David Dahlgren

A comprehensive mechanistic investigation of factors affecting intestinal absorption and bioavailability of two PROTACs in rats

Niessen, Janis; Arendt, Nathalie; Sjöblom, Markus; Dubbelboer, Ilse R. et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, 2025

• DOI för A comprehensive mechanistic investigation of factors affecting intestinal absorption and bioavailability of two PROTACs in rats
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Medicinal grade opium tincture for severe diarrhea: effect revisited in observational study

Dahlgren, David; Hellström, Per M.

Ingår i Current Opinion in Gastroenterology, s. 196-202, 2024

• DOI för Medicinal grade opium tincture for severe diarrhea: effect revisited in observational study

Melatonin mitigates chemotherapy-induced small intestinal atrophy in rats and reduces cytotoxicity in murine intestinal organoids

Peters, Karsten; Clavero, Ada Lerma; Kullenberg, Fredrik; Kopsida, Maria et al.

Ingår i PLOS ONE, 2024

• DOI för Melatonin mitigates chemotherapy-induced small intestinal atrophy in rats and reduces cytotoxicity in murine intestinal organoids
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Development and validation of LC-MS/MS methods for the pharmacokinetic assessment of the PROTACs bavdeglutamide (ARV-110) and vepdegestrant (ARV-471)

Niessen, Janis; Nilsson, Jenny M.; Peters, Karsten; Indulkar, Anura et al.

Ingår i Journal of Pharmaceutical and Biomedical Analysis, 2024

• DOI för Development and validation of LC-MS/MS methods for the pharmacokinetic assessment of the PROTACs bavdeglutamide (ARV-110) and vepdegestrant (ARV-471)
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Hypotonicity-Induced Increase in Duodenal Mucosal Permeability Is Regulated by Cholinergic Receptors in Rats

Dahlgren, David; Nylander, Olof; Sjöblom, Markus

Ingår i Digestive Diseases and Sciences, s. 1815-1823, 2023

• DOI för Hypotonicity-Induced Increase in Duodenal Mucosal Permeability Is Regulated by Cholinergic Receptors in Rats
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A comprehensive mechanistic investigation of factors affecting intestinal absorption and bioavailability of two PROTACs in rats

Niessen, Janis; Arendt, Nathalie; Sjöblom, Markus; Dubbelboer, Ilse R. et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, 2025

• DOI för A comprehensive mechanistic investigation of factors affecting intestinal absorption and bioavailability of two PROTACs in rats
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Medicinal grade opium tincture for severe diarrhea: effect revisited in observational study

Dahlgren, David; Hellström, Per M.

Ingår i Current Opinion in Gastroenterology, s. 196-202, 2024

• DOI för Medicinal grade opium tincture for severe diarrhea: effect revisited in observational study

Melatonin mitigates chemotherapy-induced small intestinal atrophy in rats and reduces cytotoxicity in murine intestinal organoids

Peters, Karsten; Clavero, Ada Lerma; Kullenberg, Fredrik; Kopsida, Maria et al.

Ingår i PLOS ONE, 2024

• DOI för Melatonin mitigates chemotherapy-induced small intestinal atrophy in rats and reduces cytotoxicity in murine intestinal organoids
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Development and validation of LC-MS/MS methods for the pharmacokinetic assessment of the PROTACs bavdeglutamide (ARV-110) and vepdegestrant (ARV-471)

Niessen, Janis; Nilsson, Jenny M.; Peters, Karsten; Indulkar, Anura et al.

Ingår i Journal of Pharmaceutical and Biomedical Analysis, 2024

• DOI för Development and validation of LC-MS/MS methods for the pharmacokinetic assessment of the PROTACs bavdeglutamide (ARV-110) and vepdegestrant (ARV-471)
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Hypotonicity-Induced Increase in Duodenal Mucosal Permeability Is Regulated by Cholinergic Receptors in Rats

Dahlgren, David; Nylander, Olof; Sjöblom, Markus

Ingår i Digestive Diseases and Sciences, s. 1815-1823, 2023

• DOI för Hypotonicity-Induced Increase in Duodenal Mucosal Permeability Is Regulated by Cholinergic Receptors in Rats
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The progression of doxorubicin-induced intestinal mucositis in rats

Kullenberg, Fredrik; Peters, Karsten; Luna-Marco, C.; Salomonsson, A. et al.

Ingår i Naunyn-Schmiedeberg's Archives of Pharmacology, s. 247-260, 2023

• DOI för The progression of doxorubicin-induced intestinal mucositis in rats
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Anakinra and dexamethasone treatment of idarubicin-induced mucositis and diarrhoea in rats

Kullenberg, Fredrik; Peters, Karsten; Sjöblom, Markus; Heindryckx, Femke et al.

Ingår i Basic & Clinical Pharmacology & Toxicology, s. 507-516, 2023

• DOI för Anakinra and dexamethasone treatment of idarubicin-induced mucositis and diarrhoea in rats
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Ulcerative colitis progression: a retrospective analysis of disease burden using electronic medical records

Dahlgren, David; Agreus, Lars; Stålhammar, Jan; Hellström, Per M.

Ingår i Upsala Journal of Medical Sciences, 2022

• DOI för Ulcerative colitis progression: a retrospective analysis of disease burden using electronic medical records
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Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding

Balgoma, David; Kullenberg, Fredrik; Peters, Karsten; Dahlgren, David et al.

Ingår i Metabolites, 2022

• DOI för Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding
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Effects of α₂-adrenoceptor stimulation on luminal alkalinisation and net fluid flux in rat duodenum

Nylander, Olof; Sjöblom, Markus; Sedin, John; Dahlgren, David

Ingår i PLOS ONE, 2022

• DOI för Effects of α₂-adrenoceptor stimulation on luminal alkalinisation and net fluid flux in rat duodenum
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Evaluation and validation of chemotherapy‐specific diarrhoea and histopathology in rats

Dahlgren, David; Rosenqvist, Evelina; Hellström, Per M.; Nygren, Peter et al.

Ingår i Basic & Clinical Pharmacology & Toxicology, s. 536-546, 2022

• DOI för Evaluation and validation of chemotherapy‐specific diarrhoea and histopathology in rats
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Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats

Peters, Karsten; Dahlgren, David; Egerszegi, Peter Pal; Lennernäs, Hans et al.

Ingår i International Journal of Molecular Sciences, 2022

• DOI för Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats
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Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats

Cano-Cebrian, Maria-Jose; Dahlgren, David; Kullenberg, Fredrik; Peters, Karsten et al.

Ingår i International Journal of Molecular Sciences, 2022

• DOI för Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats
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Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival

Sennefelt Nyman, Sofi; Ahlström, Håkan; Dimopoulou, Angeliki; Dahlgren, David et al.

Ingår i BMJ Open, 2022

• DOI för Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival
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The Impact of alpha-Adrenoceptors in the Regulation of the Hypotonicity-Induced Increase in Duodenal Mucosal Permeability In Vivo

Sedin, John; Dahlgren, David; Sjöblom, Markus; Nylander, Olof

Ingår i Pharmaceutics, 2021

• DOI för The Impact of alpha-Adrenoceptors in the Regulation of the Hypotonicity-Induced Increase in Duodenal Mucosal Permeability In Vivo
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Melatonin-Activated Receptor Signaling Pathways Mediate Protective Effects on Surfactant-Induced Increase in Jejunal Mucosal Permeability in Rats

Peters, Karsten; Dahlgren, David; Lennernäs, Hans; Sjöblom, Markus

Ingår i International Journal of Molecular Sciences, 2021

• DOI för Melatonin-Activated Receptor Signaling Pathways Mediate Protective Effects on Surfactant-Induced Increase in Jejunal Mucosal Permeability in Rats
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Fasted and fed state human duodenal fluids: Characterization, drug solubility, and comparison to simulated fluids and with human bioavailability

Dahlgren, David; Venczel, M.; Ridoux, J. -P; Skjöld, C. et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 240-251, 2021

• DOI för Fasted and fed state human duodenal fluids: Characterization, drug solubility, and comparison to simulated fluids and with human bioavailability
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Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats

Dahlgren, David; Olander, Tobias; Sjöblom, Markus; Hedeland, Mikael et al.

Ingår i Acta Pharmaceutica Sinica B, s. 1667-1675, 2021

• DOI för Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats
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Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat

Dahlgren, David; Cano-Cebrian, Maria-Jose; Olander, Tobias; Hedeland, Mikael et al.

Ingår i Pharmaceutics, 2020

• DOI för Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat
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Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol

Dahlgren, David; Cano-Cebrian, Maria-Jose; Hellström, Per M.; Wanders, Alkwin et al.

Ingår i International Journal of Molecular Sciences, 2020

• DOI för Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol
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The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin

Dahlgren, David; Sjöblom, Markus; Hedeland, Mikael; Lennernäs, Hans

Ingår i Pharmaceutics, 2020

• DOI för The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin
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Rat intestinal drug permeability: A status report and summary of repeated determinations

Dubbelboer, Ilse R; Dahlgren, David; Sjögren, Erik; Lennernäs, Hans

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 364-376, 2019

• DOI för Rat intestinal drug permeability: A status report and summary of repeated determinations

Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model

Dahlgren, David; Roos, Carl; Peters, Karsten; Lundqvist, A. et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 31-37, 2019

• DOI för Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model

Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 387-395, 2019

• DOI för Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

Intestinal absorption-modifying excipients: A current update on preclinical in vivo evaluations

Dahlgren, David; Sjöblom, Markus; Lennernäs, Hans

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 411-420, 2019

• DOI för Intestinal absorption-modifying excipients: A current update on preclinical in vivo evaluations

Time-dependent effects on small intestinal transport by absorption-modifying excipients

Dahlgren, David; Roos, Carl; Lundqvist, A.; Tannergren, C. et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 19-28, 2018

• DOI för Time-dependent effects on small intestinal transport by absorption-modifying excipients

Mechanistic modelling of intestinal drug absorption: the in vivo effects of nanoparticles, hydrodynamics, and colloidal structures

Roos, Carl; Westergren, Jan; Dahlgren, David; Lennernäs, Hans et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 70-76, 2018

• DOI för Mechanistic modelling of intestinal drug absorption: the in vivo effects of nanoparticles, hydrodynamics, and colloidal structures

Jejunal absorption of aprepitant from nanosuspensions: Role of particle size, prandial state and mucus layer.

Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 222-230, 2018

• DOI för Jejunal absorption of aprepitant from nanosuspensions: Role of particle size, prandial state and mucus layer.

Effect of absorption-modifying excipients, hypotonicity, and enteric neural activity in an in vivo model for small intestinal transport.

Dahlgren, David; Roos, Carl; Lundqvist, A; Tannergren, C et al.

Ingår i International Journal of Pharmaceutics, s. 239-248, 2018

• DOI för Effect of absorption-modifying excipients, hypotonicity, and enteric neural activity in an in vivo model for small intestinal transport.

The effects of three absorption-modifying critical excipients on the in vivo intestinal absorption of six model compounds in rats and dogs.

Dahlgren, David; Roos, Carl; Johansson, P; Tannergren, C et al.

Ingår i International Journal of Pharmaceutics, s. 158-168, 2018

• DOI för The effects of three absorption-modifying critical excipients on the in vivo intestinal absorption of six model compounds in rats and dogs.

Preclinical Effect of Absorption Modifying Excipients on Rat Intestinal Transport of Model Compounds and the Mucosal Barrier Marker ⁵¹Cr-EDTA

Dahlgren, David; Roos, Carl; Lundqvist, Anders; Tannergren, Christer et al.

Ingår i Molecular Pharmaceutics, s. 4243-4251, 2017

• DOI för Preclinical Effect of Absorption Modifying Excipients on Rat Intestinal Transport of Model Compounds and the Mucosal Barrier Marker ⁵¹Cr-EDTA

In Vivo Mechanisms of Intestinal Drug Absorption from Aprepitant Nanoformulations

Roos, Carl; Dahlgren, David; Berg, Staffan; Westergren, Jan et al.

Ingår i Molecular Pharmaceutics, s. 4233-4242, 2017

• DOI för In Vivo Mechanisms of Intestinal Drug Absorption from Aprepitant Nanoformulations

Regional Intestinal Permeability in Rats: A Comparison of Methods

Roos, Carl; Dahlgren, David; Sjögren, Erik; Tannergren, Christer et al.

Ingår i Molecular Pharmaceutics, s. 4252-4261, 2017

• DOI för Regional Intestinal Permeability in Rats: A Comparison of Methods

Optimization of the Ussing chamber setup with excised rat intestinal segments for dissolution/permeation experiments of poorly soluble drugs

Forner, Kristin; Roos, Carl; Dahlgren, David; Kesisoglou, Filippos et al.

Ingår i Drug Development and Industrial Pharmacy, s. 338-346, 2017

• DOI för Optimization of the Ussing chamber setup with excised rat intestinal segments for dissolution/permeation experiments of poorly soluble drugs

Regional Intestinal Permeability of Three Model Drugs in Human

Dahlgren, David; Roos, Carl; Lundqvist, Anders; Abrahamsson, Bertil et al.

Ingår i Molecular Pharmaceutics, s. 3013-3021, 2016

• DOI för Regional Intestinal Permeability of Three Model Drugs in Human

Regional Intestinal Permeability in Dogs: Biopharmaceutical Aspects for Development of Oral Modified-Release Dosage Forms

Dahlgren, David; Roos, Carl; Johansson, Pernilla; Lundqvist, Anders et al.

Ingår i Molecular Pharmaceutics, s. 3022-3033, 2016

• DOI för Regional Intestinal Permeability in Dogs: Biopharmaceutical Aspects for Development of Oral Modified-Release Dosage Forms

Human in Vivo Regional Intestinal Permeability: Quantitation Using Site-Specific Drug Absorption Data

Sjögren, Erik; Dahlgren, David; Roos, Carl; Lennernas, Hans

Ingår i Molecular Pharmaceutics, s. 2026-2039, 2015

• DOI för Human in Vivo Regional Intestinal Permeability: Quantitation Using Site-Specific Drug Absorption Data

Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

Ingår i European journal of pharmaceutics and biopharmaceutics

Review on the effect of chemotherapy on the intestinal barrier: Epithelial permeability, mucus and bacterial translocation

Dahlgren, David; Lennernäs, Hans

Ingår i Biomedicine and Pharmacotherapy, 2023

• DOI för Review on the effect of chemotherapy on the intestinal barrier: Epithelial permeability, mucus and bacterial translocation
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Challenges in Permeability Assessment for Oral Drug Product Development

Koziolek, Mirko; Augustijns, Patrick; Berger, Constantin; Cristofoletti, Rodrigo et al.

Ingår i Pharmaceutics, 2023

• DOI för Challenges in Permeability Assessment for Oral Drug Product Development
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Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies

Dahlgren, David; Sjöblom, Markus; Hellström, Per M.; Lennernäs, Hans

Ingår i Frontiers in Pharmacology, 2021

• DOI för Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies
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Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective

Dahlgren, David; Lennernäs, Hans

Ingår i Molecules, 2020

• DOI för Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective
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Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models

Dahlgren, David; Sjögren, Erik; Lennernäs, Hans

Ingår i ADMET & DMPK, s. 375-390, 2020

• DOI för Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models
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Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches

Dahlgren, David; Lennernäs, Hans

Ingår i Pharmaceutics, 2019

• DOI för Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches
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Direct In Vivo Human Intestinal Permeability (P-eff) Determined with Different Clinical Perfusion and Intubation Methods

Dahlgren, David; Roos, Carl; Sjögren, Erik; Lennernäs, Hans

Ingår i Journal of Pharmaceutical Sciences, s. 2702-2726, 2015

• DOI för Direct In Vivo Human Intestinal Permeability (P-eff) Determined with Different Clinical Perfusion and Intubation Methods

Biopharmaceutical aspects of intestinal drug absorption: Regional permeability and absorption-modifying excipients

Dahlgren, David

2018

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