Johanna Larsson
Forskare vid Institutionen för läkemedelskemi; Preparativ läkemedelskemi
- E-post:
- johanna.larsson@scilifelab.uu.se
- Besöksadress:
- Uppsala Biomedicinska Centrum, BMC, Husarg. 3
- Postadress:
- Box 574
751 23 UPPSALA
- ORCID:
- 0000-0002-7676-6331
Kort presentation
I’m an organic chemist working at the SciLifeLab Drug Discovery and Development platform (SciLifeLab DDD) in a team of chemists and biologists. The aim of the platform is to start from academic discoveries and work together with Swedish PI’s to progress drug development projects towards a pre-clinical proof-of-concept. My role is to design and synthesize novel drug candidates in the Hit2Lead – Lead ID phases.
https://www.scilifelab.se/platforms/ddd
Biografi
2016 -
Research Scientist, SciLifeLab Drug Discovery and Development platform (DDD)
The aim of the SciLifeLab DDD platform is to start from academic discoveries and work together with Swedish PI’s to develop small molecule and antibody leads towards a pre-clinical proof-of-concept.
The SciLifeLab DDD team consists of chemists and biologists with expertise within e.g. drug design, ADME, toxicology, biochemical and cellular screening, protein expression and crystallization, in-vitro and system pharmacology.
My role is to design and synthesize novel drug candidates in the Hit2Lead – Lead ID phases.
https://www.scilifelab.se/platforms/ddd
2014 - 2016
Research Scientist, OnTarget Chemistry / Recipharm OT Chemistry
Contract research organization, Uppsala
2008 - 2013
PhD in Organic Chemistry, Stockholm University
Development of new transition metal-catalyzed organic transformations and detailed mechanistic investigations in Prof. Kálmán Szabó’s research group
2007
Master of Science in Chemistry, Lund University
Publikationer
Senaste publikationer
-
N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
Ingår i European Journal of Medicinal Chemistry, 2024
- DOI för N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
- Ladda ner fulltext (pdf) av N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
-
Ingår i Journal of Medicinal Chemistry, s. 3915-3934, 2020
- DOI för Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability
- Ladda ner fulltext (pdf) av Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability
-
2-amino-1,3,4-thiadiazine and 2-amino-1,3,4-oxadiazine based antifungal agents
2017
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Ingår i Synlett, s. 969-976, 2016
-
Ingår i Journal of the American Chemical Society, s. 443-455, 2013
Alla publikationer
Artiklar i tidskrift
-
N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
Ingår i European Journal of Medicinal Chemistry, 2024
- DOI för N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
- Ladda ner fulltext (pdf) av N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
-
Ingår i Journal of Medicinal Chemistry, s. 3915-3934, 2020
- DOI för Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability
- Ladda ner fulltext (pdf) av Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability
-
Ingår i Synlett, s. 969-976, 2016
-
Ingår i Journal of the American Chemical Society, s. 443-455, 2013
-
Ingår i Journal of Organic Chemistry, s. 7330-7336, 2013
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Palladium-Catalyzed Oxidative Allylic C-H Silylation.
Ingår i Organic Letters, s. 1888-1891, 2011
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Ingår i Tetrahedron, s. 1374-1381, 2010
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Ingår i Organic Letters, s. 2852-2854, 2009