cell lines
1α,25-Dihydroxyvitamin D₃ exerts tissue-specific effects on estrogen and androgen metabolism

Lundqvist, Johan; Norlin, Maria; Wikvall, Kjell

Part of Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, p. 263-270, 2011
- DOI for 1α,25-Dihydroxyvitamin D₃ exerts tissue-specific effects on estrogen and androgen metabolism
Androgen receptor-mediated regulation of the anti-atherogenic enzyme CYP27A1 involves the JNK/c-jun pathway

Norlin, Maria; Pettersson, Hanna; Tang, Wanjin; Wikvall, Kjell

Part of Archives of Biochemistry and Biophysics, p. 236-241, 2011
- DOI for Androgen receptor-mediated regulation of the anti-atherogenic enzyme CYP27A1 involves the JNK/c-jun pathway
Effects on DHEA levels by estrogen in rat astrocytes and CNS co-cultures via the regulation of CYP7B1-mediated metabolism

Svenningsen, Åsa Fex; Wicher, Grzegorz; Lundqvist, Johan; Pettersson, Hanna et al.

Part of Neurochemistry International, p. 620-624, 2011
- DOI for Effects on DHEA levels by estrogen in rat astrocytes and CNS co-cultures via the regulation of CYP7B1-mediated metabolism
1α,25-Dihydroxyvitamin D₃ affects hormone production and expression of steroidogenic enzymes in human adrenocortical NCI-H295R cells

Lundqvist, Johan; Norlin, Maria; Wikvall, Kjell

Part of Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, p. 1056-1062, 2010
- DOI for 1α,25-Dihydroxyvitamin D₃ affects hormone production and expression of steroidogenic enzymes in human adrenocortical NCI-H295R cells
Effects of CYP7B1-mediated catalysis on estrogen receptor activation.

Pettersson, Hanna; Lundqvist, Johan; Norlin, Maria

Part of Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, p. 1090-1097, 2010
- DOI for Effects of CYP7B1-mediated catalysis on estrogen receptor activation.
CYP7A1 (cytochrome P450, family 7, subfamily A, polypeptide 1)

Norlin, Maria; Wikvall, Kjell

Part of Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2010
Regulation of human vitamin D(3) 25-hydroxylases in dermal fibroblasts and prostate cancer LNCaP cells

Ellfolk, Maria; Norlin, Maria; Gyllensten, Katarina; Wikvall, Kjell

Part of Molecular Pharmacology, p. 1392-1399, 2009
- DOI for Regulation of human vitamin D(3) 25-hydroxylases in dermal fibroblasts and prostate cancer LNCaP cells
Lack of evidence of stimulatory autoantibodies to platelet-derived growth factor receptor in patients with systemic sclerosis

Classen, Jean-Francois; Henrohn, Dan; Rorsman, Fredrik; Lennartsson, Johan et al.

Part of Arthritis and Rheumatism, p. 1137-1144, 2009
- DOI for Lack of evidence of stimulatory autoantibodies to platelet-derived growth factor receptor in patients with systemic sclerosis
CYP7B1-mediated metabolism of 5 alfa-androstane-3 alfa,17 beta-diol (3 alfa-Adiol): A novel pathway for potential regulation of the cellular levels of androgens and neurosteroids

Pettersson, Hanna; Lundqvist, Johan; Oliw, Ernst; Norlin, Maria

Part of Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, p. 1206-1215, 2009
- DOI for CYP7B1-mediated metabolism of 5 alfa-androstane-3 alfa,17 beta-diol (3 alfa-Adiol): A novel pathway for potential regulation of the cellular levels of androgens and neurosteroids
CYP7B1 (cytochrome P450, family 7, subfamily B, polypeptide 1)

Norlin, Maria

Part of Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2009
CYP7B1-mediated metabolism of dehydroepiandrosterone and 5alpha-androstane-3beta,17beta-diol--potential role(s) for estrogen signaling

Pettersson, Hanna; Holmberg, Lisa; Axelson, Magnus; Norlin, Maria

Part of The FEBS Journal, p. 1778-1789, 2008
- DOI for CYP7B1-mediated metabolism of dehydroepiandrosterone and 5alpha-androstane-3beta,17beta-diol--potential role(s) for estrogen signaling
Metabolism of a novel side chain modified Delta 8(14)-15-ketosterol, a potential cholesterol lowering drug: 28-hydroxylation by CYP27A1

Pettersson, Hanna; Norlin, Maria; Andersson, Ulla; Pikuleva, Irina et al.

Part of Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, p. 383-390, 2008
- DOI for Metabolism of a novel side chain modified Delta 8(14)-15-ketosterol, a potential cholesterol lowering drug: 28-hydroxylation by CYP27A1
Involvement of the PI3K/Akt pathway in estrogen-mediated regulation of human CYP7B1: identification of CYP7B1 as a novel target for PI3K/Akt and MAPK signalling

Tang, Wanjin; Pettersson, Hanna; Norlin, Maria

Part of Journal of Steroid Biochemistry and Molecular Biology, p. 63-73, 2008
- DOI for Involvement of the PI3K/Akt pathway in estrogen-mediated regulation of human CYP7B1: identification of CYP7B1 as a novel target for PI3K/Akt and MAPK signalling
Glucocorticoid receptor-mediated upregulation of human CYP27A1, a potential anti-atherogenic enzyme

Tang, Wanjin; Norlin, Maria; Wikvall, Kjell

Part of Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, p. 718-723, 2008
- DOI for Glucocorticoid receptor-mediated upregulation of human CYP27A1, a potential anti-atherogenic enzyme
Regulation of human CYP27A1 by estrogens and androgens in HepG2 and prostate cells

Tang, Wanjin; Norlin, Maria; Wikvall, Kjell

Part of Archives of Biochemistry and Biophysics, p. 13-20, 2007
- DOI for Regulation of human CYP27A1 by estrogens and androgens in HepG2 and prostate cells
Phenobarbital suppresses vitamin D3 25-hydroxylase expression: A potential new mechanism for drug-induced osteomalacia

Hosseinpour, Fardin; Ellfolk, Maria; Norlin, Maria; Wikvall, Kjell

Part of Biochemical and Biophysical Research Communications - BBRC, p. 603-607, 2007
- DOI for Phenobarbital suppresses vitamin D3 25-hydroxylase expression: A potential new mechanism for drug-induced osteomalacia
Flutamide metabolism in four different species in vitro and identification of flutamide metabolites in human patient urine by high performance liquid chromatography/tandem mass spectrometry.

Tevell, Annica; Lennernäs, Hans; Jönsson, Mats; Norlin, Maria et al.

Part of Drug Metab Dispos, p. 984-92, 2006