Fredrik Johansson Swartling

Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies

Holmberg Olausson, Karl O.; Borgenvik, Anna; Zhao, Miao; Giraud, Géraldine et al.

Ingår i Cancers, 2024

• DOI för Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies
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An Indolin-3-imine Photobase and pH Sensitive Fluorophore

Doloczki, Susanne; Kern, Christoph; Holmberg, Karl O.; Zhao, Miao et al.

Ingår i ChemPhotoChem, 2023

• DOI för An Indolin-3-imine Photobase and pH Sensitive Fluorophore
• Ladda ner fulltext (pdf) av An Indolin-3-imine Photobase and pH Sensitive Fluorophore

Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells

Lu, Xi; Zhong, Lei; Lindell, Emma; Veanes, Margus et al.

Ingår i Cell Death and Disease, 2023

• DOI för Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells
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Photoinduced ring‐opening and phototoxicity of an indolin‐3‐one derivative

Doloczki, Susanne; Kern, Christoph; Holmberg Olausson, Karl; Swartling, Fredrik J. et al.

Ingår i Chemistry - A European Journal, 2023

• DOI för Photoinduced ring‐opening and phototoxicity of an indolin‐3‐one derivative
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ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors

Mainwaring, Oliver; Weishaupt, Holger; Zhao, Miao; Rosén, Gabriela et al.

Ingår i Nature Communications, 2023

• DOI för ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors
• Ladda ner fulltext (pdf) av ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors

An Indolin-3-imine Photobase and pH Sensitive Fluorophore

Doloczki, Susanne; Kern, Christoph; Holmberg, Karl O.; Zhao, Miao et al.

Ingår i ChemPhotoChem, 2023

• DOI för An Indolin-3-imine Photobase and pH Sensitive Fluorophore
• Ladda ner fulltext (pdf) av An Indolin-3-imine Photobase and pH Sensitive Fluorophore

Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells

Lu, Xi; Zhong, Lei; Lindell, Emma; Veanes, Margus et al.

Ingår i Cell Death and Disease, 2023

• DOI för Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells
• Ladda ner fulltext (pdf) av Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells

Photoinduced ring‐opening and phototoxicity of an indolin‐3‐one derivative

Doloczki, Susanne; Kern, Christoph; Holmberg Olausson, Karl; Swartling, Fredrik J. et al.

Ingår i Chemistry - A European Journal, 2023

• DOI för Photoinduced ring‐opening and phototoxicity of an indolin‐3‐one derivative
• Ladda ner fulltext (pdf) av Photoinduced ring‐opening and phototoxicity of an indolin‐3‐one derivative

ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors

Mainwaring, Oliver; Weishaupt, Holger; Zhao, Miao; Rosén, Gabriela et al.

Ingår i Nature Communications, 2023

• DOI för ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors
• Ladda ner fulltext (pdf) av ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors

Novel cancer gene discovery using a forward genetic screen in RCAS-PDGFB-driven gliomas

Weishaupt, Holger; Čančer, Matko; Rosén, Gabriela; Holmberg, Karl O. et al.

Ingår i Neuro-Oncology, s. 97-107, 2023

• DOI för Novel cancer gene discovery using a forward genetic screen in RCAS-PDGFB-driven gliomas
• Ladda ner fulltext (pdf) av Novel cancer gene discovery using a forward genetic screen in RCAS-PDGFB-driven gliomas

Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions

Westergren Jakobsson, Amanda; Kundu, Snehangshu; Guo, Jing; Chowdhury, Azazul Islam et al.

Ingår i Cancers, 2022

• DOI för Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions
• Ladda ner fulltext (pdf) av Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions

Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma

Borgenvik, Anna; Holmberg, Karl O.; Bolin, Sara; Zhao, Miao et al.

Ingår i Cancer Research, s. 4586-4603, 2022

• DOI för Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma
• Ladda ner fulltext (pdf) av Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma

Article Basal cell carcinomas acquire secondary mutations to overcome dormancy and progress from microscopic to macroscopic disease

Trieu, Kenneth G.; Tsai, Shih-Ying; Eberl, Markus; Ju, Virginia et al.

Ingår i Cell Reports, 2022

• DOI för Article Basal cell carcinomas acquire secondary mutations to overcome dormancy and progress from microscopic to macroscopic disease
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Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples

Zhang, Hua; Polavarapu, Vamsi Krishna; Xing, Pengwei; Zhao, Miao et al.

Ingår i Genome Research, s. 150-161, 2022

• DOI för Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples
• Ladda ner fulltext (pdf) av Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples

Photophysical characterization and fluorescence cell imaging applications of 4-N-substituted benzothiadiazoles

Doloczki, Susanne; Holmberg, Karl O.; Galván, Ignacio Fdez.; Swartling, Fredrik J. et al.

Ingår i RSC Advances, s. 14544-14550, 2022

• DOI för Photophysical characterization and fluorescence cell imaging applications of 4-N-substituted benzothiadiazoles
• Ladda ner fulltext (pdf) av Photophysical characterization and fluorescence cell imaging applications of 4-N-substituted benzothiadiazoles

FACT-seq: profiling histone modifications in formalin-fixed paraffin-embedded samples with low cell numbers

Zhao, Linxuan; Xing, Pengwei; Polavarapu, Vamsi Krishna; Zhao, Miao et al.

Ingår i Nucleic Acids Research, 2021

• DOI för FACT-seq: profiling histone modifications in formalin-fixed paraffin-embedded samples with low cell numbers
• Ladda ner fulltext (pdf) av FACT-seq: profiling histone modifications in formalin-fixed paraffin-embedded samples with low cell numbers

SOX9 Defines Distinct Populations of Cells in SHH Medulloblastoma but Is Not Required for Math1-Driven Tumor Formation

Adolphe, Christelle; Millar, Amanda; Kojic, Marija; Barkauskas, Deborah S. et al.

Ingår i Molecular Cancer Research, s. 1831-1839, 2021

• DOI för SOX9 Defines Distinct Populations of Cells in SHH Medulloblastoma but Is Not Required for Math1-Driven Tumor Formation

The Irradiated Brain Microenvironment Supports Glioma Stemness and Survival via Astrocyte-Derived Transglutaminase 2

Berg, Tracy J.; Marques, Carolina; Pantazopoulou, Vasiliki; Johansson, Elinn et al.

Ingår i Cancer Research, s. 2101-2115, 2021

• DOI för The Irradiated Brain Microenvironment Supports Glioma Stemness and Survival via Astrocyte-Derived Transglutaminase 2

Indolylbenzothiadiazoles as highly tunable fluorophores for imaging lipid droplet accumulation in astrocytes and glioblastoma cells

Colas, Kilian; Holmberg Olausson, Karl; Chiang, Linus; Doloczki, Susanne et al.

Ingår i RSC Advances, s. 23960-23967, 2021

• DOI för Indolylbenzothiadiazoles as highly tunable fluorophores for imaging lipid droplet accumulation in astrocytes and glioblastoma cells
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Deep immune profiling reveals targetable mechanisms of immune evasion in immune checkpoint inhibitor-refractory glioblastoma

Simonds, Erin F.; Lu, Edbert D.; Badillo, Oscar; Karimi, Shokoufeh et al.

Ingår i Journal for ImmunoTherapy of Cancer, 2021

• DOI för Deep immune profiling reveals targetable mechanisms of immune evasion in immune checkpoint inhibitor-refractory glioblastoma
• Ladda ner fulltext (pdf) av Deep immune profiling reveals targetable mechanisms of immune evasion in immune checkpoint inhibitor-refractory glioblastoma

Perturbation-based gene regulatory network inference to unravel oncogenic mechanisms

Morgan, Daniel; Studham, Matthew; Tjarnberg, Andreas; Weishaupt, Holger et al.

Ingår i Scientific Reports, 2020

• DOI för Perturbation-based gene regulatory network inference to unravel oncogenic mechanisms
• Ladda ner fulltext (pdf) av Perturbation-based gene regulatory network inference to unravel oncogenic mechanisms

A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma

Johansson, Patrik; Krona, Cecilia; Kundu, Soumi; Doroszko, Milena et al.

Ingår i Cell Reports, 2020

• DOI för A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma
• Ladda ner fulltext (pdf) av A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma

Nuclear Receptor Binding Protein 2 Is Downregulated in Medulloblastoma, and Reduces Tumor Cell Survival upon Overexpression

Xiong, Anqi; Roy, Ananya; Spyrou, Argyris; Weishaupt, Holger et al.

Ingår i Cancers, 2020

• DOI för Nuclear Receptor Binding Protein 2 Is Downregulated in Medulloblastoma, and Reduces Tumor Cell Survival upon Overexpression
• Ladda ner fulltext (pdf) av Nuclear Receptor Binding Protein 2 Is Downregulated in Medulloblastoma, and Reduces Tumor Cell Survival upon Overexpression

Modeling SHH-driven medulloblastoma with patient iPS cell-derived neural stem cells

Susanto, Evelyn; Navarro, Ana Marin; Zhou, Leilei; Sundström, Anders et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 20127-20138, 2020

• DOI för Modeling SHH-driven medulloblastoma with patient iPS cell-derived neural stem cells
• Ladda ner fulltext (pdf) av Modeling SHH-driven medulloblastoma with patient iPS cell-derived neural stem cells

BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells

Cancer, Matko; Drews, Lisa F.; Bengtsson, Johan; Bolin, Sara et al.

Ingår i Cell Death and Disease, 2019

• DOI för BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells
• Ladda ner fulltext (pdf) av BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells

LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Xie, Yuan; Sundström, Anders; Maturi, Naga P; Tan, E-Jean et al.

Ingår i Journal of Pathology, s. 228-240, 2019

• DOI för LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Batch-normalization of cerebellar and medulloblastoma gene expression datasets utilizing empirically defined negative control genes

Weishaupt, Holger; Johansson, Patrik; Sundström, Anders; Lubovac-Pilav, Zelmina et al.

Ingår i Bioinformatics, s. 3357-3364, 2019

• DOI för Batch-normalization of cerebellar and medulloblastoma gene expression datasets utilizing empirically defined negative control genes
• Ladda ner fulltext (pdf) av Batch-normalization of cerebellar and medulloblastoma gene expression datasets utilizing empirically defined negative control genes

Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy

Čančer, Matko; Hutter, Sonja; Holmberg Olausson, Karl; Rosén, Gabriela et al.

Ingår i Cell Stem Cell, s. 855-870, 2019

• DOI för Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy
• Ladda ner fulltext (pdf) av Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy

Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis

Huang, Miller; Tailor, Jignesh; Zhen, Qiqi; Gillmor, Aaron H. et al.

Ingår i Cell Stem Cell, s. 433-+, 2019

• DOI för Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis
• Ladda ner fulltext (pdf) av Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis

Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma

Kahn, Suzana A.; Wang, Xin; Nitta, Ryan T.; Gholamin, Sharareh et al.

Ingår i Nature Communications, 2018

• DOI för Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma
• Ladda ner fulltext (pdf) av Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma

Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma

Bolin, Sara; Borgenvik, Anna; Persson, Camilla U.; Sundström, Anders et al.

Ingår i Oncogene, s. 2850-2862, 2018

• DOI för Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma
• Ladda ner fulltext (pdf) av Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma

Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity

Wallmann, Tatjana; Zhang, Xing-Mei; Wallerius, Majken; Bolin, Sara et al.

Ingår i iScience, s. 71-83, 2018

• DOI för Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity
• Ladda ner fulltext (pdf) av Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity

GMYC: A Novel Inducible Transgenic Model of Group 3 Medulloblastoma

Weishaupt, Holger; Mainwaring, Oliver; Hutter, Sonja; Kalushkova, Antonia et al.

Ingår i Neuro-Oncology, s. 137-137, 2018

• DOI för GMYC: A Novel Inducible Transgenic Model of Group 3 Medulloblastoma

Targeting PRUNE-1 in a GEMM of Metastatic Medulloblastoma: A Potential Route of Inhibition for New Future Therapies

Ferrucci, Veronica; de Antonellis, Pasqualino; Pennino, Francesco Paolo; Asadzadeh, Fatemeh et al.

Ingår i Neuro-Oncology, s. 139-139, 2018

• DOI för Targeting PRUNE-1 in a GEMM of Metastatic Medulloblastoma: A Potential Route of Inhibition for New Future Therapies

Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1–TGF-β–OTX2–SNAIL via PTEN inhibitio

Ferrucci, Veronica; de Antonellis, Pasqualino; Pennino, Francesco Paolo; Asadzadeh, Fatemeh et al.

Ingår i Brain, s. 1300-1319, 2018

• DOI för Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1–TGF-β–OTX2–SNAIL via PTEN inhibitio

Serglycin as a potential biomarker for glioma: association of serglycin expression, extent of mast cell recruitment and glioblastoma progression

Roy, Ananya; Attarha, Sanaz; Weishaupt, Holger; Edqvist, Per-Henrik et al.

Ingår i Oncotarget, s. 24815-24827, 2017

• DOI för Serglycin as a potential biomarker for glioma: association of serglycin expression, extent of mast cell recruitment and glioblastoma progression
• Ladda ner fulltext (pdf) av Serglycin as a potential biomarker for glioma: association of serglycin expression, extent of mast cell recruitment and glioblastoma progression

Mast Cell Infiltration in Human Brain Metastases Modulates the Microenvironment and Contributes to the Metastatic Potential

Roy, Ananya; Libard, Sylwia; Weishaupt, Holger; Gustavsson, Ida et al.

Ingår i Frontiers in Oncology, 2017

• DOI för Mast Cell Infiltration in Human Brain Metastases Modulates the Microenvironment and Contributes to the Metastatic Potential
• Ladda ner fulltext (pdf) av Mast Cell Infiltration in Human Brain Metastases Modulates the Microenvironment and Contributes to the Metastatic Potential

Mouse models of pediatric supratentorial high-grade glioma reveal how cell-of-origin influences tumor development and phenotype

Sreedharan, Smitha; Maturi, Naga Prathyusha; Xie, Yuan; Sundström, Anders et al.

Ingår i Cancer Research, s. 802-812, 2017

• DOI för Mouse models of pediatric supratentorial high-grade glioma reveal how cell-of-origin influences tumor development and phenotype

Targeting SOX9 for degradation to inhibit chemoresistance, metastatic spread, and recurrence

Rahmanto, Aldwin Suryo; Swartling, Fredrik J.; Sangfelt, Olle

Ingår i Molecular & Cellular Oncology, 2017

• DOI för Targeting SOX9 for degradation to inhibit chemoresistance, metastatic spread, and recurrence

Loss of Conservation of Graph Centralities in Reverse-engineered Transcriptional Regulatory Networks

Weishaupt, Holger; Johansson, Patrik; Engström, Christopher; Nelander, Sven et al.

Ingår i Methodology and Computing in Applied Probability, s. 1089-1105, 2017

• DOI för Loss of Conservation of Graph Centralities in Reverse-engineered Transcriptional Regulatory Networks
• Ladda ner fulltext (pdf) av Loss of Conservation of Graph Centralities in Reverse-engineered Transcriptional Regulatory Networks

Utilizing the Dog Genome in the Search for Novel Candidate Genes Involved in Glioma Development-Genome Wide Association Mapping followed by Targeted Massive Parallel Sequencing Identifies a Strongly Associated Locus

Truve, Katarina; Dickinson, Peter; Xiong, Anqi; York, Daniel et al.

Ingår i PLOS Genetics, 2016

• DOI för Utilizing the Dog Genome in the Search for Novel Candidate Genes Involved in Glioma Development-Genome Wide Association Mapping followed by Targeted Massive Parallel Sequencing Identifies a Strongly Associated Locus
• Ladda ner fulltext (pdf) av Utilizing the Dog Genome in the Search for Novel Candidate Genes Involved in Glioma Development-Genome Wide Association Mapping followed by Targeted Massive Parallel Sequencing Identifies a Strongly Associated Locus

FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma

Rahmanto, Aldwin Suryo; Savov, Vasil; Brunner, Andrä; Bolin, Sara et al.

Ingår i EMBO Journal, s. 2192-2212, 2016

• DOI för FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma
• Ladda ner fulltext (pdf) av FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma

Combined MYC and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease

Hill, Rebecca M.; Kuijper, Sanne; Lindsey, Janet C.; Petrie, Kevin et al.

Ingår i Cancer Cell, s. 72-84, 2015

• DOI för Combined MYC and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease
• Ladda ner fulltext (pdf) av Combined MYC and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease

BET Bromodomain Inhibition of MYC-Amplified Medulloblastoma

Bandopadhayay, Pratiti; Bergthold, Guillaume; Nguyen, Brian; Schubert, Simone et al.

Ingår i Clinical Cancer Research, s. 912-925, 2014

• DOI för BET Bromodomain Inhibition of MYC-Amplified Medulloblastoma

Metastasis and Tumor Recurrence from Rare SOX9-Positive Cells in MYCN-Driven Medulloblastoma

Swartling, Fredrik J.; Savov, Vasil; Cancer, Matko; Bolin, Sara et al.

Ingår i Neuro-Oncology, 2014

• DOI för Metastasis and Tumor Recurrence from Rare SOX9-Positive Cells in MYCN-Driven Medulloblastoma

Medulloblastoma models which harbor amplifications of myc family members are sensitive to BET-Bromodomain inhibition

Bandopadhayay, Pratiti; Bergthold, Guillaume; Nguyen, Brian; Schubert, Simone et al.

Ingår i Neuro-Oncology, s. 90-90, 2014

MYC and TP53 defects interact at medulloblastoma relapse to define rapidly progressive disease and can be targeted therapeutically

Hill, Rebecca M.; Kuijper, Sanne; Lindsey, Janet; Schwalbe, Ed C. et al.

Ingår i Cancer Research, 2014

• DOI för MYC and TP53 defects interact at medulloblastoma relapse to define rapidly progressive disease and can be targeted therapeutically

Glial origin for MYCN-driven medulloblastoma and targeted prosenescence therapies

Bolin, Sara M.; Lau, Jasmine; Chen, Justin; Savov, Vasil et al.

Ingår i Cancer Research, 2014

• DOI för Glial origin for MYCN-driven medulloblastoma and targeted prosenescence therapies

Metastasis and tumor recurrence from rare SOX9-positive cells in Group 4 medulloblastoma

Savov, Vasil; Fotaki, Grammatiki; Remke, Marc; Dubuc, Adrian M. et al.

Ingår i Cancer Research, 2014

• DOI för Metastasis and tumor recurrence from rare SOX9-positive cells in Group 4 medulloblastoma

Targeting the Translational Apparatus in Mycn-Driven Medulloblastoma

Meyerowitz, Justin G.; Gustafson, W. Clay; Nekritz, Erin A.; Swartling, Fredrik et al.

Ingår i Neuro-Oncology, s. 16-16, 2013

Humanized Mouse Models for Medulloblastoma

Huang, Miller; Persson, Anders; Swartling, Fredrik; Moriarity, Branden et al.

Ingår i Neuro-Oncology, s. 30-30, 2013

A glial origin for medulloblastoma and inhibition of MYCN stabilization

Bolin, Sara; Lau, Jasmine; Savov, Vasil; Chen, Justin et al.

Ingår i Cancer Research, 2013

• DOI för A glial origin for medulloblastoma and inhibition of MYCN stabilization

miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma

Põlajeva, Jelena; Swartling, Fredrik; Jiang, Yiwen; Singh, Umashankar et al.

Ingår i BMC Cancer, s. 378, 2012

• DOI för miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma
• Ladda ner fulltext (pdf) av miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma

Distinct Neural Stem Cell Populations Give Rise to Disparate Brain Tumors in Response to N-MYC

Swartling, Fredrik J.; Savov, Vasil; Persson, Anders I.; Chen, Justin et al.

Ingår i Cancer Cell, s. 601-613, 2012

• DOI för Distinct Neural Stem Cell Populations Give Rise to Disparate Brain Tumors in Response to N-MYC

Pleiotropic role for MYCN in medulloblastoma

Swartling, Fredrik Johansson; Grimmer, Matthew R; Hackett, Christopher S; Northcott, Paul A et al.

Ingår i Genes & Development, s. 1059-1072, 2010

• DOI för Pleiotropic role for MYCN in medulloblastoma

Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines

Swartling, Fredrik J.; Ferletta, Maria; Kastemar, Marianne; Weiss, W. A. et al.

Ingår i Oncogene, s. 3121-3131, 2009

• DOI för Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines

Expression analysis of genes involved in brain tumor progression driven by retroviral insertional mutagenesis in mice

Johansson, Fredrik K; Göransson, Hanna; Westermark, Bengt

Ingår i Oncogene, s. 3896-3905, 2005

• DOI för Expression analysis of genes involved in brain tumor progression driven by retroviral insertional mutagenesis in mice

Identification of candidate cancer-causing genes in mouse brain tumors by retroviral tagging

Johansson, Fredrik K.; Brodd, Josefin; Eklöf, Charlotta; Ferletta, Maria et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 11334-11337, 2004

• DOI för Identification of candidate cancer-causing genes in mouse brain tumors by retroviral tagging

Dormant SOX9-positive cells behind MYC-driven medulloblastoma recurrence

Bolin, Sara; Borgenvik, Anna; Savov, Vasil; Holmberg Olausson, Karl et al.

Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies

Holmberg Olausson, Karl O.; Borgenvik, Anna; Zhao, Miao; Giraud, Géraldine et al.

Ingår i Cancers, 2024

• DOI för Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies
• Ladda ner fulltext (pdf) av Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies

Targeting MYCN in Molecularly Defined Malignant Brain Tumors

Borgenvik, Anna; Cancer, Matko; Hutter, Sonja; Swartling, Fredrik J.

Ingår i Frontiers in Oncology, 2021

• DOI för Targeting MYCN in Molecularly Defined Malignant Brain Tumors
• Ladda ner fulltext (pdf) av Targeting MYCN in Molecularly Defined Malignant Brain Tumors

Medulloblastomics revisited: biological and clinical insights from thousands of patients

Hovestadt, Volker; Ayrault, Olivier; Johansson Swartling, Fredrik K.; Robinson, Giles W. et al.

Ingår i Nature Reviews. Cancer, s. 42-56, 2020

• DOI för Medulloblastomics revisited: biological and clinical insights from thousands of patients

Modeling and Targeting MYC Genes in Childhood Brain Tumors

Hutter, Sonja; Bolin, Sara; Weishaupt, Holger; Johansson, Fredrik K.

Ingår i Genes, 2017

• DOI för Modeling and Targeting MYC Genes in Childhood Brain Tumors
• Ladda ner fulltext (pdf) av Modeling and Targeting MYC Genes in Childhood Brain Tumors

Medulloblastoma: experimental models and reality

Neumann, Julia E.; Johansson, Fredrik K.; Schueller, Ulrich

Ingår i Acta Neuropathologica, s. 679-689, 2017

• DOI för Medulloblastoma: experimental models and reality

Deregulated proliferation and differentiation in brain tumors

Swartling, Fredrik J; Cančer, Matko; Frantz, Aaron; Weishaupt, Holger et al.

Ingår i Cell and Tissue Research, s. 225-254, 2015

• DOI för Deregulated proliferation and differentiation in brain tumors

Signals that regulate the oncogenic fate of neural stem cells and progenitors

Swartling, Fredrik J.; Bolin, Sara; Phillips, Joanna J; Persson, Anders I.

Ingår i Experimental Neurology, s. 56-68, 2014

• DOI för Signals that regulate the oncogenic fate of neural stem cells and progenitors

Oncoprotein stabilization in brain tumors

Hede, Sanna-Maria; Savov, Vasil; Weishaupt, Holger; Sangfelt, O. et al.

Ingår i Oncogene, s. 4709-4721, 2014

• DOI för Oncoprotein stabilization in brain tumors

What underlies the diversity of brain tumors?

Swartling, Fredrik J.; Hede, Sanna-Maria; Weiss, William A.

Ingår i Cancer Metastasis Review, s. 5-24, 2013

• DOI för What underlies the diversity of brain tumors?

Myc proteins in brain tumor development and maintenance

Swartling, Fredrik J.

Ingår i Upsala Journal of Medical Sciences, s. 122-131, 2012

• DOI för Myc proteins in brain tumor development and maintenance

Identifying Candidate Genes Involved in Brain Tumor Formation

Swartling, Fredrik Johansson

Ingår i Upsala Journal of Medical Sciences, s. 1-38, 2008

Comparing the Landcapes of Common Retroviral Insertion Sites across Tumor Models

Weishaupt, Holger; Čančer, Matko; Engström, Cristopher; Silvestrov, Sergei et al.

Ingår i ICNPAA 2016 WORLD CONGRESS, 2017

• DOI för Comparing the Landcapes of Common Retroviral Insertion Sites across Tumor Models

CDK2 as a therapeutic target in MYC-driven medulloblastoma

Borgenvik, Anna; Rosén, Gabriela; Holmberg Olausson, Karl; Larsson, Lars-Gunnar et al.

Photoreceptor-positive cells of tumor origin in MYC-driven Group 3 medulloblastoma

Zhao, Miao; Mainwaring, Oliver; Rosén, Gabriela; Rijpkema, Sanne et al.

Targeting SOX2 in glioblastoma cells reveals heterogeneity in SOX2 dependency

Dalmo, Erika; Rosén, Gabriela; Niklasson, Mia; Bergström, Tobias et al.

Prioritization of candidate cancer genes on chromosome 17q through reverse engineered transcriptional regulatory networks in medulloblastoma groups 3 and 4

Weishaupt, Holger; Johansson, Patrik; Mainwaring, Oliver; Hutter, Sonja et al.

Paired glioblastoma cell cultures of the fluorescent bulk tumor and non-fluorescent tumor margin display differential phenotypes and cell states across patients

Neves, Inês; Lu, Xi; Maturi, Nagaprathyusha; Dang, Yonglong et al.

RAP1GAP Suppression Promotes Stemness and Inhibits Glioblastoma Cell Migration

Põlajeva, Jelena; Kastemar, Marianne; Tchougounova, Elena; Zeller, Kathrin et al.