Sören Lehmann
Professor vid Institutionen för medicinska vetenskaper; Hematologi
- Mobiltelefon:
- 070-760 48 82
- E-post:
- soren.lehmann@medsci.uu.se
- Besöksadress:
- Akademiska sjukhuset, ing 101, plan 4
751 85 Uppsala - Postadress:
- Akademiska sjukhuset, ing 100, plan 2
751 85 Uppsala

Publikationer
Senaste publikationer
Pathway activation model for personalized prediction of drug synergy
Ingår i eLIFE, 2025
- DOI för Pathway activation model for personalized prediction of drug synergy
- Ladda ner fulltext (pdf) av Pathway activation model for personalized prediction of drug synergy
Ingår i Haematologica, s. 1126-1140, 2025
- DOI för Outcomes with intensive treatment for acute myeloid leukemia: an analysis of two decades of data from the HARMONY Alliance
- Ladda ner fulltext (pdf) av Outcomes with intensive treatment for acute myeloid leukemia: an analysis of two decades of data from the HARMONY Alliance
Acute promyelocytic leukemia: long-term outcomes from the HARMONY project
Ingår i Blood, s. 234-243, 2025
The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia
Ingår i Leukemia, s. 663-666, 2024
- DOI för The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia
- Ladda ner fulltext (pdf) av The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia
Ingår i Cell Reports, 2024
- DOI för Proteome-wide CETSA reveals diverse apoptosisinducing mechanisms converging on an initial apoptosis effector stage at the nuclear periphery
- Ladda ner fulltext (pdf) av Proteome-wide CETSA reveals diverse apoptosisinducing mechanisms converging on an initial apoptosis effector stage at the nuclear periphery
Alla publikationer
Artiklar i tidskrift
Pathway activation model for personalized prediction of drug synergy
Ingår i eLIFE, 2025
- DOI för Pathway activation model for personalized prediction of drug synergy
- Ladda ner fulltext (pdf) av Pathway activation model for personalized prediction of drug synergy
Ingår i Haematologica, s. 1126-1140, 2025
- DOI för Outcomes with intensive treatment for acute myeloid leukemia: an analysis of two decades of data from the HARMONY Alliance
- Ladda ner fulltext (pdf) av Outcomes with intensive treatment for acute myeloid leukemia: an analysis of two decades of data from the HARMONY Alliance
Acute promyelocytic leukemia: long-term outcomes from the HARMONY project
Ingår i Blood, s. 234-243, 2025
The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia
Ingår i Leukemia, s. 663-666, 2024
- DOI för The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia
- Ladda ner fulltext (pdf) av The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia
Ingår i Cell Reports, 2024
- DOI för Proteome-wide CETSA reveals diverse apoptosisinducing mechanisms converging on an initial apoptosis effector stage at the nuclear periphery
- Ladda ner fulltext (pdf) av Proteome-wide CETSA reveals diverse apoptosisinducing mechanisms converging on an initial apoptosis effector stage at the nuclear periphery
Ingår i Leukemia and Lymphoma, s. 1493-1501, 2024
- DOI för Cytarabine dose intensification improves survival in older patients with secondary/high-risk acute myeloid leukemia in matched real-world versus clinical trial data
- Ladda ner fulltext (pdf) av Cytarabine dose intensification improves survival in older patients with secondary/high-risk acute myeloid leukemia in matched real-world versus clinical trial data
Delineating functional and molecular impact of ex vivo sample handling in precision medicine
Ingår i npj Precision Oncology, 2024
- DOI för Delineating functional and molecular impact of ex vivo sample handling in precision medicine
- Ladda ner fulltext (pdf) av Delineating functional and molecular impact of ex vivo sample handling in precision medicine
Therapy-related MDS dissected based on primary disease and treatment: a nationwide perspective
Ingår i Leukemia, s. 1103-1112, 2023
- DOI för Therapy-related MDS dissected based on primary disease and treatment: a nationwide perspective
- Ladda ner fulltext (pdf) av Therapy-related MDS dissected based on primary disease and treatment: a nationwide perspective
Ingår i Blood, s. 73-89, 2023
- DOI för Characterization of the bone marrow niche in patients with chronic myeloid leukemia identifies CXCL14 as a new therapeutic option
- Ladda ner fulltext (pdf) av Characterization of the bone marrow niche in patients with chronic myeloid leukemia identifies CXCL14 as a new therapeutic option
Prediction model for drug response of acute myeloid leukemia patients
Ingår i npj Precision Oncology, 2023
- DOI för Prediction model for drug response of acute myeloid leukemia patients
- Ladda ner fulltext (pdf) av Prediction model for drug response of acute myeloid leukemia patients
Ingår i Haematologica, s. 1015-1025, 2023
- DOI för Characterization of therapy-related acute myeloid leukemia: increasing incidence and prognostic implications
- Ladda ner fulltext (pdf) av Characterization of therapy-related acute myeloid leukemia: increasing incidence and prognostic implications
T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes
Ingår i Nature Biotechnology, s. 488-498, 2022
- DOI för T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes
- Ladda ner fulltext (pdf) av T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes
A risk score based on real-world data to predict early death in acute promyelocytic leukemia
Ingår i Haematologica, s. 1528-1537, 2022
- DOI för A risk score based on real-world data to predict early death in acute promyelocytic leukemia
- Ladda ner fulltext (pdf) av A risk score based on real-world data to predict early death in acute promyelocytic leukemia
Ingår i Journal of Internal Medicine, s. 925-940, 2022
- DOI för Targeting SAMHD1 with hydroxyurea in first-line cytarabine-based therapy of newly diagnosed acute myeloid leukaemia: Results from the HEAT-AML trial
- Ladda ner fulltext (pdf) av Targeting SAMHD1 with hydroxyurea in first-line cytarabine-based therapy of newly diagnosed acute myeloid leukaemia: Results from the HEAT-AML trial
Ingår i Genes, Chromosomes and Cancer, s. 426-433, 2021
- DOI för Clinical and genomic characterization of patients diagnosed with the provisional entity acute myeloid leukemia with BCR-ABL1, a Swedish population-based study
- Ladda ner fulltext (pdf) av Clinical and genomic characterization of patients diagnosed with the provisional entity acute myeloid leukemia with BCR-ABL1, a Swedish population-based study
MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia
Ingår i Cancer Research, s. 5733-5744, 2021
- DOI för MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia
- Ladda ner fulltext (pdf) av MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia
Ingår i British Journal of Haematology, s. 474-483, 2021
- DOI för Prognostic scoring systems and comorbidities in chronic myelomonocytic leukaemia: a nationwide population-based study
- Ladda ner fulltext (pdf) av Prognostic scoring systems and comorbidities in chronic myelomonocytic leukaemia: a nationwide population-based study
Ingår i Leukemia and Lymphoma, s. 1973-1981, 2021
- DOI för Is there an impact of measurable residual disease as assessed by multiparameter flow cytometry on survival of AML patients treated in clinical practice?: A population-based study
- Ladda ner fulltext (pdf) av Is there an impact of measurable residual disease as assessed by multiparameter flow cytometry on survival of AML patients treated in clinical practice?: A population-based study
Ingår i American Journal of Hematology, s. 580-588, 2021
- DOI för The transcriptome-wide landscape of molecular subtype-specific mRNA expression profiles in acute myeloid leukemia
- Ladda ner fulltext (pdf) av The transcriptome-wide landscape of molecular subtype-specific mRNA expression profiles in acute myeloid leukemia
Impact of treatment delay in acute myeloid leukemia revisited
Ingår i Blood Advances, s. 787-790, 2021
Ingår i Blood Advances, s. 1003-1016, 2021
Ingår i Clinical Cancer Research, s. 3597-3607, 2020
Ingår i Blood Cancer Journal, 2020
- DOI för Integrated transcriptomic and genomic analysis improves prediction of complete remission and survival in elderly patients with acute myeloid leukemia
- Ladda ner fulltext (pdf) av Integrated transcriptomic and genomic analysis improves prediction of complete remission and survival in elderly patients with acute myeloid leukemia
Ingår i British Journal of Haematology, 2020
Ingår i EMBO Molecular Medicine, 2020
- DOI för Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy
- Ladda ner fulltext (pdf) av Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy
Ingår i Blood Advances, s. 1094-1101, 2020
Ingår i Blood, s. 339-352, 2020
Hypo, Hyper, or Combo: new paradigm for treatment of acute myeloid leukemia in older people
Ingår i Haematologica, s. 249-251, 2020
Ingår i British Journal of Haematology, s. 187-191, 2020
Improved survival of men 50 to 75 years old with acute myeloid leukemia over a 20-year period
Ingår i Blood, s. 1558-1561, 2019
Ingår i Journal of Clinical Oncology, s. 2632-2642, 2019
Expression levels of long non-coding RNAs are prognostic for AML outcome
Ingår i Journal of Hematology & Oncology, 2018
- DOI för Expression levels of long non-coding RNAs are prognostic for AML outcome
- Ladda ner fulltext (pdf) av Expression levels of long non-coding RNAs are prognostic for AML outcome
Ingår i British Journal of Haematology, s. 614-627, 2018
Ingår i Scientific Reports, 2018
- DOI för Mediation analysis reveals common mechanisms of RUNX1 point mutations and RUNX1/RUNX1T1 fusions influencing survival of patients with acute myeloid leukemia
- Ladda ner fulltext (pdf) av Mediation analysis reveals common mechanisms of RUNX1 point mutations and RUNX1/RUNX1T1 fusions influencing survival of patients with acute myeloid leukemia
Ingår i Free Radical Biology & Medicine, s. 247-257, 2018
- DOI för Selenite and methylseleninic acid epigenetically affects distinct gene sets in myeloid leukemia: A genome wide epigenetic analysis
- Ladda ner fulltext (pdf) av Selenite and methylseleninic acid epigenetically affects distinct gene sets in myeloid leukemia: A genome wide epigenetic analysis
Ingår i Journal of the National Cancer Institute, s. 1094-1101, 2018
- DOI för Development and Validation of a Novel RNA Sequencing-Based Prognostic Score for Acute Myeloid Leukemia
- Ladda ner fulltext (pdf) av Development and Validation of a Novel RNA Sequencing-Based Prognostic Score for Acute Myeloid Leukemia
Ingår i Pediatric Blood & Cancer, 2018
Ingår i Oncotarget, s. 28812-28825, 2017
- DOI för Comprehensive mapping of the effects of azacitidine on DNA methylation, repressive/permissive histone marks and gene expression in primary cells from patients with MDS and MDS-related disease
- Ladda ner fulltext (pdf) av Comprehensive mapping of the effects of azacitidine on DNA methylation, repressive/permissive histone marks and gene expression in primary cells from patients with MDS and MDS-related disease
Ingår i Blood Cancer Journal, 2017
- DOI för Bone marrow stroma cells derived from mononuclear cells at diagnosis as a source of germline control DNA for determination of somatic mutations in acute myeloid leukemia
- Ladda ner fulltext (pdf) av Bone marrow stroma cells derived from mononuclear cells at diagnosis as a source of germline control DNA for determination of somatic mutations in acute myeloid leukemia
Ex Vivo Expanded Adaptive NK Cells Effectively Kill Primary Acute Lymphoblastic Leukemia Cells
Ingår i CANCER IMMUNOLOGY RESEARCH, s. 654-665, 2017
Prevalence and characteristics of survivors from acute myeloid leukemia in Sweden
Ingår i Leukemia, s. 728-731, 2017
Ingår i Blood, 2017
Ingår i Leukemia, s. 1108-1116, 2017
- DOI för Increased proportion of mature NK cells is associated with successful imatinib discontinuation in chronic myeloid leukemia.
- Ladda ner fulltext (pdf) av Increased proportion of mature NK cells is associated with successful imatinib discontinuation in chronic myeloid leukemia.
Ingår i European Journal of Haematology, s. 493-500, 2017
Ingår i Leukemia, s. 1457-1459, 2017
Ingår i Leukemia, s. 2029-2036, 2017
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies
Ingår i Nature Medicine, s. 256-263, 2017
An open-label phase I dose-finding study of APR-246 in hematological malignancies
Ingår i Blood Cancer Journal, 2016
- DOI för An open-label phase I dose-finding study of APR-246 in hematological malignancies
- Ladda ner fulltext (pdf) av An open-label phase I dose-finding study of APR-246 in hematological malignancies
Ingår i British Journal of Haematology, s. 117-126, 2016
Ingår i Haematologica, s. 209-210, 2016
Validation Of Prognostic Scoring Systems For Myelodysplastic Syndromes In The Swedish Mds-Register
Ingår i Haematologica, s. 243-243, 2016
Ingår i American Journal of Hematology, s. 208-214, 2015
Ingår i European Journal of Haematology, s. 419-423, 2015
Epigenetic aberrations in acute myeloid leukemia: Early key events during leukemogenesis
Ingår i Experimental Hematology, s. 609-624, 2015
Prognostic significance of high hyperdiploid and triploid/tetraploid adult acute myeloid leukemia
Ingår i American Journal of Hematology, s. 800-805, 2015
Ingår i Blood, 2015
Prevalence and Characteristics of Survivors from Adult Acute Myeloid Leukemia (AML) in Sweden 2014
Ingår i Blood, 2015
Ingår i Blood, 2015
Ingår i Epigenetics, s. 1108-1119, 2014
Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence
Ingår i New England Journal of Medicine, s. 2477-2487, 2014
Ingår i Blood, s. 1284-1292, 2013