Jan Kihlberg
Forskare vid Institutionen för kemi - BMC; Organisk kemi; Kihlberg grupp
- E-post:
- jan.kihlberg@kemi.uu.se
- Besöksadress:
- Husargatan 3
752 37 Uppsala - Postadress:
- Box 576
75123 Uppsala
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Publikationer
Urval av publikationer
- Drug discovery beyond the rule of 5-Opportunities and challenges (2017)
- How Big Is Too Big for Cell Permeability? (2017)
- Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis (2016)
- Macrocyclic Prodrugs of a Selective Nonpeptidic Direct Thrombin Inhibitor Display High Permeability, Efficient Bioconversion but Low Bioavailability (2016)
- How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their Targets. (2016)
- Cell permeability beyond the rule of 5 (2016)
- Structural and conformational determinants of macrocycle cell permeability (2016)
- Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis (2016)
- Mild Oxidative Cleavage of 9-BBN-Protected Amino Acid Derivatives (2015)
- Hydroxyethylene isosteres introduced in type II collagen fragments substantially alter the structure and dynamics of class II MHC A(q)/glycopeptide complexes (2015)
- Oral Druggable Space beyond the Rule of 5 (2014)
- Macrocyclic drugs and clinical candidates - what are the limits of oral bioavailability? (2014)
- Macrocyclic drugs and clinical candidates (2014)
- Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties (2014)
Senaste publikationer
- Exploring the chemical space of orally bioavailable PROTACs (2024)
- Molecular chameleons in drug discovery (2024)
- Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice (2023)
- Conformational Sampling Deciphers the Chameleonic Properties of a VHL-Based Degrader (2023)
- Macrocycles in Drug Discovery?Learning from the Past for the Future (2023)
Alla publikationer
Artiklar
- Exploring the chemical space of orally bioavailable PROTACs (2024)
- Molecular chameleons in drug discovery (2024)
- Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice (2023)
- Conformational Sampling Deciphers the Chameleonic Properties of a VHL-Based Degrader (2023)
- Macrocycles in Drug Discovery?Learning from the Past for the Future (2023)
- Autoantibodies to Disease-Related Proteins in Joints as Novel Biomarkers for the Diagnosis of Rheumatoid Arthritis (2023)
- Structure-based virtual screening discovers potent and selective adenosine A1 receptor antagonists (2023)
- Design of Drug Efficacy Guided by Free Energy Simulations of the β2-Adrenoceptor (2023)
- Predictive Modeling of PROTAC Cell Permeability with Machine Learning (2023)
- Simulation Reveals the Chameleonic Behavior of Macrocycles (2023)
- Therapy targeting antigen-specific T cells by a peptide-based tolerizing vaccine against autoimmune arthritis (2023)
- Going Viral (2023)
- Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction (2022)
- Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor (2022)
- Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses (2022)
- Linker-Dependent Folding Rationalizes PROTAC Cell Permeability br (2022)
- PROTAC cell permeability and oral bioavailability (2022)
- Enhancing preclinical drug discovery with artificial intelligence (2022)
- Solution Conformations Shed Light on PROTAC Cell Permeability (2021)
- Cell Permeability of Isomeric Macrocycles (2021)
- Mining Natural Products for Macrocycles to Drug Difficult Targets (2021)
- Employing complementary spectroscopies to study the conformations of an epimeric pair of side-chain stapled peptides in aqueous solution (2021)
- Steering New Drug Discovery Campaigns (2021)
- Structure-Guided Design of G-Protein-Coupled Receptor Polypharmacology (2021)
- Fragment-based design of selective GPCR ligands guided by free energy simulations (2021)
- Docking Finds GPCR Ligands in Dark Chemical Matter (2020)
- Solution Conformations Explain the Chameleonic Behaviour of Macrocyclic Drugs (2020)
- Solubility prediction in the bRo5 chemical space (2020)
- Is GPR146 really the receptor for proinsulin C-peptide? (2020)
- Predicting the permeability of macrocycles from conformational sampling – limitations of molecular flexibility (2020)
- Drug Syntheses Beyond the Rule of 5 (2020)
- Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1 (2020)
- Chemical and Biochemical Approaches for the Synthesis of Substituted Dihydroxybutanones and Di-, and Tri-Hydroxypentanones (2019)
- Metabolite aberrations in early diabetes detected in rat kidney using mass spectrometry imaging (2019)
- Intramolecular hydrogen bonding (2019)
- Conformation of the Macrocyclic Drug Lorlatinib in Polar and Nonpolar Environments (2019)
- Synthesis of substrates for aldolase-catalyzed reactions (2018)
- Cyclophilin Succumbs to a Macrocyclic Chameleon (2018)
- Dynamics Determine Signaling in a Multicomponent System Associated with Rheumatoid Arthritis (2018)
- Conformational Sampling of Macrocyclic Drugs in Different Environments (2018)
- Opportunities and guidelines for discovery of orally absorbed drugs in beyond rule of 5 space (2018)
- Integrative approaches in HIV-1 non-nucleoside reverse transcriptase inhibitor design (2018)
- T cells specific for post-translational modifications escape intrathymic tolerance induction (2018)
- Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5 (2018)
- A Shared Epitope of Collagen Type XI and Type II Is Recognized by Pathogenic Antibodies in Mice and Human with Arthritis (2018)
- Toward the Design of Molecular Chameleons (2018)
- Drug discovery beyond the rule of 5-Opportunities and challenges (2017)
- Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage (2017)
- How Big Is Too Big for Cell Permeability? (2017)
- Detection And Isolation Of Antigen Specific B Cells In Patients With Rheumatoid Arthritis (2017)
- Reactive Oxygen Species Regulate Both Priming and Established Arthritis, but with Different Mechanisms (2017)
- Cutting Edge (2017)
- Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis (2016)
- Macrocyclic Prodrugs of a Selective Nonpeptidic Direct Thrombin Inhibitor Display High Permeability, Efficient Bioconversion but Low Bioavailability (2016)
- How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their Targets. (2016)
- Cell permeability beyond the rule of 5 (2016)
- Structural and conformational determinants of macrocycle cell permeability (2016)
- Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis (2016)
- Mild Oxidative Cleavage of 9-BBN-Protected Amino Acid Derivatives (2015)
- Hydroxyethylene isosteres introduced in type II collagen fragments substantially alter the structure and dynamics of class II MHC A(q)/glycopeptide complexes (2015)
- Oral Druggable Space beyond the Rule of 5 (2014)
- Macrocyclic drugs and clinical candidates - what are the limits of oral bioavailability? (2014)
- Macrocyclic drugs and clinical candidates (2014)
- Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties (2014)
- Attempts to develop a cell-based assay for Diabetic Kidney Disease
- Tissue Specific Binding of Radiolabelled C-Peptide in Healthy and Diabetic Rats