Miao Zhao
- E-post:
- miao.zhao@igp.uu.se
- Besöksadress:
- Dag Hammarskjölds väg 20
751 85 Uppsala - Postadress:
- Rudbecklaboratoriet
751 85 UPPSALA
Nyckelord
- Photoreceptor tumors: Medulloblastoma; Pineoblastoma; Retinoblastoma
- Mouse models
- Photoreceptor gene therapy
Forskning
Researcher / Project leader
Medulloblastoma (MB), Pineoblastoma (PB) and Retinoblastoma (RB), three types of malignant pediatric neural brain tumors, are anatomically situated in different parts of the brain but share a common feature: an elevated expression of a photoreceptor “program”. MYC/MYCN-amplified MBs, PBs, and RBs are often histologically indistinguishable, exhibiting aggressive growth, frequent relapse after standard treatment, and a dismal prognosis. It is crucial to comprehend the origin of these photoreceptor-positive tumors and explore whether similar treatment approaches could be effective.
RESEARCH FUNDING
- SciLifeLab (2019 - 2021)
- Swedish Childhood Cancer Foundation: Post-doc fellowship (2021-2023)
- Swedish Childhood Cancer Foundation: Childhood cancer research position (2025-2029)
- NIH (2024-2029)
EDUCATIONAL BACKGROUND
2018: Ph.D. in Cancer Cell Biology, Department of Biosciences and Nutrition, Karolinska Institutet, Sweden.
Publikationer
Senaste publikationer
Ingår i Nature Communications, 2025
- DOI för An injury-associated lobular microniche is associated with the classical tumor cell phenotype in pancreatic cancer
- Ladda ner fulltext (pdf) av An injury-associated lobular microniche is associated with the classical tumor cell phenotype in pancreatic cancer
Ingår i Cell Death and Disease, 2025
- DOI för Identification of a small molecule targeting EPLIN as a novel strategy for the treatment of pediatric neuroblastoma and medulloblastoma
- Ladda ner fulltext (pdf) av Identification of a small molecule targeting EPLIN as a novel strategy for the treatment of pediatric neuroblastoma and medulloblastoma
Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies
Ingår i Cancers, 2024
- DOI för Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies
- Ladda ner fulltext (pdf) av Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies
An Indolin-3-imine Photobase and pH Sensitive Fluorophore
Ingår i ChemPhotoChem, 2023
- DOI för An Indolin-3-imine Photobase and pH Sensitive Fluorophore
- Ladda ner fulltext (pdf) av An Indolin-3-imine Photobase and pH Sensitive Fluorophore
Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells
Ingår i Cell Death and Disease, 2023
- DOI för Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells
- Ladda ner fulltext (pdf) av Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells
Alla publikationer
Artiklar i tidskrift
Ingår i Nature Communications, 2025
- DOI för An injury-associated lobular microniche is associated with the classical tumor cell phenotype in pancreatic cancer
- Ladda ner fulltext (pdf) av An injury-associated lobular microniche is associated with the classical tumor cell phenotype in pancreatic cancer
Ingår i Cell Death and Disease, 2025
- DOI för Identification of a small molecule targeting EPLIN as a novel strategy for the treatment of pediatric neuroblastoma and medulloblastoma
- Ladda ner fulltext (pdf) av Identification of a small molecule targeting EPLIN as a novel strategy for the treatment of pediatric neuroblastoma and medulloblastoma
An Indolin-3-imine Photobase and pH Sensitive Fluorophore
Ingår i ChemPhotoChem, 2023
- DOI för An Indolin-3-imine Photobase and pH Sensitive Fluorophore
- Ladda ner fulltext (pdf) av An Indolin-3-imine Photobase and pH Sensitive Fluorophore
Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells
Ingår i Cell Death and Disease, 2023
- DOI för Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells
- Ladda ner fulltext (pdf) av Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells
Ingår i Nature Communications, 2023
- DOI för ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors
- Ladda ner fulltext (pdf) av ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors
Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma
Ingår i Cancer Research, s. 4586-4603, 2022
- DOI för Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma
- Ladda ner fulltext (pdf) av Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma
Ingår i Cancers, 2022
- DOI för Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions
- Ladda ner fulltext (pdf) av Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions
Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples
Ingår i Genome Research, s. 150-161, 2022
- DOI för Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples
- Ladda ner fulltext (pdf) av Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples
Ingår i Nucleic Acids Research, 2021
- DOI för FACT-seq: profiling histone modifications in formalin-fixed paraffin-embedded samples with low cell numbers
- Ladda ner fulltext (pdf) av FACT-seq: profiling histone modifications in formalin-fixed paraffin-embedded samples with low cell numbers
Ingår i Nature Communications, 2021
- DOI för Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma
- Ladda ner fulltext (pdf) av Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma
PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer
Ingår i Nature Communications, 2019
- DOI för PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer
- Ladda ner fulltext (pdf) av PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer
Normal mammary gland development after MMTV-Cre mediated conditional PAK4 gene depletion
Ingår i Scientific Reports, 2019
- DOI för Normal mammary gland development after MMTV-Cre mediated conditional PAK4 gene depletion
- Ladda ner fulltext (pdf) av Normal mammary gland development after MMTV-Cre mediated conditional PAK4 gene depletion
Artiklar, forskningsöversikt
Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies
Ingår i Cancers, 2024
- DOI för Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies
- Ladda ner fulltext (pdf) av Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies