Thierry Soussi

Low-penetrance TP53 variants are mainly hypomorphic: an underestimated issue with high clinical significance

Rodriguez, Lea; Leroy, Bernard; Toledo, Franck; Funk, Julianne Susanne et al.

Ingår i npj Genomic Medicine, 2026

• DOI för Low-penetrance TP53 variants are mainly hypomorphic: an underestimated issue with high clinical significance
• Ladda ner fulltext (pdf) av Low-penetrance TP53 variants are mainly hypomorphic: an underestimated issue with high clinical significance

Misclassification of TP53 germline variants: implications for survival analysis in AML transplant studies

Rodriguez, Lea; Delhommeau, Francois; Soussi, Thierry

Ingår i Leukemia, s. 3054-3055, 2025

• DOI för Misclassification of TP53 germline variants: implications for survival analysis in AML transplant studies
• Ladda ner fulltext (pdf) av Misclassification of TP53 germline variants: implications for survival analysis in AML transplant studies

A novel PML germline variant as a candidate predisposing genetic aberration in familial acute myeloid leukaemia.

Soussi, Thierry; Kundu, Snehangshu; Gerbaud, Pauline; Pandzic, Tatjana et al.

Ingår i British Journal of Haematology, s. 1118-1121, 2025

• DOI för A novel PML germline variant as a candidate predisposing genetic aberration in familial acute myeloid leukaemia.
• Ladda ner fulltext (pdf) av A novel PML germline variant as a candidate predisposing genetic aberration in familial acute myeloid leukaemia.

The TP53 tumor suppressor gene: From molecular biology to clinical investigations

Baliakas, Panagiotis; Soussi, Thierry

Ingår i Journal of Internal Medicine, s. 78-96, 2025

• DOI för The TP53 tumor suppressor gene: From molecular biology to clinical investigations
• Ladda ner fulltext (pdf) av The TP53 tumor suppressor gene: From molecular biology to clinical investigations

TP53 Mutations Detected by NGS Are a Major Clinical Risk Factor for Stratifying Mantle Cell Lymphoma

Lazarian, Grégory; Chemali, Lotfi; Bensalah, Merieme; Zindel, Carla et al.

Ingår i American Journal of Hematology, s. 933-936, 2025

• DOI för TP53 Mutations Detected by NGS Are a Major Clinical Risk Factor for Stratifying Mantle Cell Lymphoma

Low-penetrance TP53 variants are mainly hypomorphic: an underestimated issue with high clinical significance

Rodriguez, Lea; Leroy, Bernard; Toledo, Franck; Funk, Julianne Susanne et al.

Ingår i npj Genomic Medicine, 2026

• DOI för Low-penetrance TP53 variants are mainly hypomorphic: an underestimated issue with high clinical significance
• Ladda ner fulltext (pdf) av Low-penetrance TP53 variants are mainly hypomorphic: an underestimated issue with high clinical significance

Misclassification of TP53 germline variants: implications for survival analysis in AML transplant studies

Rodriguez, Lea; Delhommeau, Francois; Soussi, Thierry

Ingår i Leukemia, s. 3054-3055, 2025

• DOI för Misclassification of TP53 germline variants: implications for survival analysis in AML transplant studies
• Ladda ner fulltext (pdf) av Misclassification of TP53 germline variants: implications for survival analysis in AML transplant studies

A novel PML germline variant as a candidate predisposing genetic aberration in familial acute myeloid leukaemia.

Soussi, Thierry; Kundu, Snehangshu; Gerbaud, Pauline; Pandzic, Tatjana et al.

Ingår i British Journal of Haematology, s. 1118-1121, 2025

• DOI för A novel PML germline variant as a candidate predisposing genetic aberration in familial acute myeloid leukaemia.
• Ladda ner fulltext (pdf) av A novel PML germline variant as a candidate predisposing genetic aberration in familial acute myeloid leukaemia.

TP53 Mutations Detected by NGS Are a Major Clinical Risk Factor for Stratifying Mantle Cell Lymphoma

Lazarian, Grégory; Chemali, Lotfi; Bensalah, Merieme; Zindel, Carla et al.

Ingår i American Journal of Hematology, s. 933-936, 2025

• DOI för TP53 Mutations Detected by NGS Are a Major Clinical Risk Factor for Stratifying Mantle Cell Lymphoma

Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations

Funk, Julianne S.; Klimovich, Maria; Drangenstein, Daniel; Pielhoop, Ole et al.

Ingår i Nature Genetics, s. 140-153, 2025

• DOI för Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations
• Ladda ner fulltext (pdf) av Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations

Cancer associated variant enrichment CAVE, a gene agnostic approach to identify low burden variants in chronic lymphocytic leukemia

Yaacov, Adar; Lazarian, Gregory; Pandzic, Tatjana; Weström, Simone et al.

Ingår i Scientific Reports, 2024

• DOI för Cancer associated variant enrichment CAVE, a gene agnostic approach to identify low burden variants in chronic lymphocytic leukemia
• Ladda ner fulltext (pdf) av Cancer associated variant enrichment CAVE, a gene agnostic approach to identify low burden variants in chronic lymphocytic leukemia

The Broad Spectrum of TP53 Mutations in CLL: Evidence of Multiclonality and Novel Mutation Hotspots

Lazarian, Gregory; Leroy, Bernard; Theves, Floriane; Hormi, Myriam et al.

Ingår i Human Mutation, 2023

• DOI för The Broad Spectrum of TP53 Mutations in CLL: Evidence of Multiclonality and Novel Mutation Hotspots

Letter to the editor

Soussi, Thierry

Ingår i Human Molecular Genetics, s. 2121-2123, 2023

• DOI för Letter to the editor

Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog

Zhang, Qiang; Balourdas, Dimitrios-Ilias; Baron, Bruno; Senitzki, Alon et al.

Ingår i Cell Death and Disease, 2022

• DOI för Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog
• Ladda ner fulltext (pdf) av Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog

Colorectal Cancer Is Associated with the Presence of Cancer Driver Mutations in Normal Colon

Matas, Julia; Kohrn, Brendan; Fredrickson, Jeanne; Carter, Kelly et al.

Ingår i Cancer Research, s. 1492-1502, 2022

• DOI för Colorectal Cancer Is Associated with the Presence of Cancer Driver Mutations in Normal Colon

TP53 mutations at codon 234 are associated with chlorambucil treatment in chronic lymphocytic leukemia

Lazarian, Gregory; Theves, Floriane; Hormi, Myriam; Letestu, Remi et al.

Ingår i American Journal of Hematology, 2022

• DOI för TP53 mutations at codon 234 are associated with chlorambucil treatment in chronic lymphocytic leukemia

Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene

Doffe, Flora; Carbonnier, Vincent; Tissier, Manon; Leroy, Bernard et al.

Ingår i Cell Death and Differentiation, s. 1477-1492, 2021

• DOI för Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene
• Ladda ner fulltext (pdf) av Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene

Prevalence, distribution and predictive value of XPO1 mutation in a real-life chronic lymphocytic leukaemia cohort.

Tueur, Giulia; Lazarian, Gregory; Eclache, Virginie; Fleury, Carole et al.

Ingår i British Journal of Haematology, 2020

• DOI för Prevalence, distribution and predictive value of XPO1 mutation in a real-life chronic lymphocytic leukaemia cohort.

The TP53 tumor suppressor gene: From molecular biology to clinical investigations

Baliakas, Panagiotis; Soussi, Thierry

Ingår i Journal of Internal Medicine, s. 78-96, 2025

• DOI för The TP53 tumor suppressor gene: From molecular biology to clinical investigations
• Ladda ner fulltext (pdf) av The TP53 tumor suppressor gene: From molecular biology to clinical investigations

TP53: the unluckiest of genes?

Joerger, Andreas C.; Stiewe, Thorsten; Soussi, Thierry

Ingår i Cell Death and Differentiation, s. 219-224, 2025

• DOI för TP53: the unluckiest of genes?
• Ladda ner fulltext (pdf) av TP53: the unluckiest of genes?

ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia-2024 update

Malcikova, Jitka; Pavlova, Sarka; Baliakas, Panagiotis; Chatzikonstantinou, Thomas et al.

Ingår i Leukemia, s. 1455-1468, 2024

• DOI för ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia-2024 update
• Ladda ner fulltext (pdf) av ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia-2024 update

Benign SNPs in the Coding Region of TP53: Finding the Needles in a Haystack of Pathogenic Variants

Soussi, Thierry

Ingår i Cancer Research, s. 3420-3431, 2022

• DOI för Benign SNPs in the Coding Region of TP53: Finding the Needles in a Haystack of Pathogenic Variants

Landscape of TP53 Alterations in Chronic Lymphocytic Leukemia via Data Mining Mutation Databases

Soussi, Thierry; Baliakas, Panagiotis

Ingår i Frontiers in Oncology, 2022

• DOI för Landscape of TP53 Alterations in Chronic Lymphocytic Leukemia via Data Mining Mutation Databases
• Ladda ner fulltext (pdf) av Landscape of TP53 Alterations in Chronic Lymphocytic Leukemia via Data Mining Mutation Databases