Michael Pavlov

Antibiotic thermorubin tethers ribosomal subunits and impedes A-site interactions to perturb protein synthesis in bacteria

Parajuli, Narayan Prasad; Emmerich, Andrew G; Mandava, Chandra Sekhar; Pavlov, Michael Y. et al.

Ingår i Nature Communications, 2023

• DOI för Antibiotic thermorubin tethers ribosomal subunits and impedes A-site interactions to perturb protein synthesis in bacteria
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Dynamics of release factor recycling during translation termination in bacteria

Prabhakar, Arjun; Pavlov, Michael Y.; Zhang, Jingji; Indrisiunaite, Gabriele et al.

Ingår i Nucleic Acids Research, s. 5774-5790, 2023

• DOI för Dynamics of release factor recycling during translation termination in bacteria
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Estimation of peptide elongation times from ribosome profiling spectra

Pavlov, Michael; Ullman, Gustaf; Ignatova, Zoya; Ehrenberg, Måns

Ingår i Nucleic Acids Research, s. 5124-5142, 2021

• DOI för Estimation of peptide elongation times from ribosome profiling spectra
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Mechanistic insights into translation inhibition by aminoglycoside antibiotic arbekacin

Parajuli, Narayan Prasad; Mandava, Chandra Sekhar; Pavlov, Michael; Sanyal, Suparna

Ingår i Nucleic Acids Research, s. 6880-6892, 2021

• DOI för Mechanistic insights into translation inhibition by aminoglycoside antibiotic arbekacin

Reiterative Synthesis by the Ribosome and Recognition of the N-Terminal Formyl Group by Biosynthetic Machinery Contribute to Evolutionary Conservation of the Length of Antibiotic Microcin C Peptide Precursor

Zukher, Inna; Pavlov, Michael; Tsibulskaya, Darya; Kulikovsky, Alexey et al.

Ingår i mBio, 2019

• DOI för Reiterative Synthesis by the Ribosome and Recognition of the N-Terminal Formyl Group by Biosynthetic Machinery Contribute to Evolutionary Conservation of the Length of Antibiotic Microcin C Peptide Precursor
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Antibiotic thermorubin tethers ribosomal subunits and impedes A-site interactions to perturb protein synthesis in bacteria

Parajuli, Narayan Prasad; Emmerich, Andrew G; Mandava, Chandra Sekhar; Pavlov, Michael Y. et al.

Ingår i Nature Communications, 2023

• DOI för Antibiotic thermorubin tethers ribosomal subunits and impedes A-site interactions to perturb protein synthesis in bacteria
• Ladda ner fulltext (pdf) av Antibiotic thermorubin tethers ribosomal subunits and impedes A-site interactions to perturb protein synthesis in bacteria

Dynamics of release factor recycling during translation termination in bacteria

Prabhakar, Arjun; Pavlov, Michael Y.; Zhang, Jingji; Indrisiunaite, Gabriele et al.

Ingår i Nucleic Acids Research, s. 5774-5790, 2023

• DOI för Dynamics of release factor recycling during translation termination in bacteria
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Estimation of peptide elongation times from ribosome profiling spectra

Pavlov, Michael; Ullman, Gustaf; Ignatova, Zoya; Ehrenberg, Måns

Ingår i Nucleic Acids Research, s. 5124-5142, 2021

• DOI för Estimation of peptide elongation times from ribosome profiling spectra
• Ladda ner fulltext (pdf) av Estimation of peptide elongation times from ribosome profiling spectra

Mechanistic insights into translation inhibition by aminoglycoside antibiotic arbekacin

Parajuli, Narayan Prasad; Mandava, Chandra Sekhar; Pavlov, Michael; Sanyal, Suparna

Ingår i Nucleic Acids Research, s. 6880-6892, 2021

• DOI för Mechanistic insights into translation inhibition by aminoglycoside antibiotic arbekacin

Reiterative Synthesis by the Ribosome and Recognition of the N-Terminal Formyl Group by Biosynthetic Machinery Contribute to Evolutionary Conservation of the Length of Antibiotic Microcin C Peptide Precursor

Zukher, Inna; Pavlov, Michael; Tsibulskaya, Darya; Kulikovsky, Alexey et al.

Ingår i mBio, 2019

• DOI för Reiterative Synthesis by the Ribosome and Recognition of the N-Terminal Formyl Group by Biosynthetic Machinery Contribute to Evolutionary Conservation of the Length of Antibiotic Microcin C Peptide Precursor
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Accuracy of genetic code translation and its orthogonal corruption by aminoglycosides and Mg2+ ions

Zhang, Jingji; Pavlov, Michael; Ehrenberg, Måns

Ingår i Nucleic Acids Research, s. 1362-1374, 2018

• DOI för Accuracy of genetic code translation and its orthogonal corruption by aminoglycosides and Mg2+ ions
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The Structural Basis for Initiation Factor 2 Activation during Translation Initiation

Caban, Kelvin; Pavlov, Michael; Kaledhonkar, Sandip; Fu, Ziao et al.

Ingår i Biophysical Journal, 2018

A conformational switch in initiation factor 2 controls the fidelity of translation initiation in bacteria

Caban, Kelvin; Pavlov, Michael; Ehrenberg, Måns; Gonzalez, Ruben L.

Ingår i Nature Communications, 2017

• DOI för A conformational switch in initiation factor 2 controls the fidelity of translation initiation in bacteria
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Complete kinetic mechanism for recycling of the bacterial ribosome

Borg, Anneli; Pavlov, Michael; Ehrenberg, Måns

Ingår i RNA, s. 10-21, 2016

• DOI för Complete kinetic mechanism for recycling of the bacterial ribosome

Mechanism of fusidic acid inhibition of RRF- and EF-G-dependent splitting of the bacterial post-termination ribosome

Borg, Anneli; Pavlov, Michael; Ehrenberg, Måns

Ingår i Nucleic Acids Research, s. 3264-3275, 2016

• DOI för Mechanism of fusidic acid inhibition of RRF- and EF-G-dependent splitting of the bacterial post-termination ribosome
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On the pH Dependence of Class-1 RF-Dependent Termination of mRNA Translation

Indrisiunaite, Gabriele; Pavlov, Michael Y.; Heurgue-Hamard, Valerie; Ehrenberg, Måns

Ingår i Journal of Molecular Biology, s. 1848-1860, 2015

• DOI för On the pH Dependence of Class-1 RF-Dependent Termination of mRNA Translation
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Fusidic Acid Targets Elongation Factor G in Several Stages of Translocation on the Bacterial Ribosome

Borg, Anneli; Holm, Mikael; Shiroyama, Ikue; Hauryliuk, Vasili et al.

Ingår i Journal of Biological Chemistry, s. 3440-3454, 2015

• DOI för Fusidic Acid Targets Elongation Factor G in Several Stages of Translocation on the Bacterial Ribosome

Peptide Formation by N-Methyl Amino Acids in Translation Is Hastened by Higher pH and tRNA^Pro

Wang, Jinfan; Kwiatkowski, Marek; Pavlov, Michael Yu; Ehrenberg, Måns et al.

Ingår i ACS Chemical Biology, s. 1303-1311, 2014

• DOI för Peptide Formation by N-Methyl Amino Acids in Translation Is Hastened by Higher pH and tRNA^Pro

A tRNA body with high affinity for EF-Tu hastens ribosomal incorporation of unnatural amino acids

Ieong, Ka-Weng; Pavlov, Michael Y.; Kwiatkowski, Marek; Ehrenberg, Måns et al.

Ingår i RNA, s. 632-643, 2014

• DOI för A tRNA body with high affinity for EF-Tu hastens ribosomal incorporation of unnatural amino acids
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Optimal Strategy for Rapid Proteome Re-Arrangements in Bacterial Populations

Ehrenberg, Måns; Pavlov, Michael Yu

Ingår i Biophysical Journal, 2013

• DOI för Optimal Strategy for Rapid Proteome Re-Arrangements in Bacterial Populations

Optimal control of gene expression for fast proteome adaptation to environmental change

Pavlov, Michael Y.; Ehrenberg, Måns

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 20527-20532, 2013

• DOI för Optimal control of gene expression for fast proteome adaptation to environmental change

Inefficient delivery but fast peptide bond formation of unnatural l -aminoacyl-tRNAs in translation

Ieong, Ka-Weng; Pavlov, Michael Y.; Kwiatkowski, Marek; Forster, Anthony C. et al.

Ingår i Journal of the American Chemical Society, s. 17955-17962, 2012

• DOI för Inefficient delivery but fast peptide bond formation of unnatural l -aminoacyl-tRNAs in translation

Activation of initiation factor 2 by ligands and mutations for rapid docking of ribosomal subunits

Pavlov, Michael Y.; Zorzet, Anna; Andersson, Dan I.; Ehrenberg, Måns

Ingår i EMBO Journal, s. 289-301, 2011

• DOI för Activation of initiation factor 2 by ligands and mutations for rapid docking of ribosomal subunits

pH-sensitivity of the ribosomal peptidyl transfer reaction dependent on the identity of the A-site aminoacyl-tRNA

Johansson, Magnus; Ieong, Ka-Weng; Trobro, Stefan; Strazewski, Peter et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 79-84, 2011

• DOI för pH-sensitivity of the ribosomal peptidyl transfer reaction dependent on the identity of the A-site aminoacyl-tRNA

Identification of enzyme inhibitory mechanisms from steady-state kinetics

Fange, David; Lovmar, Martin; Pavlov, Michael Y.; Ehrenberg, Måns

Ingår i Biochimie, s. 1623-1629, 2011

• DOI för Identification of enzyme inhibitory mechanisms from steady-state kinetics

Error-prone initiation factor 2 mutations reduce the fitness cost of antibiotic resistance

Zorzet, Anna; Pavlov, Michael; Nilsson, Annika; Ehrenberg, Måns et al.

Ingår i Molecular Microbiology, s. 1299-1313, 2010

• DOI för Error-prone initiation factor 2 mutations reduce the fitness cost of antibiotic resistance
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Structure probing of tmRNA in distinct stages of trans-translation

Ivanova, Natalia; Lindell, Magnus; Pavlov, Michael; Holmberg Schiavone, Lovisa et al.

Ingår i RNA, s. 713-722, 2007

• DOI för Structure probing of tmRNA in distinct stages of trans-translation

How initiation factors tune the rate of initiation of protein synthesis in bacteria.

Antoun, Ayman; Pavlov, Michael Y; Lovmar, Martin; Ehrenberg, Måns

Ingår i EMBO Journal, s. 2539-50, 2006

• DOI för How initiation factors tune the rate of initiation of protein synthesis in bacteria.

Ribosome formation from subunits studied by stopped-flow and Rayleigh light scattering

Antoun, Ayman; Pavlov, Michael; Tenson, Tanel; Ehrenberg, Måns

Ingår i Biol Procedure Online, 2004

Targeting and insertion of heterologous membrane proteins in E. coli

Raine, A; Ullers, R; Pavlov, M; Luirink, J et al.

Ingår i Biochimie, s. 659-668, 2003

Substrate-Induced Formation of Ribosomal Decoding Center for Accurate and Rapid Genetic Code Translation

Pavlov, Michael; Ehrenberg, Måns

Ingår i Annual Review of Biophysics, s. 525-548, 2018

• DOI för Substrate-Induced Formation of Ribosomal Decoding Center for Accurate and Rapid Genetic Code Translation

A recent intermezzo at the Ribosome Club

Pavlov, Michael; Liljas, Anders; Ehrenberg, Måns

Ingår i Philosophical Transactions of the Royal Society of London. Biological Sciences, 2017

• DOI för A recent intermezzo at the Ribosome Club
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Rate and accuracy of ribosomal peptidyl transfer

Johansson, Magnus; Ieong, Ka-Weng; Pavlov, Michael Y.; Ehrenberg, Måns

Ingår i Ribosomes, s. 225-235, 2011

Initiation of bacterial protein synthesis with wild type and novel mutants of initiation factor

Pavlov, Michael Y.; Sanyal, Suparna; Ehrenberg, Måns

Ingår i Ribosomes, s. 129-141, 2011