Richard Svensson

Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib

Zhang, Xiaonan; Rameika, Natallia; Zhong, Lei; Veanes, Margus et al.

Ingår i EBioMedicine, 2024

• DOI för Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib
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Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa

Cotman, Andrej Emanuel; Durcik, Martina; Tiz, Davide Benedetto; Fulgheri, Federica et al.

Ingår i Journal of Medicinal Chemistry, s. 1380-1425, 2023

• DOI för Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa
• Ladda ner fulltext (pdf) av Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa

Topically Administered NOX4 Inhibitor, GLX7013114, Is Efficacious in Treating the Early Pathological Events of Diabetic Retinopathy

Dionysopoulou, Stavroula; Wikstrom, Per; Bucolo, Claudio; Romano, Giovanni Luca et al.

Ingår i Diabetes, s. 638-652, 2023

• DOI för Topically Administered NOX4 Inhibitor, GLX7013114, Is Efficacious in Treating the Early Pathological Events of Diabetic Retinopathy

New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus

Durcik, Martina; Cotman, Andrej Emanuel; Toplak, Zan; Mozina, Stefan et al.

Ingår i Journal of Medicinal Chemistry, s. 3968-3994, 2023

• DOI för New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus
• Ladda ner fulltext (pdf) av New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus

Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration

Hellinen, Laura; Koskela, Ali; Vattulainen, Elina; Liukkonen, Mikko et al.

Ingår i Biomedicine and Pharmacotherapy, 2022

• DOI för Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration
• Ladda ner fulltext (pdf) av Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration

Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib

Zhang, Xiaonan; Rameika, Natallia; Zhong, Lei; Veanes, Margus et al.

Ingår i EBioMedicine, 2024

• DOI för Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib
• Ladda ner fulltext (pdf) av Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib

Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa

Cotman, Andrej Emanuel; Durcik, Martina; Tiz, Davide Benedetto; Fulgheri, Federica et al.

Ingår i Journal of Medicinal Chemistry, s. 1380-1425, 2023

• DOI för Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa
• Ladda ner fulltext (pdf) av Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa

Topically Administered NOX4 Inhibitor, GLX7013114, Is Efficacious in Treating the Early Pathological Events of Diabetic Retinopathy

Dionysopoulou, Stavroula; Wikstrom, Per; Bucolo, Claudio; Romano, Giovanni Luca et al.

Ingår i Diabetes, s. 638-652, 2023

• DOI för Topically Administered NOX4 Inhibitor, GLX7013114, Is Efficacious in Treating the Early Pathological Events of Diabetic Retinopathy

New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus

Durcik, Martina; Cotman, Andrej Emanuel; Toplak, Zan; Mozina, Stefan et al.

Ingår i Journal of Medicinal Chemistry, s. 3968-3994, 2023

• DOI för New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus
• Ladda ner fulltext (pdf) av New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus

Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration

Hellinen, Laura; Koskela, Ali; Vattulainen, Elina; Liukkonen, Mikko et al.

Ingår i Biomedicine and Pharmacotherapy, 2022

• DOI för Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration
• Ladda ner fulltext (pdf) av Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration

Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ

Al-Amin, Rasel A.; Johansson, Lars; Abdurakhmanov, Eldar; Landegren, Nils et al.

Ingår i Nucleic Acids Research, 2022

• DOI för Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ
• Ladda ner fulltext (pdf) av Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ

Broad-Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve-Agent-Inhibited Acetylcholinesterase

Lindgren, Cecilia; Forsgren, Nina; Hoster, Norman; Akfur, Christine et al.

Ingår i Chemistry - A European Journal, 2022

• DOI för Broad-Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve-Agent-Inhibited Acetylcholinesterase
• Ladda ner fulltext (pdf) av Broad-Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve-Agent-Inhibited Acetylcholinesterase

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Bonagas, Nadilly; Gustafsson, Nina M. S.; Henriksson, Martin; Marttila, Petra et al.

Ingår i NATURE CANCER, s. 156, 2022

• DOI för Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
• Ladda ner fulltext (pdf) av Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Defining eligible patients for allele-selective chemotherapies targeting NAT2 in colorectal cancer

Rendo, Verónica; Kundu, Snehangshu; Rameika, Natallia; Ljungström, Viktor et al.

Ingår i Scientific Reports, 2020

• DOI för Defining eligible patients for allele-selective chemotherapies targeting NAT2 in colorectal cancer
• Ladda ner fulltext (pdf) av Defining eligible patients for allele-selective chemotherapies targeting NAT2 in colorectal cancer

Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Rendo, Verónica; Stoimenov, Ivaylo; Mateus, André; Sjöberg, Elin et al.

Ingår i Nature Communications, 2020

• DOI för Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy
• Ladda ner fulltext (pdf) av Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors

Kulen, Martina; Nunez-Otero, Carlos; Cairns, Andrew G.; Silver, Jim et al.

Ingår i MedChemComm, s. 1966-1987, 2019

• DOI för Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors
• Ladda ner fulltext (pdf) av Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Ladds, Marcus J. G. W.; van Leeuwen, Ingeborg M. M.; Drummond, Catherine J.; Chu, Su et al.

Ingår i Nature Communications, 2018

• DOI för A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
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Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound

Islam, Md. Koushikul; Strand, Mårten; Saleeb, Michael; Svensson, Richard et al.

Ingår i Scientific Reports, 2018

• DOI för Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound
• Ladda ner fulltext (pdf) av Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound

An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice

Skogh, Anna; Lesniak, Anna; Sköld, Christian; Karlgren, Maria et al.

Ingår i Bioorganic & Medicinal Chemistry Letters, s. 2446-2450, 2018

• DOI för An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice

Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib

Ladds, Marcus J. G. W.; Pastor-Fernandez, Andres; Popova, Gergana; van Leeuwen, Ingeborg M. M. et al.

Ingår i PLOS ONE, 2018

• DOI för Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib
• Ladda ner fulltext (pdf) av Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib

Global Kinetic Mechanism of Microsomal Glutathione Transferase 1 and Insights into Dynamic Enzyme Activation

Spahiu, Linda; Alander, Johan; Ottosson-Wadlund, Astrid; Svensson, Richard et al.

Ingår i Biochemistry, s. 3089-3098, 2017

• DOI för Global Kinetic Mechanism of Microsomal Glutathione Transferase 1 and Insights into Dynamic Enzyme Activation

Importance of N-and C-terminal residues of substance P 1-7 for alleviating allodynia in mice after peripheral administration

Skogh, Anna; Lesniak, Anna; Gaugaz, Fabienne Z.; Svensson, Richard et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 345-351, 2017

• DOI för Importance of N-and C-terminal residues of substance P 1-7 for alleviating allodynia in mice after peripheral administration

Impact of N-methylation of the substance P 1-7 amide on anti-allodynic effect in mice after peripheral administration

Skogh, Anna; Lesniak, Anna; Gaugaz, Fabienne Z.; Svensson, Richard et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 533-540, 2017

• DOI för Impact of N-methylation of the substance P 1-7 amide on anti-allodynic effect in mice after peripheral administration

N-aryl 2-aryloxyacetamides as a new class of fatty acid amide hydrolase (FAAH) inhibitors.

Svensson, Richard

Ingår i Journal of enzyme inhibition and medicinal chemistry (Print), 2017

Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures

Diwakarla, Shanti; Nylander, Erik; Grönbladh, Alfhild; Vanga, Sudarsana Reddy et al.

Ingår i ACS Chemical Neuroscience, s. 1383-1392, 2016

• DOI för Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures

Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity

Good, James A. D.; Silver, Jim; Nunez-Otero, Carlos; Bahnan, Wael et al.

Ingår i Journal of Medicinal Chemistry, s. 2094-2108, 2016

• DOI för Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

Llona-Minguez, Sabin; Höglund, Andreas; Jacques, Sylvain A.; Johanson, Lars et al.

Ingår i Journal of Medicinal Chemistry, s. 1140-1148, 2016

• DOI för Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

Preclinical Characterization of Acyl Sulfonimidamides: Potential Carboxylic Acid Bioisosteres with Tunable Properties

Borhade, Sanjay R.; Svensson, Richard; Brandt, Peter; Artursson, Per et al.

Ingår i ChemMedChem, s. 455-460, 2015

• DOI för Preclinical Characterization of Acyl Sulfonimidamides: Potential Carboxylic Acid Bioisosteres with Tunable Properties

Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo

Caraballo, Remi; Larsson, Mikael; Nilsson, Stefan K.; Ericsson, Madelene et al.

Ingår i European Journal of Medicinal Chemistry, s. 191-209, 2015

• DOI för Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo

Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Lampa, Anna; Alogheli, Hiba; Ehrenberg, Angelica E.; Åkerblom, Eva et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 6595-6615, 2014

• DOI för Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Lampa, Anna; Bergman, Sara; Svahn Gustafsson, Sofia; Alogheli, Hiba et al.

Ingår i ACS Medicinal Chemistry Letters, s. 249-254, 2014

• DOI för Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues

Fransson, Rebecca; Nordvall, Gunnar; Bylund, Johan; Carlsson-Jonsson, Anna et al.

Ingår i ACS Medicinal Chemistry Letters, s. 1272-1277, 2014

• DOI för Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Gad, Helge; Koolmeister, Tobias; Jemth, Ann-Sofie; Eshtad, Saeed et al.

Ingår i Nature, s. 215-221, 2014

• DOI för MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule

Kitambi, Satish Srinivas; Toledo, Enrique M.; Usoskin, Dmitry; Wee, Shimei et al.

Ingår i Cell, s. 313-328, 2014

• DOI för Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule

Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Over, Bjorn; McCarren, Patrick; Artursson, Per; Foley, Michael et al.

Ingår i Journal of Medicinal Chemistry, s. 2746-2754, 2014

• DOI för Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Gising, Johan; Belfrage, Anna Karin; Alogheli, Hiba; Ehrenberg, Angelica et al.

Ingår i Journal of Medicinal Chemistry, s. 1790-1801, 2014

• DOI för Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice

Tehler, Ulrika; Fagerberg, Jonas H.; Svensson, Richard; Larhed, Mats et al.

Ingår i Journal of Medicinal Chemistry, s. 2690-2694, 2013

• DOI för Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice

Constrained H-Phe-Phe-NH₂ Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability

Fransson, Rebecca; Sköld, Christian; Kratz, Jadel M; Svensson, Richard et al.

Ingår i Journal of Medicinal Chemistry, s. 4953-4965, 2013

• DOI för Constrained H-Phe-Phe-NH₂ Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability

The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: Results from the European Project ACuteTox

Prieto, P.; Kinsner-Ovaskainen, A.; Stanzel, S.; Albella, B. et al.

Ingår i Toxicology in Vitro, s. 1357-1376, 2013

• DOI för The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: Results from the European Project ACuteTox

Structure-Activity Relationships of Synthetic Cordycepin Analogues as Experimental Therapeutics for African Trypanosomiasis

Vodnala, Suman K.; Lundback, Thomas; Yeheskieli, Esther; Sjoberg, Birger et al.

Ingår i Journal of Medicinal Chemistry, s. 9861-9873, 2013

• DOI för Structure-Activity Relationships of Synthetic Cordycepin Analogues as Experimental Therapeutics for African Trypanosomiasis

In Vitro and In Vivo Activities of 2-Aminopyrazines and 2-Aminopyridines in Experimental Models of Human African Trypanosomiasis

Vodnala, Suman K.; Lundback, Thomas; Sjoberg, Birger; Svensson, Richard et al.

Ingår i Antimicrobial Agents and Chemotherapy, s. 1012-1018, 2013

• DOI för In Vitro and In Vivo Activities of 2-Aminopyrazines and 2-Aminopyridines in Experimental Models of Human African Trypanosomiasis

In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug-Drug Interactions

Karlgren, Maria; Ahlin, Gustav; Bergström, Christel A. S; Svensson, Richard et al.

Ingår i Pharmaceutical research, s. 411-426, 2012

• DOI för In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug-Drug Interactions

Integrated cell models for prediction of drug transport and drug metabolism in the human hepatocyte

Karlgren, Maria; Svensson, Richard; Artursson, Per

Ingår i Drug metabolism reviews (Softcover ed.), s. 306-307, 2010

Target Engagement-Mediated Amplification for Monitoring Drug-Target Interactions in Situ

Al-Amin, Rasel A.; Johansson, Lars; Landegren, Nils; Löf, Liza et al.