Sven Nelander

Modeling glioblastoma heterogeneity as a dynamic network of cell states

Larsson, Ida; Lundin, Erika; Elgendy, Ramy; Niklasson, Mia et al.

Ingår i Molecular Systems Biology, 2021

• DOI för Modeling glioblastoma heterogeneity as a dynamic network of cell states
• Ladda ner fulltext (pdf) av Modeling glioblastoma heterogeneity as a dynamic network of cell states

Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma

Vinel, Claire; Rosser, Gabriel; Guglielmi, Loredana; Constantinou, Myrianni et al.

Ingår i Nature Communications, 2021

• DOI för Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma
• Ladda ner fulltext (pdf) av Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma

Single-cell RNAseq and longitudinal proteomic analysis of a novel semi-spontaneous urothelial cancer model reveals tumor cell heterogeneity and pretumoral urine protein alterations

Kerzeli, Iliana Kyriaki; Lord, Martin; Doroszko, Milena; Elgendy, Ramy et al.

Ingår i PLOS ONE, 2021

• DOI för Single-cell RNAseq and longitudinal proteomic analysis of a novel semi-spontaneous urothelial cancer model reveals tumor cell heterogeneity and pretumoral urine protein alterations
• Ladda ner fulltext (pdf) av Single-cell RNAseq and longitudinal proteomic analysis of a novel semi-spontaneous urothelial cancer model reveals tumor cell heterogeneity and pretumoral urine protein alterations

Real-time evaluation of glioblastoma growth in patient-specific zebrafish xenografts

Almstedt, Elin; Rosén, Emil; Gloger, Marleen; Rebecka, Stockard et al.

Ingår i Neuro-Oncology, s. 726-738, 2021

• DOI för Real-time evaluation of glioblastoma growth in patient-specific zebrafish xenografts
• Ladda ner fulltext (pdf) av Real-time evaluation of glioblastoma growth in patient-specific zebrafish xenografts

A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma

Johansson, Patrik; Krona, Cecilia; Kundu, Soumi; Doroszko, Milena et al.

Ingår i Cell Reports, 2020

• DOI för A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma
• Ladda ner fulltext (pdf) av A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma

Integrative discovery of treatments for high-risk neuroblastoma

Almstedt, Elin; Elgendy, Ramy; Hekmati, Neda; Rosén, Emil et al.

Ingår i Nature Communications, 2020

• DOI för Integrative discovery of treatments for high-risk neuroblastoma
• Ladda ner fulltext (pdf) av Integrative discovery of treatments for high-risk neuroblastoma

HCN Channel Activity Balances Quiescence and Proliferation in Neural Stem Cells and Is a Selective Target for Neuroprotection During Cancer Treatment

Johard, Helena; Omelyanenko, Anna; Fei, Gao; Zilberter, Misha et al.

Ingår i Molecular Cancer Research, s. 1522-1533, 2020

• DOI för HCN Channel Activity Balances Quiescence and Proliferation in Neural Stem Cells and Is a Selective Target for Neuroprotection During Cancer Treatment

BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells

Cancer, Matko; Drews, Lisa F.; Bengtsson, Johan; Bolin, Sara et al.

Ingår i Cell Death and Disease, 2019

• DOI för BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells
• Ladda ner fulltext (pdf) av BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells

LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Xie, Yuan; Sundström, Anders; Maturi, Naga P; Tan, E-Jean et al.

Ingår i Journal of Pathology, s. 228-240, 2019

• DOI för LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Primary glioblastoma cells for precision medicine: a quantitative portrait of genomic (in)stability during the first 30 passages

Baskaran, Sathishkumar; Mayrhofer, Markus; Göransson Kultima, Hanna; Bergström, Tobias et al.

Ingår i Neuro-Oncology, s. 1080-1091, 2018

• DOI för Primary glioblastoma cells for precision medicine: a quantitative portrait of genomic (in)stability during the first 30 passages
• Ladda ner fulltext (pdf) av Primary glioblastoma cells for precision medicine: a quantitative portrait of genomic (in)stability during the first 30 passages

Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin

Jiang, Yiwen; Marinescu, Voichita Dana; Xie, Yuan; Jarvius, Malin et al.

Ingår i Cell Reports, s. 977-990, 2017

• DOI för Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin
• Ladda ner fulltext (pdf) av Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin

Mathematical modeling of multicellular tumor spheroids quantifies inter-patient and intra-tumor heterogeneity

Malik, Adam A.; Nguyen, Kyle C.; Nardini, John T.; Krona, Cecilia et al.

Ingår i npj Systems Biology and Applications, 2025

• DOI för Mathematical modeling of multicellular tumor spheroids quantifies inter-patient and intra-tumor heterogeneity
• Ladda ner fulltext (pdf) av Mathematical modeling of multicellular tumor spheroids quantifies inter-patient and intra-tumor heterogeneity

Brain tumors induce immunoregulatory dendritic cells in draining lymph nodes that can be targeted by OX40 agonist treatment

Badillo-Godinez, Oscar; Niemi, Jenni; Helfridsson, Liam; Karimi, Shokoufeh et al.

Ingår i Journal for ImmunoTherapy of Cancer, 2025

• DOI för Brain tumors induce immunoregulatory dendritic cells in draining lymph nodes that can be targeted by OX40 agonist treatment
• Ladda ner fulltext (pdf) av Brain tumors induce immunoregulatory dendritic cells in draining lymph nodes that can be targeted by OX40 agonist treatment

Reconstructing the regulatory programs underlying the phenotypic plasticity of neural cancers

Larsson, Ida; Held, Felix; Popova, Gergana; Koc, Alper et al.

Ingår i Nature Communications, 2024

• DOI för Reconstructing the regulatory programs underlying the phenotypic plasticity of neural cancers
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Lineage specification in glioblastoma is regulated by METTL7B

Constantinou, Myrianni; Nicholson, James; Zhang, Xinyu; Maniati, Eleni et al.

Ingår i Cell Reports, 2024

• DOI för Lineage specification in glioblastoma is regulated by METTL7B
• Ladda ner fulltext (pdf) av Lineage specification in glioblastoma is regulated by METTL7B

Inference of glioblastoma migration and proliferation rates using single time-point images

Rosén, Emil; Mangukiya, Hitesh; Elfineh, Lioudmila; Stockgard, Rebecka et al.

Ingår i Communications Biology, 2023

• DOI för Inference of glioblastoma migration and proliferation rates using single time-point images
• Ladda ner fulltext (pdf) av Inference of glioblastoma migration and proliferation rates using single time-point images

Mathematical modeling of multicellular tumor spheroids quantifies inter-patient and intra-tumor heterogeneity

Malik, Adam A.; Nguyen, Kyle C.; Nardini, John T.; Krona, Cecilia et al.

Ingår i npj Systems Biology and Applications, 2025

• DOI för Mathematical modeling of multicellular tumor spheroids quantifies inter-patient and intra-tumor heterogeneity
• Ladda ner fulltext (pdf) av Mathematical modeling of multicellular tumor spheroids quantifies inter-patient and intra-tumor heterogeneity

Brain tumors induce immunoregulatory dendritic cells in draining lymph nodes that can be targeted by OX40 agonist treatment

Badillo-Godinez, Oscar; Niemi, Jenni; Helfridsson, Liam; Karimi, Shokoufeh et al.

Ingår i Journal for ImmunoTherapy of Cancer, 2025

• DOI för Brain tumors induce immunoregulatory dendritic cells in draining lymph nodes that can be targeted by OX40 agonist treatment
• Ladda ner fulltext (pdf) av Brain tumors induce immunoregulatory dendritic cells in draining lymph nodes that can be targeted by OX40 agonist treatment

Reconstructing the regulatory programs underlying the phenotypic plasticity of neural cancers

Larsson, Ida; Held, Felix; Popova, Gergana; Koc, Alper et al.

Ingår i Nature Communications, 2024

• DOI för Reconstructing the regulatory programs underlying the phenotypic plasticity of neural cancers
• Ladda ner fulltext (pdf) av Reconstructing the regulatory programs underlying the phenotypic plasticity of neural cancers

Lineage specification in glioblastoma is regulated by METTL7B

Constantinou, Myrianni; Nicholson, James; Zhang, Xinyu; Maniati, Eleni et al.

Ingår i Cell Reports, 2024

• DOI för Lineage specification in glioblastoma is regulated by METTL7B
• Ladda ner fulltext (pdf) av Lineage specification in glioblastoma is regulated by METTL7B

Inference of glioblastoma migration and proliferation rates using single time-point images

Rosén, Emil; Mangukiya, Hitesh; Elfineh, Lioudmila; Stockgard, Rebecka et al.

Ingår i Communications Biology, 2023

• DOI för Inference of glioblastoma migration and proliferation rates using single time-point images
• Ladda ner fulltext (pdf) av Inference of glioblastoma migration and proliferation rates using single time-point images

Live Detection of Neural Progenitors and Glioblastoma Cells by an Oligothiophene Derivative

Ilkhanizadeh, Shirin; Gracias, Aileen; Aslund, Andreas K. O.; Back, Marcus et al.

Ingår i ACS Applied Bio Materials, s. 3790-3797, 2023

• DOI för Live Detection of Neural Progenitors and Glioblastoma Cells by an Oligothiophene Derivative
• Ladda ner fulltext (pdf) av Live Detection of Neural Progenitors and Glioblastoma Cells by an Oligothiophene Derivative

Knowledge of the perturbation design is essential for accurate gene regulatory network inference

Secilmis, Deniz; Hillerton, Thomas; Tjärnberg, Andreas; Nelander, Sven et al.

Ingår i Scientific Reports, 2022

• DOI för Knowledge of the perturbation design is essential for accurate gene regulatory network inference
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Fast and accurate gene regulatory network inference by normalized least squares regression

Hillerton, Thomas; Secilmi, Deniz; Nelander, Sven; Sonnhammer, Erik L. L. et al.

Ingår i Bioinformatics, s. 2263-2268, 2022

• DOI för Fast and accurate gene regulatory network inference by normalized least squares regression
• Ladda ner fulltext (pdf) av Fast and accurate gene regulatory network inference by normalized least squares regression

Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape

Boot, James; Rosser, Gabriel; Kancheva, Dailya; Vinel, Claire et al.

Ingår i eLIFE, 2022

• DOI för Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape
• Ladda ner fulltext (pdf) av Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape

Optimal Sparsity Selection Based on an Information Criterion for Accurate Gene Regulatory Network Inference

Secilmis, Deniz; Nelander, Sven; Sonnhammer, Erik L. L.

Ingår i Frontiers in Genetics, 2022

• DOI för Optimal Sparsity Selection Based on an Information Criterion for Accurate Gene Regulatory Network Inference
• Ladda ner fulltext (pdf) av Optimal Sparsity Selection Based on an Information Criterion for Accurate Gene Regulatory Network Inference

MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner

Castell, Alina; Yan, Qinzi; Fawkner, Karin; Bazzar, Wesam et al.

Ingår i Cancer Research Communications, s. 182-201, 2022

• DOI för MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner
• Ladda ner fulltext (pdf) av MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner

Autocrine signaling can explain the emergence of Allee effects in cancer cell populations

Gerlee, Philip; Altrock, Philipp M.; Malik, Adam; Krona, Cecilia et al.

Ingår i PloS Computational Biology, 2022

• DOI för Autocrine signaling can explain the emergence of Allee effects in cancer cell populations
• Ladda ner fulltext (pdf) av Autocrine signaling can explain the emergence of Allee effects in cancer cell populations

Inferring the experimental design for accurate gene regulatory network inference

Secilmis, Deniz; Hillerton, Thomas; Nelander, Sven; Sonnhammer, Erik L. L.

Ingår i Bioinformatics, s. 3553-3559, 2021

• DOI för Inferring the experimental design for accurate gene regulatory network inference
• Ladda ner fulltext (pdf) av Inferring the experimental design for accurate gene regulatory network inference

p53-Mediated Radiosensitization of ¹⁷⁷Lu-DOTATATE in Neuroblastoma Tumor Spheroids

Lundsten, Sara; Berglund, Hanna; Jha, Preeti; Krona, Cecilia et al.

Ingår i Biomolecules, 2021

• DOI för p53-Mediated Radiosensitization of ¹⁷⁷Lu-DOTATATE in Neuroblastoma Tumor Spheroids
• Ladda ner fulltext (pdf) av p53-Mediated Radiosensitization of ¹⁷⁷Lu-DOTATATE in Neuroblastoma Tumor Spheroids

Modeling glioblastoma heterogeneity as a dynamic network of cell states

Larsson, Ida; Lundin, Erika; Elgendy, Ramy; Niklasson, Mia et al.

Ingår i Molecular Systems Biology, 2021

• DOI för Modeling glioblastoma heterogeneity as a dynamic network of cell states
• Ladda ner fulltext (pdf) av Modeling glioblastoma heterogeneity as a dynamic network of cell states

Modeling glioblastoma heterogeneity as a dynamic network of cell states

Larsson, Ida; Dalmo, Erika; Elgendy, Ramy; Niklasson, Mia et al.

Ingår i Molecular Systems Biology, 2021

Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma

Vinel, Claire; Rosser, Gabriel; Guglielmi, Loredana; Constantinou, Myrianni et al.

Ingår i Nature Communications, 2021

• DOI för Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma
• Ladda ner fulltext (pdf) av Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma

NF1 regulates mesenchymal gliblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1

Marques, Carolina; Unterkircher, Thomas; Kroon, Paula; Oldrini, Barbara et al.

Ingår i eLIFE, 2021

• DOI för NF1 regulates mesenchymal gliblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1
• Ladda ner fulltext (pdf) av NF1 regulates mesenchymal gliblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1

Single-cell RNAseq and longitudinal proteomic analysis of a novel semi-spontaneous urothelial cancer model reveals tumor cell heterogeneity and pretumoral urine protein alterations

Kerzeli, Iliana Kyriaki; Lord, Martin; Doroszko, Milena; Elgendy, Ramy et al.

Ingår i PLOS ONE, 2021

• DOI för Single-cell RNAseq and longitudinal proteomic analysis of a novel semi-spontaneous urothelial cancer model reveals tumor cell heterogeneity and pretumoral urine protein alterations
• Ladda ner fulltext (pdf) av Single-cell RNAseq and longitudinal proteomic analysis of a novel semi-spontaneous urothelial cancer model reveals tumor cell heterogeneity and pretumoral urine protein alterations

Real-time evaluation of glioblastoma growth in patient-specific zebrafish xenografts

Almstedt, Elin; Rosén, Emil; Gloger, Marleen; Rebecka, Stockard et al.

Ingår i Neuro-Oncology, s. 726-738, 2021

• DOI för Real-time evaluation of glioblastoma growth in patient-specific zebrafish xenografts
• Ladda ner fulltext (pdf) av Real-time evaluation of glioblastoma growth in patient-specific zebrafish xenografts

Uncovering cancer gene regulation by accurate regulatory network inference from uninformative data

Secilmis, Deniz; Hillerton, Thomas; Morgan, Daniel; Tjärnberg, Andreas et al.

Ingår i npj Systems Biology and Applications, 2020

• DOI för Uncovering cancer gene regulation by accurate regulatory network inference from uninformative data
• Ladda ner fulltext (pdf) av Uncovering cancer gene regulation by accurate regulatory network inference from uninformative data

A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma

Johansson, Patrik; Krona, Cecilia; Kundu, Soumi; Doroszko, Milena et al.

Ingår i Cell Reports, 2020

• DOI för A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma
• Ladda ner fulltext (pdf) av A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma

Integrative discovery of treatments for high-risk neuroblastoma

Almstedt, Elin; Elgendy, Ramy; Hekmati, Neda; Rosén, Emil et al.

Ingår i Nature Communications, 2020

• DOI för Integrative discovery of treatments for high-risk neuroblastoma
• Ladda ner fulltext (pdf) av Integrative discovery of treatments for high-risk neuroblastoma

Growth-Inhibitory Activity of Bone Morphogenetic Protein 4 in Human Glioblastoma Cell Lines Is Heterogeneous and Dependent on Reduced SOX2 Expression

Dalmo, Erika; Johansson, Patrik; Niklasson, Mia; Gustavsson, Ida et al.

Ingår i Molecular Cancer Research, s. 981-991, 2020

• DOI för Growth-Inhibitory Activity of Bone Morphogenetic Protein 4 in Human Glioblastoma Cell Lines Is Heterogeneous and Dependent on Reduced SOX2 Expression

Monotherapy efficacy of blood-brain barrier permeable small molecule reactivators of protein phosphatase 2A in glioblastoma

Merisaari, Joni; Denisova, Oxana; Doroszko, Milena; Le Joncour, Vadim et al.

Ingår i Brain Communications, 2020

• DOI för Monotherapy efficacy of blood-brain barrier permeable small molecule reactivators of protein phosphatase 2A in glioblastoma
• Ladda ner fulltext (pdf) av Monotherapy efficacy of blood-brain barrier permeable small molecule reactivators of protein phosphatase 2A in glioblastoma

Astrocytes enhance glioblastoma growth.

Mega, Alessandro; Hartmark Nilsen, Mette; Leiss, Lina Wik; Tobin, Nicholas P et al.

Ingår i Glia, s. 316-327, 2020

• DOI för Astrocytes enhance glioblastoma growth.

HCN Channel Activity Balances Quiescence and Proliferation in Neural Stem Cells and Is a Selective Target for Neuroprotection During Cancer Treatment

Johard, Helena; Omelyanenko, Anna; Fei, Gao; Zilberter, Misha et al.

Ingår i Molecular Cancer Research, s. 1522-1533, 2020

• DOI för HCN Channel Activity Balances Quiescence and Proliferation in Neural Stem Cells and Is a Selective Target for Neuroprotection During Cancer Treatment

BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells

Cancer, Matko; Drews, Lisa F.; Bengtsson, Johan; Bolin, Sara et al.

Ingår i Cell Death and Disease, 2019

• DOI för BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells
• Ladda ner fulltext (pdf) av BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells

Increasing the accuracy of glioblastoma subtypes: Factoring in the tumor's cell of origin

Nelander, Sven

Ingår i Molecular & Cellular Oncology, 2019

• DOI för Increasing the accuracy of glioblastoma subtypes: Factoring in the tumor's cell of origin
• Ladda ner fulltext (pdf) av Increasing the accuracy of glioblastoma subtypes: Factoring in the tumor's cell of origin

Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors

Kaffes, Ioannis; Szulzewsky, Frank; Chen, Zhihong; Herting, Cameron J. et al.

Ingår i Oncoimmunology, 2019

• DOI för Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors
• Ladda ner fulltext (pdf) av Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors

Batch-normalization of cerebellar and medulloblastoma gene expression datasets utilizing empirically defined negative control genes

Weishaupt, Holger; Johansson, Patrik; Sundström, Anders; Lubovac-Pilav, Zelmina et al.

Ingår i Bioinformatics, s. 3357-3364, 2019

• DOI för Batch-normalization of cerebellar and medulloblastoma gene expression datasets utilizing empirically defined negative control genes
• Ladda ner fulltext (pdf) av Batch-normalization of cerebellar and medulloblastoma gene expression datasets utilizing empirically defined negative control genes

Integrin alpha 10, a Novel Therapeutic Target in Glioblastoma, Regulates Cell Migration, Proliferation, and Survival

Thoren, Matilda Munksgaard; Masoumi, Katarzyna Chmielarska; Krona, Cecilia; Huang, Xiaoli et al.

Ingår i Cancers, 2019

• DOI för Integrin alpha 10, a Novel Therapeutic Target in Glioblastoma, Regulates Cell Migration, Proliferation, and Survival
• Ladda ner fulltext (pdf) av Integrin alpha 10, a Novel Therapeutic Target in Glioblastoma, Regulates Cell Migration, Proliferation, and Survival

LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Xie, Yuan; Sundström, Anders; Maturi, Naga P; Tan, E-Jean et al.

Ingår i Journal of Pathology, s. 228-240, 2019

• DOI för LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Image-Based Detection of Patient-Specific Drug-Induced Cell-Cycle Effects in Glioblastoma

Matuszewski, Damian J.; Wählby, Carolina; Krona, Cecilia; Nelander, Sven et al.

Ingår i SLAS Discovery, s. 1030-1039, 2018

• DOI för Image-Based Detection of Patient-Specific Drug-Induced Cell-Cycle Effects in Glioblastoma

Primary glioblastoma cells for precision medicine: a quantitative portrait of genomic (in)stability during the first 30 passages

Baskaran, Sathishkumar; Mayrhofer, Markus; Göransson Kultima, Hanna; Bergström, Tobias et al.

Ingår i Neuro-Oncology, s. 1080-1091, 2018

• DOI för Primary glioblastoma cells for precision medicine: a quantitative portrait of genomic (in)stability during the first 30 passages
• Ladda ner fulltext (pdf) av Primary glioblastoma cells for precision medicine: a quantitative portrait of genomic (in)stability during the first 30 passages

c-Jun-N-terminal phosphorylation regulates DNMT1 expression and genome wide methylation in gliomas

Heiland, Dieter H.; Ferrarese, Roberto; Claus, Rainer; Dai, Fangping et al.

Ingår i Oncotarget, s. 6940-6954, 2017

• DOI för c-Jun-N-terminal phosphorylation regulates DNMT1 expression and genome wide methylation in gliomas

Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin

Jiang, Yiwen; Marinescu, Voichita Dana; Xie, Yuan; Jarvius, Malin et al.

Ingår i Cell Reports, s. 977-990, 2017

• DOI för Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin
• Ladda ner fulltext (pdf) av Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin

Safe and effective treatment of experimental neuroblastoma and glioblastoma using systemically administered triple microRNA-detargeted oncolytic Semliki Forest virus

Ramachandran, Mohanraj; Yu, Di; Dyczynski, Matheus; Baskaran, Sathishkumar et al.

Ingår i Clinical Cancer Research, s. 1519-1530, 2017

• DOI för Safe and effective treatment of experimental neuroblastoma and glioblastoma using systemically administered triple microRNA-detargeted oncolytic Semliki Forest virus

Loss of Conservation of Graph Centralities in Reverse-engineered Transcriptional Regulatory Networks

Weishaupt, Holger; Johansson, Patrik; Engström, Christopher; Nelander, Sven et al.

Ingår i Methodology and Computing in Applied Probability, s. 1089-1105, 2017

• DOI för Loss of Conservation of Graph Centralities in Reverse-engineered Transcriptional Regulatory Networks
• Ladda ner fulltext (pdf) av Loss of Conservation of Graph Centralities in Reverse-engineered Transcriptional Regulatory Networks

Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses

Niklasson, Mia; Maddalo, Gianluca; Sramkova, Zuzana; Mutlu, Ercan et al.

Ingår i Cancer Research, s. 1741-1752, 2017

• DOI för Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses

Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression

Fedele, Vita; Dai, Fangping; Masilamani, Anie P.; Heiland, Dieter H. et al.

Ingår i Molecular Cancer Research, s. 998-1011, 2017

• DOI för Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression

FC1000: normalized gene expression changes of systematically perturbed human cells

Lönnstedt, Ingrid M.; Nelander, Sven

Ingår i Statistical Applications in Genetics and Molecular Biology, s. 217-242, 2017

• DOI för FC1000: normalized gene expression changes of systematically perturbed human cells
• Ladda ner fulltext (pdf) av FC1000: normalized gene expression changes of systematically perturbed human cells

Case-specific potentiation of glioblastoma drugs by pterostilbene

Schmidt, Linnéa; Baskaran, Sathishkumar; Johansson, Patrik; Padhan, Narendra et al.

Ingår i Oncotarget, s. 73200-73215, 2016

• DOI för Case-specific potentiation of glioblastoma drugs by pterostilbene

High sensitivity isoelectric focusing to establish a signaling biomarker for the diagnosis of human colorectal cancer

Padhan, Narendra; Nordling, Torbjorn E. M.; Sundström, Magnus; Åkerud, Peter et al.

Ingår i BMC Cancer, 2016

• DOI för High sensitivity isoelectric focusing to establish a signaling biomarker for the diagnosis of human colorectal cancer
• Ladda ner fulltext (pdf) av High sensitivity isoelectric focusing to establish a signaling biomarker for the diagnosis of human colorectal cancer

Simultaneous Multiplexed Measurement of RNA and Proteins in Single Cells

Darmanis, Spyros; Gallant, Caroline Julie; Marinescu, Voichita Dana; Niklasson, Mia et al.

Ingår i Cell Reports, s. 380-389, 2016

• DOI för Simultaneous Multiplexed Measurement of RNA and Proteins in Single Cells
• Ladda ner fulltext (pdf) av Simultaneous Multiplexed Measurement of RNA and Proteins in Single Cells

Genome-wide association study identifies multiple susceptibility loci for multiple myeloma

Mitchell, Jonathan S.; Li, Ni; Weinhold, Niels; Försti, Asta et al.

Ingår i Nature Communications, 2016

• DOI för Genome-wide association study identifies multiple susceptibility loci for multiple myeloma
• Ladda ner fulltext (pdf) av Genome-wide association study identifies multiple susceptibility loci for multiple myeloma

ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells

Wee, Boyoung; Pietras, Alexander; Ozawa, Tatsuya; Bazzoli, Elena et al.

Ingår i Scientific Reports, 2016

• DOI för ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells
• Ladda ner fulltext (pdf) av ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells

Origin of the U87MG glioma cell line: Good news and bad news

Allen, Marie; Bjerke, Mia; Edlund, Hanna; Nelander, Sven et al.

Ingår i Science Translational Medicine, 2016

• DOI för Origin of the U87MG glioma cell line: Good news and bad news

Integrative Modeling Reveals Annexin A2-mediated Epigenetic Control of Mesenchymal Glioblastoma

Kling, Teresia; Ferrarese, Roberto; Ailin, Darren Oh; Johansson, Patrik et al.

Ingår i EBioMedicine, s. 72-85, 2016

• DOI för Integrative Modeling Reveals Annexin A2-mediated Epigenetic Control of Mesenchymal Glioblastoma
• Ladda ner fulltext (pdf) av Integrative Modeling Reveals Annexin A2-mediated Epigenetic Control of Mesenchymal Glioblastoma

Travelling wave analysis of a mathematical model of glioblastoma growth

Gerlee, Philip; Nelander, Sven

Ingår i Mathematical Biosciences, s. 75-81, 2016

• DOI för Travelling wave analysis of a mathematical model of glioblastoma growth

Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates the recruitment of LRP1 positive mast cells

Roy, Ananya; Coum, Antoine; Marinescu, Voichita D; Põlajeva, Jelena et al.

Ingår i Oncotarget, s. 23647-23661, 2015

• DOI för Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates the recruitment of LRP1 positive mast cells
• Ladda ner fulltext (pdf) av Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates the recruitment of LRP1 positive mast cells

Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma

Swaminathan, Bhairavi; Thorleifsson, Guomar; Joud, Magnus; Ali, Mina et al.

Ingår i Nature Communications, 2015

• DOI för Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma
• Ladda ner fulltext (pdf) av Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma

Efficient exploration of multi-cancer networks by generalized covariance selection and interactive web content

Kling, Teresia; Johansson, Patrik; Sanchez, Jose; Marinescu, Voichita D. et al.

Ingår i Cancer Research, 2015

• DOI för Efficient exploration of multi-cancer networks by generalized covariance selection and interactive web content

Avoiding pitfalls in L-1-regularised inference of gene networks

Tjarnberg, Andreas; Nordling, Torbjörn E. M.; Studham, Matthew; Nelander, Sven et al.

Ingår i Molecular Biosystems, s. 287-296, 2015

• DOI för Avoiding pitfalls in L-1-regularised inference of gene networks

High levels of WNT-5A in human glioma correlate with increased presence of tumor-associated microglia/monocytes

Dijksterhuis, Jacomijn P.; Arthofer, Elisa; Marinescu, Voichita D.; Nelander, Sven et al.

Ingår i Experimental Cell Research, s. 280-288, 2015

• DOI för High levels of WNT-5A in human glioma correlate with increased presence of tumor-associated microglia/monocytes

The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes

Xie, Yuan; Bergström, Tobias; Jiang, Yiwen; Johansson, Patrik et al.

Ingår i EBioMedicine, s. 1351-1363, 2015

• DOI för The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes
• Ladda ner fulltext (pdf) av The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes

Efficient exploration of pan-cancer networks by generalized covariance selection and interactive web content

Kling, Teresia; Johansson, Patrik; Sanchez, Jose; Marinescu, Voichita D. et al.

Ingår i Nucleic Acids Research, 2015

• DOI för Efficient exploration of pan-cancer networks by generalized covariance selection and interactive web content
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Selective Calcium Sensitivity in Immature Glioma Cancer Stem Cells

Wee, Shimei; Niklasson, Maria; Marinescu, Voichita Dana; Segerman, Anna et al.

Ingår i PLOS ONE, 2014

• DOI för Selective Calcium Sensitivity in Immature Glioma Cancer Stem Cells
• Ladda ner fulltext (pdf) av Selective Calcium Sensitivity in Immature Glioma Cancer Stem Cells

Functional association networks as priors for gene regulatory network inference

Studham, Matthew E.; Tjarnberg, Andreas; Nordling, Torbjörn; Nelander, Sven et al.

Ingår i Bioinformatics, s. 130-138, 2014

• DOI för Functional association networks as priors for gene regulatory network inference
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Meta-Analysis of Neural Childhood Cancer Networks

Olsson, Maja; Kling, Teresia; Nelander, Sven

Ingår i Neuro-Oncology, s. 140-140, 2014

Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule

Kitambi, Satish Srinivas; Toledo, Enrique M.; Usoskin, Dmitry; Wee, Shimei et al.

Ingår i Cell, s. 313-328, 2014

• DOI för Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule

Searching for Synergies: Matrix Algebraic Approaches for Efficient Pair Screening

Gerlee, Philip; Schmidt, Linnea; Monsefi, Naser; Kling, Teresia et al.

Ingår i PLOS ONE, 2013

• DOI för Searching for Synergies: Matrix Algebraic Approaches for Efficient Pair Screening
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Comparative drug pair screening across multiple glioblastoma cell lines reveals novel drug-drug interactions

Schmidt, Linnea; Kling, Teresia; Monsefi, Naser; Olsson, Maja et al.

Ingår i Neuro-Oncology, s. 1469-1478, 2013

• DOI för Comparative drug pair screening across multiple glioblastoma cell lines reveals novel drug-drug interactions

Bridging the gaps in systems biology

Cvijovic, Marija; Almquist, Joachim; Hagmar, Jonas; Hohmann, Stefan et al.

Ingår i Molecular Genetics and Genomics, s. 727-734, 2014

• DOI för Bridging the gaps in systems biology

Identification of Biomarkers and Signatures in Protein Data

Nordling, Torbjörn E. M.; Padhan, Narendra; Nelander, Sven; Claesson-Welsh, Lena

Ingår i 2015 IEEE 11Th International Conference On E-Science, s. 411-419, 2015

• DOI för Identification of Biomarkers and Signatures in Protein Data

Exploring large scale integrative networks of glioblastoma using hypothesis driven pattern search

Johansson, Patrik; Rosén, Emil; Weishaupt, Holger; Jörnsten, Rebecka et al.

Decoding glioblastoma drug responses using an open access library of patient derived cell models

Johansson, Patrik; Schmidt, Linnéa; Baskaran, Sathishkumar; Kundu, Soumi et al.

Prioritization of candidate cancer genes on chromosome 17q through reverse engineered transcriptional regulatory networks in medulloblastoma groups 3 and 4

Weishaupt, Holger; Johansson, Patrik; Mainwaring, Oliver; Hutter, Sonja et al.

Targeting SOX2 in glioblastoma cells reveals heterogeneity in SOX2 dependency

Dalmo, Erika; Rosén, Gabriela; Niklasson, Mia; Bergström, Tobias et al.

The tumour microenvironment across tumour evolution in bladder cancer profiled by single-cell RNA-sequencing analysis and spatial transcriptomics

Kostakis, Alexandros; Beháňová, Andrea; Kyriaki Kerzeli, Iliana; Elgendy, Ramy et al.