Sunithi Gunasekera

Making Ends Meet: Microwave-Accelerated Synthesis of Cyclic and Disulfide Rich Proteins Via In Situ Thioesterification and Native Chemical Ligation

Gunasekera, Sunithi; Aboye, Teshome L.; Madian, Walid A.; El-Seedi, Hesham R. et al.

Ingår i International Journal of Peptide Research and Therapeutics, s. 43-54, 2013

• DOI för Making Ends Meet: Microwave-Accelerated Synthesis of Cyclic and Disulfide Rich Proteins Via In Situ Thioesterification and Native Chemical Ligation

Circular Proteins from Plants and Fungi

Göransson, Ulf; Burman, Robert; Gunasekera, Sunithi; Strömstedt, Adam A. et al.

Ingår i Journal of Biological Chemistry, s. 27001-27006, 2012

• DOI för Circular Proteins from Plants and Fungi

Fmoc-SPPS based synthesis of bioactive cyclic peptides via N-acylurea intermediates

Gunasekera, Sunithi; Göransson, Ulf

Ingår i Journal of Peptide Science, 2012

• DOI för Fmoc-SPPS based synthesis of bioactive cyclic peptides via N-acylurea intermediates

Synthetic antimicrobial peptide LD4-PP protects the host against E. coli-induced cell death

Mohanty, Soumitra; White, John Kerr; Yin, Yundi; Muhammad, Taj et al.

Ingår i Frontiers in Immunology, 2025

• DOI för Synthetic antimicrobial peptide LD4-PP protects the host against E. coli-induced cell death
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Ribosomally synthesised and post-translationally modified peptides (RiPPs) from marine demosponges and their microsymbionts

Kosgahakumbura, Lakmini; Gamage, Jayani; Hettiarachchi, Chamari M.; Cárdenas, Paco et al.

Ingår i Australian journal of chemistry (Print), 2025

• DOI för Ribosomally synthesised and post-translationally modified peptides (RiPPs) from marine demosponges and their microsymbionts
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Screening for antibacterial and cytotoxic activities of Sri Lankan marine sponges through microfractionation: Isolation of bromopyrrole alkaloids from Stylissa massa

Kosgahakumbura, Lakmini; Gamage, Jayani; Robertson, Luke; Muhammad, Taj et al.

Ingår i PLOS ONE, 2024

• DOI för Screening for antibacterial and cytotoxic activities of Sri Lankan marine sponges through microfractionation: Isolation of bromopyrrole alkaloids from Stylissa massa
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Kalata B1 Enhances Temozolomide Toxicity to Glioblastoma Cells

Gerlach, Samantha L.; Metcalf, James S.; Dunlop, Rachael A.; Banack, Sandra Anne et al.

Ingår i Biomedicines, 2024

• DOI för Kalata B1 Enhances Temozolomide Toxicity to Glioblastoma Cells
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Transforming Cross-Linked Cyclic Dimers of KR-12 into Stable and Potent Antimicrobial Drug Leads

Muhammad, Taj; Strömstedt, Adam A.; Gunasekera, Sunithi; Göransson, Ulf

Ingår i Biomedicines, 2023

• DOI för Transforming Cross-Linked Cyclic Dimers of KR-12 into Stable and Potent Antimicrobial Drug Leads
• Ladda ner fulltext (pdf) av Transforming Cross-Linked Cyclic Dimers of KR-12 into Stable and Potent Antimicrobial Drug Leads

Synthetic antimicrobial peptide LD4-PP protects the host against E. coli-induced cell death

Mohanty, Soumitra; White, John Kerr; Yin, Yundi; Muhammad, Taj et al.

Ingår i Frontiers in Immunology, 2025

• DOI för Synthetic antimicrobial peptide LD4-PP protects the host against E. coli-induced cell death
• Ladda ner fulltext (pdf) av Synthetic antimicrobial peptide LD4-PP protects the host against E. coli-induced cell death

Ribosomally synthesised and post-translationally modified peptides (RiPPs) from marine demosponges and their microsymbionts

Kosgahakumbura, Lakmini; Gamage, Jayani; Hettiarachchi, Chamari M.; Cárdenas, Paco et al.

Ingår i Australian journal of chemistry (Print), 2025

• DOI för Ribosomally synthesised and post-translationally modified peptides (RiPPs) from marine demosponges and their microsymbionts
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Screening for antibacterial and cytotoxic activities of Sri Lankan marine sponges through microfractionation: Isolation of bromopyrrole alkaloids from Stylissa massa

Kosgahakumbura, Lakmini; Gamage, Jayani; Robertson, Luke; Muhammad, Taj et al.

Ingår i PLOS ONE, 2024

• DOI för Screening for antibacterial and cytotoxic activities of Sri Lankan marine sponges through microfractionation: Isolation of bromopyrrole alkaloids from Stylissa massa
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Kalata B1 Enhances Temozolomide Toxicity to Glioblastoma Cells

Gerlach, Samantha L.; Metcalf, James S.; Dunlop, Rachael A.; Banack, Sandra Anne et al.

Ingår i Biomedicines, 2024

• DOI för Kalata B1 Enhances Temozolomide Toxicity to Glioblastoma Cells
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Transforming Cross-Linked Cyclic Dimers of KR-12 into Stable and Potent Antimicrobial Drug Leads

Muhammad, Taj; Strömstedt, Adam A.; Gunasekera, Sunithi; Göransson, Ulf

Ingår i Biomedicines, 2023

• DOI för Transforming Cross-Linked Cyclic Dimers of KR-12 into Stable and Potent Antimicrobial Drug Leads
• Ladda ner fulltext (pdf) av Transforming Cross-Linked Cyclic Dimers of KR-12 into Stable and Potent Antimicrobial Drug Leads

Epitopes displayed in a cyclic peptide scaffold bind SARS-CoV-2 antibodies

Eriksson, Camilla; Gunasekera, Sunithi; Muhammad, Taj; Zhang, Mingshu et al.

Ingår i ChemBioChem, 2023

• DOI för Epitopes displayed in a cyclic peptide scaffold bind SARS-CoV-2 antibodies
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Exploring the limits of cyanobactin macrocyclase PatGmac: Cyclization of PawS-derived peptide sunflower trypsin inhibitor-1 and cyclotide kalata B1

Muhammad, Taj; Houssen, Wael E.; Thomas, Louise; Alexandru-Crivac, Cristina-Nicoleta et al.

Ingår i Journal of Natural Products, s. 566-573, 2023

• DOI för Exploring the limits of cyanobactin macrocyclase PatGmac: Cyclization of PawS-derived peptide sunflower trypsin inhibitor-1 and cyclotide kalata B1
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Antibacterial eremophilane sesquiterpenoids from Xylaria feejeensis, an endophytic fungi of the medicinal plant Geophila repens

Rajendran, Sanjeevan; Robertson, Luke P.; Kosgahakumbura, Lakmini; Fernando, Chathurika et al.

Ingår i Fitoterapia, 2023

• DOI för Antibacterial eremophilane sesquiterpenoids from Xylaria feejeensis, an endophytic fungi of the medicinal plant Geophila repens
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Editorial: Plant antimicrobial peptides (PAMPs) as biotechnological tools

Chan, Lai Yue; Candido, Elizabete; Gunasekera, Sunithi

Ingår i Frontiers in Molecular Biosciences, 2023

• DOI för Editorial: Plant antimicrobial peptides (PAMPs) as biotechnological tools
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Screening for Cyclotides in Sri Lankan Medicinal Plants: Discovery, Characterization, and Bioactivity Screening of Cyclotides from Geophila repens

Rajendran, Sanjeevan; Slazak, Blazej; Mohotti, Supun; Muhammad, Taj et al.

Ingår i Journal of Natural Products, s. 52-65, 2023

• DOI för Screening for Cyclotides in Sri Lankan Medicinal Plants: Discovery, Characterization, and Bioactivity Screening of Cyclotides from Geophila repens
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Good Practices in Sponge Natural Product Studies: Revising Vouchers with Isomalabaricane Triterpenes

Cárdenas, Paco; Gamage, Jayani; Hettiarachchi, Chamari M.; Gunasekera, Sunithi

Ingår i Marine Drugs, 2022

• DOI för Good Practices in Sponge Natural Product Studies: Revising Vouchers with Isomalabaricane Triterpenes
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A stable cyclized antimicrobial peptide derived from LL-37 with host immunomodulatory effects and activity against uropathogens

White, John Kerr; Muhammad, Taj; Alsheim, Emelie; Mohanty, Soumitra et al.

Ingår i Cellular and Molecular Life Sciences (CMLS), 2022

• DOI för A stable cyclized antimicrobial peptide derived from LL-37 with host immunomodulatory effects and activity against uropathogens
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Tropical vibes from Sri Lanka - cyclotides from Viola betonicifolia by transcriptome and mass spectrometry analysis

Rajendran, Sanjeevan; Slazak, Blazej; Mohotti, Supun; Strömstedt, Adam A. et al.

Ingår i Phytochemistry, 2021

• DOI för Tropical vibes from Sri Lanka - cyclotides from Viola betonicifolia by transcriptome and mass spectrometry analysis
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Barrettides: A Peptide Family Specifically Produced by the Deep-Sea Sponge Geodia barretti

Steffen, Karin; Laborde, Quentin; Gunasekera, Sunithi; Payne, Colton D. et al.

Ingår i Journal of Natural Products, s. 3138-3146, 2021

• DOI för Barrettides: A Peptide Family Specifically Produced by the Deep-Sea Sponge Geodia barretti
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Backbone Cyclization and Dimerization of LL-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability

Gunasekera, Sunithi; Muhammad, Taj; Strömstedt, Adam A.; Rosengren, K. Johan et al.

Ingår i Frontiers in Microbiology, 2020

• DOI för Backbone Cyclization and Dimerization of LL-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability
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Screening for bioactive secondary metabolites in Sri Lankan medicinal plants by microfractionation and targeted isolation of antimicrobial flavonoids from Derris scandens

Mohotti, Supun; Rajendran, Sanjeevan; Muhammad, Taj; Strömstedt, Adam A. et al.

Ingår i Journal of Ethnopharmacology, 2020

• DOI för Screening for bioactive secondary metabolites in Sri Lankan medicinal plants by microfractionation and targeted isolation of antimicrobial flavonoids from Derris scandens
• Ladda ner fulltext (pdf) av Screening for bioactive secondary metabolites in Sri Lankan medicinal plants by microfractionation and targeted isolation of antimicrobial flavonoids from Derris scandens

Alanine and Lysine Scans of the LL-37-Derived Peptide Fragment KR-12 Reveal Key Residues for Antimicrobial Activity

Gunasekera, Sunithi; Muhammad, Taj; Strömstedt, Adam A.; Rosengren, K. Johan et al.

Ingår i ChemBioChem, s. 931-939, 2018

• DOI för Alanine and Lysine Scans of the LL-37-Derived Peptide Fragment KR-12 Reveal Key Residues for Antimicrobial Activity

Repertoire Studies in Rheumatoid Arthritis Reveal B-Cell Distortions and Baseline Shifts in Unmutated IgG

Wang, Yan; Lloyd, Katy A.; Gunasekera, Sunithi; Eriksson, Camilla et al.

Ingår i Arthritis & Rheumatology, 2018

Stabilized Cyclic Peptides as Scavengers of Autoantibodies: Neutralization of Anticitrullinated Protein/Peptide Antibodies in Rheumatoid Arthritis

Gunasekera, Sunithi; Fernandes-Cerqueira, Catia; Wennmalm, Stefan; Wahamaa, Heidi et al.

Ingår i ACS Chemical Biology, s. 1525-1535, 2018

• DOI för Stabilized Cyclic Peptides as Scavengers of Autoantibodies: Neutralization of Anticitrullinated Protein/Peptide Antibodies in Rheumatoid Arthritis

Demosponge steroid biomarker 26-methylstigmastane provides evidence for Neoproterozoic animals

Zumberge, J. Alex; Love, Gordon D.; Cárdenas, Paco; Sperling, Erik A. et al.

Ingår i Nature Ecology & Evolution, s. 1709-1714, 2018

• DOI för Demosponge steroid biomarker 26-methylstigmastane provides evidence for Neoproterozoic animals

Chemical Proteomics for Target Discovery of Head-to-Tail Cyclized Mini-Proteins

Hellinger, Roland; Thell, Kathrin; Vasileva, Mina; Muhammad, Taj et al.

Ingår i Frontiers in Chemistry, 2017

• DOI för Chemical Proteomics for Target Discovery of Head-to-Tail Cyclized Mini-Proteins
• Ladda ner fulltext (pdf) av Chemical Proteomics for Target Discovery of Head-to-Tail Cyclized Mini-Proteins

Engineering Of A Minimalized Domain Derived From Human Host Defense Peptide LL-37 Into A Stable And Potent Antimicrobial Drug Lead

Muhammad, Taj; Gunasekera, Sunithi; Strömstedt, Adam A.; Göransson, Ulf

Ingår i Journal of Peptide Science, 2016

• DOI för Engineering Of A Minimalized Domain Derived From Human Host Defense Peptide LL-37 Into A Stable And Potent Antimicrobial Drug Lead

Anti-Citrullinated Peptide Antibody Inhibitors Based On Sunflower Trypsin Inhibitor-1 Scaffold For Potential Anti-Rheumatoid Arthritis Activity

Gunasekera, Sunithi; Fernandes-Cerqueira, C.; Eriksson, Camilla; Jakobsson, P-J et al.

Ingår i Journal of Peptide Science, 2016

• DOI för Anti-Citrullinated Peptide Antibody Inhibitors Based On Sunflower Trypsin Inhibitor-1 Scaffold For Potential Anti-Rheumatoid Arthritis Activity

Synthesis of cyclic citrullinated peptides targeting rheumatoid arthritis autoantibodies based on sunflower trypsin inhibitors

Eriksson, Camilla; Gunasekera, Sunithi; Cerqueira, C.; Jacobsson, P. J. et al.

Ingår i Planta Medica, 2016

• DOI för Synthesis of cyclic citrullinated peptides targeting rheumatoid arthritis autoantibodies based on sunflower trypsin inhibitors

Circular disulfide-rich peptide scaffolds as anti-citrullinated peptide antibody inhibitors

Gunasekera, Sunithi; Fernandes-Cerqueira, C.; Eriksson, Camilla; Jakobsson, P. J. et al.

Ingår i Planta Medica, 2016

• DOI för Circular disulfide-rich peptide scaffolds as anti-citrullinated peptide antibody inhibitors

Peptide biodiscovery from plants and animals: structure to function

Göransson, Ulf; Gunasekera, Sunithi; Malik, S.; Park, S. et al.

Ingår i Planta Medica, 2016

• DOI för Peptide biodiscovery from plants and animals: structure to function

A bioactivity-guided screening of Sri Lankan plants in the search for novel antibacterial and anticancer agents

Mohotti, S.; Rajendran, S.; Muhammad, Taj; Strömstedt, Adam A. et al.

Ingår i Planta Medica, 2016

• DOI för A bioactivity-guided screening of Sri Lankan plants in the search for novel antibacterial and anticancer agents

Engineering of KR-12: A minimalized domain derived from human host defense peptide LL-37 into a potent antimicrobial drug lead

Muhammad, Taj; Gunasekera, Sunithi; Strömstedt, Adam A.; Göransson, Ulf

Ingår i Planta Medica, 2016

• DOI för Engineering of KR-12: A minimalized domain derived from human host defense peptide LL-37 into a potent antimicrobial drug lead

Selective membrane disruption by the cyclotide kalata B7: complex ions and essential functional groups in the phosphatidylethanolamine binding pocket

Strömstedt, Adam A.; Kristiansen, Per Eugen; Gunasekera, Sunithi; Grob, Nathalie et al.

Ingår i Biochimica et Biophysica Acta, s. 1317-1327, 2016

• DOI för Selective membrane disruption by the cyclotide kalata B7: complex ions and essential functional groups in the phosphatidylethanolamine binding pocket

A Cactus-Derived Toxin-Like Cystine Knot Peptide with Selective Antimicrobial Activity

Aboye, Teshome L.; Strömstedt, Adam A.; Gunasekera, Sunithi; Bruhn, Jan G. et al.

Ingår i ChemBioChem, s. 1068-1077, 2015

• DOI för A Cactus-Derived Toxin-Like Cystine Knot Peptide with Selective Antimicrobial Activity

Targeting of anti-citrullinated protein/peptide antibodies in rheumatoid arthritis using peptides mimicking endogenously citrullinated fibrinogen antigens

Fernandes-Cerqueira, Catia; Ossipova, Elena; Gunasekera, Sunithi; Hansson, Monika et al.

Ingår i Arthritis Research & Therapy, 2015

• DOI för Targeting of anti-citrullinated protein/peptide antibodies in rheumatoid arthritis using peptides mimicking endogenously citrullinated fibrinogen antigens
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Synthesis, Structural Characterization, and Bioactivity of the Stable Peptide RCB-1 from Ricinus communis

Boldbaatar, Delgerbat; Gunasekera, Sunithi; El-Seedi, Hesham R.; Göransson, Ulf

Ingår i Journal of natural products (Print), s. 2545-2551, 2015

• DOI för Synthesis, Structural Characterization, and Bioactivity of the Stable Peptide RCB-1 from Ricinus communis

Isolation, Characterization, and Synthesis of the Barrettides: Disulfide-Containing Peptides from the Marine Sponge Geodia barretti

Carstens, Bodil B.; Rosengren, K. Johan; Gunasekera, Sunithi; Schempp, Stefanie et al.

Ingår i Journal of natural products (Print), s. 1886-1893, 2015

• DOI för Isolation, Characterization, and Synthesis of the Barrettides: Disulfide-Containing Peptides from the Marine Sponge Geodia barretti

Structure and Activity Relationship of the Echinochloa Crus-Galli Antimicrobial Peptide 1

Khan, T. M.; Gunasekera, Sunithi; Roy, D.; Strömstedt, Adam A. et al.

Ingår i Journal of Peptide Science, 2014

Backbone-Cyclized Peptide Dimers Derived from Human Cathelicidin Peptide LL-37 Mediate Potent Antimicrobial Activity

Gunasekera, Sunithi; Muhammad, Taj; Strömstedt, Adam A.; Göransson, Ulf

Ingår i Journal of Peptide Science, 2014

Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design

Koehbach, Johannes; O'Brien, Margaret; Muttenthaler, Markus; Miazzo, Marion et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 21183-21188, 2013

• DOI för Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design

Making Ends Meet: Microwave-Accelerated Synthesis of Cyclic and Disulfide Rich Proteins Via In Situ Thioesterification and Native Chemical Ligation

Gunasekera, Sunithi; Aboye, Teshome L.; Madian, Walid A.; El-Seedi, Hesham R. et al.

Ingår i International Journal of Peptide Research and Therapeutics, s. 43-54, 2013

• DOI för Making Ends Meet: Microwave-Accelerated Synthesis of Cyclic and Disulfide Rich Proteins Via In Situ Thioesterification and Native Chemical Ligation

Fmoc-SPPS based synthesis of bioactive cyclic peptides via N-acylurea intermediates

Gunasekera, Sunithi; Göransson, Ulf

Ingår i Journal of Peptide Science, 2012

• DOI för Fmoc-SPPS based synthesis of bioactive cyclic peptides via N-acylurea intermediates

An Efficient Approach for the Total Synthesis of Cyclotides by Microwave Assisted Fmoc-SPPS

Park, Sungkyu; Gunasekera, Sunithi; Aboye, Teshome Leta; Göransson, Ulf

Ingår i International Journal of Peptide Research and Therapeutics, s. 167-176, 2010

• DOI för An Efficient Approach for the Total Synthesis of Cyclotides by Microwave Assisted Fmoc-SPPS

Microwave-assisted total synthesis of macrocyclic cystine knot miniproteins

Park, SungKyu; Gunasekera, Sunithi; Aboye, Teshome L.; Göransson, Ulf

Ingår i Journal of Peptide Science, s. 79-79, 2010

• DOI för Microwave-assisted total synthesis of macrocyclic cystine knot miniproteins

Mechanism of action of cytotoxic cyclotides: cycloviolacin O2 disrupts lipid membranes

Svangård, Erika; Burman, Robert; Gunasekera, Sunithi; Lövborg, Henrik et al.

Ingår i Journal of natural products (Print), s. 643-647, 2007

• DOI för Mechanism of action of cytotoxic cyclotides: cycloviolacin O2 disrupts lipid membranes

Chemistry and Biology of Cyclotides: Circular Plant Peptides Outside the Box

Burman, Robert; Gunasekera, Sunithi; Strömstedt, Adam A.; Göransson, Ulf

Ingår i Journal of natural products (Print), s. 724-736, 2014

• DOI för Chemistry and Biology of Cyclotides: Circular Plant Peptides Outside the Box

Circular Proteins from Plants and Fungi

Göransson, Ulf; Burman, Robert; Gunasekera, Sunithi; Strömstedt, Adam A. et al.

Ingår i Journal of Biological Chemistry, s. 27001-27006, 2012

• DOI för Circular Proteins from Plants and Fungi

Microwave-assisted solid phase peptide synthesis of Asteropine A

Koptina, Anna; Gunasekera, Sunithi; Muhammad, Taj; Bohlin, Lars et al.

Ingår i Phytopharm 2014, Saint-Petersburg, Russia 3-5 July 2014, s. 36, 2014

• Ladda ner fulltext (pdf) av Microwave-assisted solid phase peptide synthesis of Asteropine A

Strategies for macrocyclic cyclotide synthesis

Gunasekera, Sunithi; Park, SungKyu; Aboye, Teshome Leta; Göransson, Ulf

Ingår i Posters 001-067: Synthetic Chemistry of Amino Acids and Peptides, s. 65-65, 2010

• DOI för Strategies for macrocyclic cyclotide synthesis

Transformation of KR-12 derived cross-linked cyclic dimers into stable and potent antimicrobial drug leads

Muhammad, Taj; Strömstedt, Adam A.; Skogman, Malena; Fallarero, Adyary et al.

Immobilisation of semi-pure butelase 1 and its applications to produce head-to-tail cyclic peptides

Muhammad, Taj; Shafiullah, Md.; Gunasekera, Sunithi; Göransson, Ulf

Grafted epitopes on a peptide scaffold efficiently scavenge anti-citrullinated protein antibodies

Eriksson, Camilla; Gunasekera, Sunithi; Fernandes-Cerqueira, Cátia; Jakobsson, Per-Johan et al.

Impact of scaffolds for epitope display: Exploring the PawS family for peptide engineering

Zhang, Mingshu; Eriksson, Camilla; Gunasekera, Sunithi; Jakobsson, Per-Johan et al.

Assessment of SARS-CoV-2 antibodies by antibody proximity extension assay employing peptide epitopes derived from spike protein

Gunasekera, Sunithi; Hammond, Maria; Eriksson, Camilla; Zhang, Mingshu et al.

Discovery of a novel nemertean peptide toxin subfamily (delta-nemertides) from the epidermal mucus of Lineus viridis.

Laborde, Quentin; Peigneur, Steve; Jacobsson, Erik; Gunasekera, Sunithi et al.