Erik Sjögren

Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project

Abrahamsson, B.; McAllister, M.; Augustijns, P.; Zane, P. et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 236-247, 2020

• DOI för Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project

Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link: a Workshop Summary Report

Heimbach, Tycho; Suarez-Sharp, Sandra; Kakhi, Maziar; Holmstock, Nico et al.

Ingår i AAPS Journal, 2019

• DOI för Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link: a Workshop Summary Report

Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences

Lippert, Joerg; Burghaus, Rolf; Edginton, Andrea; Frechen, Sebastian et al.

Ingår i CPT, s. 878-882, 2019

• DOI för Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences
• Ladda ner fulltext (pdf) av Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences

Mechanistic modelling of intestinal drug absorption: the in vivo effects of nanoparticles, hydrodynamics, and colloidal structures

Roos, Carl; Westergren, Jan; Dahlgren, David; Lennernäs, Hans et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 70-76, 2018

• DOI för Mechanistic modelling of intestinal drug absorption: the in vivo effects of nanoparticles, hydrodynamics, and colloidal structures

In vivo Drug Delivery Performance of Lipiodol-based Emulsion or Drug-eluting Beads in Patients with Hepatocellular Carcinoma

Lilienberg, Elsa; Dubbelboer, Ilse R.; Karalli, Amar; Axelsson, Rimma et al.

Ingår i Molecular Pharmaceutics, s. 448-458, 2017

• DOI för In vivo Drug Delivery Performance of Lipiodol-based Emulsion or Drug-eluting Beads in Patients with Hepatocellular Carcinoma

In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically Based Absorption Models

Sjögren, Erik; Thorn, Helena; Tannergren, Christer

Ingår i Molecular Pharmaceutics, s. 1763-1778, 2016

• DOI för In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically Based Absorption Models

Human in Vivo Regional Intestinal Permeability: Quantitation Using Site-Specific Drug Absorption Data

Sjögren, Erik; Dahlgren, David; Roos, Carl; Lennernas, Hans

Ingår i Molecular Pharmaceutics, s. 2026-2039, 2015

• DOI för Human in Vivo Regional Intestinal Permeability: Quantitation Using Site-Specific Drug Absorption Data

Direct In Vivo Human Intestinal Permeability (P-eff) Determined with Different Clinical Perfusion and Intubation Methods

Dahlgren, David; Roos, Carl; Sjögren, Erik; Lennernäs, Hans

Ingår i Journal of Pharmaceutical Sciences, s. 2702-2726, 2015

• DOI för Direct In Vivo Human Intestinal Permeability (P-eff) Determined with Different Clinical Perfusion and Intubation Methods

In vivo methods for drug absorption - Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects

Sjögren, Erik; Abrahamsson, Bertil; Augustijns, Patrick; Becker, Dieter et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 99-151, 2014

• DOI för In vivo methods for drug absorption - Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects

In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: Application of the mechanistic absorption model GI-Sim

Sjögren, Erik; Westergren, Jan; Grant, Iain; Hanisch, Gunilla et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 679-698, 2013

• DOI för In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: Application of the mechanistic absorption model GI-Sim

Best Practices in Physiologically Based Pharmacokinetic (PBPK) Modeling

Chenel, Marylore; Dallmann, Andre; Ince, Ibrahim; Meyer, Michaela et al.

Ingår i CPT, 2026

• DOI för Best Practices in Physiologically Based Pharmacokinetic (PBPK) Modeling
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Accelerating Subcutaneous Drug Development: A Mechanistic Absorption Model for the Open Systems Pharmacology Framework

Pellowe, Moriah; Dubbelboer, Ilse R.; Sjögren, Erik

Ingår i CPT, 2026

• DOI för Accelerating Subcutaneous Drug Development: A Mechanistic Absorption Model for the Open Systems Pharmacology Framework
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Rational formulation design through retrospective machine learning methodology: Case study ibuprofen

Garamani, Dylan; Sjögren, Erik; Mihranyan, Albert

Ingår i International Journal of Pharmaceutics, 2026

• DOI för Rational formulation design through retrospective machine learning methodology: Case study ibuprofen
• Ladda ner fulltext (pdf) av Rational formulation design through retrospective machine learning methodology: Case study ibuprofen

Open Systems Pharmacology Community Conference (OSP-CC) Proceedings 2025

Cordes, Henrik; Annaert, Pieter; Balazki, Pavel; Benamara, Salih et al.

Ingår i CPT, 2026

• DOI för Open Systems Pharmacology Community Conference (OSP-CC) Proceedings 2025
• Ladda ner fulltext (pdf) av Open Systems Pharmacology Community Conference (OSP-CC) Proceedings 2025

Whole-Body Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling for Interspecies Translation and Mechanistic Characterization of Plasma and Tissue Disposition of GalNAc-siRNAs

Langeskov, Emilie Salim; Kristensen, Kim; Chopda, Girish; Sjögren, Erik

Ingår i Pharmaceutics, 2025

• DOI för Whole-Body Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling for Interspecies Translation and Mechanistic Characterization of Plasma and Tissue Disposition of GalNAc-siRNAs
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Accelerating Subcutaneous Drug Development: A Mechanistic Absorption Model for the Open Systems Pharmacology Framework

Pellowe, Moriah; Dubbelboer, Ilse R.; Sjögren, Erik

Ingår i CPT, 2026

• DOI för Accelerating Subcutaneous Drug Development: A Mechanistic Absorption Model for the Open Systems Pharmacology Framework
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Rational formulation design through retrospective machine learning methodology: Case study ibuprofen

Garamani, Dylan; Sjögren, Erik; Mihranyan, Albert

Ingår i International Journal of Pharmaceutics, 2026

• DOI för Rational formulation design through retrospective machine learning methodology: Case study ibuprofen
• Ladda ner fulltext (pdf) av Rational formulation design through retrospective machine learning methodology: Case study ibuprofen

Open Systems Pharmacology Community Conference (OSP-CC) Proceedings 2025

Cordes, Henrik; Annaert, Pieter; Balazki, Pavel; Benamara, Salih et al.

Ingår i CPT, 2026

• DOI för Open Systems Pharmacology Community Conference (OSP-CC) Proceedings 2025
• Ladda ner fulltext (pdf) av Open Systems Pharmacology Community Conference (OSP-CC) Proceedings 2025

Whole-Body Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling for Interspecies Translation and Mechanistic Characterization of Plasma and Tissue Disposition of GalNAc-siRNAs

Langeskov, Emilie Salim; Kristensen, Kim; Chopda, Girish; Sjögren, Erik

Ingår i Pharmaceutics, 2025

• DOI för Whole-Body Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling for Interspecies Translation and Mechanistic Characterization of Plasma and Tissue Disposition of GalNAc-siRNAs
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Integrated Physiologically-based Pharmacokinetic Model with a Quantitative Systems Pharmacology and Toxicology Model for Statins in Disease Population. Part 2: MIDD and MIPD Applications

Prieto Garcia, Luna; Nordell, Pär; Ahlström, Christine; Lennernäs, Hans et al.

Ingår i AAPS Journal, 2025

• DOI för Integrated Physiologically-based Pharmacokinetic Model with a Quantitative Systems Pharmacology and Toxicology Model for Statins in Disease Population. Part 2: MIDD and MIPD Applications
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Integrated Physiologically-Based Pharmacokinetic Model with a Quantitative Systems Pharmacology and Toxicology Model for Statins in Disease Population. Part 1: Model Development and Validation

Prieto Garcia, Luna; Nordell, Par; Ahlstrom, Christine; Lennernäs, Hans et al.

Ingår i AAPS Journal, 2025

• DOI för Integrated Physiologically-Based Pharmacokinetic Model with a Quantitative Systems Pharmacology and Toxicology Model for Statins in Disease Population. Part 1: Model Development and Validation
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Harnessing Open-Source Solutions: Insights From the First Open Systems Pharmacology (OSP) Community Conference

Dallmann, André; Feick, Denise; Balazki, Pavel; Benamara, Salih et al.

Ingår i CPT, s. 822-827, 2025

• DOI för Harnessing Open-Source Solutions: Insights From the First Open Systems Pharmacology (OSP) Community Conference
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Whole-Body Physiologically Based Pharmacokinetic Modeling of GalNAc-Conjugated siRNAs

Langeskov Salim, Emilie; Kristensen, Kim; Sjögren, Erik

Ingår i Pharmaceutics, 2025

• DOI för Whole-Body Physiologically Based Pharmacokinetic Modeling of GalNAc-Conjugated siRNAs
• Ladda ner fulltext (pdf) av Whole-Body Physiologically Based Pharmacokinetic Modeling of GalNAc-Conjugated siRNAs

Skin pharmacokinetics of miltefosine in the treatment of post-kala-azar dermal leishmaniasis in South Asia

Palic, Semra; Chu, Wan-Yu; Sundar, Shyam; Mondal, Dinesh et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 1547-1554, 2024

• DOI för Skin pharmacokinetics of miltefosine in the treatment of post-kala-azar dermal leishmaniasis in South Asia
• Ladda ner fulltext (pdf) av Skin pharmacokinetics of miltefosine in the treatment of post-kala-azar dermal leishmaniasis in South Asia

PBPK modeling of recombinant factor IX Fc fusion protein (rFIXFc) and rFIX to characterize the binding to type 4 collagen in the extravascular space

Cloesmeijer, Michael E.; Sjögren, Erik; Koopman, Sjoerd F.; Lenting, Peter. J. et al.

Ingår i CPT, s. 1630-1640, 2024

• DOI för PBPK modeling of recombinant factor IX Fc fusion protein (rFIXFc) and rFIX to characterize the binding to type 4 collagen in the extravascular space
• Ladda ner fulltext (pdf) av PBPK modeling of recombinant factor IX Fc fusion protein (rFIXFc) and rFIX to characterize the binding to type 4 collagen in the extravascular space

Physiologically based pharmacokinetics modeling and transporter proteomics to predict systemic and local liver and muscle disposition of statins

Garcia, Luna Prieto; Vildhede, Anna; Nordell, Pär; Ahlström, Christine et al.

Ingår i CPT, s. 1029-1043, 2024

• DOI för Physiologically based pharmacokinetics modeling and transporter proteomics to predict systemic and local liver and muscle disposition of statins
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Physiologically based biopharmaceutics modeling of regional and colon absorption in humans

Tannergren, Christer; Jadhav, Harshad; Eckernas, Emma; Fagerberg, Jonas et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 144-159, 2023

• DOI för Physiologically based biopharmaceutics modeling of regional and colon absorption in humans

Quantitative imaging of doxorubicin diffusion and cellular uptake in biomimetic gels with human liver tumor cells

Degerstedt, Oliver; O'Callaghan, Paul; Clavero, Ada Lerma; Gråsjö, Johan et al.

Ingår i Drug Delivery and Translational Research, s. 970-983, 2023

• DOI för Quantitative imaging of doxorubicin diffusion and cellular uptake in biomimetic gels with human liver tumor cells
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Understanding Statin-Roxadustat Drug–Drug-Disease Interaction Using Physiologically-Based Pharmacokinetic Modeling

Dong, Jin; Garcia, Luna Prieto; Huang, Yingbo; Tang, Weifeng et al.

Ingår i Clinical Pharmacology and Therapeutics, s. 825-835, 2023

• DOI för Understanding Statin-Roxadustat Drug–Drug-Disease Interaction Using Physiologically-Based Pharmacokinetic Modeling
• Ladda ner fulltext (pdf) av Understanding Statin-Roxadustat Drug–Drug-Disease Interaction Using Physiologically-Based Pharmacokinetic Modeling

Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival

Sennefelt Nyman, Sofi; Ahlström, Håkan; Dimopoulou, Angeliki; Dahlgren, David et al.

Ingår i BMJ Open, 2022

• DOI för Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival
• Ladda ner fulltext (pdf) av Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival

Physiological based pharmacokinetic and biopharmaceutics modelling of subcutaneously administered compounds - An overview of in silico models

Dubbelboer, Ilse R.; Sjögren, Erik

Ingår i International Journal of Pharmaceutics, 2022

• DOI för Physiological based pharmacokinetic and biopharmaceutics modelling of subcutaneously administered compounds - An overview of in silico models
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Overview of authorized drug products for subcutaneous administration: Pharmaceutical, therapeutic, and physicochemical properties

Dubbelboer, Ilse R.; Sjögren, Erik

Ingår i European Journal of Pharmaceutical Sciences, 2022

• DOI för Overview of authorized drug products for subcutaneous administration: Pharmaceutical, therapeutic, and physicochemical properties
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Drug diffusion in biomimetic hydrogels: importance for drug transport and delivery in non-vascular tumor tissue

Degerstedt, Oliver; Gråsjö, Johan; Norberg, Anton; Sjögren, Erik et al.

Ingår i European Journal of Pharmaceutical Sciences, 2022

• DOI för Drug diffusion in biomimetic hydrogels: importance for drug transport and delivery in non-vascular tumor tissue
• Ladda ner fulltext (pdf) av Drug diffusion in biomimetic hydrogels: importance for drug transport and delivery in non-vascular tumor tissue

Does the choice of applied physiologically-based pharmacokinetics platform matter?: A case study on simvastatin disposition and drug-drug interaction

Garcia, Luna Prieto; Lundahl, Anna; Ahlstrom, Christine; Vildhede, Anna et al.

Ingår i CPT, s. 1194-1209, 2022

• DOI för Does the choice of applied physiologically-based pharmacokinetics platform matter?: A case study on simvastatin disposition and drug-drug interaction
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In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma

Kullenberg, Fredrik; Degerstedt, Oliver; Calitz, Carlemi; Pavlovic, Natasa et al.

Ingår i Cells, 2021

• DOI för In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma
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Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption

Eriksson, Johanna; Sjögren, Erik; Lennernäs, Hans; Thörn, Helena

Ingår i AAPS Journal, 2020

• DOI för Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption
• Ladda ner fulltext (pdf) av Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption

Pulmonary drug absorption and systemic exposure in human: Predictions using physiologically based biopharmaceutics modeling

Eriksson, Johanna; Thorn, Helena; Lennernäs, Hans; Sjögren, Erik

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 191-202, 2020

• DOI för Pulmonary drug absorption and systemic exposure in human: Predictions using physiologically based biopharmaceutics modeling

Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project

Abrahamsson, B.; McAllister, M.; Augustijns, P.; Zane, P. et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 236-247, 2020

• DOI för Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project

Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link: a Workshop Summary Report

Heimbach, Tycho; Suarez-Sharp, Sandra; Kakhi, Maziar; Holmstock, Nico et al.

Ingår i AAPS Journal, 2019

• DOI för Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link: a Workshop Summary Report

Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality

Ahnfelt, Emelie; Degerstedt, Oliver; Lilienberg, Elsa; Sjögren, Erik et al.

Ingår i Journal of Drug Delivery Science and Technology, 2019

• DOI för Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality
• Ladda ner fulltext (pdf) av Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality

Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile

Dubbelboer, Ilse R; Pavlovic, Natasa; Heindryckx, Femke; Sjögren, Erik et al.

Ingår i Cancers, 2019

• DOI för Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile
• Ladda ner fulltext (pdf) av Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile

Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences

Lippert, Joerg; Burghaus, Rolf; Edginton, Andrea; Frechen, Sebastian et al.

Ingår i CPT, s. 878-882, 2019

• DOI för Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences
• Ladda ner fulltext (pdf) av Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences

Pulmonary Dissolution of Poorly Soluble Compounds Studied in an ex Vivo Rat Lung Model

Eriksson, Johanna; Thorn, Helena; Sjögren, Erik; Holmsten, Lisa et al.

Ingår i Molecular Pharmaceutics, s. 3053-3064, 2019

• DOI för Pulmonary Dissolution of Poorly Soluble Compounds Studied in an ex Vivo Rat Lung Model

The effect of intradermal microdosing of a transient receptor potential cation channel subfamily V member 1 antagonist on heat evoked pain and thermal thresholds in normal and ultraviolet-C exposed skin in healthy volunteers

Sjögren, Erik; Stahle, Lars; Quiding, Hans; Jonzon, Bror et al.

Ingår i European Journal of Pain, s. 1767-1779, 2019

• DOI för The effect of intradermal microdosing of a transient receptor potential cation channel subfamily V member 1 antagonist on heat evoked pain and thermal thresholds in normal and ultraviolet-C exposed skin in healthy volunteers

Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model

Dahlgren, David; Roos, Carl; Peters, Karsten; Lundqvist, A. et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 31-37, 2019

• DOI för Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model

Rat intestinal drug permeability: A status report and summary of repeated determinations

Dubbelboer, Ilse R; Dahlgren, David; Sjögren, Erik; Lennernäs, Hans

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 364-376, 2019

• DOI för Rat intestinal drug permeability: A status report and summary of repeated determinations

Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 387-395, 2019

• DOI för Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

Does the Intake of Ethanol Affect Oral Absorption of Poorly Soluble Drugs?

Keemink, Janneke; Sjögren, Erik; Holm, Rene; Bergström, Christel A. S.

Ingår i Journal of Pharmaceutical Sciences, s. 1765-1771, 2019

• DOI för Does the Intake of Ethanol Affect Oral Absorption of Poorly Soluble Drugs?
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Porcine and Human In Vivo Simulations for Doxorubicin-Containing Formulations Used in Locoregional Hepatocellular Carcinoma Treatment

Dubbelboer, Ilse R; Sjögren, Erik; Lennernäs, Hans

Ingår i AAPS Journal, 2018

• DOI för Porcine and Human In Vivo Simulations for Doxorubicin-Containing Formulations Used in Locoregional Hepatocellular Carcinoma Treatment
• Ladda ner fulltext (pdf) av Porcine and Human In Vivo Simulations for Doxorubicin-Containing Formulations Used in Locoregional Hepatocellular Carcinoma Treatment

Applications of Clinically Relevant Dissolution Testing: Workshop Summary Report

Suarez-Sharp, Sandra; Cohen, Michael; Kesisoglou, Filippos; Abend, Andreas et al.

Ingår i AAPS Journal, 2018

• DOI för Applications of Clinically Relevant Dissolution Testing: Workshop Summary Report

Single bead investigation of a clinical drug delivery system – a novel release mechanism

Ahnfelt, Emelie; Al-Tikriti, Yassir; Sjögren, Erik; Lennernäs, Hans et al.

Ingår i Journal of Controlled Release, s. 235-247, 2018

• DOI för Single bead investigation of a clinical drug delivery system – a novel release mechanism
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Time-dependent effects on small intestinal transport by absorption-modifying excipients

Dahlgren, David; Roos, Carl; Lundqvist, A.; Tannergren, C. et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 19-28, 2018

• DOI för Time-dependent effects on small intestinal transport by absorption-modifying excipients

Mechanistic modelling of intestinal drug absorption: the in vivo effects of nanoparticles, hydrodynamics, and colloidal structures

Roos, Carl; Westergren, Jan; Dahlgren, David; Lennernäs, Hans et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 70-76, 2018

• DOI för Mechanistic modelling of intestinal drug absorption: the in vivo effects of nanoparticles, hydrodynamics, and colloidal structures

Jejunal absorption of aprepitant from nanosuspensions: Role of particle size, prandial state and mucus layer.

Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 222-230, 2018

• DOI för Jejunal absorption of aprepitant from nanosuspensions: Role of particle size, prandial state and mucus layer.

Effect of absorption-modifying excipients, hypotonicity, and enteric neural activity in an in vivo model for small intestinal transport.

Dahlgren, David; Roos, Carl; Lundqvist, A; Tannergren, C et al.

Ingår i International Journal of Pharmaceutics, s. 239-248, 2018

• DOI för Effect of absorption-modifying excipients, hypotonicity, and enteric neural activity in an in vivo model for small intestinal transport.

Clinical testing of three novel transient receptor potential cation channel subfamily V member 1 antagonists in a pharmacodynamic intradermal capsaicin model

Sjögren, Erik; Kullenberg, T.; Jonzon, B.; Segerdahl, M. et al.

Ingår i European Journal of Pain, s. 1214-1228, 2018

• DOI för Clinical testing of three novel transient receptor potential cation channel subfamily V member 1 antagonists in a pharmacodynamic intradermal capsaicin model

The effects of three absorption-modifying critical excipients on the in vivo intestinal absorption of six model compounds in rats and dogs.

Dahlgren, David; Roos, Carl; Johansson, P; Tannergren, C et al.

Ingår i International Journal of Pharmaceutics, s. 158-168, 2018

• DOI för The effects of three absorption-modifying critical excipients on the in vivo intestinal absorption of six model compounds in rats and dogs.

Preclinical characterization of three transient receptor potential vanilloid receptor 1 antagonists for early use in human intradermal microdose analgesic studies

Sjögren, Erik; Halldin, M. M.; Stålberg, O.; Sundgren-Andersson, A. K.

Ingår i European Journal of Pain, s. 889-903, 2018

• DOI för Preclinical characterization of three transient receptor potential vanilloid receptor 1 antagonists for early use in human intradermal microdose analgesic studies

Pulmonary absorption - estimation of effective pulmonary permeability and tissue retention of ten drugs using an ex vivo rat model and computational analysis

Eriksson, Johanna; Sjögren, Erik; Thörn, Helena; Rubin, Katarina et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 1-12, 2018

• DOI för Pulmonary absorption - estimation of effective pulmonary permeability and tissue retention of ten drugs using an ex vivo rat model and computational analysis

Reply to "Comment on 'In Vivo Drug Delivery Performance of Lipiodol-Based Emulsion or Drug-Eluting Beads in Patients with Hepatocellular Carcinoma'"

Dubbelboer, Ilse R; Lilienberg, Elsa; Karalli, Amar; Axelsson, Rimma et al.

Ingår i Molecular Pharmaceutics, s. 336-340, 2018

• DOI för Reply to "Comment on 'In Vivo Drug Delivery Performance of Lipiodol-Based Emulsion or Drug-Eluting Beads in Patients with Hepatocellular Carcinoma'"

Preclinical Effect of Absorption Modifying Excipients on Rat Intestinal Transport of Model Compounds and the Mucosal Barrier Marker ⁵¹Cr-EDTA

Dahlgren, David; Roos, Carl; Lundqvist, Anders; Tannergren, Christer et al.

Ingår i Molecular Pharmaceutics, s. 4243-4251, 2017

• DOI för Preclinical Effect of Absorption Modifying Excipients on Rat Intestinal Transport of Model Compounds and the Mucosal Barrier Marker ⁵¹Cr-EDTA

Computational fluid dynamics (CFD) studies of a miniaturized dissolution system

Frenning, Göran; Ahnfelt, Emelie; Sjögren, Erik; Lennernäs, Hans

Ingår i International Journal of Pharmaceutics, s. 274-281, 2017

• DOI för Computational fluid dynamics (CFD) studies of a miniaturized dissolution system
• Ladda ner fulltext (pdf) av Computational fluid dynamics (CFD) studies of a miniaturized dissolution system

In vivo Drug Delivery Performance of Lipiodol-based Emulsion or Drug-eluting Beads in Patients with Hepatocellular Carcinoma

Lilienberg, Elsa; Dubbelboer, Ilse R.; Karalli, Amar; Axelsson, Rimma et al.

Ingår i Molecular Pharmaceutics, s. 448-458, 2017

• DOI för In vivo Drug Delivery Performance of Lipiodol-based Emulsion or Drug-eluting Beads in Patients with Hepatocellular Carcinoma

Regional Intestinal Permeability in Rats: A Comparison of Methods

Roos, Carl; Dahlgren, David; Sjögren, Erik; Tannergren, Christer et al.

Ingår i Molecular Pharmaceutics, s. 4252-4261, 2017

• DOI för Regional Intestinal Permeability in Rats: A Comparison of Methods

In Vivo Mechanisms of Intestinal Drug Absorption from Aprepitant Nanoformulations

Roos, Carl; Dahlgren, David; Berg, Staffan; Westergren, Jan et al.

Ingår i Molecular Pharmaceutics, s. 4233-4242, 2017

• DOI för In Vivo Mechanisms of Intestinal Drug Absorption from Aprepitant Nanoformulations

In Vivo Predictive Dissolution (IPD) and Biopharmaceutical Modeling and Simulation: Future Use of Modern Approaches and Methodologies in a Regulatory Context

Lennernäs, Hans; Lindahl, A.; Van Peer, A.; Ollier, C. et al.

Ingår i Molecular Pharmaceutics, s. 1307-1314, 2017

• DOI för In Vivo Predictive Dissolution (IPD) and Biopharmaceutical Modeling and Simulation: Future Use of Modern Approaches and Methodologies in a Regulatory Context

A Model -Based Approach To Assessing the Importance of Intracellular Binding Sites in Doxorubicin Disposition

Dubbelboer, Ilse R.; Lilienberg, Elsa; Sjögren, Erik; Lennernäs, Hans

Ingår i Molecular Pharmaceutics, s. 686-698, 2017

• DOI för A Model -Based Approach To Assessing the Importance of Intracellular Binding Sites in Doxorubicin Disposition

Lipiodol does not affect the tissue distribution of intravenous doxorubicin infusion in pigs

Lilienberg, Elsa; Dubbelboer, Ilse R; Sjögren, Erik; Lennernäs, Hans

Ingår i Journal of Pharmacy and Pharmacology (JPP), s. 135-142, 2017

• DOI för Lipiodol does not affect the tissue distribution of intravenous doxorubicin infusion in pigs

Reply to "Comment on 'In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically Based Absorption Models'"

Sjögren, Erik; Thorn, Helena; Tannergren, Christer

Ingår i Molecular Pharmaceutics, s. 340-343, 2017

• DOI för Reply to "Comment on 'In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically Based Absorption Models'"

Regional Intestinal Permeability of Three Model Drugs in Human

Dahlgren, David; Roos, Carl; Lundqvist, Anders; Abrahamsson, Bertil et al.

Ingår i Molecular Pharmaceutics, s. 3013-3021, 2016

• DOI för Regional Intestinal Permeability of Three Model Drugs in Human

In Vitro Release Mechanisms of Doxorubicin From a Clinical Bead Drug-Delivery System

Ahnfelt, Emelie; Sjögren, Erik; Hansson, Per; Lennernäs, Hans

Ingår i Journal of Pharmaceutical Sciences, s. 3387-3398, 2016

• DOI för In Vitro Release Mechanisms of Doxorubicin From a Clinical Bead Drug-Delivery System

Regional Intestinal Permeability in Dogs: Biopharmaceutical Aspects for Development of Oral Modified-Release Dosage Forms

Dahlgren, David; Roos, Carl; Johansson, Pernilla; Lundqvist, Anders et al.

Ingår i Molecular Pharmaceutics, s. 3022-3033, 2016

• DOI för Regional Intestinal Permeability in Dogs: Biopharmaceutical Aspects for Development of Oral Modified-Release Dosage Forms

Assessment of Free Drug Concentration in Cyclodextrin Formulations Is Essential to Determine Drug Potency in Functional In Vitro Assays

Sjögren, Erik; Andersson, Sara; Sundgren-Andersson, Anna K.; Halldin, Magnus M. et al.

Ingår i Journal of Pharmaceutical Sciences, s. 2913-2920, 2016

• DOI för Assessment of Free Drug Concentration in Cyclodextrin Formulations Is Essential to Determine Drug Potency in Functional In Vitro Assays

In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically Based Absorption Models

Sjögren, Erik; Thorn, Helena; Tannergren, Christer

Ingår i Molecular Pharmaceutics, s. 1763-1778, 2016

• DOI för In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically Based Absorption Models

Excised segments of rat small intestine in Ussing chamber studies: A comparison of native and stripped tissue viability and permeability to drugs

Sjögren, Erik; Eriksson, Johanna; Vedin, Charlotta; Breitholtz, Katarina et al.

Ingår i International Journal of Pharmaceutics, s. 361-368, 2016

• DOI för Excised segments of rat small intestine in Ussing chamber studies: A comparison of native and stripped tissue viability and permeability to drugs

Concomitant intake of alcohol may increase the absorption of poorly soluble drugs

Fagerberg, Jonas H.; Sjögren, Erik; Bergström, Christel A. S.

Ingår i European Journal of Pharmaceutical Sciences, s. 12-20, 2015

• DOI för Concomitant intake of alcohol may increase the absorption of poorly soluble drugs
• Ladda ner fulltext (pdf) av Concomitant intake of alcohol may increase the absorption of poorly soluble drugs

A miniaturized in vitro release method for investigating drug-release mechanisms

Ahnfelt, Emelie; Sjögren, Erik; Axén, N.; Lennernäs, Hans

Ingår i International Journal of Pharmaceutics, s. 339-349, 2015

• DOI för A miniaturized in vitro release method for investigating drug-release mechanisms
• Ladda ner fulltext (pdf) av A miniaturized in vitro release method for investigating drug-release mechanisms

Human in Vivo Regional Intestinal Permeability: Quantitation Using Site-Specific Drug Absorption Data

Sjögren, Erik; Dahlgren, David; Roos, Carl; Lennernas, Hans

Ingår i Molecular Pharmaceutics, s. 2026-2039, 2015

• DOI för Human in Vivo Regional Intestinal Permeability: Quantitation Using Site-Specific Drug Absorption Data

Treatment of intermediate stage hepatocellular carcinoma: a review of intrahepatic doxorubicin drug-delivery systems

Dubbelboer, Ilse R; Lilienberg, Elsa; Ahnfelt, Emelie; Sjögren, Erik et al.

Ingår i Therapeutic delivery, s. 447-466, 2014

• DOI för Treatment of intermediate stage hepatocellular carcinoma: a review of intrahepatic doxorubicin drug-delivery systems

Combining in vitro and in silico methods for better prediction of surfactant effects on the absorption of poorly water soluble drugs-a fenofibrate case example

Berthelsen, Ragna; Sjögren, Erik; Jacobsen, Jette; Kristensen, Jakob et al.

Ingår i International Journal of Pharmaceutics, s. 356-365, 2014

• DOI för Combining in vitro and in silico methods for better prediction of surfactant effects on the absorption of poorly water soluble drugs-a fenofibrate case example

Pharmacokinetics of an Injectable Modified-Release 2-Hydroxyflutamide Formulation in the Human Prostate Gland Using a Semiphysiologically Based Biopharmaceutical Model

Sjögren, Erik; Tammela, Teuvo L.; Lennernas, Bo; Taari, Kimmo et al.

Ingår i Molecular Pharmaceutics, s. 3097-3111, 2014

• DOI för Pharmacokinetics of an Injectable Modified-Release 2-Hydroxyflutamide Formulation in the Human Prostate Gland Using a Semiphysiologically Based Biopharmaceutical Model

In vivo methods for drug absorption - Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects

Sjögren, Erik; Abrahamsson, Bertil; Augustijns, Patrick; Becker, Dieter et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 99-151, 2014

• DOI för In vivo methods for drug absorption - Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects

Effects of verapamil on the pharmacokinetics and hepatobiliary disposition of fexofenadine in pigs

Sjögren, Erik; Hedeland, Mikael; Bondesson, Ulf; Lennernäs, Hans

Ingår i European Journal of Pharmaceutical Sciences, s. 214-223, 2014

• DOI för Effects of verapamil on the pharmacokinetics and hepatobiliary disposition of fexofenadine in pigs

The Effects of Lipiodol and Cyclosporin A on the Hepatobiliary Disposition of Doxorubicin in Pigs

Dubbelboer, Ilse R; Lilienberg, Elsa; Hedeland, Mikael; Bondesson, Ulf et al.

Ingår i Molecular Pharmaceutics, s. 1301-1313, 2014

• DOI för The Effects of Lipiodol and Cyclosporin A on the Hepatobiliary Disposition of Doxorubicin in Pigs

In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: Application of the mechanistic absorption model GI-Sim

Sjögren, Erik; Westergren, Jan; Grant, Iain; Hanisch, Gunilla et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 679-698, 2013

• DOI för In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: Application of the mechanistic absorption model GI-Sim

Binding processes determine the stereoselective intestinal and hepatic extraction of verapamil in vivo

Thörn, Helena Anna; Sjögren, Erik; Dickinson, Paul Alfred; Lennernäs, Hans

Ingår i Molecular Pharmaceutics, s. 3034-3045, 2012

• DOI för Binding processes determine the stereoselective intestinal and hepatic extraction of verapamil in vivo

The pharmacokinetics and hepatic disposition of repaglinide in pigs: mechanistic modeling of metabolism and transport

Sjögren, Erik; Bredberg, Ulf; Lennernäs, Hans

Ingår i Molecular Pharmaceutics, s. 823-841, 2012

• DOI för The pharmacokinetics and hepatic disposition of repaglinide in pigs: mechanistic modeling of metabolism and transport

Optimized Experimental Design for the Estimation of Enzyme Kinetic Parameters: An Experimental Evaluation

Sjögren, Erik; Svanberg, Petter; Kanebratt, Kajsa P.

Ingår i Drug Metabolism And Disposition, s. 2273-2279, 2012

• DOI för Optimized Experimental Design for the Estimation of Enzyme Kinetic Parameters: An Experimental Evaluation

Optimal experimental design for assessment of enzyme kinetics in a drug discovery screening environment

Sjögren, Erik; Nyberg, Joakim; Magnusson, Mats O.; Lennernäs, Hans et al.

Ingår i Drug Metabolism And Disposition, s. 858-863, 2011

• DOI för Optimal experimental design for assessment of enzyme kinetics in a drug discovery screening environment

Hepatic disposition of ximelagatran and its metabolites in pig; prediction of the impact of membrane transporters through a simple disposition model

Sjögren, Erik; Bredberg, Ulf; Allard, Erik; Arvidsson, Björn et al.

Ingår i Pharmaceutical research, s. 597-607, 2010

• DOI för Hepatic disposition of ximelagatran and its metabolites in pig; prediction of the impact of membrane transporters through a simple disposition model

Online capillary solid phase extraction and liquid chromatographic separation with quantitative tandem mass spectrometric detection (SPE-LC-MS/MS) of ximelagatran and its metabolites in a complex matrix.

Arvidsson, Björn; Allard, Erik; Sjögren, Erik; Lennernäs, Hans et al.

Ingår i Journal of chromatography. B, s. 291-297, 2009

• DOI för Online capillary solid phase extraction and liquid chromatographic separation with quantitative tandem mass spectrometric detection (SPE-LC-MS/MS) of ximelagatran and its metabolites in a complex matrix.

The multiple depletion curves method provides accurate estimates of intrinsic clearance (CLint), maximum velocity of the metabolic reaction (Vmax), and Michaelis constant (Km): accuracy and robustness evaluated through experimental data and Monte Carlo simulations

Sjögren, Erik; Lennernäs, Hans; Andersson, Tommy B; Gråsjö, Johan et al.

Ingår i Drug Metabolism And Disposition, s. 47-58, 2009

• DOI för The multiple depletion curves method provides accurate estimates of intrinsic clearance (CLint), maximum velocity of the metabolic reaction (Vmax), and Michaelis constant (Km): accuracy and robustness evaluated through experimental data and Monte Carlo simulations

Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

Ingår i European journal of pharmaceutics and biopharmaceutics

Best Practices in Physiologically Based Pharmacokinetic (PBPK) Modeling

Chenel, Marylore; Dallmann, Andre; Ince, Ibrahim; Meyer, Michaela et al.

Ingår i CPT, 2026

• DOI för Best Practices in Physiologically Based Pharmacokinetic (PBPK) Modeling
• Ladda ner fulltext (pdf) av Best Practices in Physiologically Based Pharmacokinetic (PBPK) Modeling

Current State and New Horizons in Applications of Physiologically Based Biopharmaceutics Modeling (PBBM): A Workshop Report

Tannergren, Christer; Arora, Sumit; Babiskin, Andrew; Borges, Luiza et al.

Ingår i Molecular Pharmaceutics, s. 5-27, 2024

• DOI för Current State and New Horizons in Applications of Physiologically Based Biopharmaceutics Modeling (PBBM): A Workshop Report
• Ladda ner fulltext (pdf) av Current State and New Horizons in Applications of Physiologically Based Biopharmaceutics Modeling (PBBM): A Workshop Report

Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models

Dahlgren, David; Sjögren, Erik; Lennernäs, Hans

Ingår i ADMET & DMPK, s. 375-390, 2020

• DOI för Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models
• Ladda ner fulltext (pdf) av Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models

Direct In Vivo Human Intestinal Permeability (P-eff) Determined with Different Clinical Perfusion and Intubation Methods

Dahlgren, David; Roos, Carl; Sjögren, Erik; Lennernäs, Hans

Ingår i Journal of Pharmaceutical Sciences, s. 2702-2726, 2015

• DOI för Direct In Vivo Human Intestinal Permeability (P-eff) Determined with Different Clinical Perfusion and Intubation Methods

Hepatic Disposition of Drugs and the Utility of Mechanistic Modelling and Simulation

Sjögren, Erik

2010

• Ladda ner fulltext (pdf) av Hepatic Disposition of Drugs and the Utility of Mechanistic Modelling and Simulation

Diffusion of therapeutic proteins in extracellular matrix mimetic hydrogels: Predicting in vivo absorption after subcutaneous injection

Parlow, Julia; Sjögren, Erik; Al-Tikriti, Yassir; Sjögren, Helen et al.

Pharmacokinetics and safety profile of idarubicin-lipiodol chemoembolization of hepatocellular carcinoma

Dahlgren, David; Sennefelt Nyman, Sofi; Niessen, Janis; Dimopoulou, Angeliki et al.