Sara Mangsbo

Enhanced tumor eradication by combining CTLA-4 or PD-1 blockade with CpG therapy

Mangsbo, Sara; Sandin, Linda; Anger, Kerstin; Korman, Alan et al.

Ingår i Journal of immunotherapy (1997), s. 225-235, 2010

• DOI för Enhanced tumor eradication by combining CTLA-4 or PD-1 blockade with CpG therapy

Complement Activation by CpG in a Human Whole Blood Loop System: Mechanisms and Immunomodulatory Effects

Mangsbo, Sara M; Sanchez, Javier; Anger, Kerstin; Lambris, John D et al.

Ingår i Journal of Immunology, s. 6724-6732, 2009

• DOI för Complement Activation by CpG in a Human Whole Blood Loop System: Mechanisms and Immunomodulatory Effects

CpG Therapy is Superior to BCG in an Orthotopic Bladder Cancer Model and Generates CD4+ T-cell Immunity

Mangsbo, Sara M; Ninalga, Christina; Essand, Magnus; Loskog, Angelica et al.

Ingår i Journal of immunotherapy (1997), s. 34-42, 2008

• DOI för CpG Therapy is Superior to BCG in an Orthotopic Bladder Cancer Model and Generates CD4+ T-cell Immunity

Preclinical development and clinical safety assessment of a synthetic peptide conjugate enabling endogenous antibody binding to promote innate receptor engagement

Fletcher, Erika A. K.; Cordfunke, Robert A.; Nasi, Aikaterini; Törnqvist, Gunilla et al.

Ingår i Molecular Therapy: Oncology, 2025

• DOI för Preclinical development and clinical safety assessment of a synthetic peptide conjugate enabling endogenous antibody binding to promote innate receptor engagement
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Repeated positron emission tomography tracing neutrophil elastase in a porcine intensive-care sepsis model

Wilske, Frida; Eriksson, Olof; Amini, Rose-Marie; Estrada, Sergio et al.

Ingår i Intensive Care Medicine Experimental, 2025

• DOI för Repeated positron emission tomography tracing neutrophil elastase in a porcine intensive-care sepsis model
• Ladda ner fulltext (pdf) av Repeated positron emission tomography tracing neutrophil elastase in a porcine intensive-care sepsis model

Bridging responses to a human telomerase reverse transcriptase-based peptide cancer vaccine candidate in a mechanism-based model

Ibrahim, Eman I. K.; Ellingsen, Espen B.; Mangsbo, Sara M.; Friberg, Lena

Ingår i International Immunopharmacology, 2024

• DOI för Bridging responses to a human telomerase reverse transcriptase-based peptide cancer vaccine candidate in a mechanism-based model
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A bispecific CD40 agonistic antibody allowing for antibody-peptide conjugate formation to enable cancer-specific peptide delivery, resulting in improved T proliferation and anti-tumor immunity in mice

Mebrahtu, Aman; Laurén, Ida; Veerman, Rosanne; Güclüler Akpinar, Gözde et al.

Ingår i Nature Communications, 2024

• DOI för A bispecific CD40 agonistic antibody allowing for antibody-peptide conjugate formation to enable cancer-specific peptide delivery, resulting in improved T proliferation and anti-tumor immunity in mice
• Ladda ner fulltext (pdf) av A bispecific CD40 agonistic antibody allowing for antibody-peptide conjugate formation to enable cancer-specific peptide delivery, resulting in improved T proliferation and anti-tumor immunity in mice

MALT1 inhibition suppresses antigen-specific T cell responses

Kerzeli, Iliana K.; Nasi, Aikaterini; Fletcher, Erika; Chourlia, Aikaterini et al.

Ingår i Cellular Immunology, 2024

• DOI för MALT1 inhibition suppresses antigen-specific T cell responses
• Ladda ner fulltext (pdf) av MALT1 inhibition suppresses antigen-specific T cell responses

Preclinical development and clinical safety assessment of a synthetic peptide conjugate enabling endogenous antibody binding to promote innate receptor engagement

Fletcher, Erika A. K.; Cordfunke, Robert A.; Nasi, Aikaterini; Törnqvist, Gunilla et al.

Ingår i Molecular Therapy: Oncology, 2025

• DOI för Preclinical development and clinical safety assessment of a synthetic peptide conjugate enabling endogenous antibody binding to promote innate receptor engagement
• Ladda ner fulltext (pdf) av Preclinical development and clinical safety assessment of a synthetic peptide conjugate enabling endogenous antibody binding to promote innate receptor engagement

Repeated positron emission tomography tracing neutrophil elastase in a porcine intensive-care sepsis model

Wilske, Frida; Eriksson, Olof; Amini, Rose-Marie; Estrada, Sergio et al.

Ingår i Intensive Care Medicine Experimental, 2025

• DOI för Repeated positron emission tomography tracing neutrophil elastase in a porcine intensive-care sepsis model
• Ladda ner fulltext (pdf) av Repeated positron emission tomography tracing neutrophil elastase in a porcine intensive-care sepsis model

Bridging responses to a human telomerase reverse transcriptase-based peptide cancer vaccine candidate in a mechanism-based model

Ibrahim, Eman I. K.; Ellingsen, Espen B.; Mangsbo, Sara M.; Friberg, Lena

Ingår i International Immunopharmacology, 2024

• DOI för Bridging responses to a human telomerase reverse transcriptase-based peptide cancer vaccine candidate in a mechanism-based model
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A bispecific CD40 agonistic antibody allowing for antibody-peptide conjugate formation to enable cancer-specific peptide delivery, resulting in improved T proliferation and anti-tumor immunity in mice

Mebrahtu, Aman; Laurén, Ida; Veerman, Rosanne; Güclüler Akpinar, Gözde et al.

Ingår i Nature Communications, 2024

• DOI för A bispecific CD40 agonistic antibody allowing for antibody-peptide conjugate formation to enable cancer-specific peptide delivery, resulting in improved T proliferation and anti-tumor immunity in mice
• Ladda ner fulltext (pdf) av A bispecific CD40 agonistic antibody allowing for antibody-peptide conjugate formation to enable cancer-specific peptide delivery, resulting in improved T proliferation and anti-tumor immunity in mice

MALT1 inhibition suppresses antigen-specific T cell responses

Kerzeli, Iliana K.; Nasi, Aikaterini; Fletcher, Erika; Chourlia, Aikaterini et al.

Ingår i Cellular Immunology, 2024

• DOI för MALT1 inhibition suppresses antigen-specific T cell responses
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Whole protein or long peptides in therapeutic vaccination strategies, does it make a difference?

Mangsbo, Sara M

Ingår i Expert Opinion on Biological Therapy, s. 115-117, 2023

• DOI för Whole protein or long peptides in therapeutic vaccination strategies, does it make a difference?

Elevated levels of MMP12 sourced from macrophages are associated with poor prognosis in urothelial bladder cancer

Kerzeli, Iliana Kyriaki; Kostakis, Alexandros; Türker, Polat; Malmström, Per-Uno et al.

Ingår i BMC Cancer, 2023

• DOI för Elevated levels of MMP12 sourced from macrophages are associated with poor prognosis in urothelial bladder cancer
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Antibodies from serum and CSF of multiple sclerosis patients bind to oligodendroglial and neuronal cell-lines

Nazir, Faisal Hayat; Wiberg, Anna; Müller, Malin; Mangsbo, Sara et al.

Ingår i Brain Communications, 2023

• DOI för Antibodies from serum and CSF of multiple sclerosis patients bind to oligodendroglial and neuronal cell-lines
• Ladda ner fulltext (pdf) av Antibodies from serum and CSF of multiple sclerosis patients bind to oligodendroglial and neuronal cell-lines

Epitopes displayed in a cyclic peptide scaffold bind SARS-CoV-2 antibodies

Eriksson, Camilla; Gunasekera, Sunithi; Muhammad, Taj; Zhang, Mingshu et al.

Ingår i ChemBioChem, 2023

• DOI för Epitopes displayed in a cyclic peptide scaffold bind SARS-CoV-2 antibodies
• Ladda ner fulltext (pdf) av Epitopes displayed in a cyclic peptide scaffold bind SARS-CoV-2 antibodies

Correlates of protection and viral load trajectories in omicron breakthrough infections in triple vaccinated healthcare workers

Marking, Ulrika; Havervall, Sebastian; Norin, Nina Greilert; Bladh, Oscar et al.

Ingår i Nature Communications, 2023

• DOI för Correlates of protection and viral load trajectories in omicron breakthrough infections in triple vaccinated healthcare workers
• Ladda ner fulltext (pdf) av Correlates of protection and viral load trajectories in omicron breakthrough infections in triple vaccinated healthcare workers

An Adaptable Antibody-Based Platform for Flexible Synthetic Peptide Delivery Built on Agonistic CD40 Antibodies

Eltahir, Mohamed; Lauren, Ida; Lord, Martin; Chourlia, Aikaterini et al.

Ingår i Advanced Therapeutics, 2022

• DOI för An Adaptable Antibody-Based Platform for Flexible Synthetic Peptide Delivery Built on Agonistic CD40 Antibodies
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Duration of SARS-CoV-2 Immune Responses Up to Six Months Following Homologous or Heterologous Primary Immunization with ChAdOx1 nCoV-19 and BNT162b2 mRNA Vaccines

Marking, Ulrika; Havervall, Sebastian; Greilert-Norin, Nina; Ng, Henry et al.

Ingår i Vaccines, 2022

• DOI för Duration of SARS-CoV-2 Immune Responses Up to Six Months Following Homologous or Heterologous Primary Immunization with ChAdOx1 nCoV-19 and BNT162b2 mRNA Vaccines
• Ladda ner fulltext (pdf) av Duration of SARS-CoV-2 Immune Responses Up to Six Months Following Homologous or Heterologous Primary Immunization with ChAdOx1 nCoV-19 and BNT162b2 mRNA Vaccines

Characterization of the T cell receptor repertoire and melanoma tumor microenvironment upon combined treatment with ipilimumab and hTERT vaccination

Ellingsen, Espen Basmo; Bounova, Gergana; Kerzeli, Iliana Kyriaki; Anzar, Irantzu et al.

Ingår i Journal of Translational Medicine, 2022

• DOI för Characterization of the T cell receptor repertoire and melanoma tumor microenvironment upon combined treatment with ipilimumab and hTERT vaccination
• Ladda ner fulltext (pdf) av Characterization of the T cell receptor repertoire and melanoma tumor microenvironment upon combined treatment with ipilimumab and hTERT vaccination

Immune responses after omicron infection in triple-vaccinated health-care workers with and without previous SARS-CoV-2 infection

Blom, Kim; Marking, Ulrika; Havervall, Sebastian; Norin, Nina Greilert et al.

Ingår i The Lancet - Infectious diseases, s. 943-945, 2022

• DOI för Immune responses after omicron infection in triple-vaccinated health-care workers with and without previous SARS-CoV-2 infection

Robust humoral and cellular immune responses and low risk for reinfection at least 8 months following asymptomatic to mild COVID-19

Havervall, Sebastian; Ng, Henry; Jernbom Falk, August; Greilert-Norin, Nina et al.

Ingår i Journal of Internal Medicine, s. 72-80, 2022

• DOI för Robust humoral and cellular immune responses and low risk for reinfection at least 8 months following asymptomatic to mild COVID-19
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Impact of SARS-CoV-2 infection on vaccine-induced immune responses over time

Havervall, Sebastian; Marking, Ulrika; Greilert-Norin, Nina; Gordon, Max et al.

Ingår i Clinical & Translational Immunology (CTI), 2022

• DOI för Impact of SARS-CoV-2 infection on vaccine-induced immune responses over time
• Ladda ner fulltext (pdf) av Impact of SARS-CoV-2 infection on vaccine-induced immune responses over time

Durable and dynamic hTERT immune responses following vaccination with the long-peptide cancer vaccine UV1: long-term follow-up of three phase I clinical trials

Ellingsen, Espen Basmo; Aamdal, Elin; Guren, Tormod; Lilleby, Wolfgang et al.

Ingår i Journal for ImmunoTherapy of Cancer, 2022

• DOI för Durable and dynamic hTERT immune responses following vaccination with the long-peptide cancer vaccine UV1: long-term follow-up of three phase I clinical trials
• Ladda ner fulltext (pdf) av Durable and dynamic hTERT immune responses following vaccination with the long-peptide cancer vaccine UV1: long-term follow-up of three phase I clinical trials

Factors Associated With Serological Response to SARS-CoV-2 Vaccination in Patients With Multiple Sclerosis Treated With Rituximab

Tolf, Andreas; Wiberg, Anna; Müller, Malin; Nazir, Faisal Hayat et al.

Ingår i JAMA Network Open, 2022

• DOI för Factors Associated With Serological Response to SARS-CoV-2 Vaccination in Patients With Multiple Sclerosis Treated With Rituximab
• Ladda ner fulltext (pdf) av Factors Associated With Serological Response to SARS-CoV-2 Vaccination in Patients With Multiple Sclerosis Treated With Rituximab

Long-term SARS-CoV-2-specific and cross-reactive cellular immune responses correlate with humoral responses, disease severity, and symptomatology

Lauren, Ida; Havervall, Sebastian; Ng, Henry; Lord, Martin et al.

Ingår i Immunity, Inflammation and Disease, 2022

• DOI för Long-term SARS-CoV-2-specific and cross-reactive cellular immune responses correlate with humoral responses, disease severity, and symptomatology
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SARS-CoV-2 induces a durable and antigen specific humoral immunity after asymptomatic to mild COVID-19 infection

Havervall, Sebastian; Falk, August Jernbom; Klingstrom, Jonas; Ng, Henry et al.

Ingår i PLOS ONE, 2022

• DOI för SARS-CoV-2 induces a durable and antigen specific humoral immunity after asymptomatic to mild COVID-19 infection
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Symptoms and Functional Impairment Assessed 8 Months After Mild COVID-19 Among Health Care Workers

Havervall, Sebastian; Rosell, Axel; Phillipson, Mia; Mangsbo, Sara et al.

Ingår i Journal of the American Medical Association (JAMA), s. 2015-2016, 2021

• DOI för Symptoms and Functional Impairment Assessed 8 Months After Mild COVID-19 Among Health Care Workers

Fed-batch production assessment of a tetravalent bispecific antibody: A case study on piggyBac stably transfected HEK293 cells

Napoleone, Antonino; Laurén, Ida; Linkgreim, Triinu; Dahllund, Leif et al.

Ingår i New Biotechnology, s. 9-19, 2021

• DOI för Fed-batch production assessment of a tetravalent bispecific antibody: A case study on piggyBac stably transfected HEK293 cells
• Ladda ner fulltext (pdf) av Fed-batch production assessment of a tetravalent bispecific antibody: A case study on piggyBac stably transfected HEK293 cells

Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma

van Hooren, Luuk; Vaccaro, Alessandra; Ramachandran, Mohanraj; Vazaios, Konstantinos et al.

Ingår i Nature Communications, 2021

• DOI för Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma
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Antibody responses after a single dose of ChAdOx1 nCoV-19 vaccine in healthcare workers previously infected with SARS-CoV-2

Havervall, Sebastian; Marking, Ulrika; Greilert-Norin, Nina; Ng, Henry et al.

Ingår i EBioMedicine, 2021

• DOI för Antibody responses after a single dose of ChAdOx1 nCoV-19 vaccine in healthcare workers previously infected with SARS-CoV-2
• Ladda ner fulltext (pdf) av Antibody responses after a single dose of ChAdOx1 nCoV-19 vaccine in healthcare workers previously infected with SARS-CoV-2

Profiling of donor-specific immune effector signatures in response to rituximab in a human whole blood loop assay using blood from CLL patients

Eltahir, mohmo394; Fletcher, E.; Dynesius, L.; Jarblad, J. L. et al.

Ingår i International Immunopharmacology, 2021

• DOI för Profiling of donor-specific immune effector signatures in response to rituximab in a human whole blood loop assay using blood from CLL patients
• Ladda ner fulltext (pdf) av Profiling of donor-specific immune effector signatures in response to rituximab in a human whole blood loop assay using blood from CLL patients

Single-cell RNAseq and longitudinal proteomic analysis of a novel semi-spontaneous urothelial cancer model reveals tumor cell heterogeneity and pretumoral urine protein alterations

Kerzeli, Iliana Kyriaki; Lord, Martin; Doroszko, Milena; Elgendy, Ramy et al.

Ingår i PLOS ONE, 2021

• DOI för Single-cell RNAseq and longitudinal proteomic analysis of a novel semi-spontaneous urothelial cancer model reveals tumor cell heterogeneity and pretumoral urine protein alterations
• Ladda ner fulltext (pdf) av Single-cell RNAseq and longitudinal proteomic analysis of a novel semi-spontaneous urothelial cancer model reveals tumor cell heterogeneity and pretumoral urine protein alterations

An evaluation of a FluoroSpot assay as a diagnostic tool to determine SARS-CoV-2 specific T cell responses

Mangsbo, Sara; Havervall, Sebastian; Laurén, Ida; Lindsay, Robin et al.

Ingår i PLOS ONE, 2021

• DOI för An evaluation of a FluoroSpot assay as a diagnostic tool to determine SARS-CoV-2 specific T cell responses
• Ladda ner fulltext (pdf) av An evaluation of a FluoroSpot assay as a diagnostic tool to determine SARS-CoV-2 specific T cell responses

Plasma Proteomic Analysis in Non-Small Cell Lung Cancer Patients Treated with PD-1/PD-L1 Blockade

Eltahir, Mohamed; Isaksson, Johan; Mattsson, Johanna Sofia Margareta; Karre, Klas et al.

Ingår i Cancers, 2021

• DOI för Plasma Proteomic Analysis in Non-Small Cell Lung Cancer Patients Treated with PD-1/PD-L1 Blockade
• Ladda ner fulltext (pdf) av Plasma Proteomic Analysis in Non-Small Cell Lung Cancer Patients Treated with PD-1/PD-L1 Blockade

Infiltration of NK and plasma cells is associated with a distinct immune subset in non‐small cell lung cancer

Backman, Max; La Fleur, Linnea; Kurppa, Pinja; Djureinovic, Dijana et al.

Ingår i Journal of Pathology, s. 243-256, 2021

• DOI för Infiltration of NK and plasma cells is associated with a distinct immune subset in non‐small cell lung cancer
• Ladda ner fulltext (pdf) av Infiltration of NK and plasma cells is associated with a distinct immune subset in non‐small cell lung cancer

Flodvåg av långtidssjuka covid-19-patienter väntar

Rostedt Punga, Anna; Strømme, Maria; Alimohammadi, Mohammad; Eltahir, Mohamed et al.

Ingår i Dagens Nyheter, s. 5-5, 2020

Reactive oxygen species as an initiator of toxic innate immune responses in retort to SARS-CoV-2 in an ageing population, consider N-acetylcysteine as early therapeutic intervention

Nasi, Aikaterini; McArdle, Stephanie; Gaudernack, Gustav; Westman, Gabriel et al.

Ingår i Toxicology reports, s. 768-771, 2020

• DOI för Reactive oxygen species as an initiator of toxic innate immune responses in retort to SARS-CoV-2 in an ageing population, consider N-acetylcysteine as early therapeutic intervention
• Ladda ner fulltext (pdf) av Reactive oxygen species as an initiator of toxic innate immune responses in retort to SARS-CoV-2 in an ageing population, consider N-acetylcysteine as early therapeutic intervention

Tumor localized agonistic anti-CD40 therapy and beyond

Eltahir, Mohamed; Persson, Helena; Mangsbo, Sara

Ingår i Expert Opinion on Biological Therapy, s. 215-217, 2020

• DOI för Tumor localized agonistic anti-CD40 therapy and beyond

Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy

Georganaki, Maria; Ramachandran, Mohanraj; Tuit, Sander; Nunez, Nicolas Gonzalo et al.

Ingår i Oncoimmunology, 2020

• DOI för Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy
• Ladda ner fulltext (pdf) av Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy

BCG-induced cytokine release in bladder cancer cells is regulated by Ca2+ signaling

Ibarra, Cristian; Karlsson, Marie; Codeluppi, Simone; Varas-Godoy, Manuel et al.

Ingår i Molecular Oncology, s. 202-211, 2019

• DOI för BCG-induced cytokine release in bladder cancer cells is regulated by Ca2+ signaling
• Ladda ner fulltext (pdf) av BCG-induced cytokine release in bladder cancer cells is regulated by Ca2+ signaling

Extracorporeal human whole blood in motion, as a tool to predict first-infusion reactions and mechanism-of-action of immunotherapeutics

Fletcher, Erika A. K.; Eltahir, Mohamed; Lindqvist, Frida; Rieth, Jonas et al.

Ingår i International Immunopharmacology, s. 1-11, 2018

• DOI för Extracorporeal human whole blood in motion, as a tool to predict first-infusion reactions and mechanism-of-action of immunotherapeutics
• Ladda ner fulltext (pdf) av Extracorporeal human whole blood in motion, as a tool to predict first-infusion reactions and mechanism-of-action of immunotherapeutics

Formation of Immune Complexes with a Tetanus-Derived B Cell Epitope Boosts Human T Cell Responses to Covalently Linked Peptides in an Ex Vivo Blood Loop System

Fletcher, Erika; van Maren, Wendy; Cordfunke, Robert; Dinkelaar, Jasper et al.

Ingår i Journal of Immunology, s. 87-97, 2018

• DOI för Formation of Immune Complexes with a Tetanus-Derived B Cell Epitope Boosts Human T Cell Responses to Covalently Linked Peptides in an Ex Vivo Blood Loop System

Linking T cell epitopes to a common linear B cell epitope: A targeting and adjuvant strategy to improve T cell responses

Mangsbo, Sara; Fletcher, Erika; van Maren, Wendy; Redeker, Anke et al.

Ingår i Molecular Immunology, s. 115-124, 2018

• DOI för Linking T cell epitopes to a common linear B cell epitope: A targeting and adjuvant strategy to improve T cell responses

Adenovirus-mediated CD40L gene transfer increases Teffector/Tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients

Schiza, Aglaia; Wenthe, Jessica; Mangsbo, Sara; Svensson, Emma et al.

Ingår i Journal of Translational Medicine, 2017

• DOI för Adenovirus-mediated CD40L gene transfer increases Teffector/Tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients
• Ladda ner fulltext (pdf) av Adenovirus-mediated CD40L gene transfer increases Teffector/Tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients

Local irradiation does not enhance the effect of immunostimulatory AdCD40L gene therapy combined with low dose cyclophosphamide in melanoma patients

Irenaeus, Sandra; Schiza, Aglaia; Mangsbo, Sara M.; Wenthe, Jessica et al.

Ingår i Oncotarget, s. 78573-78587, 2017

• DOI för Local irradiation does not enhance the effect of immunostimulatory AdCD40L gene therapy combined with low dose cyclophosphamide in melanoma patients
• Ladda ner fulltext (pdf) av Local irradiation does not enhance the effect of immunostimulatory AdCD40L gene therapy combined with low dose cyclophosphamide in melanoma patients

Local checkpoint inhibition of CTLA-4 as a monotherapy or in combination with anti-PD1 prevents the growth of murine bladder cancer

van Hooren, Luuk; Sandin, Linda C.; Moskalev, Igor; Ellmark, Peter et al.

Ingår i European Journal of Immunology, s. 385-393, 2017

• DOI för Local checkpoint inhibition of CTLA-4 as a monotherapy or in combination with anti-PD1 prevents the growth of murine bladder cancer

Adenovirus-mediated CD40L gene transfer increases teffector/tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients

Schiza, Aglaia; Wenthe, Jessica; Mangsbo, Sara; Eriksson, Emma et al.

Ingår i Scandinavian Journal of Immunology, s. 337-337, 2017

Activation of myeloid and endothelial cells by CD40L gene therapy supports T-cell expansion and migration into the tumor microenvironment

Eriksson, Emma; Moreno, R; Milenova, I. Yoanna; Liljenfeldt, L et al.

Ingår i Gene Therapy, s. 92-103, 2017

• DOI för Activation of myeloid and endothelial cells by CD40L gene therapy supports T-cell expansion and migration into the tumor microenvironment
• Ladda ner fulltext (pdf) av Activation of myeloid and endothelial cells by CD40L gene therapy supports T-cell expansion and migration into the tumor microenvironment

Sunitinib enhances the antitumor responses of agonistic CD40-antibody by reducing MDSCs and synergistically improving endothelial activation and T-cell recruitment

van Hooren, Luuk; Georganaki, Maria; Huang, Hua; Mangsbo, Sara M. et al.

Ingår i Oncotarget, s. 50277-50289, 2016

• DOI för Sunitinib enhances the antitumor responses of agonistic CD40-antibody by reducing MDSCs and synergistically improving endothelial activation and T-cell recruitment
• Ladda ner fulltext (pdf) av Sunitinib enhances the antitumor responses of agonistic CD40-antibody by reducing MDSCs and synergistically improving endothelial activation and T-cell recruitment

Immunostimulatory AdCD40L gene therapy combined with low-dose cyclophosphamide in metastatic melanoma patients

Loskog, Angelica; Maleka, Aglaia; Mangsbo, Sara; Svensson, Emma et al.

Ingår i British Journal of Cancer, s. 872-880, 2016

• DOI för Immunostimulatory AdCD40L gene therapy combined with low-dose cyclophosphamide in metastatic melanoma patients

Selective Fc gamma R engagement by human agonistic anti-CD40 antibodies

Ellmark, Peter; Mangsbo, Sara M.; Lindstedt, Malin

Ingår i Translational Cancer Research, 2016

• DOI för Selective Fc gamma R engagement by human agonistic anti-CD40 antibodies

Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64(+) cells

Vogel, Stephanie; Grabski, Elena; Buschjaeger, Daniela; Klawonn, Frank et al.

Ingår i Scientific Reports, 2015

• DOI för Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64(+) cells
• Ladda ner fulltext (pdf) av Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64(+) cells

The Tyrosine Kinase Inhibitors Imatinib and Dasatinib Reduce Myeloid Suppressor Cells and Release Effector Lymphocyte Responses

Christiansson, Lisa; Söderlund, Stina; Mangsbo, Sara; Hjorth-Hansen, Henrik et al.

Ingår i Molecular Cancer Therapeutics, s. 1181-1191, 2015

• DOI för The Tyrosine Kinase Inhibitors Imatinib and Dasatinib Reduce Myeloid Suppressor Cells and Release Effector Lymphocyte Responses

Kick-starting the cancer-immunity cycle by targeting CD40

Ellmark, P.; Mangsbo, Sara M.; Furebring, C.; Tötterman, Thomas H. et al.

Ingår i Oncoimmunology, 2015

• DOI för Kick-starting the cancer-immunity cycle by targeting CD40

The human agonistic CD40 antibody ADC-1013 eradicates bladder tumors and generates T cell dependent tumor immunity

Mangsbo, Sara M; Broos, Sissela; Fletcher, Erika; Veitonmäki, Niina et al.

Ingår i Clinical Cancer Research, s. 1115-1126, 2015

• DOI för The human agonistic CD40 antibody ADC-1013 eradicates bladder tumors and generates T cell dependent tumor immunity

AdCD40L Immunostimulatory Gene Therapy in Combination with Cyclophosphamide Prolongs 6-Months Survival in a Phase I/II Trial for Malignant Melanoma

Loskog, Angelica; Maleka, Aglaia; Mangsbo, Sara; Svensson, Emma et al.

Ingår i Molecular Therapy, 2014

• DOI för AdCD40L Immunostimulatory Gene Therapy in Combination with Cyclophosphamide Prolongs 6-Months Survival in a Phase I/II Trial for Malignant Melanoma

The use of multiplex platforms for absolute and relative protein quantification of clinical material

Christiansson, Lisa; Mustjoki, Satu; Simonsson, Bengt; Olsson-Strömberg, Ulla et al.

Ingår i EuPA Open Proteomics, s. 37-47, 2014

• DOI för The use of multiplex platforms for absolute and relative protein quantification of clinical material

A Hexon and Fiber-modified Adenovirus Expressing CD40L Improves the Antigen Presentation Capacity of Dendritic Cells

Liljenfeldt, Lina; Yu, Di; Chen, Liye; Essand, Magnus et al.

Ingår i Journal of immunotherapy (1997), s. 155-162, 2014

• DOI för A Hexon and Fiber-modified Adenovirus Expressing CD40L Improves the Antigen Presentation Capacity of Dendritic Cells

Local immunotherapy based on agonistic CD40 antibodies effectively inhibits experimental bladder cancer

Sandin, Linda C.; Tötterman, Thomas H.; Mangsbo, Sara M.

Ingår i Oncoimmunology, 2014

• DOI för Local immunotherapy based on agonistic CD40 antibodies effectively inhibits experimental bladder cancer

Local CTLA4 blockade effectively restrains experimental pancreatic adenocarcinoma growth in vivo

Sandin, Linda C.; Eriksson, Fredrik; Ellmark, Peter; Loskog, Angelica S. I. et al.

Ingår i Oncoimmunology, 2014

• DOI för Local CTLA4 blockade effectively restrains experimental pancreatic adenocarcinoma growth in vivo

Locally delivered CD40 agonist antibody accumulates in secondary lymphoid organs and eradicates experimental disseminated bladder cancer

Sandin, Linda; Orlova, Anna; Gustafsson, Erika; Ellmark, Peter et al.

Ingår i Cancer Immunology Research, s. 80-90, 2014

• DOI för Locally delivered CD40 agonist antibody accumulates in secondary lymphoid organs and eradicates experimental disseminated bladder cancer
• Ladda ner fulltext (pdf) av Locally delivered CD40 agonist antibody accumulates in secondary lymphoid organs and eradicates experimental disseminated bladder cancer

FcγRIIb on myeloid cells rather than on B cells protects from collagen-induced arthritis

Yilmaz-Elis, A Seda; Ramirez, Javier Martin; Asmawidjaja, Patrick; van der Kaa, Jos et al.

Ingår i Journal of Immunology, s. 5540-5547, 2014

• DOI för FcγRIIb on myeloid cells rather than on B cells protects from collagen-induced arthritis

Tim-3 and PD-1: Regulators of adaptive immunity in multiple sclerosis

Burman, Joachim; Svensson, Emma; Fransson, Moa; Loskog, Angelica et al.

Ingår i Journal of Neuroimmunology, s. 141-141, 2014

• DOI för Tim-3 and PD-1: Regulators of adaptive immunity in multiple sclerosis

The cerebrospinal fluid cytokine signature of multiple sclerosis: A homogenous response that does not conform to the Th1/Th2/Th17 convention

Burman, Joachim; Svensson, Emma; Fransson, Moa; Loskog, Angelica S I et al.

Ingår i Journal of Neuroimmunology, s. 153-159, 2014

• DOI för The cerebrospinal fluid cytokine signature of multiple sclerosis: A homogenous response that does not conform to the Th1/Th2/Th17 convention

CD40L gene therapy tilts the myeloid cell profile and promotes infiltration of activated T lymphocytes

Liljenfeldt, Lina; Dieterich, Lothar C.; Dimberg, Anna; Mangsbo, Sara M. et al.

Ingår i Cancer Gene Therapy, s. 95-102, 2014

• DOI för CD40L gene therapy tilts the myeloid cell profile and promotes infiltration of activated T lymphocytes

FcγRIIb on Myeloid Cells and Intrinsic Renal Cells Rather than B Cells Protects from Nephrotoxic Nephritis

Sharp, Phoebe E H; Martin-Ramirez, Javier; Mangsbo, Sara M; Boross, Peter et al.

Ingår i Journal of Immunology, s. 340-348, 2013

• DOI för FcγRIIb on Myeloid Cells and Intrinsic Renal Cells Rather than B Cells Protects from Nephrotoxic Nephritis

AdCD40L immunostimulatory gene therapy shifts the MDSC- and macrophage profiles and promotes T cell infiltration in the tumor microenvironment

Liljenfeldt, Lina; Svensson, E.; Huang, H.; Dieterich, L. et al.

Ingår i Human Gene Therapy, 2013

T-cell responses after haematopoietic stem cell transplantation for aggressive relapsing-remitting multiple sclerosis

Burman, Joachim; Fransson, Moa; Tötterman, Thomas H.; Fagius, Jan et al.

Ingår i Immunology, s. 211-219, 2013

• DOI för T-cell responses after haematopoietic stem cell transplantation for aggressive relapsing-remitting multiple sclerosis

Increased incidence of anti-GBM disease in Fcgamma receptor 2b deficient mice, but not mice with conditional deletion of Fcgr2b on either B cells or myeloid cells alone

Sharp, Phoebe E H; Martin-Ramirez, Javier; Boross, Peter; Mangsbo, Sara M et al.

Ingår i Molecular Immunology, s. 49-56, 2012

• DOI för Increased incidence of anti-GBM disease in Fcgamma receptor 2b deficient mice, but not mice with conditional deletion of Fcgr2b on either B cells or myeloid cells alone

Fcγ receptor IIb strongly regulates Fcγ receptor-facilitated T cell activation by dendritic cells

van Montfoort, Nadine; 't Hoen, Peter A C; Mangsbo, Sara M; Camps, Marcel G M et al.

Ingår i Journal of Immunology, s. 92-101, 2012

• DOI för Fcγ receptor IIb strongly regulates Fcγ receptor-facilitated T cell activation by dendritic cells

Circulating specific antibodies enhance systemic cross-priming by delivery of complexed antigen to dendritic cells in vivo

van Montfoort, Nadine; Mangsbo, Sara M; Camps, Marcel G M; van Maren, Wendy W C et al.

Ingår i European Journal of Immunology, s. 598-606, 2012

• DOI för Circulating specific antibodies enhance systemic cross-priming by delivery of complexed antigen to dendritic cells in vivo

Both CD4(+) FoxP3(+) and CD4(+) FoxP3(-) T cells from patients with B-cell malignancy express cytolytic markers and kill autologous leukaemic B cells in vitro.

Lindqvist, Camilla; Christiansson, Lisa; Thörn, Ingrid; Mangsbo, Sara et al.

Ingår i Immunology, s. 296-306, 2011

• DOI för Both CD4(+) FoxP3(+) and CD4(+) FoxP3(-) T cells from patients with B-cell malignancy express cytolytic markers and kill autologous leukaemic B cells in vitro.

AdCD40L Immunogene Therapy for Bladder Carcinoma: The First Phase I/IIa Trial

Malmström, Per-Uno; Loskog, Angelica S. I.; Lindqvist, Camilla A.; Mangsbo, Sara M. et al.

Ingår i Clinical Cancer Research, s. 3279-3287, 2010

• DOI för AdCD40L Immunogene Therapy for Bladder Carcinoma: The First Phase I/IIa Trial

Resolvin E1 Reduces Proinflammatory Markers in Human Pancreatic Islets in vitro

Lund, T.; Mangsbo, Sara M.; Scholz, H.; Gjorstrup, P. et al.

Ingår i Experimental and clinical endocrinology & diabetes, s. 237-244, 2010

• DOI för Resolvin E1 Reduces Proinflammatory Markers in Human Pancreatic Islets in vitro

Enhanced tumor eradication by combining CTLA-4 or PD-1 blockade with CpG therapy

Mangsbo, Sara; Sandin, Linda; Anger, Kerstin; Korman, Alan et al.

Ingår i Journal of immunotherapy (1997), s. 225-235, 2010

• DOI för Enhanced tumor eradication by combining CTLA-4 or PD-1 blockade with CpG therapy

Complement Activation by CpG in a Human Whole Blood Loop System: Mechanisms and Immunomodulatory Effects

Mangsbo, Sara M; Sanchez, Javier; Anger, Kerstin; Lambris, John D et al.

Ingår i Journal of Immunology, s. 6724-6732, 2009

• DOI för Complement Activation by CpG in a Human Whole Blood Loop System: Mechanisms and Immunomodulatory Effects

Tumor-Specific Bacteriophages Induce Tumor Destruction through Activation of Tumor-Associated Macrophages

Eriksson, Fredrik; Tsagozis, Panagiotis; Lundberg, Kajsa; Parsa, Roham et al.

Ingår i Journal of Immunology, s. 3105-3111, 2009

• DOI för Tumor-Specific Bacteriophages Induce Tumor Destruction through Activation of Tumor-Associated Macrophages

CpG Therapy is Superior to BCG in an Orthotopic Bladder Cancer Model and Generates CD4+ T-cell Immunity

Mangsbo, Sara M; Ninalga, Christina; Essand, Magnus; Loskog, Angelica et al.

Ingår i Journal of immunotherapy (1997), s. 34-42, 2008

• DOI för CpG Therapy is Superior to BCG in an Orthotopic Bladder Cancer Model and Generates CD4+ T-cell Immunity

CpG oligonucleotides demonstrate increased therapeutic efficacy compared to BCG in an aggressive orthotopic bladder cancer model

Ninalga, Christina; Mangsbo, Sara; Loskog, Angelica; Essand, Magnus et al.

Ingår i Journal of immunotherapy (1997), s. 34-42, 2008

• DOI för CpG oligonucleotides demonstrate increased therapeutic efficacy compared to BCG in an aggressive orthotopic bladder cancer model

Telomerase as a Target for Therapeutic Cancer Vaccines and Considerations for Optimizing Their Clinical Potential

Basmo Ellingsen, Espen; Mangsbo, Sara M.; Hovig, Eivind; Gaudernack, Gustav

Ingår i Frontiers in Immunology, 2021

• DOI för Telomerase as a Target for Therapeutic Cancer Vaccines and Considerations for Optimizing Their Clinical Potential
• Ladda ner fulltext (pdf) av Telomerase as a Target for Therapeutic Cancer Vaccines and Considerations for Optimizing Their Clinical Potential

Cancer Vaccines: Adjuvant Potency, Importance of Age, Lifestyle, and Treatments

Cuzzubbo, Stefania; Mangsbo, Sara; Nagarajan, Divya; Habra, Kinana et al.

Ingår i Frontiers in Immunology, 2021

• DOI för Cancer Vaccines: Adjuvant Potency, Importance of Age, Lifestyle, and Treatments
• Ladda ner fulltext (pdf) av Cancer Vaccines: Adjuvant Potency, Importance of Age, Lifestyle, and Treatments

Tumor-directed immunotherapy can generate tumor-specific T cell responses through localized co-stimulation

Ellmark, Peter; Mangsbo, Sara M.; Furebring, Christina; Norlén, Per et al.

Ingår i Cancer Immunology and Immunotherapy, s. 1-7, 2017

• DOI för Tumor-directed immunotherapy can generate tumor-specific T cell responses through localized co-stimulation
• Ladda ner fulltext (pdf) av Tumor-directed immunotherapy can generate tumor-specific T cell responses through localized co-stimulation

Immunological Checkpoint Blockade and TLR Stimulation for Improved Cancer Therapy

Mangsbo, Sara

2009

• Ladda ner fulltext (pdf) av Immunological Checkpoint Blockade and TLR Stimulation for Improved Cancer Therapy

Extending the immune phenotypes of lung cancer: Oasis in the desert

Backman, Max; La Fleur, Linnea; Kurppa, Pinja; Djureinovic, Dijana et al.

An adaptable antibody-based platform for flexible synthetic peptide-based cargo delivery based on agonistic CD40-directed antibodies

Eltahir, Mohamed; Lauren, Ida; Lord, Martin; Chourlia, Aikaterini et al.

Plasma proteomic analysis in non-small cell lung cancer patients treated with PD1/PD-L1 blockade

Eltahir, Mohamed; Isaksson, Johan; Mattsson, Johanna Sofia Margareta; Kärre, Klas et al.

The tumour microenvironment across tumour evolution in bladder cancer profiled by single-cell RNA-sequencing analysis and spatial transcriptomics

Kostakis, Alexandros; Beháňová, Andrea; Kyriaki Kerzeli, Iliana; Elgendy, Ramy et al.

Optimizing T cell responses of targeted peptide antigen delivery by modulating antigen processing through amino acid exchange

Laurén, Ida; Kostakis, Alexandros; Lord, Martin; Björklund, Elvira et al.