Ingela Lanekoff
Professor vid Institutionen för kemi inom livsvetenskaperna; Analytisk kemi; Lanekoff grupp
- Telefon:
- 018-471 36 73
- E-post:
- ingela.lanekoff@kemi.uu.se
- Besöksadress:
- Husargatan 3 (D5)
752 37 Uppsala - Postadress:
- Box 599
75124 Uppsala
Kort presentation
Lanekoff-gruppens forskning är fokuserad på att använda och utveckla tekniker för masspektrometrisk analys och avbildning av lipider och metaboliter på biologiska ytor, såsom tunna vävnadssnitt och celler.
Nyckelord
- analytical chemistry
- mass spectrometry
- mass spectrometry imaging (msi)
- nanospray desorption electrospray ionization (nano-desi)
- surface sampling capillary electrophoresis mass spectrometry
- direct infusion probe (dip)
- spatial metabolomics
- single-cell metabolomics
- ion-to-image (i2i)

Publikationer
Senaste publikationer
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Microglial 5-LOX-activating protein antagonism alleviates leukotriene-driven neuroinflammation
Ingår i Acta Neuropathologica, 2026
- DOI för Microglial 5-LOX-activating protein antagonism alleviates leukotriene-driven neuroinflammation
- Ladda ner fulltext (pdf) av Microglial 5-LOX-activating protein antagonism alleviates leukotriene-driven neuroinflammation
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CellMate-A Deep Learning-Assisted Single-Cell Data Processing Platform
Ingår i Analytical Chemistry, s. 5561-5569, 2026
- DOI för CellMate-A Deep Learning-Assisted Single-Cell Data Processing Platform
- Ladda ner fulltext (pdf) av CellMate-A Deep Learning-Assisted Single-Cell Data Processing Platform
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Ingår i eBioMedicine, 2026
- DOI för Metabolomic signatures of SSRI exposure during neural differentiation and correlation of lysophosphatidylcholines with early symptoms of neurodevelopmental disorders
- Ladda ner fulltext (pdf) av Metabolomic signatures of SSRI exposure during neural differentiation and correlation of lysophosphatidylcholines with early symptoms of neurodevelopmental disorders
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Ingår i Angewandte Chemie International Edition, 2026
- DOI för Multiplexed tandem mass spectrometry imaging enables large-scale isomer mapping and annotation in tissues
- Ladda ner fulltext (pdf) av Multiplexed tandem mass spectrometry imaging enables large-scale isomer mapping and annotation in tissues
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Ingår i Talanta, 2026
- DOI för Quantitative approaches for spatial metabolomics with isomer differentiation using surface sampling capillary electrophoresis mass spectrometry
- Ladda ner fulltext (pdf) av Quantitative approaches for spatial metabolomics with isomer differentiation using surface sampling capillary electrophoresis mass spectrometry
Alla publikationer
Artiklar i tidskrift
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Microglial 5-LOX-activating protein antagonism alleviates leukotriene-driven neuroinflammation
Ingår i Acta Neuropathologica, 2026
- DOI för Microglial 5-LOX-activating protein antagonism alleviates leukotriene-driven neuroinflammation
- Ladda ner fulltext (pdf) av Microglial 5-LOX-activating protein antagonism alleviates leukotriene-driven neuroinflammation
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CellMate-A Deep Learning-Assisted Single-Cell Data Processing Platform
Ingår i Analytical Chemistry, s. 5561-5569, 2026
- DOI för CellMate-A Deep Learning-Assisted Single-Cell Data Processing Platform
- Ladda ner fulltext (pdf) av CellMate-A Deep Learning-Assisted Single-Cell Data Processing Platform
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Ingår i eBioMedicine, 2026
- DOI för Metabolomic signatures of SSRI exposure during neural differentiation and correlation of lysophosphatidylcholines with early symptoms of neurodevelopmental disorders
- Ladda ner fulltext (pdf) av Metabolomic signatures of SSRI exposure during neural differentiation and correlation of lysophosphatidylcholines with early symptoms of neurodevelopmental disorders
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Ingår i Angewandte Chemie International Edition, 2026
- DOI för Multiplexed tandem mass spectrometry imaging enables large-scale isomer mapping and annotation in tissues
- Ladda ner fulltext (pdf) av Multiplexed tandem mass spectrometry imaging enables large-scale isomer mapping and annotation in tissues
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Ingår i Talanta, 2026
- DOI för Quantitative approaches for spatial metabolomics with isomer differentiation using surface sampling capillary electrophoresis mass spectrometry
- Ladda ner fulltext (pdf) av Quantitative approaches for spatial metabolomics with isomer differentiation using surface sampling capillary electrophoresis mass spectrometry
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Standard Addition as a Method for Quantitative Mass Spectrometry Imaging
Ingår i Analytical Chemistry, s. 11572-11580, 2025
- DOI för Standard Addition as a Method for Quantitative Mass Spectrometry Imaging
- Ladda ner fulltext (pdf) av Standard Addition as a Method for Quantitative Mass Spectrometry Imaging
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Ingår i Analytica Chimica Acta, 2025
- DOI för Multimodal mass spectrometry - Raman imaging reveals solvent dependent structural and chemical tissue alterations
- Ladda ner fulltext (pdf) av Multimodal mass spectrometry - Raman imaging reveals solvent dependent structural and chemical tissue alterations
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Spatial mapping of the AA-PGE2-EP axis in multiple sclerosis lesions
Ingår i Acta Neuropathologica, 2025
- DOI för Spatial mapping of the AA-PGE2-EP axis in multiple sclerosis lesions
- Ladda ner fulltext (pdf) av Spatial mapping of the AA-PGE2-EP axis in multiple sclerosis lesions
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Ingår i Talanta, 2025
- DOI för Spatial metabolomics platform combining mass spectrometry imaging and in-depth chemical characterization with capillary electrophoresis
- Ladda ner fulltext (pdf) av Spatial metabolomics platform combining mass spectrometry imaging and in-depth chemical characterization with capillary electrophoresis
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Enhancing isomer specificity in mass spectrometry by combining silver ion adduction and ion mobility
Ingår i Talanta Open, 2024
- DOI för Enhancing isomer specificity in mass spectrometry by combining silver ion adduction and ion mobility
- Ladda ner fulltext (pdf) av Enhancing isomer specificity in mass spectrometry by combining silver ion adduction and ion mobility
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Ingår i International Journal of Molecular Sciences, 2024
- DOI för Interleukin-13 Treatment of Living Lung Tissue Model Alters the Metabolome and Proteome: A Nano-DESI MS Metabolomics and Shotgun Proteomics Study
- Ladda ner fulltext (pdf) av Interleukin-13 Treatment of Living Lung Tissue Model Alters the Metabolome and Proteome: A Nano-DESI MS Metabolomics and Shotgun Proteomics Study
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Ingår i Metabolites, 2024
- DOI för Online Direct Infusion Mass Spectrometry of Liquid-Liquid Extraction Phases for Metabolite and Lipid Profiling with the Direct Infusion Probe
- Ladda ner fulltext (pdf) av Online Direct Infusion Mass Spectrometry of Liquid-Liquid Extraction Phases for Metabolite and Lipid Profiling with the Direct Infusion Probe
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Ingår i Electrophoresis, s. 387-394, 2023
- DOI för Surface sampling capillary electrophoresis–mass spectrometry for a direct chemical characterization of tissue and blood samples
- Ladda ner fulltext (pdf) av Surface sampling capillary electrophoresis–mass spectrometry for a direct chemical characterization of tissue and blood samples
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Ingår i Analytical Chemistry, s. 17843-17850, 2023
- DOI för Revealing Structure and Localization of Steroid Regioisomers through Predictive Fragmentation Patterns in Mass Spectrometry Imaging
- Ladda ner fulltext (pdf) av Revealing Structure and Localization of Steroid Regioisomers through Predictive Fragmentation Patterns in Mass Spectrometry Imaging
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Ingår i Journal of the American Society for Mass Spectrometry, s. 2518-2524, 2023
- DOI för Global and Spatial Metabolomics of Individual Cells Using a Tapered Pneumatically Assisted nano-DESI Probe
- Ladda ner fulltext (pdf) av Global and Spatial Metabolomics of Individual Cells Using a Tapered Pneumatically Assisted nano-DESI Probe
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Ingår i Scientific Reports, 2023
- DOI för Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics
- Ladda ner fulltext (pdf) av Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics
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Ischemic Stroke Causes Disruptions in the Carnitine Shuttle System
Ingår i Metabolites, 2023
- DOI för Ischemic Stroke Causes Disruptions in the Carnitine Shuttle System
- Ladda ner fulltext (pdf) av Ischemic Stroke Causes Disruptions in the Carnitine Shuttle System
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Ingår i Journal of the American Society for Mass Spectrometry, s. 2341-2349, 2023
- DOI för Identification and Imaging of Prostaglandin Isomers Utilizing MS3 Product Ions and Silver Cationization
- Ladda ner fulltext (pdf) av Identification and Imaging of Prostaglandin Isomers Utilizing MS3 Product Ions and Silver Cationization
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Ingår i Analytical Chemistry, s. 11589-11595, 2023
- DOI för Ion-to-Image, i2i, a Mass Spectrometry Imaging Data Analysis Platform for Continuous Ionization Techniques
- Ladda ner fulltext (pdf) av Ion-to-Image, i2i, a Mass Spectrometry Imaging Data Analysis Platform for Continuous Ionization Techniques
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A Direct Infusion Probe for Rapid Metabolomics of Low-Volume Samples
Ingår i Analytical Chemistry, s. 12875-12883, 2022
- DOI för A Direct Infusion Probe for Rapid Metabolomics of Low-Volume Samples
- Ladda ner fulltext (pdf) av A Direct Infusion Probe for Rapid Metabolomics of Low-Volume Samples
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Ingår i Environmental Science and Technology, s. 3096-3105, 2022
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Ingår i Analytical Chemistry, s. 2391-2398, 2022
- DOI för Host-Guest Chemistry for Simultaneous Imaging of Endogenous Alkali Metals and Metabolites with Mass Spectrometry
- Ladda ner fulltext (pdf) av Host-Guest Chemistry for Simultaneous Imaging of Endogenous Alkali Metals and Metabolites with Mass Spectrometry
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Ingår i Vietnam Journal of Food Control, s. 89-103, 2022
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Quantitative determination of sn-positional phospholipid isomers in MSn using silver cationization
Ingår i Analytical and Bioanalytical Chemistry, s. 7473-7482, 2022
- DOI för Quantitative determination of sn-positional phospholipid isomers in MSn using silver cationization
- Ladda ner fulltext (pdf) av Quantitative determination of sn-positional phospholipid isomers in MSn using silver cationization
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Ingår i Communications Biology, 2021
- DOI för In situ imaging reveals disparity between prostaglandin localization and abundance of prostaglandin synthases
- Ladda ner fulltext (pdf) av In situ imaging reveals disparity between prostaglandin localization and abundance of prostaglandin synthases
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Ingår i Analytical and Bioanalytical Chemistry, s. 2735-2745, 2021
- DOI för CpG preconditioning reduces accumulation of lysophosphatidylcholine in ischemic brain tissue after middle cerebral artery occlusion
- Ladda ner fulltext (pdf) av CpG preconditioning reduces accumulation of lysophosphatidylcholine in ischemic brain tissue after middle cerebral artery occlusion
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Ingår i Journal of the American Society for Mass Spectrometry, s. 2479-2487, 2020
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PDMS leaching and its implications for on-chip studies focusing on bone regeneration applications
Ingår i Organs-on-a-Chip, 2020
- DOI för PDMS leaching and its implications for on-chip studies focusing on bone regeneration applications
- Ladda ner fulltext (pdf) av PDMS leaching and its implications for on-chip studies focusing on bone regeneration applications
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Metabolite aberrations in early diabetes detected in rat kidney using mass spectrometry imaging
Ingår i Analytical and Bioanalytical Chemistry, s. 2809-2816, 2019
- DOI för Metabolite aberrations in early diabetes detected in rat kidney using mass spectrometry imaging
- Ladda ner fulltext (pdf) av Metabolite aberrations in early diabetes detected in rat kidney using mass spectrometry imaging
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Spatially Defined Surface Sampling Capillary Electrophoresis Mass Spectrometry
Ingår i Analytical Chemistry, s. 7819-7827, 2019
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Ingår i International Journal of Mass Spectrometry, s. 49-57, 2019
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Ingår i Analytical Chemistry, s. 7246-7252, 2018
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Oversampling To Improve Spatial Resolution for Liquid Extraction Mass Spectrometry Imaging
Ingår i Analytical Chemistry, s. 2451-2455, 2018
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Profiling and quantifying endogenous molecules in single cells using nano-DESI MS
Ingår i The Analyst, s. 3639-3647, 2017
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Ingår i The Analyst, s. 3424-3431, 2017
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PACAP suppresses dry eye signs by stimulating tear secretion
Ingår i Nature Communications, 2016
- DOI för PACAP suppresses dry eye signs by stimulating tear secretion
- Ladda ner fulltext (pdf) av PACAP suppresses dry eye signs by stimulating tear secretion
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Ingår i Scientific Reports, 2016
- DOI för Trp53 deficient mice predisposed to preterm birth display region-specific lipid alterations at the embryo implantation site
- Ladda ner fulltext (pdf) av Trp53 deficient mice predisposed to preterm birth display region-specific lipid alterations at the embryo implantation site
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Ingår i The Analyst, s. 3686-3695, 2016
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Direct Analysis of Pharmaceutical Drugs Using Nano-DESI MS
Ingår i Journal of Analytical Methods in Chemistry, 2016
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Towards Adaptive, Streaming Analysis of X-ray Tomography Data
Ingår i Synchrotron Radiation News, s. 10-14, 2015
- DOI för Towards Adaptive, Streaming Analysis of X-ray Tomography Data
- Ladda ner fulltext (pdf) av Towards Adaptive, Streaming Analysis of X-ray Tomography Data
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Ingår i Analytical and Bioanalytical Chemistry, s. 2063-2071, 2015
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Ingår i Analytical Chemistry, s. 1872-80, 2014
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Matrix effects in biological mass spectrometry imaging: identification and compensation
Ingår i The Analyst, s. 3528-3532, 2014
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Ingår i Analytical Chemistry, s. 9596-9603, 2013
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C60-ToF SIMS imaging of frozen hydrated HeLa cells
Ingår i Surface and Interface Analysis, s. 302-304, 2013
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Mass spectrometry imaging of freeze-dried membrane phospholipids of dividing Tetrahymena pyriformis
Ingår i Surface and Interface Analysis, s. 211-214, 2013
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Ingår i The Analyst, s. 1971-1978, 2013
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Ingår i Analytical Chemistry, s. 882-889, 2013
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Ingår i Analytical Chemistry, s. 8351-8356, 2012
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Ingår i Analytical Chemistry, s. 5737-5743, 2012
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An in situ fracture device to image lipids in single cells using ToF-SIMS
Ingår i Surface and Interface Analysis, s. 257-260, 2011
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Ingår i Analytical Chemistry, s. 5337-5343, 2011
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HAMLET interacts with lipid membranes and perturbs their structure and integrity.
Ingår i PLOS ONE, 2010
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Ingår i Analytical Chemistry, s. 6652-9, 2010
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Ingår i Analytical and Bioanalytical Chemistry, s. 3543-3551, 2010
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Ingår i Scandinavian Journal of Gastroenterology, s. 1089-1096, 2002
Artiklar, forskningsöversikt
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Single cell metabolism: current and future trends
Ingår i Metabolomics, 2022
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Single-cell metabolomics: where are we and where are we going?
Ingår i Current Opinion in Biotechnology, 2022
- DOI för Single-cell metabolomics: where are we and where are we going?
- Ladda ner fulltext (pdf) av Single-cell metabolomics: where are we and where are we going?
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Advances in mass spectrometry based single-cell metabolomics
Ingår i The Analyst, s. 782-793, 2019
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Ambient Mass Spectrometry Imaging Using Direct Liquid Extraction Techniques
Ingår i Analytical Chemistry, s. 52-73, 2016
Kapitel i böcker, delar av antologi
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Matrix Effects Free Imaging of Thin Tissue Sections Using Pneumatically Assisted Nano-DESI MSI
Ingår i Imaging Mass Spectrometry, s. 107-121, Humana Press, 2023
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Ingår i Advanced Mass Spectrometry-Based Analytical Separation Techniques for Probing the Polar Metabolome, s. 125-164, Royal Society of Chemistry, 2021
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Quantitative Mass Spectrometry Imaging of Molecules in Biological Systems
Ingår i Advances In Chromatography, Vol 54, s. 43-72, CRC Press, 2018
- DOI för Quantitative Mass Spectrometry Imaging of Molecules in Biological Systems
- Ladda ner fulltext (pdf) av Quantitative Mass Spectrometry Imaging of Molecules in Biological Systems
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Ingår i Encyclopedia of Analytical Chemistry, Wiley-VCH Verlagsgesellschaft, 2018
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Ingår i Methods in molecular biology, s. 99-106, Springer, 2015
Konferensbidrag
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Tailoring the biocompatibility of the elastomer PDMS for on-chip applications
2018
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Improving the biocompatibility of PDMS by improving its curing time and temperature
2018
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Velo and REXAN – Integrated Data Management and High Speed Analysis for Experimental Facilities
Ingår i Proceeding IEEE International Conference on E-Science 2012, s. 1-9, 2012