Nils Welsh

The Welander TIA1 mutation dedifferentiates insulin-producing cells: Reversal by a GLP-1 receptor agonist

Zhao, Tongjian; Cen, Jing; Wang, Xuan; Yang, Mingyu et al.

Ingår i Journal of Biological Chemistry, 2026

• DOI för The Welander TIA1 mutation dedifferentiates insulin-producing cells: Reversal by a GLP-1 receptor agonist
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GDF15 Protects Insulin-Producing Beta Cells against Pro-Inflammatory Cytokines and Metabolic Stress via Increased Deamination of Intracellular Adenosine

Ngamjariyawat, Anongnad; Cen, Jing; Wang, Xuan; Welsh, Nils

Ingår i International Journal of Molecular Sciences, 2024

• DOI för GDF15 Protects Insulin-Producing Beta Cells against Pro-Inflammatory Cytokines and Metabolic Stress via Increased Deamination of Intracellular Adenosine
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CLEC11A improves insulin secretion and promotes cell proliferation in human beta-cells

Shi, Ruifeng; Cen, Jing; Westermark, Gunilla; Zhao, Sheng et al.

Ingår i Journal of Molecular Endocrinology, 2023

• DOI för CLEC11A improves insulin secretion and promotes cell proliferation in human beta-cells
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The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets

Elksnis, Andris; Welsh, Nils; Wikström, Per; Lau, Joey et al.

Ingår i Free radical research, s. 460-469, 2023

• DOI för The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets
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Metabolic stress-induced human beta-cell death is mediated by increased intracellular levels of adenosine

Ngamjariyawat, Anongnad; Cen, Jing; Said, Romain; Incedal, Ceren et al.

Ingår i Frontiers in Endocrinology, 2023

• DOI för Metabolic stress-induced human beta-cell death is mediated by increased intracellular levels of adenosine
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The Welander TIA1 mutation dedifferentiates insulin-producing cells: Reversal by a GLP-1 receptor agonist

Zhao, Tongjian; Cen, Jing; Wang, Xuan; Yang, Mingyu et al.

Ingår i Journal of Biological Chemistry, 2026

• DOI för The Welander TIA1 mutation dedifferentiates insulin-producing cells: Reversal by a GLP-1 receptor agonist
• Ladda ner fulltext (pdf) av The Welander TIA1 mutation dedifferentiates insulin-producing cells: Reversal by a GLP-1 receptor agonist

GDF15 Protects Insulin-Producing Beta Cells against Pro-Inflammatory Cytokines and Metabolic Stress via Increased Deamination of Intracellular Adenosine

Ngamjariyawat, Anongnad; Cen, Jing; Wang, Xuan; Welsh, Nils

Ingår i International Journal of Molecular Sciences, 2024

• DOI för GDF15 Protects Insulin-Producing Beta Cells against Pro-Inflammatory Cytokines and Metabolic Stress via Increased Deamination of Intracellular Adenosine
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CLEC11A improves insulin secretion and promotes cell proliferation in human beta-cells

Shi, Ruifeng; Cen, Jing; Westermark, Gunilla; Zhao, Sheng et al.

Ingår i Journal of Molecular Endocrinology, 2023

• DOI för CLEC11A improves insulin secretion and promotes cell proliferation in human beta-cells
• Ladda ner fulltext (pdf) av CLEC11A improves insulin secretion and promotes cell proliferation in human beta-cells

The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets

Elksnis, Andris; Welsh, Nils; Wikström, Per; Lau, Joey et al.

Ingår i Free radical research, s. 460-469, 2023

• DOI för The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets
• Ladda ner fulltext (pdf) av The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets

Metabolic stress-induced human beta-cell death is mediated by increased intracellular levels of adenosine

Ngamjariyawat, Anongnad; Cen, Jing; Said, Romain; Incedal, Ceren et al.

Ingår i Frontiers in Endocrinology, 2023

• DOI för Metabolic stress-induced human beta-cell death is mediated by increased intracellular levels of adenosine
• Ladda ner fulltext (pdf) av Metabolic stress-induced human beta-cell death is mediated by increased intracellular levels of adenosine

Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK

Elksnis, Andris; Schiffer, Tomas A.; Palm, Fredrik; Wang, Yun et al.

Ingår i Clinical Science, s. 2243-2263, 2021

• DOI för Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK

ZBED6 counteracts high-fat diet-induced glucose intolerance by maintaining beta cell area and reducing excess mitochondrial activation

Wang, Xuan; Younis, Shady; Cen, Jing; Wang, Yun et al.

Ingår i Diabetologia, s. 2292-2305, 2021

• DOI för ZBED6 counteracts high-fat diet-induced glucose intolerance by maintaining beta cell area and reducing excess mitochondrial activation
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Pharmacological Inhibition of NOX4 Improves Mitochondrial Function and Survival in Human Beta-Cells

Elksnis, Andris; Cen, Jing; Wikström, Per; Carlsson, Per-Ola et al.

Ingår i Biomedicines, 2021

• DOI för Pharmacological Inhibition of NOX4 Improves Mitochondrial Function and Survival in Human Beta-Cells
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The importance of the ZBED6-IGF2 axis for metabolic regulation in mouse myoblast cells

Younis, Shady; Naboulsi, Rakan; Wang, Xuan; Cao, Xiaofang et al.

Ingår i The FASEB Journal, s. 10250-10266, 2020

• DOI för The importance of the ZBED6-IGF2 axis for metabolic regulation in mouse myoblast cells
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The protein synthesis inhibitor brusatol normalizes high-fat diet-induced glucose intolerance in male C57BL/6 mice: role of translation factor eIF5A hypusination

Turpaev, Kyril; Krizhanovskii, Camilla; Wang, Xuan; Sargsyan, Ernest et al.

Ingår i The FASEB Journal, s. 3510-3522, 2019

• DOI för The protein synthesis inhibitor brusatol normalizes high-fat diet-induced glucose intolerance in male C57BL/6 mice: role of translation factor eIF5A hypusination

ZBED6 negatively regulates insulin production, neuronal differentiation, and cell aggregation in MIN6 cells

Wang, Xuan; Jiang, Lin; Wallerman, Ola; Younis, Shady et al.

Ingår i The FASEB Journal, s. 88-100, 2019

• DOI för ZBED6 negatively regulates insulin production, neuronal differentiation, and cell aggregation in MIN6 cells

The BRICHOS domain of Bri2 inhibits islet amyloid polypeptide (IAPP) fibril formation and toxicity in human beta cells

Oskarsson, Marie E.; Hermansson, Erik; Wang, Ye; Welsh, Nils et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2018

• DOI för The BRICHOS domain of Bri2 inhibits islet amyloid polypeptide (IAPP) fibril formation and toxicity in human beta cells

The novel NADPH oxidase 4 selective inhibitor GLX7013114 counteracts human islet cell death in vitro

Wang, Xuan; Elksnis, Andris; Wikström, Per; Walum, Erik et al.

Ingår i PLOS ONE, 2018

• DOI för The novel NADPH oxidase 4 selective inhibitor GLX7013114 counteracts human islet cell death in vitro
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Addition of exogenous sodium palmitate increases the IAPP/insulin mRNA ratio via GPR40 in human EndoC-beta H1 cells

Krizhanovskii, Camilla; Fred, Rikard G; Oskarsson, Marie E.; Westermark, Gunilla T. et al.

Ingår i Upsala Journal of Medical Sciences, s. 149-159, 2017

• DOI för Addition of exogenous sodium palmitate increases the IAPP/insulin mRNA ratio via GPR40 in human EndoC-beta H1 cells
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EndoC-beta H1 cells display increased sensitivity to sodium palmitate when cultured in DMEM/F12 medium

Krizhanovskii, Camilla; Kristinsson, Hjalti; Elksnis, Andris; Wang, Xuan et al.

Ingår i Islets, s. 43-48, 2017

• DOI för EndoC-beta H1 cells display increased sensitivity to sodium palmitate when cultured in DMEM/F12 medium

Knock-down of ZBED6 in insulin-producing cells promotes N-cadherin junctions between beta-cells and neural crest stem cells in vitro

Wang, Xuan; Xie, Beichen; Qi, Yu; Wallerman, Ola et al.

Ingår i Scientific Reports, 2016

• DOI för Knock-down of ZBED6 in insulin-producing cells promotes N-cadherin junctions between beta-cells and neural crest stem cells in vitro
• Ladda ner fulltext (pdf) av Knock-down of ZBED6 in insulin-producing cells promotes N-cadherin junctions between beta-cells and neural crest stem cells in vitro

Aromatic malononitriles stimulate the resistance of insulin-producing beta-cells to oxidants and inflammatory cytokines

Turpaev, Kyril; Welsh, Nils

Ingår i European Journal of Pharmacology, s. 69-80, 2016

• DOI för Aromatic malononitriles stimulate the resistance of insulin-producing beta-cells to oxidants and inflammatory cytokines

PTB and TIAR binding to insulin mRNA 3'- and 5'UTRs; implications for insulin biosynthesis and messenger stability.

Fred, Rikard G; Mehrabi, Syrina; Adams, Christopher M; Welsh, Nils

Ingår i Heliyon, 2016

• DOI för PTB and TIAR binding to insulin mRNA 3'- and 5'UTRs; implications for insulin biosynthesis and messenger stability.
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Imatinib prevents beta cell death in vitro but does not improve islet transplantation outcome

King, Aileen J. F.; Griffiths, Lisa A.; Persaud, Shanta J.; Jones, Peter M. et al.

Ingår i Upsala Journal of Medical Sciences, s. 140-145, 2016

• DOI för Imatinib prevents beta cell death in vitro but does not improve islet transplantation outcome
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ZBED6 negatively regulates insulin content, glucose-stimulated insulin secretion, neuronal differentiation and cell aggregation in MIN6 cells

Wang, Xuan; Jiang, L.; Wallerman, Ola; Yu, Qian et al.

Ingår i Diabetologia, 2016

The H1-receptor antagonist cetirizine ameliorates high-fat diet-induced glucose intolerance in male C57BL/6 mice, but not diabetes outcome in female non-obese diabetic (NOD) mice

Anvari, Ebrahim; Wang, Xuan; Sandler, Stellan; Welsh, Nils

Ingår i Upsala Journal of Medical Sciences, s. 40-46, 2015

• DOI för The H1-receptor antagonist cetirizine ameliorates high-fat diet-induced glucose intolerance in male C57BL/6 mice, but not diabetes outcome in female non-obese diabetic (NOD) mice

Role of the AMP kinase in cytokine-induced human EndoC-beta H1 cell death

Fred, Rikard G.; Kappe, Camilla; Ameur, Adam; Cen, Jing et al.

Ingår i Molecular and Cellular Endocrinology, s. 53-63, 2015

• DOI för Role of the AMP kinase in cytokine-induced human EndoC-beta H1 cell death
• Ladda ner fulltext (pdf) av Role of the AMP kinase in cytokine-induced human EndoC-beta H1 cell death

Activated pancreatic stellate cells can impair pancreatic islet function in mice

Zang, Guangxiang; Sandberg, Monica; Carlsson, Per-Ola; Welsh, Nils et al.

Ingår i Upsala Journal of Medical Sciences, s. 169-180, 2015

• DOI för Activated pancreatic stellate cells can impair pancreatic islet function in mice

Brusatol inhibits the response of cultured beta-cells to pro-inflammatory cytokines in vitro

Turpaev, Kyril; Welsh, Nils

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 868-872, 2015

• DOI för Brusatol inhibits the response of cultured beta-cells to pro-inflammatory cytokines in vitro
• Ladda ner fulltext (pdf) av Brusatol inhibits the response of cultured beta-cells to pro-inflammatory cytokines in vitro

The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice

Anvari, Ebrahim; Wikström, Per; Walum, Erik; Welsh, Nils

Ingår i Free radical research, s. 1308-1318, 2015

• DOI för The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice
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Imatinib mesylate stimulates low-density lipoprotein receptor-related protein 1-mediated ERK phosphorylation in insulin-producing cells

Fred, Rikard G.; Boddeti, Santosh Kumar; Lundberg, Marcus; Welsh, Nils

Ingår i Clinical Science, s. 17-28, 2015

• DOI för Imatinib mesylate stimulates low-density lipoprotein receptor-related protein 1-mediated ERK phosphorylation in insulin-producing cells

The H-1-Receptor Antagonist Cetirizine Protects Partially Against Cytokine- and Hydrogen Peroxide-Induced beta-TC6 Cell Death In Vitro

Anvari, Ebrahim; Fred, Rikard G.; Welsh, Nils

Ingår i Pancreas, s. 624-629, 2014

• DOI för The H-1-Receptor Antagonist Cetirizine Protects Partially Against Cytokine- and Hydrogen Peroxide-Induced beta-TC6 Cell Death In Vitro

Temporal profiling of cytokine-induced genes in pancreatic beta-cells by meta-analysis and network inference

Lopes, Miguel; Kutlu, Burak; Miani, Michela; Bang-Berthelsen, Claus H. et al.

Ingår i Genomics, s. 264-275, 2014

• DOI för Temporal profiling of cytokine-induced genes in pancreatic beta-cells by meta-analysis and network inference

Bcl-2 maintains the mitochondrial membrane potential, but fails to affect production of reactive oxygen species and endoplasmic reticulum stress, in sodium palmitate-induced beta-cell death

Wang, Xuan; Welsh, Nils

Ingår i Upsala Journal of Medical Sciences, s. 306-315, 2014

• DOI för Bcl-2 maintains the mitochondrial membrane potential, but fails to affect production of reactive oxygen species and endoplasmic reticulum stress, in sodium palmitate-induced beta-cell death
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Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5'-phosphatase interaction with c-Abl

Mokhtari, Dariush; Al-Amin, Abdullah; Turpaev, Kyrill; Li, Tingting et al.

Ingår i Diabetologia, s. 1327-1338, 2013

• DOI för Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5'-phosphatase interaction with c-Abl
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Co-Culture of Neural Crest Stem Cells (NCSC) and Insulin Producing Beta-TC6 Cells Results in Cadherin Junctions and Protection against Cytokine-Induced Beta-Cell Death

Ngamjariyawat, Anongnad; Turpaev, Kyril; Vasylovska, Svitlana; Kozlova, Elena N et al.

Ingår i PLOS ONE, 2013

• DOI för Co-Culture of Neural Crest Stem Cells (NCSC) and Insulin Producing Beta-TC6 Cells Results in Cadherin Junctions and Protection against Cytokine-Induced Beta-Cell Death
• Ladda ner fulltext (pdf) av Co-Culture of Neural Crest Stem Cells (NCSC) and Insulin Producing Beta-TC6 Cells Results in Cadherin Junctions and Protection against Cytokine-Induced Beta-Cell Death

Transcription factor ZBED6 affects gene expression, proliferation, and cell death in pancreatic beta cells

Wang, Xuan; Jiang, Lin; Wallerman, Ola; Engström, Ulla et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 15997-16002, 2013

• DOI för Transcription factor ZBED6 affects gene expression, proliferation, and cell death in pancreatic beta cells

Vascular Heterogeneity Between Native Pancreatic Islets Determines Their Fate of Survival and Revascularization Posttransplantation

Ullsten, Sara; Lau, Joey; Welsh, Nils; Carlsson, Per-Ola

Ingår i Transplantation, 2013

Cytokine-induced human islet cell death in vitro correlateswith a persistently high phosphorylation of STAT-1, but not with NF-κB activation

Hindlycke, Henrietta; Lu, Tao; Welsh, Nils

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 845-850, 2012

• DOI för Cytokine-induced human islet cell death in vitro correlateswith a persistently high phosphorylation of STAT-1, but not with NF-κB activation
• Ladda ner fulltext (pdf) av Cytokine-induced human islet cell death in vitro correlateswith a persistently high phosphorylation of STAT-1, but not with NF-κB activation

C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in beta-cells

Allagnat, F.; Fukaya, M.; Nogueira, T. C.; Delaroche, D. et al.

Ingår i Cell Death and Differentiation, s. 1836-1846, 2012

• DOI för C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in beta-cells

Coculture of Insulin-Producing RIN5AH Cells With Neural Crest Stem Cells Protects Partially Against Cytokine-Induced Cell Death

Ngamjariyawat, Anongnad; Turpaev, Kyril; Welsh, Nils; Kozlova, Elena N.

Ingår i Pancreas, s. 490-492, 2012

• DOI för Coculture of Insulin-Producing RIN5AH Cells With Neural Crest Stem Cells Protects Partially Against Cytokine-Induced Cell Death

Effects of Imatinib Mesylate (Gleevec) on Human Islet NF-kappaB Activation and Chemokine Production In Vitro

Mokhtari, Dariush; Li, Tingting; Lu, Tao; Welsh, Nils

Ingår i PLOS ONE, 2011

• DOI för Effects of Imatinib Mesylate (Gleevec) on Human Islet NF-kappaB Activation and Chemokine Production In Vitro

The human insulin mRNA is partly translated via a cap- and eIF4A-independent mechanism

Fred, Rikard G.; Sandberg, Monica; Pelletier, Jerry; Welsh, Nils

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 693-698, 2011

• DOI för The human insulin mRNA is partly translated via a cap- and eIF4A-independent mechanism

Potential utility of small tyrosine kinase inhibitors in the treatment of diabetes

Mokhtari, Dariush; Welsh, Nils

Ingår i Clinical Science, s. 241-247, 2010

• DOI för Potential utility of small tyrosine kinase inhibitors in the treatment of diabetes

High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression

Fred, Rikard G; Bang-Berthelsen, Claus H; Mandrup-Poulsen, Thomas; Grunnet, Lars G et al.

Ingår i PLOS ONE, 2010

• DOI för High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression

Detailed transcriptome atlas of the pancreatic beta cell

Kutlu, Burak; Burdick, David; Baxter, David; Rasschaert, Joanne et al.

Ingår i BMC Medical Genomics, s. 3, 2009

• DOI för Detailed transcriptome atlas of the pancreatic beta cell

Overexpression of the Nuclear Factor-{kappa}B subunit c-Rel protects against human islet cell death in vitro

Mokhtari, Dariush; Barbu, Andreea; Mehmeti, Ilir; Vercamer, Chantal et al.

Ingår i American Journal of Physiology. Endocrinology and Metabolism, 2009

• DOI för Overexpression of the Nuclear Factor-{kappa}B subunit c-Rel protects against human islet cell death in vitro

Increased Hsp70 expression attenuates cytokine-induced cell death in islets of Langerhans from Shb knockout mice

Mokhtari, Dariush; Åkerblom, Björn; Mehmeti, Ilir; Wang, Xuan et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 553-557, 2009

• DOI för Increased Hsp70 expression attenuates cytokine-induced cell death in islets of Langerhans from Shb knockout mice

Possible role of an ischemic preconditioning-like response mechanism in K(ATP) channel opener-mediated protection against streptozotocin-induced suppression of rat pancreatic islet function

Sandler, Stellan; Andersson, Annika K.; Larsson, Jenny; Makeeva, Natalia et al.

Ingår i Biochemical Pharmacology, s. 1748-1756, 2008

• DOI för Possible role of an ischemic preconditioning-like response mechanism in K(ATP) channel opener-mediated protection against streptozotocin-induced suppression of rat pancreatic islet function

Transforming growth factor-beta-activated protein kinase 1-binding protein (TAB)-1alpha, but not TAB1beta, mediates cytokine-induced p38 mitogen-activated protein kinase phosphorylation and cell death in insulin-producing cells

Makeeva, Natalia; Roomans, Godfried M; Myers, Jason W; Welsh, Nils

Ingår i Endocrinology, s. 302-309, 2008

• DOI för Transforming growth factor-beta-activated protein kinase 1-binding protein (TAB)-1alpha, but not TAB1beta, mediates cytokine-induced p38 mitogen-activated protein kinase phosphorylation and cell death in insulin-producing cells

MAPK kinase kinase-1 is essential for cytokine-induced c-Jun NH2-terminal kinase and nuclear factor-kappaB activation in human pancreatic islet cells

Mokhtari, Dariush; Myers, Jason W; Welsh, Nils

Ingår i Diabetes, s. 1896-1904, 2008

• DOI för MAPK kinase kinase-1 is essential for cytokine-induced c-Jun NH2-terminal kinase and nuclear factor-kappaB activation in human pancreatic islet cells

The MAPK kinase kinase-1 is essential for stress-induced pancreatic islet cell death

Mokhtari, Dariush; Myers, Jason W; Welsh, Nils

Ingår i Endocrinology, s. 3046-3053, 2008

• DOI för The MAPK kinase kinase-1 is essential for stress-induced pancreatic islet cell death

Imatinib mesylate improves insulin sensitivity and glucose disposal rates in rats fed a high-fat diet

Hägerkvist, Robert; Jansson, Leif; Welsh, Nils

Ingår i Clinical Science, s. 65-71, 2008

• DOI för Imatinib mesylate improves insulin sensitivity and glucose disposal rates in rats fed a high-fat diet

Improved vascular engraftment and graft function after inhibition of the angiostatic factor thrombospondin-1 in mouse pancreatic islets

Olerud, Johan; Johansson, Magnus; Lawler, Jack; Welsh, Nils et al.

Ingår i Diabetes, s. 1870-1877, 2008

• DOI för Improved vascular engraftment and graft function after inhibition of the angiostatic factor thrombospondin-1 in mouse pancreatic islets

Role of TAB1 in nitric oxide-induced p38 activation in insulin-producing cells

Makeeva, Natalia; Roomans, Godfried M.; Welsh, Nils

Ingår i International Journal of Biological Sciences, s. 71-76, 2007

Lipofection of insulin-producing RINm5F cells: methodological improvements

Barbu, Andreea; Welsh, Nils

Ingår i Journal of liposome research, s. 49-62, 2007

• DOI för Lipofection of insulin-producing RINm5F cells: methodological improvements

Claes Hellerström: a friendly islet explorer

Andersson, Arne; Eriksson, Ulf J.; Jansson, Leif; Sandler, Stellan et al.

Ingår i Diabetologia, 2007

Consequences of Shb and c-Abl interactions for cell death in response to various stress stimuli

Hägerkvist, Robert; Mokhtari, Dariush; Lindholm, Cecilia; Farnebo, Filip et al.

Ingår i Experimental Cell Research, s. 284-291, 2007

• DOI för Consequences of Shb and c-Abl interactions for cell death in response to various stress stimuli

Amelioration of diabetes by imatinib mesylate (Gleevec): role of beta-cell NF-kappaB activation and anti-apoptotic preconditioning

Hägerkvist, Robert; Sandler, Stellan; Mokhtari, Dariush; Welsh, Nils

Ingår i The FASEB Journal, s. 618-628, 2007

• DOI för Amelioration of diabetes by imatinib mesylate (Gleevec): role of beta-cell NF-kappaB activation and anti-apoptotic preconditioning

A perfusion protocol for highly efficient transduction of intact pancreatic islets of Langerhans

Barbu, Andreea R.; Bodin, Birgitta; Welsh, Michael; Jansson, Leif et al.

Ingår i Diabetologia, s. 2388-2391, 2006

• DOI för A perfusion protocol for highly efficient transduction of intact pancreatic islets of Langerhans

The role of PTB in insulin mRNA stability contol

Fred, R G; Tillmar, L; Welsh, N

Ingår i Current Diabetes Reviews, s. 363-366, 2006

Adenoviral-mediated transduction of human pancreatic islets: importance of adenoviral genome for cell viability and association with a deficient antiviral response

Barbu, Andreea R; Akusjärvi, Göran; Welsh, Nils

Ingår i Endocrinology, s. 2406-2414, 2005

• DOI för Adenoviral-mediated transduction of human pancreatic islets: importance of adenoviral genome for cell viability and association with a deficient antiviral response

Increased expression of polypyrimidine tract binding protein results in higher insulin mRNA levels

Fred, Rikard G; Welsh, Nils

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 38-42, 2005

• DOI för Increased expression of polypyrimidine tract binding protein results in higher insulin mRNA levels

Mechanisms of Pancreatic {beta}-Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few Similarities.

Cnop, Miriam; Welsh, Nils; Jonas, Jean-Christophe; Jörns, Anne et al.

Ingår i Diabetes, 2005

siRNA Produced by Recombinant Dicer Mediates Efficient Gene Silencing in Islet Cells.

Hägerkvist, Robert; Mokhtari, Dariush; Myers, Jason W; Tengholm, Anders et al.

Ingår i Ann N Y Acad Sci, s. 114-22, 2005

Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?

Welsh, Nils; Cnop, Miriam; Kharroubi, Ilham; Bugliani, Marco et al.

Ingår i Diabetes, s. 3238-44, 2005

P38 MAPK inhibits JMK2 and mediates cytokine-activated iNOS induction and apoptosis independently of NF-kB translocation in insulinproducing cells

Saleen, Johan; Welsh, Nils

Ingår i Eur Cyt Netw, s. 47-52, 2004

The use of tetrazolium salt-based methods for determination of islet cell viability in response to cytokines: a cautionary note.

Barbu, Andreea; Welsh, Nils

Ingår i Diabetologia, s. 2042-2043, 2004

Promoting islet cell function after transplantation

Andersson, Arne; Carlsson, Per-Ola; Carlsson, Carina; Olsson, Richard et al.

Ingår i Cell Biochem Biophys, s. 55-64, 2004

Glucose-induced binding of the polypyrimidine tract-binding protein (PTB) to the 3'-untranslated region of the insulin mRNA (ins-PRS) is inhibited by rapamycin.

Tillmar, Linda; Welsh, Nils

Ingår i Mol and Cell Biochem, s. 85-90, 2004

Overexpression of the Shb SH2 domain-protein in insulin-producing cells leads to altered signaling through the IRS-1 and IRS-2 proteins

Welsh, Nils; Makeeva, Natalia; Welsh, Michael

Ingår i Molecular Medicine, s. 695-704, 2002

Developmental damage, increased lipid peroxidation, diminished cyclooxygenase-2 gene expression, and lowered PGE-2 levels in rat embryos exposed to a diabetic environment

Wentzel, Parri; Welsh, Nils; Eriksson, Ulf J.

Ingår i Diabetes, s. 813-820, 1999

• DOI för Developmental damage, increased lipid peroxidation, diminished cyclooxygenase-2 gene expression, and lowered PGE-2 levels in rat embryos exposed to a diabetic environment

Transgeneic mice expressing the Shb adaptor protein under the control of  rat insulin promoter exhibit altered viability of pancreatic islet cells

Welsh, Michael; Christmansson, L; Karlsson, T; Sandler, Stellan et al.

Ingår i Molecular Medicine, s. 169-180, 1999

Are off-target effects of imatinib the key to improving beta-cell function in diabetes?

Welsh, Nils

Ingår i Upsala Journal of Medical Sciences, 2022

• DOI för Are off-target effects of imatinib the key to improving beta-cell function in diabetes?
• Ladda ner fulltext (pdf) av Are off-target effects of imatinib the key to improving beta-cell function in diabetes?

Does the small tyrosine kinase inhibitor imatinib mesylate counteract diabetes by affecting pancreatic islet amyloidosis and fibrosis?

Welsh, Nils

Ingår i Expert Opinion on Investigational Drugs, s. 1743-1750, 2012

• DOI för Does the small tyrosine kinase inhibitor imatinib mesylate counteract diabetes by affecting pancreatic islet amyloidosis and fibrosis?
• Ladda ner fulltext (pdf) av Does the small tyrosine kinase inhibitor imatinib mesylate counteract diabetes by affecting pancreatic islet amyloidosis and fibrosis?

The importance of RNA binding proteins in preproinsulin mRNA stability

Fred, Rikard G.; Welsh, Nils

Ingår i Molecular and Cellular Endocrinology, s. 28-33, 2009

• DOI för The importance of RNA binding proteins in preproinsulin mRNA stability

Gene therapy in diabetes mellitus

Welsh, Nils

Nature publishing group, 2003

Gene Therapy

Barbu, Andrea R; Welsh, Nils

Ingår i Textbook of Diabetes, s. 1064-1069, Wiley-Blackwell, 2010

Diabetes Mellitus: Gene Therapy

Barbu, Andreea; Welsh, Nils

Ingår i ENCYCLOPEDIA OF LIFE SCIENCES, John Wiley & Sons, 2007

• DOI för Diabetes Mellitus: Gene Therapy

Type III phosphatidylinositol 4-kinases mediate plasma membrane PIP2 synthesis in insulin-secreting cells

Wuttke, Anne; Sagetorp, J.; Welsh, Nils; Tengholm, Anders

Ingår i 43rd easd annual meeting of the european association for the study of diabetes, 2007

• DOI för Type III phosphatidylinositol 4-kinases mediate plasma membrane PIP2 synthesis in insulin-secreting cells

Department of Medical Cell Biology: Annual Report 2016

Welsh, Nils

Uppsala University, 2017

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Department of Medical Cell Biology: Annual Report 2015

Welsh, Nils

Uppsala University, 2016

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Department of Medical Cell Biology: Annual Report 2014

Welsh, Nils

Uppsala universitet, 2015

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