Xueliang Ge
Forskare vid Institutionen för cell- och molekylärbiologi; Molekylärbiologi
- E-post:
- xueliang.ge@icm.uu.se
- Besöksadress:
- Husargatan 3
752 37 Uppsala - Postadress:
- Box 596
751 24 Uppsala
Biografi
20 14 to now Senior researcher, In Dept. of Cell & Molecular biology, BMC Uppsala University, Sweden
20 10 to 2014 Post doc. In Dept. of Cell & Molecular biology, BMC Uppsala University, Sweden
2007 to 2010 Ph.D. in Molecular Cell Biology , Northeast Forestry University, PR China
2004 to 2007 Master in Molecular Cell Biology , Northeast Forestry University PRChina
Forskning
My research studies mechanisms of protein synthesis in bacteria and the effect of antibiotics on protein translation. I am particularly interested in the research project below.
- The molecular mechanisms of protein synthesis in E. coli and M. smegmatis .
- Design and application of high throughput in vitro reconstituted protein translation system to low molecular weight compound screening.
- Mechanism of ribosome assembly in E. coli .
- Characterization of ribosomal stalk bL12 on protein translation and the development of anti-L12 drug.
- The mechanism of methylation and phosphorylation of translation factor on the regulation of translation in bacteria.
- The mechanism of bacterial environmental stress factors on the regulation of protein translation.
Publikationer
Senaste publikationer
Structural mechanism of FusB-mediated rescue from fusidic acid inhibition of protein synthesis
Ingår i Nature Communications, 2025
- DOI för Structural mechanism of FusB-mediated rescue from fusidic acid inhibition of protein synthesis
- Ladda ner fulltext (pdf) av Structural mechanism of FusB-mediated rescue from fusidic acid inhibition of protein synthesis
Ingår i Scientific Reports, 2025
- DOI för Structure-function comparison of Arbekacin with other aminoglycosides elucidates its higher potency as bacterial translation inhibitor
- Ladda ner fulltext (pdf) av Structure-function comparison of Arbekacin with other aminoglycosides elucidates its higher potency as bacterial translation inhibitor
Ingår i FEMS Microbiology Letters, 2024
Molecular basis of the pleiotropic effects by the antibiotic amikacin on the ribosome
Ingår i Nature Communications, 2023
- DOI för Molecular basis of the pleiotropic effects by the antibiotic amikacin on the ribosome
- Ladda ner fulltext (pdf) av Molecular basis of the pleiotropic effects by the antibiotic amikacin on the ribosome
Uncovering translation roadblocks during the development of a synthetic tRNA
Ingår i Nucleic Acids Research, s. 10201-10211, 2022
- DOI för Uncovering translation roadblocks during the development of a synthetic tRNA
- Ladda ner fulltext (pdf) av Uncovering translation roadblocks during the development of a synthetic tRNA
Alla publikationer
Artiklar i tidskrift
Structural mechanism of FusB-mediated rescue from fusidic acid inhibition of protein synthesis
Ingår i Nature Communications, 2025
- DOI för Structural mechanism of FusB-mediated rescue from fusidic acid inhibition of protein synthesis
- Ladda ner fulltext (pdf) av Structural mechanism of FusB-mediated rescue from fusidic acid inhibition of protein synthesis
Ingår i Scientific Reports, 2025
- DOI för Structure-function comparison of Arbekacin with other aminoglycosides elucidates its higher potency as bacterial translation inhibitor
- Ladda ner fulltext (pdf) av Structure-function comparison of Arbekacin with other aminoglycosides elucidates its higher potency as bacterial translation inhibitor
Ingår i FEMS Microbiology Letters, 2024
Molecular basis of the pleiotropic effects by the antibiotic amikacin on the ribosome
Ingår i Nature Communications, 2023
- DOI för Molecular basis of the pleiotropic effects by the antibiotic amikacin on the ribosome
- Ladda ner fulltext (pdf) av Molecular basis of the pleiotropic effects by the antibiotic amikacin on the ribosome
Uncovering translation roadblocks during the development of a synthetic tRNA
Ingår i Nucleic Acids Research, s. 10201-10211, 2022
- DOI för Uncovering translation roadblocks during the development of a synthetic tRNA
- Ladda ner fulltext (pdf) av Uncovering translation roadblocks during the development of a synthetic tRNA
Ingår i Journal of Biological Chemistry, 2021
- DOI för GGQ methylation enhances both speed and accuracy of stop codon recognition by bacterial class-I release factors
- Ladda ner fulltext (pdf) av GGQ methylation enhances both speed and accuracy of stop codon recognition by bacterial class-I release factors
Collateral toxicity limits the evolution of bacterial Release Factor 2 towards total omnipotence
Ingår i Molecular biology and evolution, s. 2918-2930, 2020
- DOI för Collateral toxicity limits the evolution of bacterial Release Factor 2 towards total omnipotence
- Ladda ner fulltext (pdf) av Collateral toxicity limits the evolution of bacterial Release Factor 2 towards total omnipotence
Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 15609-15619, 2020
Selective translation by alternative bacterial ribosomes
Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 19487-19496, 2020
- DOI för Selective translation by alternative bacterial ribosomes
- Ladda ner fulltext (pdf) av Selective translation by alternative bacterial ribosomes
Inhibition of translation termination by small molecules targeting ribosomal release factors
Ingår i Scientific Reports, 2019
- DOI för Inhibition of translation termination by small molecules targeting ribosomal release factors
- Ladda ner fulltext (pdf) av Inhibition of translation termination by small molecules targeting ribosomal release factors
Ingår i Protein & Cell, s. 384-388, 2018
- DOI för Cryo-EM structure of Mycobacterium smegmatis ribosome reveals two unidentified ribosomal proteins close to the functional centers
- Ladda ner fulltext (pdf) av Cryo-EM structure of Mycobacterium smegmatis ribosome reveals two unidentified ribosomal proteins close to the functional centers
Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 4649-4654, 2018
Experimental Evolution of Escherichia coli Harboring an Ancient Translation Protein
Ingår i Journal of Molecular Evolution, s. 69-84, 2017
- DOI för Experimental Evolution of Escherichia coli Harboring an Ancient Translation Protein
- Ladda ner fulltext (pdf) av Experimental Evolution of Escherichia coli Harboring an Ancient Translation Protein
Ingår i npj Biofilms and Microbiomes, 2017
- DOI för New melanocortin-like peptide of E. coli can suppress inflammation via the mammalian melanocortin-1 receptor (MC1R): possible endocrine-like function for microbes of the gut.
- Ladda ner fulltext (pdf) av New melanocortin-like peptide of E. coli can suppress inflammation via the mammalian melanocortin-1 receptor (MC1R): possible endocrine-like function for microbes of the gut.
Spatial Distribution and Ribosome-Binding Dynamics of EF-P in Live Escherichia coli
Ingår i mBio, 2017
- DOI för Spatial Distribution and Ribosome-Binding Dynamics of EF-P in Live Escherichia coli
- Ladda ner fulltext (pdf) av Spatial Distribution and Ribosome-Binding Dynamics of EF-P in Live Escherichia coli
Micrococcin P1-A bactericidal thiopeptide active against Mycobacterium tuberculosis
Ingår i Tuberculosis, s. 95-101, 2016
Organization of Ribosomes and Nucleoids in Escherichia coli Cells during Growth and in Quiescence
Ingår i Journal of Biological Chemistry, s. 11342-11352, 2014
Ingår i Nucleic Acids Research, s. 2054-2064, 2012
- DOI för Bacterial ribosome requires multiple L12 dimers for efficient initiation and elongation of protein synthesis involving IF2 and EF-G
- Ladda ner fulltext (pdf) av Bacterial ribosome requires multiple L12 dimers for efficient initiation and elongation of protein synthesis involving IF2 and EF-G
Ingår i International Immunology, s. 421-431, 2010