Pharmaceutical Physics

Illustration from https://doi.org/10.1016/j.ijpharm.2018.12.064
Research in Pharmaceutical Physics at Uppsala University
Description
In the research area of Pharmaceutical Physics, the design, manufacturing and performance of drug-delivery systems are studied. Our ambition is to conduct methodological and basic mechanistic research that contributes to the development of effective, patient oriented and more cost-effective medicines.
We develop, firstly, new and improved drug-delivery solutions and, secondly, tools that enable a more effective development and manufacturing of drug products. The core expertise of the group is powder science and technology which is a scientific discipline with applications to different type of products, including pharmaceuticals. An important and common research question is how critical properties of particles and particle systems can be assessed, controlled and predicted. The main applications of the research are formulation of medicines for peroral and pulmonary administration.
The research group is led by professor Göran Frenning. Other senior researchers in the group are emeritus professor Göran Alderborn and lecturers Erik Björk, Josefina Nordström and Ann-Sofie Persson. The research group is involved in the competence centre SweDeliver.
Formulation of solid oral dosage forms
Determing compression parameters to characterize particle properties and predict tablet-forming abilities.

Formulation of inhaled medicines
Studies of physical and formulation properties of carrier-based formulations, so called adhesive mixtures.

Modelling and simulation
Developing non local contact models and simulation methods for efficient and accurate particle-scale modelling of powders.

Publications
Part of Powder Technology, 2025
- DOI for The interplay between compression mechanisms and compaction pressure in relation to the loss of tabletability of dry granulated particles
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Part of Clinical Pharmacology in Drug Development, 2025
Single-particle fabric tensors for assemblies of spherical particles
Part of Computer Methods in Applied Mechanics and Engineering, 2024
- DOI for Single-particle fabric tensors for assemblies of spherical particles
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Effect of drug load on the aerosolisation propensity of binary adhesive mixtures for inhalation
Part of International Journal of Pharmaceutics, 2024
- DOI for Effect of drug load on the aerosolisation propensity of binary adhesive mixtures for inhalation
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Part of European Journal of Pharmaceutical Sciences, 2024
- DOI for Influence of particle diameter on aerosolization performance and release of budesonide loaded mesoporous silica particles
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Mechanical characterization of tablets using post compression in-die cyclic loading
Part of Powder Technology, 2024
- DOI for Mechanical characterization of tablets using post compression in-die cyclic loading
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Part of Computer Methods in Applied Mechanics and Engineering, 2024
- DOI for A mean-strain estimate for plastic particles intended for distinct-particle simulations at high relative density
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Compaction behavior of freeze-dried and spray-dried trypsin/lactose particulate systems
Part of Powder Technology, 2024
- DOI for Compaction behavior of freeze-dried and spray-dried trypsin/lactose particulate systems
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Part of Powder Technology, 2023
- DOI for Effective friction in adhesive mixtures intended for inhalation: Simulation of oblique impact of adhesive units
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A new modelling approach for dissolution of polydisperse powders
Part of International Journal of Pharmaceutics, 2023
- DOI for A new modelling approach for dissolution of polydisperse powders
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A Voronoi strain-based method for granular materials and continua
Part of Computational particle mechanics, p. 427-443, 2023
- DOI for A Voronoi strain-based method for granular materials and continua
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Segregation in inhalable powders: Quantification of the effect of vibration on adhesive mixtures
Part of European journal of pharmaceutics and biopharmaceutics, p. 107-119, 2023
- DOI for Segregation in inhalable powders: Quantification of the effect of vibration on adhesive mixtures
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Part of Pharmaceutical development and technology (Print), p. 509-519, 2023
- DOI for Tabletability and compactibility of alpha-lactose monohydrate powders of different particle size. II: predicted relationships
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Part of International Journal of Pharmaceutics, 2023
- DOI for Engineered microparticles of hyaluronic acid hydrogel for controlled pulmonary release of salbutamol sulphate
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Part of Powder Technology, 2023
- DOI for On the thermodynamic consistency of the Drucker-Prager Cap model: Modification of the plastic potential and analysis of unloading
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Effect of fluid velocity and particle size on the hydrodynamic diffusion layer thickness
Part of European journal of pharmaceutics and biopharmaceutics, p. 1-10, 2022
- DOI for Effect of fluid velocity and particle size on the hydrodynamic diffusion layer thickness
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Part of COMPUTATIONAL PARTICLE MECHANICS, p. 1105-1118, 2022
- DOI for Towards a macroscopically consistent discrete method for granular materials: Delaunay strain-based formulation
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Part of Molecular Pharmaceutics, p. 3114-3124, 2022
- DOI for Characterization of Membrane-Type Dissolution Profiles of Clinically Available Orally Inhaled Products Using a Weibull Fit and a Mechanistic Model
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Part of International Journal of Pharmaceutics, 2022
- DOI for Effect of pressure drop on the in vitro dispersion of adhesive mixtures of different blend states for inhalation
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Part of Obesity, p. 2222-2232, 2022
- DOI for Effects of a novel weight-loss combination product containing orlistat and acarbose on obesity: A randomized, placebo-controlled trial
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Part of Powder Technology, 2022
- DOI for Effect of excipient properties and blend ratio on the compression properties of dry granulated particles prepared from microcrystalline cellulose and lactose
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Part of Powder Technology, 2022
- DOI for Deciphering the role of granule deformation and fragmentation for the tableting performance of some dry granulated powders
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Part of Pharmaceutical development and technology (Print), p. 319-330, 2022
- DOI for Tabletability and compactibility of alpha-lactose monohydrate powders of different particle size. I. Experimental comparison
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Part of International Journal of Pharmaceutics, 2021
- DOI for On the relationship between blend state and dispersibility of adhesive mixtures containing active pharmaceutical ingredients
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Part of Powder Technology, p. 230-239, 2021
- DOI for Effect of carrier size and mechanical properties on adhesive unit stability for inhalation: A numerical study
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Part of Powder Technology, p. 299-305, 2021
- DOI for Effect of fine particle shape on the stability and performance of adhesive mixtures intended for inhalation
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Safety of a Novel Weight Loss Combination Product Containing Orlistat and Acarbose.
Part of Clinical Pharmacology in Drug Development, p. 1242-1247, 2021
- DOI for Safety of a Novel Weight Loss Combination Product Containing Orlistat and Acarbose.
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Hyaluronic Acid Hydrogels for Controlled Pulmonary Drug Delivery-A Particle Engineering Approach
Part of Pharmaceutics, 2021
- DOI for Hyaluronic Acid Hydrogels for Controlled Pulmonary Drug Delivery-A Particle Engineering Approach
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Part of Pharmaceutics, 2021
- DOI for Determination of Intrinsic Drug Dissolution and Solute Effective Transport Rate during Laminar Fluid Flow at Different Velocities
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Part of Journal of Colloid and Interface Science, p. 92-100, 2020
- DOI for Nanoscale characterization of PEGylated phospholipid coatings formed by spray drying on silica microparticles
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Part of Obesity Science & Practice, p. 313-323, 2020
- DOI for Effects of a novel combination of orlistat and acarbose on tolerability, appetite, and glucose metabolism in persons with obesity
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Part of Chemical Engineering Science: X, 2020
- DOI for Numerical modeling of collision of adhesive units: Stability and mechanical properties during handling
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Model for the Analysis of Membrane-Type Dissolution Tests for Inhaled Drugs
Part of Molecular Pharmaceutics, p. 2426-2434, 2020
- DOI for Model for the Analysis of Membrane-Type Dissolution Tests for Inhaled Drugs
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Part of International Journal of Pharmaceutics, p. 130-137, 2019
Part of Powder Technology, p. 74-81, 2019
Part of International Journal of Pharmaceutics, p. 148-160, 2019
- DOI for Linking carrier morphology to the powder mechanics of adhesive mixtures for dry powder inhalers via a blend-state model
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Part of International Journal of Pharmaceutics, 2019
- DOI for Atypical compaction behaviour of disordered lactose explained by a shift in type of compact fracture pattern
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Milling induced amorphisation and recrystallization of alpha-lactose monohydrate
Part of International Journal of Pharmaceutics, p. 140-147, 2018
Part of European journal of pharmaceutics and biopharmaceutics, p. 28-37, 2018
- DOI for A hybrid approach to predict the relationship between tablet tensile strength and compaction pressure using analytical powder compression
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Effect of milling on the plastic and the elastic stiffness of lactose particles
Part of European Journal of Pharmaceutical Sciences, p. 138-145, 2018
- DOI for Effect of milling on the plastic and the elastic stiffness of lactose particles
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Part of Journal of Pharmaceutical Sciences, p. 1920-1927, 2018
Determination of interfacial amorphicity in functional powders
Part of Abstracts of Papers of the American Chemical Society, 2018
Part of International Journal of Pharmaceutics, p. 143-156, 2018
Part of International Journal of Pharmaceutics, p. 120-131, 2018
Determination of Interfacial Amorphicity in Functional Powders
Part of Langmuir, p. 920-926, 2017
Part of International Journal of Pharmaceutics, p. 215-227, 2017
- DOI for Comminution-amorphisation relationships during ball milling of lactose at different milling conditions
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Powder compression mechanics of spray-dried lactose nanocomposites
Part of International Journal of Pharmaceutics, p. 1-10, 2017
Peptide loaded microgels as antimicrobial surface coatings
Part of Abstracts of Papers of the American Chemical Society, 2017
Part of Powder Technology, p. 347-355, 2017
- DOI for Mechanical behaviour of ideal elastic-plastic particles subjected to different triaxial loading conditions
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Computational fluid dynamics (CFD) studies of a miniaturized dissolution system
Part of International Journal of Pharmaceutics, p. 274-281, 2017
- DOI for Computational fluid dynamics (CFD) studies of a miniaturized dissolution system
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