Maris Lapins

Discovery of a novel inhibitor of macropinocytosis with antiviral activity

Porebski, Bartlomiej; Christ, Wanda; Corman, Alba; Haraldsson, Martin et al.

Ingår i Molecular Therapy, s. 3012-3024, 2024

• DOI för Discovery of a novel inhibitor of macropinocytosis with antiviral activity
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Morphological profiling of environmental chemicals enables efficient and untargeted exploration of combination effects

Rietdijk, Jonne; Aggarwal, Tanya; Georgiev, Polina; Lapins, Maris et al.

Ingår i Science of the Total Environment, 2022

• DOI för Morphological profiling of environmental chemicals enables efficient and untargeted exploration of combination effects
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A phenomics approach for antiviral drug discovery

Rietdijk, Jonne; Tampere, Marianna; Pettke, Aleksandra; Georgiev, Polina et al.

Ingår i BMC Biology, 2021

• DOI för A phenomics approach for antiviral drug discovery
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A confidence predictor for logD using conformal regression and a support-vector machine

Lapins, Maris; Arvidsson, Staffan; Lampa, Samuel; Berg, Arvid et al.

Ingår i Journal of Cheminformatics, 2018

• DOI för A confidence predictor for logD using conformal regression and a support-vector machine
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Origin of aromatase inhibitory activity via proteochemometric modeling

Simeon, Saw; Spjuth, Ola; Lapins, Maris; Nabu, Sunanta et al.

Ingår i PeerJ, 2016

• DOI för Origin of aromatase inhibitory activity via proteochemometric modeling
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Discovery of a novel inhibitor of macropinocytosis with antiviral activity

Porebski, Bartlomiej; Christ, Wanda; Corman, Alba; Haraldsson, Martin et al.

Ingår i Molecular Therapy, s. 3012-3024, 2024

• DOI för Discovery of a novel inhibitor of macropinocytosis with antiviral activity
• Ladda ner fulltext (pdf) av Discovery of a novel inhibitor of macropinocytosis with antiviral activity

Morphological profiling of environmental chemicals enables efficient and untargeted exploration of combination effects

Rietdijk, Jonne; Aggarwal, Tanya; Georgiev, Polina; Lapins, Maris et al.

Ingår i Science of the Total Environment, 2022

• DOI för Morphological profiling of environmental chemicals enables efficient and untargeted exploration of combination effects
• Ladda ner fulltext (pdf) av Morphological profiling of environmental chemicals enables efficient and untargeted exploration of combination effects

A phenomics approach for antiviral drug discovery

Rietdijk, Jonne; Tampere, Marianna; Pettke, Aleksandra; Georgiev, Polina et al.

Ingår i BMC Biology, 2021

• DOI för A phenomics approach for antiviral drug discovery
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A confidence predictor for logD using conformal regression and a support-vector machine

Lapins, Maris; Arvidsson, Staffan; Lampa, Samuel; Berg, Arvid et al.

Ingår i Journal of Cheminformatics, 2018

• DOI för A confidence predictor for logD using conformal regression and a support-vector machine
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Origin of aromatase inhibitory activity via proteochemometric modeling

Simeon, Saw; Spjuth, Ola; Lapins, Maris; Nabu, Sunanta et al.

Ingår i PeerJ, 2016

• DOI för Origin of aromatase inhibitory activity via proteochemometric modeling
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Extending proteochemometric modeling for unraveling the sorption behavior of compound-soil interaction

Shoombuatong, Watshara; Nabu, Sunanta; Simeon, Saw; Prachayasittikul, Virapong et al.

Ingår i Chemometrics and Intelligent Laboratory Systems, s. 219-227, 2016

• DOI för Extending proteochemometric modeling for unraveling the sorption behavior of compound-soil interaction

Proteochemometric model for predicting the inhibition of penicillin-binding proteins

Nabu, Sunanta; Nantasenamat, Chanin; Owasirikul, Wiwat; Lawung, Ratana et al.

Ingår i Journal of Computer-Aided Molecular Design, s. 127-141, 2015

• DOI för Proteochemometric model for predicting the inhibition of penicillin-binding proteins

A Unified Proteochemometric Model for Prediction of Inhibition of Cytochrome P450 Isoforms

Lapins, Maris; Worachartcheewan, Apilak; Spjuth, Ola; Georgiev, Valentin et al.

Ingår i PLOS ONE, 2013

• DOI för A Unified Proteochemometric Model for Prediction of Inhibition of Cytochrome P450 Isoforms
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Design and evaluation of substrate-based octapeptide and non substrate-based tetrapeptide inhibitors of dengue virus NS2B-NS3 proteases

Prusis, Peteris; Junaid, Muhammad; Petrovska, Ramona; Yahorava, Sviatlana et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 767-772, 2013

• DOI för Design and evaluation of substrate-based octapeptide and non substrate-based tetrapeptide inhibitors of dengue virus NS2B-NS3 proteases
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Melanocortin 4 receptor in silico mutagenesis and docking studies

Shutava, Iryna; Lapinsh, Maris; Wikberg, Jarl

Ingår i European Biophysics Journal, 2013

­­­­­­­­Enzymatic Analysis of Recombinant Japanese Encephalitis Virus NS2B(H)-NS3pro Protease with Fluorogenic Model Peptide Substrates

Junaid, Muhammad; Chalayut, Chakard; Sehgelmeble Torrejon, Anna; Angsuthanasombat, Chanan et al.

Ingår i PLOS ONE, 2012

• DOI för ­­­­­­­­Enzymatic Analysis of Recombinant Japanese Encephalitis Virus NS2B(H)-NS3pro Protease with Fluorogenic Model Peptide Substrates
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Identification and analysis of functionally important amino acids in human purinergic 12 receptor using a Saccharomyces cerevisiae expression system

Ignatovica, Vita; Megnis, Kaspars; Lapins, Maris; Schiöth, Helgi B et al.

Ingår i The FEBS Journal, s. 180-191, 2012

• DOI för Identification and analysis of functionally important amino acids in human purinergic 12 receptor using a Saccharomyces cerevisiae expression system

Linking the Resource Description Framework to cheminformatics and proteochemometrics

Willighagen, Egon; Alvarsson, Jonathan; Andersson, Annsofie; Eklund, Martin et al.

Ingår i Journal of Biomedical Semantics, s. 6, 2011

• DOI för Linking the Resource Description Framework to cheminformatics and proteochemometrics

Services for prediction of drug susceptibility for HIV proteases and reverse transcriptases at the HIV Drug Research Centre

Spjuth, Ola; Eklund, Martin; Lapins, Maris; Junaid, Muhammad et al.

Ingår i Bioinformatics, s. 1719-1720, 2011

• DOI för Services for prediction of drug susceptibility for HIV proteases and reverse transcriptases at the HIV Drug Research Centre

Proteochemometric Modeling of the Susceptibility of Mutated Variants of the HIV-1 Virus to Reverse Transcriptase Inhibitors

Junaid, Muhammad; Lapins, Maris; Eklund, Martin; Spjuth, Ola et al.

Ingår i PLoS ONE, 2010

• DOI för Proteochemometric Modeling of the Susceptibility of Mutated Variants of the HIV-1 Virus to Reverse Transcriptase Inhibitors

Kinome-wide interaction modelling using alignment-based and alignment-independent approaches for kinase description and linear and non-linear data analysis techniques

Lapins, Maris; Wikberg, Jarl E. S.

Ingår i BMC Bioinformatics, s. 339, 2010

• DOI för Kinome-wide interaction modelling using alignment-based and alignment-independent approaches for kinase description and linear and non-linear data analysis techniques

Towards proteome-wide interaction models using the proteochemometrics approach

Strömbergsson, Helena; Lapins, Maris; Kleywegt, Gerard J.; Wikberg, Jarl E. S.

Ingår i Molecular Informatics, s. 499-508, 2010

• DOI för Towards proteome-wide interaction models using the proteochemometrics approach

Proteochemometric Modeling of Drug Resistance over the Mutational Space for Multiple HIV Protease Variants and Multiple Protease Inhibitors

Lapins, Maris; Wikberg, Jarl E. S

Ingår i Journal of chemical information and modeling, s. 1202-1210, 2009

• DOI för Proteochemometric Modeling of Drug Resistance over the Mutational Space for Multiple HIV Protease Variants and Multiple Protease Inhibitors

Proteochemometric modeling of HIV protease susceptibility

Lapins, Maris; Eklund, Martin; Spjuth, Ola; Prusis, Peteris et al.

Ingår i BMC Bioinformatics, s. 181, 2008

• DOI för Proteochemometric modeling of HIV protease susceptibility

Proteochemometrics analysis of substrate interactions with dengue virus NS3 proteases

Prusis, Peteris; Lapins, Maris; Yahorava, Sviatlana; Petrovska, Ramona et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 9369-9377, 2008

• DOI för Proteochemometrics analysis of substrate interactions with dengue virus NS3 proteases

Proteochemometric modeling reveals the interaction site for Trp9 modified alpha-MSH peptides in melanocortin receptors

Lapinsh, Maris; Prusis, Peteris; Petrovska, Ramona; Uhlén, Staffan et al.

Ingår i Proteins, s. 653-660, 2007

• DOI för Proteochemometric modeling reveals the interaction site for Trp9 modified alpha-MSH peptides in melanocortin receptors

Introduction to Pharmaceutical Bioinformatics

Wikberg, Jarl; Eklund, Martin; Willighagen, Egon; Spjuth, Ola et al.

Oakleaf Academic, 2010

Chemoinformatics taking Biology into Account: Proteochemometrics

Wikberg, Jarl; Spjuth, Ola; Eklund, Martin; Lapins, Maris

Ingår i Computational Approaches in Cheminformatics and Bioinformatics, John Wiley & Sons, 2012

• DOI för Chemoinformatics taking Biology into Account: Proteochemometrics

Design and Evaluation of Substrate-based Octapeptide and Nonsubstrate-based Tetrapeptide Inhibitors of Dengue Virus NS2B/NS3 Proteases

Prusis, Peteris; Junaid, Muhammad; Petrovska, Ramona; Yahorava, Sviatlana et al.

Design and Evaluation of Dengue NS3 Protease Peptide Inhibitors

Junaid, Muhammad; Lapins, Maris; Katzenmeier, Gerd; Cui, Taian et al.

AROS: Open Source Lab Automation Enables Fully Automated CellPainting

Dahlö, Martin; Larsson, Anders; Rosén, Dan; Francisco Rodríguez, María Andreína et al.

Novel anti-cancer agents targeting NAT2 loss in colorectal cancer

Rameika, Natallia; Tsiara, Ioanna; Haberek, Wawrzyniec; Akcan, Ece et al.

A Systematic Host-Centric Approach to Identifying Repurposed Drugs for Viral Infections

Asp, Elin; Rietdijk, Jonne; Tampere, Marianna; Axelsson, Hanna et al.