Joakim Näsvall

Collateral toxicity limits the evolution of bacterial Release Factor 2 towards total omnipotence

Abdalaal, Hind; Pundir, Shreya; Ge, Xueliang; Sanyal, Suparna et al.

Ingår i Molecular biology and evolution, s. 2918-2930, 2020

• DOI för Collateral toxicity limits the evolution of bacterial Release Factor 2 towards total omnipotence
• Ladda ner fulltext (pdf) av Collateral toxicity limits the evolution of bacterial Release Factor 2 towards total omnipotence

Synonymous mutations in rpsT lead to ribosomal assembly defects that can be compensated by mutations in fis and rpoA

Knöppel, Anna; Andersson, Dan I; Näsvall, Joakim

Ingår i Frontiers in Microbiology, 2020

• DOI för Synonymous mutations in rpsT lead to ribosomal assembly defects that can be compensated by mutations in fis and rpoA
• Ladda ner fulltext (pdf) av Synonymous mutations in rpsT lead to ribosomal assembly defects that can be compensated by mutations in fis and rpoA

Genetic adaptation to growth under laboratory conditions in Escherichia coli and Salmonella enterica

Knöppel, Anna; Knopp, Michael; Albrecht, Lisa M; Lundin, Erik et al.

Ingår i Frontiers in Microbiology, 2018

• DOI för Genetic adaptation to growth under laboratory conditions in Escherichia coli and Salmonella enterica
• Ladda ner fulltext (pdf) av Genetic adaptation to growth under laboratory conditions in Escherichia coli and Salmonella enterica

Experimental Determination and Prediction of the Fitness Effects of Random Point Mutations in the Biosynthetic Enzyme HisA

Lundin, Erik; Tang, Po-Cheng; Guy, Lionel; Näsvall, Joakim et al.

Ingår i Molecular biology and evolution, s. 704-718, 2018

• DOI för Experimental Determination and Prediction of the Fitness Effects of Random Point Mutations in the Biosynthetic Enzyme HisA
• Ladda ner fulltext (pdf) av Experimental Determination and Prediction of the Fitness Effects of Random Point Mutations in the Biosynthetic Enzyme HisA

Direct and Inverted Repeat stimulated excision (DIRex): Simple, single-step, and scar-free mutagenesis of bacterial genes

Näsvall, Joakim

Ingår i PLOS ONE, 2017

• DOI för Direct and Inverted Repeat stimulated excision (DIRex): Simple, single-step, and scar-free mutagenesis of bacterial genes
• Ladda ner fulltext (pdf) av Direct and Inverted Repeat stimulated excision (DIRex): Simple, single-step, and scar-free mutagenesis of bacterial genes

Duplication-Insertion Recombineering: a fast and scar-free method for efficient transfer of multiple mutations in bacteria

Näsvall, Joakim; Knöppel, Anna; Andersson, Dan I.

Ingår i Nucleic Acids Research, 2017

• DOI för Duplication-Insertion Recombineering: a fast and scar-free method for efficient transfer of multiple mutations in bacteria
• Ladda ner fulltext (pdf) av Duplication-Insertion Recombineering: a fast and scar-free method for efficient transfer of multiple mutations in bacteria

Evolution of New Functions De Novo and from Preexisting Genes

Andersson, Dan I.; Jerlström-Hultqvist, Jon; Näsvall, Joakim

Ingår i Cold Spring Harbor Perspectives in Biology, 2015

• DOI för Evolution of New Functions De Novo and from Preexisting Genes

Real-Time Evolution of New Genes by Innovation, Amplification, and Divergence

Näsvall, Joakim; Sun, Lei; Roth, John R.; Andersson, Dan I.

Ingår i Science, s. 384-387, 2012

• DOI för Real-Time Evolution of New Genes by Innovation, Amplification, and Divergence

Activation of cryptic aminoglycoside resistance in Salmonella enterica

Koskiniemi, Sanna; Pränting, Maria; Gullberg, Erik; Näsvall, Joakim et al.

Ingår i Molecular Microbiology, s. 1464-1478, 2011

• DOI för Activation of cryptic aminoglycoside resistance in Salmonella enterica

Collateral toxicity limits the evolution of bacterial Release Factor 2 towards total omnipotence

Abdalaal, Hind; Pundir, Shreya; Ge, Xueliang; Sanyal, Suparna et al.

Ingår i Molecular biology and evolution, s. 2918-2930, 2020

• DOI för Collateral toxicity limits the evolution of bacterial Release Factor 2 towards total omnipotence
• Ladda ner fulltext (pdf) av Collateral toxicity limits the evolution of bacterial Release Factor 2 towards total omnipotence

Synonymous mutations in rpsT lead to ribosomal assembly defects that can be compensated by mutations in fis and rpoA

Knöppel, Anna; Andersson, Dan I; Näsvall, Joakim

Ingår i Frontiers in Microbiology, 2020

• DOI för Synonymous mutations in rpsT lead to ribosomal assembly defects that can be compensated by mutations in fis and rpoA
• Ladda ner fulltext (pdf) av Synonymous mutations in rpsT lead to ribosomal assembly defects that can be compensated by mutations in fis and rpoA

Mutational Pathways and Trade-Offs Between HisA and TrpF Functions: Implications for Evolution via Gene Duplication and Divergence

Lundin, Erik; Näsvall, Joakim; Andersson, Dan I.

Ingår i Frontiers in Microbiology, 2020

• DOI för Mutational Pathways and Trade-Offs Between HisA and TrpF Functions: Implications for Evolution via Gene Duplication and Divergence
• Ladda ner fulltext (pdf) av Mutational Pathways and Trade-Offs Between HisA and TrpF Functions: Implications for Evolution via Gene Duplication and Divergence

Selection for novel metabolic capabilities in Salmonella enterica

Warsi, Omar M.; Lundin, Erik; Lustig, Ulrika; Näsvall, Joakim et al.

Ingår i Evolution, s. 990-1000, 2019

• DOI för Selection for novel metabolic capabilities in Salmonella enterica
• Ladda ner fulltext (pdf) av Selection for novel metabolic capabilities in Salmonella enterica

Structural mechanism of AadA, a dual specificity aminoglycoside adenylyltransferase from Salmonella enterica

Stern, Ana Laura; Van der Verren, Sander Egbert; Kanchugal Puttaswamy, Sandesh; Näsvall, Joakim et al.

Ingår i Journal of Biological Chemistry, s. 11481-11490, 2018

• DOI för Structural mechanism of AadA, a dual specificity aminoglycoside adenylyltransferase from Salmonella enterica
• Ladda ner fulltext (pdf) av Structural mechanism of AadA, a dual specificity aminoglycoside adenylyltransferase from Salmonella enterica

Collateral toxicity limits the evolution of bacterial Release Factor 2 towards total omnipotence

Abdalaal, Hind; Pundir, Shreya; Ge, Xueliang; Sanyal, Suparna et al.

Ingår i Molecular biology and evolution, s. 2918-2930, 2020

• DOI för Collateral toxicity limits the evolution of bacterial Release Factor 2 towards total omnipotence
• Ladda ner fulltext (pdf) av Collateral toxicity limits the evolution of bacterial Release Factor 2 towards total omnipotence

Synonymous mutations in rpsT lead to ribosomal assembly defects that can be compensated by mutations in fis and rpoA

Knöppel, Anna; Andersson, Dan I; Näsvall, Joakim

Ingår i Frontiers in Microbiology, 2020

• DOI för Synonymous mutations in rpsT lead to ribosomal assembly defects that can be compensated by mutations in fis and rpoA
• Ladda ner fulltext (pdf) av Synonymous mutations in rpsT lead to ribosomal assembly defects that can be compensated by mutations in fis and rpoA

Mutational Pathways and Trade-Offs Between HisA and TrpF Functions: Implications for Evolution via Gene Duplication and Divergence

Lundin, Erik; Näsvall, Joakim; Andersson, Dan I.

Ingår i Frontiers in Microbiology, 2020

• DOI för Mutational Pathways and Trade-Offs Between HisA and TrpF Functions: Implications for Evolution via Gene Duplication and Divergence
• Ladda ner fulltext (pdf) av Mutational Pathways and Trade-Offs Between HisA and TrpF Functions: Implications for Evolution via Gene Duplication and Divergence

Selection for novel metabolic capabilities in Salmonella enterica

Warsi, Omar M.; Lundin, Erik; Lustig, Ulrika; Näsvall, Joakim et al.

Ingår i Evolution, s. 990-1000, 2019

• DOI för Selection for novel metabolic capabilities in Salmonella enterica
• Ladda ner fulltext (pdf) av Selection for novel metabolic capabilities in Salmonella enterica

Structural mechanism of AadA, a dual specificity aminoglycoside adenylyltransferase from Salmonella enterica

Stern, Ana Laura; Van der Verren, Sander Egbert; Kanchugal Puttaswamy, Sandesh; Näsvall, Joakim et al.

Ingår i Journal of Biological Chemistry, s. 11481-11490, 2018

• DOI för Structural mechanism of AadA, a dual specificity aminoglycoside adenylyltransferase from Salmonella enterica
• Ladda ner fulltext (pdf) av Structural mechanism of AadA, a dual specificity aminoglycoside adenylyltransferase from Salmonella enterica

Genetic adaptation to growth under laboratory conditions in Escherichia coli and Salmonella enterica

Knöppel, Anna; Knopp, Michael; Albrecht, Lisa M; Lundin, Erik et al.

Ingår i Frontiers in Microbiology, 2018

• DOI för Genetic adaptation to growth under laboratory conditions in Escherichia coli and Salmonella enterica
• Ladda ner fulltext (pdf) av Genetic adaptation to growth under laboratory conditions in Escherichia coli and Salmonella enterica

Experimental Determination and Prediction of the Fitness Effects of Random Point Mutations in the Biosynthetic Enzyme HisA

Lundin, Erik; Tang, Po-Cheng; Guy, Lionel; Näsvall, Joakim et al.

Ingår i Molecular biology and evolution, s. 704-718, 2018

• DOI för Experimental Determination and Prediction of the Fitness Effects of Random Point Mutations in the Biosynthetic Enzyme HisA
• Ladda ner fulltext (pdf) av Experimental Determination and Prediction of the Fitness Effects of Random Point Mutations in the Biosynthetic Enzyme HisA

Direct and Inverted Repeat stimulated excision (DIRex): Simple, single-step, and scar-free mutagenesis of bacterial genes

Näsvall, Joakim

Ingår i PLOS ONE, 2017

• DOI för Direct and Inverted Repeat stimulated excision (DIRex): Simple, single-step, and scar-free mutagenesis of bacterial genes
• Ladda ner fulltext (pdf) av Direct and Inverted Repeat stimulated excision (DIRex): Simple, single-step, and scar-free mutagenesis of bacterial genes

Duplication-Insertion Recombineering: a fast and scar-free method for efficient transfer of multiple mutations in bacteria

Näsvall, Joakim; Knöppel, Anna; Andersson, Dan I.

Ingår i Nucleic Acids Research, 2017

• DOI för Duplication-Insertion Recombineering: a fast and scar-free method for efficient transfer of multiple mutations in bacteria
• Ladda ner fulltext (pdf) av Duplication-Insertion Recombineering: a fast and scar-free method for efficient transfer of multiple mutations in bacteria

Structural and functional innovations in the real-time evolution of new (βα)₈ barrel enzymes

Newton, Matilda S.; Guo, Xiaohu; Söderholm, Annika; Näsvall, Joakim et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 4727-4732, 2017

• DOI för Structural and functional innovations in the real-time evolution of new (βα)₈ barrel enzymes

Evolution of antibiotic resistance without antibiotic exposure

Knöppel, Anna; Näsvall, Joakim; Andersson, Dan I.

Ingår i Antimicrobial Agents and Chemotherapy, 2017

• DOI för Evolution of antibiotic resistance without antibiotic exposure
• Ladda ner fulltext (pdf) av Evolution of antibiotic resistance without antibiotic exposure

Compensating the fitness costs of synonymous mutations

Knöppel, Anna; Näsvall, Joakim; Andersson, Dan I.

Ingår i Molecular biology and evolution, s. 1461-1477, 2016

• DOI för Compensating the fitness costs of synonymous mutations
• Ladda ner fulltext (pdf) av Compensating the fitness costs of synonymous mutations

Two-step Ligand Binding in a (βα)8 Barrel Enzyme: Substrate-bound Structures Shed New Light on the Catalytic Cycle of HisA

Söderholm, Annika; Guo, Xiaohu; Newton, Matilda S.; Evans, Gary B. et al.

Ingår i Journal of Biological Chemistry, s. 24657-24668, 2015

• DOI för Two-step Ligand Binding in a (βα)8 Barrel Enzyme: Substrate-bound Structures Shed New Light on the Catalytic Cycle of HisA

Structure of AadA from Salmonella enterica: a monomeric aminoglycoside (3'')(9) adenyltransferase

Chen, Yang; Näsvall, Joakim; Wu, Shiying; Andersson, Dan I. et al.

Ingår i Acta Crystallographica Section D, s. 2267-2277, 2015

• DOI för Structure of AadA from Salmonella enterica: a monomeric aminoglycoside (3'')(9) adenyltransferase
• Ladda ner fulltext (pdf) av Structure of AadA from Salmonella enterica: a monomeric aminoglycoside (3'')(9) adenyltransferase

Minor Fitness Costs in an Experimental Model of Horizontal Gene Transfer in Bacteria

Knöppel, Anna; Lind, Peter A.; Lustig, Ulrika; Näsvall, Joakim et al.

Ingår i Molecular biology and evolution, s. 1220-1227, 2014

• DOI för Minor Fitness Costs in an Experimental Model of Horizontal Gene Transfer in Bacteria

Real-Time Evolution of New Genes by Innovation, Amplification, and Divergence

Näsvall, Joakim; Sun, Lei; Roth, John R.; Andersson, Dan I.

Ingår i Science, s. 384-387, 2012

• DOI för Real-Time Evolution of New Genes by Innovation, Amplification, and Divergence

Activation of cryptic aminoglycoside resistance in Salmonella enterica

Koskiniemi, Sanna; Pränting, Maria; Gullberg, Erik; Näsvall, Joakim et al.

Ingår i Molecular Microbiology, s. 1464-1478, 2011

• DOI för Activation of cryptic aminoglycoside resistance in Salmonella enterica

Evolution of New Functions De Novo and from Preexisting Genes

Andersson, Dan I.; Jerlström-Hultqvist, Jon; Näsvall, Joakim

Ingår i Cold Spring Harbor Perspectives in Biology, 2015

• DOI för Evolution of New Functions De Novo and from Preexisting Genes

Synonymous mutations that reduce S20 levels can be compensated by mutations in fis and rpoA 

Knöppel, Anna; Joakim, Näsvall; Andersson, Dan I

Genetic adaptations to growth under laboratory conditions in Escherichia coli and Salmonella enterica

Knöppel, Anna; Knopp, Michael; Albrecht, Lisa; Lundin, Erik et al.

Functional trade-offs during evolution of new functions in the HisA-TrpF system

Lundin, Erik; Näsvall, Joakim; Andersson, Dan I

Experimental evolution of novel metabolic capabilities in Salmonella enterica

Warsi, Omar M.; Lundin, Erik; Lustig, Ulrika; Näsvall, Joakim et al.

Ribosomal protein L1 is required for balanced formation of ribosomal subunits

Tobin, Christina; Nord, Stefan; Wikström, P. Mikael; Näsvall, Joakim et al.

Crystal structure of AadA at 2.5 Å resolution - an aminoglycoside 3" adenyltransferase

Chen, Yang; Näsvall, Joakim; Andersson, Dan I.; Selmer, Maria

Intermittent selection directs evolution of a specialist enzyme to become a generalist

Abdalaal, Hind; Näsvall, Joakim

Evolvability of orthologous genes

Abdalaal, Hind; Näsvall, Joakim