Ekaterina Bezverkhniaia

Linker modifications in radiolabeled RM26-based antagonists to gastrin-releasing peptide receptor (GRPR) improved tracers' pharmacokinetics

Bezverkhniaia, Ekaterina; Abouzayed, Ayman; Kanellopoulos, Panagiotis; Tolmachev, Vladimir M. et al.

Ingår i European Journal of Pharmaceutical Sciences, 2025

• DOI för Linker modifications in radiolabeled RM26-based antagonists to gastrin-releasing peptide receptor (GRPR) improved tracers' pharmacokinetics
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Reduction of negative charge in mercaptoacetyl-based chelators influences the biodistribution of prostate-specific membrane antigen-targeting pseudopeptides labeled with technetium-99m

Bezverkhniaia, Ekaterina; Kanellopoulos, Panagiotis; Rosenström, Ulrika; Tolmachev, Vladimir M. et al.

Ingår i ACS Pharmacology & Translational Science, s. 3600-3612, 2025

• DOI för Reduction of negative charge in mercaptoacetyl-based chelators influences the biodistribution of prostate-specific membrane antigen-targeting pseudopeptides labeled with technetium-99m
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A preclinical study on the influence of linkers in [⁶⁸Ga]Ga-NOTA-X-RM26 radiotracers for PET imaging of GRPR expression

Olaniran Håkansson, Esther; Zelepukin, Ivan V.; Obeid, Karim; Bitzios, Athanasios et al.

Ingår i EJNMMI Research, 2025

• DOI för A preclinical study on the influence of linkers in [⁶⁸Ga]Ga-NOTA-X-RM26 radiotracers for PET imaging of GRPR expression
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RM2 and DB15 analogues bearing [¹⁷⁷Lu]Lu-DOTAGA via different linkers, as radiotherapeutics: a head-to-head comparative study

Kanellopoulos, Panagiotis; Bitzios, Athanasios; Zelepukin, Ivan; Bezverkhniaia, Ekaterina et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2025

• DOI för RM2 and DB15 analogues bearing [¹⁷⁷Lu]Lu-DOTAGA via different linkers, as radiotherapeutics: a head-to-head comparative study
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Single-Photon Emission Computer Tomography Imaging of Prostate-Specific Membrane Antigen (PSMA) Expression in Prostate Cancer Patients Using a Novel Peptide-Based Probe [^99mTc]Tc-BQ0413 with Picomolar Affinity to PSMA: A Phase I/II Clinical Study

Medvedeva, Anna; Chernov, Vladimir; Larkina, Maria; Rybina, Anastasiya et al.

Ingår i ACS Pharmacology & Translational Science, s. 736-747, 2025

• DOI för Single-Photon Emission Computer Tomography Imaging of Prostate-Specific Membrane Antigen (PSMA) Expression in Prostate Cancer Patients Using a Novel Peptide-Based Probe [^99mTc]Tc-BQ0413 with Picomolar Affinity to PSMA: A Phase I/II Clinical Study
• Ladda ner fulltext (pdf) av Single-Photon Emission Computer Tomography Imaging of Prostate-Specific Membrane Antigen (PSMA) Expression in Prostate Cancer Patients Using a Novel Peptide-Based Probe [^99mTc]Tc-BQ0413 with Picomolar Affinity to PSMA: A Phase I/II Clinical Study

Linker modifications in radiolabeled RM26-based antagonists to gastrin-releasing peptide receptor (GRPR) improved tracers' pharmacokinetics

Bezverkhniaia, Ekaterina; Abouzayed, Ayman; Kanellopoulos, Panagiotis; Tolmachev, Vladimir M. et al.

Ingår i European Journal of Pharmaceutical Sciences, 2025

• DOI för Linker modifications in radiolabeled RM26-based antagonists to gastrin-releasing peptide receptor (GRPR) improved tracers' pharmacokinetics
• Ladda ner fulltext (pdf) av Linker modifications in radiolabeled RM26-based antagonists to gastrin-releasing peptide receptor (GRPR) improved tracers' pharmacokinetics

Reduction of negative charge in mercaptoacetyl-based chelators influences the biodistribution of prostate-specific membrane antigen-targeting pseudopeptides labeled with technetium-99m

Bezverkhniaia, Ekaterina; Kanellopoulos, Panagiotis; Rosenström, Ulrika; Tolmachev, Vladimir M. et al.

Ingår i ACS Pharmacology & Translational Science, s. 3600-3612, 2025

• DOI för Reduction of negative charge in mercaptoacetyl-based chelators influences the biodistribution of prostate-specific membrane antigen-targeting pseudopeptides labeled with technetium-99m
• Ladda ner fulltext (pdf) av Reduction of negative charge in mercaptoacetyl-based chelators influences the biodistribution of prostate-specific membrane antigen-targeting pseudopeptides labeled with technetium-99m

A preclinical study on the influence of linkers in [⁶⁸Ga]Ga-NOTA-X-RM26 radiotracers for PET imaging of GRPR expression

Olaniran Håkansson, Esther; Zelepukin, Ivan V.; Obeid, Karim; Bitzios, Athanasios et al.

Ingår i EJNMMI Research, 2025

• DOI för A preclinical study on the influence of linkers in [⁶⁸Ga]Ga-NOTA-X-RM26 radiotracers for PET imaging of GRPR expression
• Ladda ner fulltext (pdf) av A preclinical study on the influence of linkers in [⁶⁸Ga]Ga-NOTA-X-RM26 radiotracers for PET imaging of GRPR expression

RM2 and DB15 analogues bearing [¹⁷⁷Lu]Lu-DOTAGA via different linkers, as radiotherapeutics: a head-to-head comparative study

Kanellopoulos, Panagiotis; Bitzios, Athanasios; Zelepukin, Ivan; Bezverkhniaia, Ekaterina et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2025

• DOI för RM2 and DB15 analogues bearing [¹⁷⁷Lu]Lu-DOTAGA via different linkers, as radiotherapeutics: a head-to-head comparative study
• Ladda ner fulltext (pdf) av RM2 and DB15 analogues bearing [¹⁷⁷Lu]Lu-DOTAGA via different linkers, as radiotherapeutics: a head-to-head comparative study

Single-Photon Emission Computer Tomography Imaging of Prostate-Specific Membrane Antigen (PSMA) Expression in Prostate Cancer Patients Using a Novel Peptide-Based Probe [^99mTc]Tc-BQ0413 with Picomolar Affinity to PSMA: A Phase I/II Clinical Study

Medvedeva, Anna; Chernov, Vladimir; Larkina, Maria; Rybina, Anastasiya et al.

Ingår i ACS Pharmacology & Translational Science, s. 736-747, 2025

• DOI för Single-Photon Emission Computer Tomography Imaging of Prostate-Specific Membrane Antigen (PSMA) Expression in Prostate Cancer Patients Using a Novel Peptide-Based Probe [^99mTc]Tc-BQ0413 with Picomolar Affinity to PSMA: A Phase I/II Clinical Study
• Ladda ner fulltext (pdf) av Single-Photon Emission Computer Tomography Imaging of Prostate-Specific Membrane Antigen (PSMA) Expression in Prostate Cancer Patients Using a Novel Peptide-Based Probe [^99mTc]Tc-BQ0413 with Picomolar Affinity to PSMA: A Phase I/II Clinical Study

Impact of Radiometal Chelates on In Vivo Visualization of Immune Checkpoint Protein Using Radiolabeled Affibody Molecules

Tolmachev, Vladimir M.; Papalanis, Eleftherios; Bezverkhniaia, Ekaterina A.; Rosly, Alia Hani et al.

Ingår i ACS Pharmacology & Translational Science, s. 706-717, 2025

• DOI för Impact of Radiometal Chelates on In Vivo Visualization of Immune Checkpoint Protein Using Radiolabeled Affibody Molecules
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Evaluation of maSSS/maSES-PEG2-RM26 for their potential therapeutic use after labeling with Re-188. Could their [^99mTc]Tc-labeled counterparts be used to estimate dosimetry?

Kanellopoulos, Panagiotis; Yu, Quanyi; Abouzayed, Abouzayed; Bezverkhniaia, Ekaterina et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2025

• DOI för Evaluation of maSSS/maSES-PEG2-RM26 for their potential therapeutic use after labeling with Re-188. Could their [^99mTc]Tc-labeled counterparts be used to estimate dosimetry?
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Half-life extension via ABD-fusion leads to higher tumor uptake of an affibody-drug conjugate compared to PAS- and XTENylation.

Zhang, Jie; Bodenko, Vitalina; Larkina, Maria; Bezverkhniaia, Ekaterina et al.

Ingår i Journal of Controlled Release, s. 468-478, 2024

• DOI för Half-life extension via ABD-fusion leads to higher tumor uptake of an affibody-drug conjugate compared to PAS- and XTENylation.
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Evaluation of ABD-Linked RM26 Conjugates for GRPR-Targeted Drug Delivery

Nagy, Abel; Abouzayed, Ayman; Kanellopoulos, Panagiotis; Landmark, Fredrika et al.

Ingår i ACS Omega, s. 36122-36133, 2024

• DOI för Evaluation of ABD-Linked RM26 Conjugates for GRPR-Targeted Drug Delivery
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Synthesis and Preclinical Evaluation of Urea-Based Prostate-Specific Membrane Antigen-Targeted Conjugates Labeled with ¹⁷⁷Lu

Machulkin, Aleksei E.; Petrov, Stanislav A.; Bodenko, Vitalina; Larkina, Mariia S. et al.

Ingår i ACS Pharmacology & Translational Science, s. 1457-1473, 2024

• DOI för Synthesis and Preclinical Evaluation of Urea-Based Prostate-Specific Membrane Antigen-Targeted Conjugates Labeled with ¹⁷⁷Lu

Two Novel [⁶⁸Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar¹¹]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer

Kanellopoulos, Panagiotis; Bezverkhniaia, Ekaterina; Abouzayed, Ayman; Rosenström, Ulrika et al.

Ingår i ACS Omega, s. 18608-18616, 2024

• DOI för Two Novel [⁶⁸Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar¹¹]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer
• Ladda ner fulltext (pdf) av Two Novel [⁶⁸Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar¹¹]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer

Influence of Molecular Design on the Tumor Targeting and Biodistribution of PSMA-Binding Tracers Labeled with Technetium-99m

Bezverkhniaia, Ekaterina; Kanellopoulos, Panagiotis; Rosenström, Ulrika; Tolmachev, Vladimir et al.

Ingår i International Journal of Molecular Sciences, 2024

• DOI för Influence of Molecular Design on the Tumor Targeting and Biodistribution of PSMA-Binding Tracers Labeled with Technetium-99m
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Evaluation of affinity matured Affibody molecules for imaging of the immune checkpoint protein B7-H3

Oroujeni, Maryam; Bezverkhniaia, Ekaterina A.; Xu, Tianqi; Liu, Yongsheng et al.

Ingår i Nuclear Medicine and Biology, 2023

• DOI för Evaluation of affinity matured Affibody molecules for imaging of the immune checkpoint protein B7-H3
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Preclinical Evaluation of a Novel High-Affinity Radioligand [^99mTc]Tc-BQ0413 Targeting Prostate-Specific Membrane Antigen (PSMA)

Bezverkhniaia, Ekaterina; Kanellopoulos, Panagiotis; Abouzayed, Ayman; Larkina, Mariia et al.

Ingår i International Journal of Molecular Sciences, 2023

• DOI för Preclinical Evaluation of a Novel High-Affinity Radioligand [^99mTc]Tc-BQ0413 Targeting Prostate-Specific Membrane Antigen (PSMA)
• Ladda ner fulltext (pdf) av Preclinical Evaluation of a Novel High-Affinity Radioligand [^99mTc]Tc-BQ0413 Targeting Prostate-Specific Membrane Antigen (PSMA)