Wen Liu
Forskningsinfrastrukturspecialist vid Institutionen för kirurgiska vetenskaper; Medicinsk epidemiologi
- E-post:
- wen.liu@uu.se
- Besöksadress:
- Epihubben, Dag Hammarskjölds väg 14 B
75185 Uppsala - Postadress:
- Epihubben, MTC-huset
75185 Uppsala
Kort presentation
Docent i cancerepidemiologi. Min forskning fokuserar på genetiska och miljömässiga bestämningsfaktorer för cancer, särskilt bröst-, endometrie- och kolorektalcancer. Jag använder metoder inom molekylär epidemiologi och statistisk genetik, inklusive haplotypbaserade genome-wide-analyser, för att studera cancersusceptibilitet, gen–miljöinteraktioner och faktorer som påverkar sjukdomsutveckling och behandlingssvar i populationsbaserade kohorter. Jag är forskningsinfrastrukturspecialist inom SIMPLER
Nyckelord
- Cancerepidemiologi
- Molekylär epidemiologi
- Genetisk epidemiologi
- Statistisk genetik
- Genome-wide associationsstudier (GWAS)
- Haplotypbaserad analys
- Genetisk mottaglighet
- Gen–miljöinteraktioner Miljöexponeringa
- Bröstcancer
- Endometriecancer
- Kolorektalcancer
- Populationsbaserade kohorter
- Biobanksbaserad forskning

Publikationer
Senaste publikationer
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Ingår i Science of the Total Environment, 2025
- DOI för Extensive analysis of pollutant interactions: Identification of deleterious synergistic effects at environmentally relevant dose levels using Drosophila and mammalian cells
- Ladda ner fulltext (pdf) av Extensive analysis of pollutant interactions: Identification of deleterious synergistic effects at environmentally relevant dose levels using Drosophila and mammalian cells
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Ingår i International Journal of Molecular Sciences, 2025
- DOI för Novel Shared Heritable Candidate Risk Loci of Breast and Endometrial Cancer-A Swedish Haplotype Genome-Wide Association Study
- Ladda ner fulltext (pdf) av Novel Shared Heritable Candidate Risk Loci of Breast and Endometrial Cancer-A Swedish Haplotype Genome-Wide Association Study
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Ingår i PLOS ONE, 2025
- DOI för A Swedish genome-wide haplotype association analysis identifies novel candidate loci associated with endometrial cancer risk
- Ladda ner fulltext (pdf) av A Swedish genome-wide haplotype association analysis identifies novel candidate loci associated with endometrial cancer risk
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A Haplotype GWAS in Syndromic Familial Colorectal Cancer
Ingår i International Journal of Molecular Sciences, 2025
- DOI för A Haplotype GWAS in Syndromic Familial Colorectal Cancer
- Ladda ner fulltext (pdf) av A Haplotype GWAS in Syndromic Familial Colorectal Cancer
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Ingår i Science of the Total Environment, 2024
- DOI för Perfluorooctanoic acid induces transgenerational modifications in reproduction, metabolism, locomotor activity, and sleep behavior in Drosophila melanogaster and deleterious effects in human cancer cells
- Ladda ner fulltext (pdf) av Perfluorooctanoic acid induces transgenerational modifications in reproduction, metabolism, locomotor activity, and sleep behavior in Drosophila melanogaster and deleterious effects in human cancer cells
Alla publikationer
Artiklar i tidskrift
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Ingår i Science of the Total Environment, 2025
- DOI för Extensive analysis of pollutant interactions: Identification of deleterious synergistic effects at environmentally relevant dose levels using Drosophila and mammalian cells
- Ladda ner fulltext (pdf) av Extensive analysis of pollutant interactions: Identification of deleterious synergistic effects at environmentally relevant dose levels using Drosophila and mammalian cells
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Ingår i International Journal of Molecular Sciences, 2025
- DOI för Novel Shared Heritable Candidate Risk Loci of Breast and Endometrial Cancer-A Swedish Haplotype Genome-Wide Association Study
- Ladda ner fulltext (pdf) av Novel Shared Heritable Candidate Risk Loci of Breast and Endometrial Cancer-A Swedish Haplotype Genome-Wide Association Study
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Ingår i PLOS ONE, 2025
- DOI för A Swedish genome-wide haplotype association analysis identifies novel candidate loci associated with endometrial cancer risk
- Ladda ner fulltext (pdf) av A Swedish genome-wide haplotype association analysis identifies novel candidate loci associated with endometrial cancer risk
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A Haplotype GWAS in Syndromic Familial Colorectal Cancer
Ingår i International Journal of Molecular Sciences, 2025
- DOI för A Haplotype GWAS in Syndromic Familial Colorectal Cancer
- Ladda ner fulltext (pdf) av A Haplotype GWAS in Syndromic Familial Colorectal Cancer
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Ingår i Science of the Total Environment, 2024
- DOI för Perfluorooctanoic acid induces transgenerational modifications in reproduction, metabolism, locomotor activity, and sleep behavior in Drosophila melanogaster and deleterious effects in human cancer cells
- Ladda ner fulltext (pdf) av Perfluorooctanoic acid induces transgenerational modifications in reproduction, metabolism, locomotor activity, and sleep behavior in Drosophila melanogaster and deleterious effects in human cancer cells
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Ingår i Hereditary Cancer in Clinical Practice, 2024
- DOI för A genome-wide association study in Swedish colorectal cancer patients with gastric- and prostate cancer in relatives
- Ladda ner fulltext (pdf) av A genome-wide association study in Swedish colorectal cancer patients with gastric- and prostate cancer in relatives
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Ingår i British Journal of Pharmacology, s. 2750-2773, 2024
- DOI för Hydroxymethylglutaryl-CoA reductase activity is essential for mitochondrial β-oxidation of fatty acids to prevent lethal accumulation of long-chain acylcarnitines in the mouse liver
- Ladda ner fulltext (pdf) av Hydroxymethylglutaryl-CoA reductase activity is essential for mitochondrial β-oxidation of fatty acids to prevent lethal accumulation of long-chain acylcarnitines in the mouse liver
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Ingår i Genes, 2024
- DOI för Swedish Genome-Wide Haplotype Association Analysis Suggests Breast Cancer Loci with Varying Risk-Modifying Effects
- Ladda ner fulltext (pdf) av Swedish Genome-Wide Haplotype Association Analysis Suggests Breast Cancer Loci with Varying Risk-Modifying Effects
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Ingår i Science of the Total Environment, 2024
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Ingår i Journal of Applied Toxicology, s. 458-469, 2023
- DOI för Interaction between environmental pollutants and cancer drug efficacy: Bisphenol A, Bisphenol A diglycidyl ether and Perfluorooctanoic acid reduce vincristine cytotoxicity in acute lymphoblastic leukemia cells
- Ladda ner fulltext (pdf) av Interaction between environmental pollutants and cancer drug efficacy: Bisphenol A, Bisphenol A diglycidyl ether and Perfluorooctanoic acid reduce vincristine cytotoxicity in acute lymphoblastic leukemia cells
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Ingår i Clinica Chimica Acta, 2023
- DOI för Identification and validation of volatile organic compounds in bile for differential diagnosis of perihilar cholangiocarcinoma
- Ladda ner fulltext (pdf) av Identification and validation of volatile organic compounds in bile for differential diagnosis of perihilar cholangiocarcinoma
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Ingår i International Journal of Molecular Sciences, 2023
- DOI för A Swedish Familial Genome-Wide Haplotype Analysis Identified Five Novel Breast Cancer Susceptibility Loci on 9p24.3, 11q22.3, 15q11.2, 16q24.1 and Xq21.31
- Ladda ner fulltext (pdf) av A Swedish Familial Genome-Wide Haplotype Analysis Identified Five Novel Breast Cancer Susceptibility Loci on 9p24.3, 11q22.3, 15q11.2, 16q24.1 and Xq21.31
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Ingår i Biomedicines, 2022
- DOI för Generation of Endogenous Promoter-Driven Luciferase Reporter System Using CRISPR/Cas9 for Investigating Transcriptional Regulation of the Core Clock Gene BMAL1
- Ladda ner fulltext (pdf) av Generation of Endogenous Promoter-Driven Luciferase Reporter System Using CRISPR/Cas9 for Investigating Transcriptional Regulation of the Core Clock Gene BMAL1
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Ingår i Cancers, 2022
- DOI för A Swedish Genome-Wide Haplotype Association Analysis Identifies a Novel Breast Cancer Susceptibility Locus in 8p21.2 and Characterizes Three Loci on Chromosomes 10, 11 and 16
- Ladda ner fulltext (pdf) av A Swedish Genome-Wide Haplotype Association Analysis Identifies a Novel Breast Cancer Susceptibility Locus in 8p21.2 and Characterizes Three Loci on Chromosomes 10, 11 and 16
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Colorectal cancer risk susceptibility loci in a Swedish population
Ingår i Molecular Carcinogenesis, s. 288-300, 2022
- DOI för Colorectal cancer risk susceptibility loci in a Swedish population
- Ladda ner fulltext (pdf) av Colorectal cancer risk susceptibility loci in a Swedish population
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Ingår i Molecules, 2022
- DOI för Enhanced Toxicity of Bisphenols Together with UV Filters in Water: Identification of Synergy and Antagonism in Three-Component Mixtures
- Ladda ner fulltext (pdf) av Enhanced Toxicity of Bisphenols Together with UV Filters in Water: Identification of Synergy and Antagonism in Three-Component Mixtures
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Ingår i International Journal of Environmental Research and Public Health, s. 2064-2064, 2022
- DOI för Can Exposure to Environmental Pollutants Be Associated with Less Effective Chemotherapy in Cancer Patients?
- Ladda ner fulltext (pdf) av Can Exposure to Environmental Pollutants Be Associated with Less Effective Chemotherapy in Cancer Patients?
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Ingår i Membranes, 2021
- DOI för Multidrug Resistance Like Protein 1 Activity in Malpighian Tubules Regulates Lipid Homeostasis in Drosophila
- Ladda ner fulltext (pdf) av Multidrug Resistance Like Protein 1 Activity in Malpighian Tubules Regulates Lipid Homeostasis in Drosophila
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Dibutyl phthalate disrupts conserved circadian rhythm in Drosophila and human cells
Ingår i Science of the Total Environment, 2021
- DOI för Dibutyl phthalate disrupts conserved circadian rhythm in Drosophila and human cells
- Ladda ner fulltext (pdf) av Dibutyl phthalate disrupts conserved circadian rhythm in Drosophila and human cells
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Ingår i Science of the Total Environment, 2021
Artiklar, forskningsöversikt
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Ingår i Basic & Clinical Pharmacology & Toxicology, s. 130-141, 2023
- DOI för The effect of sunscreen 4-methylbenzylidene camphor in different and reproductive models, its bioaccumulation and molecular effects on ligand-receptor interaction, and protein expression
- Ladda ner fulltext (pdf) av The effect of sunscreen 4-methylbenzylidene camphor in different and reproductive models, its bioaccumulation and molecular effects on ligand-receptor interaction, and protein expression
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Ingår i Critical reviews in environmental science and technology, s. 4094-4112, 2022
- DOI för The potential interaction of environmental pollutants and circadian rhythm regulations that may cause leukemia
- Ladda ner fulltext (pdf) av The potential interaction of environmental pollutants and circadian rhythm regulations that may cause leukemia
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Ingår i Frontiers in Pharmacology, 2022
- DOI för Recent developments of phosphodiesterase inhibitors: Clinical trials, emerging indications and novel molecules
- Ladda ner fulltext (pdf) av Recent developments of phosphodiesterase inhibitors: Clinical trials, emerging indications and novel molecules