Mikael Hedeland

Mapping the polar metabolome in Huh-7 liver cancer cells reveal the role of atorvastatin in enhancing chemotherapeutic efficacy of doxorubicin.

Kopsida, Maria; Regtop, Lotta; Lennernäs, Hans; Hedeland, Mikael et al.

Ingår i Journal of Pharmaceutical and Biomedical Analysis, s. 117012, 2025

• DOI för Mapping the polar metabolome in Huh-7 liver cancer cells reveal the role of atorvastatin in enhancing chemotherapeutic efficacy of doxorubicin.
• Ladda ner fulltext (pdf) av Mapping the polar metabolome in Huh-7 liver cancer cells reveal the role of atorvastatin in enhancing chemotherapeutic efficacy of doxorubicin.

Canagliflozin: Pharmacokinetics, tolerability and glucose/insulin effects of supratherapeutic doses in healthy horses

Michanek, Peter; Bröjer, Johan; Lilliehöök, Inger; Fjordbakk, Cathrine et al.

Ingår i The Veterinary Journal, 2025

• DOI för Canagliflozin: Pharmacokinetics, tolerability and glucose/insulin effects of supratherapeutic doses in healthy horses
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A comprehensive mechanistic investigation of factors affecting intestinal absorption and bioavailability of two PROTACs in rats

Niessen, Janis; Arendt, Nathalie; Sjöblom, Markus; Dubbelboer, Ilse R. et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, 2025

• DOI för A comprehensive mechanistic investigation of factors affecting intestinal absorption and bioavailability of two PROTACs in rats
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Pharmacokinetics and Alterations in Glucose and Insulin Levels After a Single Dose of Canagliflozin in Healthy Icelandic Horses

Michanek, Peter; Bröjer, Johan; Lilliehöök, Inger; Fjordbakk, Cathrine T et al.

Ingår i Journal of Veterinary Pharmacology and Therapeutics, s. 41-49, 2025

• DOI för Pharmacokinetics and Alterations in Glucose and Insulin Levels After a Single Dose of Canagliflozin in Healthy Icelandic Horses
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Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells

Kopsida, Maria; Clavero, Ada Lerma; Khaled, Jaafar; Balgoma, David et al.

Ingår i Molecular Metabolism, 2024

• DOI för Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells
• Ladda ner fulltext (pdf) av Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells

Mapping the polar metabolome in Huh-7 liver cancer cells reveal the role of atorvastatin in enhancing chemotherapeutic efficacy of doxorubicin.

Kopsida, Maria; Regtop, Lotta; Lennernäs, Hans; Hedeland, Mikael et al.

Ingår i Journal of Pharmaceutical and Biomedical Analysis, s. 117012, 2025

• DOI för Mapping the polar metabolome in Huh-7 liver cancer cells reveal the role of atorvastatin in enhancing chemotherapeutic efficacy of doxorubicin.
• Ladda ner fulltext (pdf) av Mapping the polar metabolome in Huh-7 liver cancer cells reveal the role of atorvastatin in enhancing chemotherapeutic efficacy of doxorubicin.

Canagliflozin: Pharmacokinetics, tolerability and glucose/insulin effects of supratherapeutic doses in healthy horses

Michanek, Peter; Bröjer, Johan; Lilliehöök, Inger; Fjordbakk, Cathrine et al.

Ingår i The Veterinary Journal, 2025

• DOI för Canagliflozin: Pharmacokinetics, tolerability and glucose/insulin effects of supratherapeutic doses in healthy horses
• Ladda ner fulltext (pdf) av Canagliflozin: Pharmacokinetics, tolerability and glucose/insulin effects of supratherapeutic doses in healthy horses

A comprehensive mechanistic investigation of factors affecting intestinal absorption and bioavailability of two PROTACs in rats

Niessen, Janis; Arendt, Nathalie; Sjöblom, Markus; Dubbelboer, Ilse R. et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, 2025

• DOI för A comprehensive mechanistic investigation of factors affecting intestinal absorption and bioavailability of two PROTACs in rats
• Ladda ner fulltext (pdf) av A comprehensive mechanistic investigation of factors affecting intestinal absorption and bioavailability of two PROTACs in rats

Pharmacokinetics and Alterations in Glucose and Insulin Levels After a Single Dose of Canagliflozin in Healthy Icelandic Horses

Michanek, Peter; Bröjer, Johan; Lilliehöök, Inger; Fjordbakk, Cathrine T et al.

Ingår i Journal of Veterinary Pharmacology and Therapeutics, s. 41-49, 2025

• DOI för Pharmacokinetics and Alterations in Glucose and Insulin Levels After a Single Dose of Canagliflozin in Healthy Icelandic Horses
• Ladda ner fulltext (pdf) av Pharmacokinetics and Alterations in Glucose and Insulin Levels After a Single Dose of Canagliflozin in Healthy Icelandic Horses

Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells

Kopsida, Maria; Clavero, Ada Lerma; Khaled, Jaafar; Balgoma, David et al.

Ingår i Molecular Metabolism, 2024

• DOI för Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells
• Ladda ner fulltext (pdf) av Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells

Text Mining and Computational Chemistry Reveal Trends in Applications of Laser Desorption/Ionization Techniques to Small Molecules

Bergman, Nina P.; Bergquist, Jonas; Hedeland, Mikael; Palmblad, Magnus

Ingår i Journal of the American Society for Mass Spectrometry, s. 2507-2515, 2024

• DOI för Text Mining and Computational Chemistry Reveal Trends in Applications of Laser Desorption/Ionization Techniques to Small Molecules
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Elevated plasma level of arginine and its metabolites at labor among women with preeclampsia: A prospective cohort study

Akhter, Tansim; Hedeland, Mikael; Bergquist, Jonas; Larsson, Anders et al.

Ingår i American Journal of Hypertension, s. 184-191, 2024

• DOI för Elevated plasma level of arginine and its metabolites at labor among women with preeclampsia: A prospective cohort study
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Elevated Plasma Levels of Arginines During Labor Among Women with Spontaneous Preterm Birth: A Prospective Cohort Study

Akhter, Tansim; Hedeland, Mikael; Bergquist, Jonas; Ubhayasekera, Kumari et al.

Ingår i American Journal of Reproductive Immunology, 2024

• DOI för Elevated Plasma Levels of Arginines During Labor Among Women with Spontaneous Preterm Birth: A Prospective Cohort Study
• Ladda ner fulltext (pdf) av Elevated Plasma Levels of Arginines During Labor Among Women with Spontaneous Preterm Birth: A Prospective Cohort Study

Development and validation of LC-MS/MS methods for the pharmacokinetic assessment of the PROTACs bavdeglutamide (ARV-110) and vepdegestrant (ARV-471)

Niessen, Janis; Nilsson, Jenny M.; Peters, Karsten; Indulkar, Anura et al.

Ingår i Journal of Pharmaceutical and Biomedical Analysis, 2024

• DOI för Development and validation of LC-MS/MS methods for the pharmacokinetic assessment of the PROTACs bavdeglutamide (ARV-110) and vepdegestrant (ARV-471)
• Ladda ner fulltext (pdf) av Development and validation of LC-MS/MS methods for the pharmacokinetic assessment of the PROTACs bavdeglutamide (ARV-110) and vepdegestrant (ARV-471)

Ammonium bicarbonate buffers combined with hybrid surface technology columns improve the peak shape of strongly tailing lipids

Nilsson, Jenny M.; Balgoma, David; Pettersson, Curt; Lennernäs, Hans et al.

Ingår i Analytica Chimica Acta, 2024

• DOI för Ammonium bicarbonate buffers combined with hybrid surface technology columns improve the peak shape of strongly tailing lipids
• Ladda ner fulltext (pdf) av Ammonium bicarbonate buffers combined with hybrid surface technology columns improve the peak shape of strongly tailing lipids

Plasma levels of arginines at term pregnancy in relation to mode of onset of labor and mode of childbirth

Akhter, Tansim; Hedeland, Mikael; Bergquist, Jonas; Ubhayasekera, Kumari et al.

Ingår i American Journal of Reproductive Immunology, 2023

• DOI för Plasma levels of arginines at term pregnancy in relation to mode of onset of labor and mode of childbirth
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A multivariate data analysis approach for the investigation of in vitro derived metabolites of ACP-105 in comparison with human in vivo metabolites

Nilsson Broberg, Malin; Tillgren Ohlsson, Rebecca; Bondesson, Ulf; Pettersson, Curt et al.

Ingår i Journal of chromatography. B, 2023

• DOI för A multivariate data analysis approach for the investigation of in vitro derived metabolites of ACP-105 in comparison with human in vivo metabolites
• Ladda ner fulltext (pdf) av A multivariate data analysis approach for the investigation of in vitro derived metabolites of ACP-105 in comparison with human in vivo metabolites

Equine in vivo metabolite profiling of the selective androgen receptor modulator LGD-3303 for doping control

Nilsson Broberg, Malin; Knych, Heather; Bondesson, Ulf; Pettersson, Curt et al.

Ingår i Journal of Pharmaceutical and Biomedical Analysis, 2023

• DOI för Equine in vivo metabolite profiling of the selective androgen receptor modulator LGD-3303 for doping control
• Ladda ner fulltext (pdf) av Equine in vivo metabolite profiling of the selective androgen receptor modulator LGD-3303 for doping control

Trials and tribulations of statistical significance in biochemistry and omics

Montero, Olimpio; Hedeland, Mikael; Balgoma, David

Ingår i TIBS -Trends in Biochemical Sciences. Regular ed., s. 503-512, 2023

• DOI för Trials and tribulations of statistical significance in biochemistry and omics
• Ladda ner fulltext (pdf) av Trials and tribulations of statistical significance in biochemistry and omics

Functionalization of cellulose nanofibrils to develop novel ROS-sensitive biomaterials

Palo-Nieto, Carlos; Blasi-Romero, Anna; Sandström, Corine; Balgoma, David et al.

Ingår i Materials Advances, s. 1555-1565, 2023

• DOI för Functionalization of cellulose nanofibrils to develop novel ROS-sensitive biomaterials
• Ladda ner fulltext (pdf) av Functionalization of cellulose nanofibrils to develop novel ROS-sensitive biomaterials

Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival

Sennefelt Nyman, Sofi; Ahlström, Håkan; Dimopoulou, Angeliki; Dahlgren, David et al.

Ingår i BMJ Open, 2022

• DOI för Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival
• Ladda ner fulltext (pdf) av Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival

Pharmaceuticals are identified in insects in River Fyris – A study with both tandem quadrupole and quadrupole-time-of-flight mass spectrometry

Sedvall, Emelie; Fick, Jerker; Pettersson, Curt; Hedeland, Mikael

Ingår i Environmental Advances, 2022

• DOI för Pharmaceuticals are identified in insects in River Fyris – A study with both tandem quadrupole and quadrupole-time-of-flight mass spectrometry

Neomycin removal using the white rot fungus Trametes versicolor

Stenholm, Åke; Hedeland, Mikael; Pettersson, Curt

Ingår i Journal of Environmental Science and Health. Part A, s. 436-447, 2022

• DOI för Neomycin removal using the white rot fungus Trametes versicolor
• Ladda ner fulltext (pdf) av Neomycin removal using the white rot fungus Trametes versicolor

Comprehensive Peak Characterization (CPC) in Untargeted LC-MS Analysis

Pirttilä, Kristian; Balgoma, David; Rainer, Johannes; Pettersson, Curt et al.

Ingår i Metabolites, 2022

• DOI för Comprehensive Peak Characterization (CPC) in Untargeted LC-MS Analysis
• Ladda ner fulltext (pdf) av Comprehensive Peak Characterization (CPC) in Untargeted LC-MS Analysis

Oogenesis and lipid metabolism in the deep-sea sponge Phakellia ventilabrum (Linnaeus, 1767)

Koutsouveli, Vasiliki; Balgoma, David; Checa, Antonio; Hedeland, Mikael et al.

Ingår i Scientific Reports, 2022

• DOI för Oogenesis and lipid metabolism in the deep-sea sponge Phakellia ventilabrum (Linnaeus, 1767)
• Ladda ner fulltext (pdf) av Oogenesis and lipid metabolism in the deep-sea sponge Phakellia ventilabrum (Linnaeus, 1767)

Investigation of neomycin biodegradation conditions using ericoid mycorrhizal and white rot fungal species

Stenholm, Åke; Hedeland, Mikael; Pettersson, Curt

Ingår i BMC Biotechnology, 2022

• DOI för Investigation of neomycin biodegradation conditions using ericoid mycorrhizal and white rot fungal species
• Ladda ner fulltext (pdf) av Investigation of neomycin biodegradation conditions using ericoid mycorrhizal and white rot fungal species

Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding

Balgoma, David; Kullenberg, Fredrik; Peters, Karsten; Dahlgren, David et al.

Ingår i Metabolites, 2022

• DOI för Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding
• Ladda ner fulltext (pdf) av Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding

Plasma atropine concentrations associated with decreased intestinal motility in horses

Ekstrand, Carl; Michanek, Peter; Gehring, Ronette; Sundell, Anna et al.

Ingår i Frontiers in Veterinary Science, 2022

• DOI för Plasma atropine concentrations associated with decreased intestinal motility in horses
• Ladda ner fulltext (pdf) av Plasma atropine concentrations associated with decreased intestinal motility in horses

Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death

Balgoma, David; Kullenberg, Fredrik; Calitz, Carlemi; Kopsida, Maria et al.

Ingår i Cells, 2021

• DOI för Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death
• Ladda ner fulltext (pdf) av Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death

Modification and validation of the Endopep-mass spectrometry method for botulinum neurotoxin detection in liver samples with application to samples collected during animal botulism outbreaks

Tevell Åberg, Annica; Karlsson, Ida; Hedeland, Mikael

Ingår i Analytical and Bioanalytical Chemistry, s. 345-354, 2021

• DOI för Modification and validation of the Endopep-mass spectrometry method for botulinum neurotoxin detection in liver samples with application to samples collected during animal botulism outbreaks
• Ladda ner fulltext (pdf) av Modification and validation of the Endopep-mass spectrometry method for botulinum neurotoxin detection in liver samples with application to samples collected during animal botulism outbreaks

Investigation of Equine In Vivo and In Vitro Derived Metabolites of the Selective Androgen Receptor Modulator (SARM) ACP-105 for Improved Doping Control

Nilsson Broberg, Malin; Knych, Heather; Bondesson, Ulf; Pettersson, Curt et al.

Ingår i Metabolites, 2021

• DOI för Investigation of Equine In Vivo and In Vitro Derived Metabolites of the Selective Androgen Receptor Modulator (SARM) ACP-105 for Improved Doping Control
• Ladda ner fulltext (pdf) av Investigation of Equine In Vivo and In Vitro Derived Metabolites of the Selective Androgen Receptor Modulator (SARM) ACP-105 for Improved Doping Control

Dimethylarginines correlate to common carotid artery wall layer dimensions and cardiovascular risk factors in pregnant women with/without preeclampsia: A group comparative study

Akhter, Tansim; Wikström, Gerhard; Larsson, Marita; Bondesson, Ulf et al.

Ingår i European Journal of Obstetrics, Gynecology, and Reproductive Biology, s. 288-293, 2021

• DOI för Dimethylarginines correlate to common carotid artery wall layer dimensions and cardiovascular risk factors in pregnant women with/without preeclampsia: A group comparative study
• Ladda ner fulltext (pdf) av Dimethylarginines correlate to common carotid artery wall layer dimensions and cardiovascular risk factors in pregnant women with/without preeclampsia: A group comparative study

Automated Sequential Analysis of Hydrophilic and Lipophilic Fractions of Biological Samples: Increasing Single-Injection Chemical Coverage in Untargeted Metabolomics

Pirttilä, Kristian; Laurell, Göran; Pettersson, Curt; Hedeland, Mikael

Ingår i Metabolites, 2021

• DOI för Automated Sequential Analysis of Hydrophilic and Lipophilic Fractions of Biological Samples: Increasing Single-Injection Chemical Coverage in Untargeted Metabolomics
• Ladda ner fulltext (pdf) av Automated Sequential Analysis of Hydrophilic and Lipophilic Fractions of Biological Samples: Increasing Single-Injection Chemical Coverage in Untargeted Metabolomics

Improved sensitivity in hydrophilic interaction liquid chromatography-electrospray-mass spectrometry after removal of sodium and potassium ions from biological samples

Erngren, Ida; Nestor, Marika; Pettersson, Curt; Hedeland, Mikael

Ingår i Metabolites, 2021

• DOI för Improved sensitivity in hydrophilic interaction liquid chromatography-electrospray-mass spectrometry after removal of sodium and potassium ions from biological samples
• Ladda ner fulltext (pdf) av Improved sensitivity in hydrophilic interaction liquid chromatography-electrospray-mass spectrometry after removal of sodium and potassium ions from biological samples

Survival and growth of saprotrophic and mycorrhizal fungi in recalcitrant amine, amide and ammonium containing media

Stenholm, Åke; Backlund, Anders; Holmström, Sara; Backlund, Maria et al.

Ingår i PLOS ONE, 2021

• DOI för Survival and growth of saprotrophic and mycorrhizal fungi in recalcitrant amine, amide and ammonium containing media
• Ladda ner fulltext (pdf) av Survival and growth of saprotrophic and mycorrhizal fungi in recalcitrant amine, amide and ammonium containing media

Prednisolone in Dogs: Plasma Exposure and White Blood Cell Response

Ekstrand, Carl; Pettersson, Helena; Gehring, Ronette; Hedeland, Mikael et al.

Ingår i Frontiers in Veterinary Science, 2021

• DOI för Prednisolone in Dogs: Plasma Exposure and White Blood Cell Response
• Ladda ner fulltext (pdf) av Prednisolone in Dogs: Plasma Exposure and White Blood Cell Response

The effects of sampling and storage conditions on the metabolite profile of the marine sponge Geodia barretti

Erngren, Ida; Smit, Eva; Pettersson, Curt; Cárdenas, Paco et al.

Ingår i Frontiers in Chemistry, 2021

• DOI för The effects of sampling and storage conditions on the metabolite profile of the marine sponge Geodia barretti
• Ladda ner fulltext (pdf) av The effects of sampling and storage conditions on the metabolite profile of the marine sponge Geodia barretti

Etherglycerophospholipids and ferroptosis: structure, regulation, and location

Balgoma, David; Hedeland, Mikael

Ingår i Trends in endocrinology and metabolism, s. 960-962, 2021

• DOI för Etherglycerophospholipids and ferroptosis: structure, regulation, and location
• Ladda ner fulltext (pdf) av Etherglycerophospholipids and ferroptosis: structure, regulation, and location

Topical ophthalmic atropine in horses, pharmacokinetics and effect on intestinal motility

Strom, L.; Dalin, F.; Domberg, M.; Stenlund, C. et al.

Ingår i BMC Veterinary Research, 2021

• DOI för Topical ophthalmic atropine in horses, pharmacokinetics and effect on intestinal motility
• Ladda ner fulltext (pdf) av Topical ophthalmic atropine in horses, pharmacokinetics and effect on intestinal motility

In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma

Kullenberg, Fredrik; Degerstedt, Oliver; Calitz, Carlemi; Pavlovic, Natasa et al.

Ingår i Cells, 2021

• DOI för In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma
• Ladda ner fulltext (pdf) av In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma

Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats

Dahlgren, David; Olander, Tobias; Sjöblom, Markus; Hedeland, Mikael et al.

Ingår i Acta Pharmaceutica Sinica B, s. 1667-1675, 2021

• DOI för Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats
• Ladda ner fulltext (pdf) av Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats

Removal of nonylphenol polyethoxylates by adsorption on polyurethane foam and biodegradation using immobilized Trametes versicolor

Stenholm, Åke; Hedeland, Mikael; Arvidsson, Torbjörn; Pettersson, Curt E.

Ingår i Science of the Total Environment, 2020

• DOI för Removal of nonylphenol polyethoxylates by adsorption on polyurethane foam and biodegradation using immobilized Trametes versicolor

Anabolic androgenic steroids exert a selective remodeling of the plasma lipidome that mirrors the decrease of the de novo lipogenesis in the liver

Balgoma, David; Zelleroth, Sofia; Grönbladh, Alfhild; Hallberg, Mathias et al.

Ingår i Metabolomics, 2020

• DOI för Anabolic androgenic steroids exert a selective remodeling of the plasma lipidome that mirrors the decrease of the de novo lipogenesis in the liver
• Ladda ner fulltext (pdf) av Anabolic androgenic steroids exert a selective remodeling of the plasma lipidome that mirrors the decrease of the de novo lipogenesis in the liver

Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat

Dahlgren, David; Cano-Cebrian, Maria-Jose; Olander, Tobias; Hedeland, Mikael et al.

Ingår i Pharmaceutics, 2020

• DOI för Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat
• Ladda ner fulltext (pdf) av Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat

The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin

Dahlgren, David; Sjöblom, Markus; Hedeland, Mikael; Lennernäs, Hans

Ingår i Pharmaceutics, 2020

• DOI för The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin
• Ladda ner fulltext (pdf) av The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin

Bioavailability of subcutaneous and intramuscular administrated buprenorphine in New Zealand White rabbits

Askar, Raad; Fredriksson, Elin; Manell, Elin; Hedeland, Mikael et al.

Ingår i BMC Veterinary Research, 2020

• DOI för Bioavailability of subcutaneous and intramuscular administrated buprenorphine in New Zealand White rabbits
• Ladda ner fulltext (pdf) av Bioavailability of subcutaneous and intramuscular administrated buprenorphine in New Zealand White rabbits

Removal of diclofenac from a non-sterile aqueous system using Trametes versicolor with an emphasis on adsorption and biodegradation mechanisms

Stenholm, Åke; Hedeland, Mikael; Arvidsson, Torbjörn; Pettersson, Curt E.

Ingår i Environmental technology, s. 2460-2472, 2019

• DOI för Removal of diclofenac from a non-sterile aqueous system using Trametes versicolor with an emphasis on adsorption and biodegradation mechanisms

Exploring Radiation Response in Two Head and Neck Squamous Carcinoma Cell Lines Through Metabolic Profiling

Lindell Jonsson, Eva; Erngren, Ida; Engskog, Mikael; Haglöf, Jakob et al.

Ingår i Frontiers in Oncology, 2019

• DOI för Exploring Radiation Response in Two Head and Neck Squamous Carcinoma Cell Lines Through Metabolic Profiling
• Ladda ner fulltext (pdf) av Exploring Radiation Response in Two Head and Neck Squamous Carcinoma Cell Lines Through Metabolic Profiling

Disposition and effect of intra-articularly administered dexamethasone on lipopolysaccharide induced equine synovitis

Ekstrand, Carl; Bondesson, Ulf; Giving, Ellen; Hedeland, Mikael et al.

Ingår i Acta Veterinaria Scandinavica, 2019

• DOI för Disposition and effect of intra-articularly administered dexamethasone on lipopolysaccharide induced equine synovitis
• Ladda ner fulltext (pdf) av Disposition and effect of intra-articularly administered dexamethasone on lipopolysaccharide induced equine synovitis

An LCMS-based untargeted metabolomics protocol for cochlear perilymph: highlighting metabolic effects of hydrogen gas on the inner ear of noise exposed Guinea pigs

Pirttilä, Kristian; Pierre, Pernilla Videhult; Haglöf, Jakob; Engskog, Mikael et al.

Ingår i Metabolomics, 2019

• DOI för An LCMS-based untargeted metabolomics protocol for cochlear perilymph: highlighting metabolic effects of hydrogen gas on the inner ear of noise exposed Guinea pigs
• Ladda ner fulltext (pdf) av An LCMS-based untargeted metabolomics protocol for cochlear perilymph: highlighting metabolic effects of hydrogen gas on the inner ear of noise exposed Guinea pigs

Removal of toluene diamine and its derivatives frompolyurethane foam using immobilized Trametes versicolor

Stenholm, Åke; Hedeland, Mikael; Arvidsson, Torbjörn; Pettersson, Curt

Ingår i Advances in Environmental Biology, 2019

• DOI för Removal of toluene diamine and its derivatives frompolyurethane foam using immobilized Trametes versicolor

Adduct formation in electrospray ionisation-mass spectrometry with hydrophilic interaction liquid chromatography is strongly affected by the inorganic ion concentration of the samples

Erngren, Ida; Haglöf, Jakob; Engskog, Mikael K R; Nestor, Marika et al.

Ingår i Journal of Chromatography A, s. 174-182, 2019

• DOI för Adduct formation in electrospray ionisation-mass spectrometry with hydrophilic interaction liquid chromatography is strongly affected by the inorganic ion concentration of the samples

Common Fatty Markers in Diseases with Dysregulated Lipogenesis

Balgoma, David; Pettersson, Curt; Hedeland, Mikael

Ingår i Trends in endocrinology and metabolism, s. 283-285, 2019

• DOI för Common Fatty Markers in Diseases with Dysregulated Lipogenesis

Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 387-395, 2019

• DOI för Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

Dimethylarginines correlate to common carotid artery wall layer dimensions and cardiovascular risk factors in pregnant women with and without preeclampsia

Akhter, Tansim; Wikström, Gerhard; Larsson, Margareta; Bondesson, Ulf et al.

Ingår i Atherosclerosis, 2018

• DOI för Dimethylarginines correlate to common carotid artery wall layer dimensions and cardiovascular risk factors in pregnant women with and without preeclampsia

Alterations in plasma L-arginine and methylarginines in heart failure and after heart transplantation

Lundgren, Jakob; Sandqvist, Anna; Hedeland, Mikael; Bondesson, Ulf et al.

Ingår i Scandinavian Cardiovascular Journal, s. 196-204, 2018

• DOI för Alterations in plasma L-arginine and methylarginines in heart failure and after heart transplantation

Plasma l-arginine levels distinguish pulmonary arterial hypertension from left ventricular systolic dysfunction

Sandqvist, Anna; Schneede, Jörn; Kylhammar, David; Henrohn, D et al.

Ingår i Heart and Vessels, s. 255-263, 2018

• DOI för Plasma l-arginine levels distinguish pulmonary arterial hypertension from left ventricular systolic dysfunction
• Ladda ner fulltext (pdf) av Plasma l-arginine levels distinguish pulmonary arterial hypertension from left ventricular systolic dysfunction

Cetirizine per os: exposure and antihistamine effect in the dog

Ekstrand, Carl; Ingvast-Larsson, Carina; Bondesson, Ulf; Hedeland, Mikael et al.

Ingår i Acta Veterinaria Scandinavica, 2018

• DOI för Cetirizine per os: exposure and antihistamine effect in the dog
• Ladda ner fulltext (pdf) av Cetirizine per os: exposure and antihistamine effect in the dog

Effects of Oral Supplementation With Nitrate-Rich Beetroot Juice in Patients With Pulmonary Arterial Hypertension-Results From BEET-PAH, an Exploratory Randomized, Double-Blind, Placebo-Controlled, Crossover Study.

Henrohn, Dan; Björkstrand, Kristoffer; Lundberg, Jon O; Granstam, Sven-Olof et al.

Ingår i Journal of Cardiac Failure, s. 640-653, 2018

• DOI för Effects of Oral Supplementation With Nitrate-Rich Beetroot Juice in Patients With Pulmonary Arterial Hypertension-Results From BEET-PAH, an Exploratory Randomized, Double-Blind, Placebo-Controlled, Crossover Study.

Jejunal absorption of aprepitant from nanosuspensions: Role of particle size, prandial state and mucus layer.

Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 222-230, 2018

• DOI för Jejunal absorption of aprepitant from nanosuspensions: Role of particle size, prandial state and mucus layer.

Major signal suppression from metal ion clusters in SFC/ESI-MS: Cause and Effects

Haglind, Alfred; Hedeland, Mikael; Arvidsson, Torbjörn; Pettersson, Curt E

Ingår i Journal of chromatography. B, s. 96-105, 2018

• DOI för Major signal suppression from metal ion clusters in SFC/ESI-MS: Cause and Effects

Equine in vivo-derived metabolites of the SARM LGD-4033 and comparison with human and fungal metabolites.

Hansson, Annelie; Knych, Heather; Stanley, Scott; Berndtson, Emma et al.

Ingår i Journal of chromatography. B, s. 91-98, 2018

• DOI för Equine in vivo-derived metabolites of the SARM LGD-4033 and comparison with human and fungal metabolites.

Reply to "Comment on 'In Vivo Drug Delivery Performance of Lipiodol-Based Emulsion or Drug-Eluting Beads in Patients with Hepatocellular Carcinoma'"

Dubbelboer, Ilse R; Lilienberg, Elsa; Karalli, Amar; Axelsson, Rimma et al.

Ingår i Molecular Pharmaceutics, s. 336-340, 2018

• DOI för Reply to "Comment on 'In Vivo Drug Delivery Performance of Lipiodol-Based Emulsion or Drug-Eluting Beads in Patients with Hepatocellular Carcinoma'"

The differences in matrix effect between supercritical fluid chromatography and reversed phase liquid chromatography coupled to ESI/MS

Svan, Alfred; Hedeland, Mikael; Arvidsson, Torbjörn; Pettersson, Curt

Ingår i Analytica Chimica Acta, s. 163-171, 2018

• DOI för The differences in matrix effect between supercritical fluid chromatography and reversed phase liquid chromatography coupled to ESI/MS

Structural elucidation of major selective androgen receptor modulator (SARM) metabolites for doping control

Garg, Neeraj; Hansson, Annelie; Knych, Heather K.; Stanley, Scott D. et al.

Ingår i Organic and biomolecular chemistry, s. 698-702, 2018

• DOI för Structural elucidation of major selective androgen receptor modulator (SARM) metabolites for doping control

In vivo Drug Delivery Performance of Lipiodol-based Emulsion or Drug-eluting Beads in Patients with Hepatocellular Carcinoma

Lilienberg, Elsa; Dubbelboer, Ilse R.; Karalli, Amar; Axelsson, Rimma et al.

Ingår i Molecular Pharmaceutics, s. 448-458, 2017

• DOI för In vivo Drug Delivery Performance of Lipiodol-based Emulsion or Drug-eluting Beads in Patients with Hepatocellular Carcinoma

Investigation of the metabolites of the HIF stabilizer FG-4592 (roxadustat) in five different in vitro models and in a human doping control sample using high resolution mass spectrometry

Hansson, Annelie; Thevis, Mario; Cox, Holly; Miller, Geoff et al.

Ingår i Journal of Pharmaceutical and Biomedical Analysis, s. 228-236, 2017

• DOI för Investigation of the metabolites of the HIF stabilizer FG-4592 (roxadustat) in five different in vitro models and in a human doping control sample using high resolution mass spectrometry

Antitumoral effect and reduced systemic toxicity in mice after intra-tumoral injection of an in vivo solidifying calcium sulfate formulation with docetaxel

Grudén, Stefan; Sandelin, Martin; Rasanen, Veera; Micke, Patrick et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 186-193, 2017

• DOI för Antitumoral effect and reduced systemic toxicity in mice after intra-tumoral injection of an in vivo solidifying calcium sulfate formulation with docetaxel
• Ladda ner fulltext (pdf) av Antitumoral effect and reduced systemic toxicity in mice after intra-tumoral injection of an in vivo solidifying calcium sulfate formulation with docetaxel

Pharmacokinetics and pharmacodynamics of meldonium in exercised thoroughbred horses

Knych, Heather K.; Stanley, Scott D.; McKemie, Dan S.; Arthur, Rick M. et al.

Ingår i Drug Testing and Analysis, s. 1392-1399, 2017

• DOI för Pharmacokinetics and pharmacodynamics of meldonium in exercised thoroughbred horses

Quantification of dimethylsulfoxide (DMSO) in equine plasma and urine using HILIC-MS/MS

Salomonsson, Matilda L.; Bondesson, Ulf; Hedeland, Mikael

Ingår i Drug Testing and Analysis, s. 935-941, 2017

• DOI för Quantification of dimethylsulfoxide (DMSO) in equine plasma and urine using HILIC-MS/MS

Investigation of the selective androgen receptor modulators S1, S4 and S22 and their metabolites in equine plasma using high-resolution mass spectrometry

Hansson, Annelie; Knych, Heather; Stanley, Scott; Thevis, Mario et al.

Ingår i Rapid Communications in Mass Spectrometry, s. 833-842, 2016

• DOI för Investigation of the selective androgen receptor modulators S1, S4 and S22 and their metabolites in equine plasma using high-resolution mass spectrometry

Nickel in equine sports drug testing - pilot study results on urinary nickel concentrations

Thevis, M.; Machnik, M.; Schenk, I.; Krug, O. et al.

Ingår i Rapid Communications in Mass Spectrometry, s. 982-984, 2016

• DOI för Nickel in equine sports drug testing - pilot study results on urinary nickel concentrations

Identification of Leachables from Trametes versicolor in Biodegradation Experiments

Stenholm, Åke; Hedeland, Mikael; Arvidsson, Torbjörn; Pettersson, Curt

Ingår i Trends in Green Chemistry, 2016

• DOI för Identification of Leachables from Trametes versicolor in Biodegradation Experiments

Identification of transformation products from -blocking agents formed in wetland microcosms using LC-Q-ToF

Svan, Alfred; Hedeland, Mikael; Arvidsson, Torbjörn; Jasper, Justin T. et al.

Ingår i Journal of Mass Spectrometry, s. 207-218, 2016

• DOI för Identification of transformation products from -blocking agents formed in wetland microcosms using LC-Q-ToF

Fully automated determination of nicotine and its major metabolites in whole blood by means of a DBS online-SPE LC-HR-MS/MS approach for sports drug testing

Tretzel, Laura; Thomas, Andreas; Piper, Thomas; Hedeland, Mikael et al.

Ingår i Journal of Pharmaceutical and Biomedical Analysis, s. 132-140, 2016

• DOI för Fully automated determination of nicotine and its major metabolites in whole blood by means of a DBS online-SPE LC-HR-MS/MS approach for sports drug testing

A quantitative approach to analysing cortisol response in the horse

Ekstrand, C.; Ingvast-Larsson, C.; Olsen, L.; Hedeland, Mikael et al.

Ingår i Journal of Veterinary Pharmacology and Therapeutics, s. 255-263, 2016

• DOI för A quantitative approach to analysing cortisol response in the horse

Changes in plasma levels of asymmetric dimethylarginine, symmetric dimethylarginine, and arginine after a single dose of vardenafil in patients with pulmonary hypertension

Henrohn, Dan; Sandqvist, Anna; Egerod, Hanna; Hedeland, Mikael et al.

Ingår i Vascular pharmacology, s. 71-77, 2015

• DOI för Changes in plasma levels of asymmetric dimethylarginine, symmetric dimethylarginine, and arginine after a single dose of vardenafil in patients with pulmonary hypertension

Seafood sold in Sweden contains BMAA: A study of free and total concentrations with UHPLC-MS/MS and dansyl chloride derivatization

Salomonsson, Matilda Lampinen; Fredriksson, Elisabeth; Alfjorden, Anders; Hedeland, Mikael et al.

Ingår i Toxicology reports, s. 1473-1481, 2015

• DOI för Seafood sold in Sweden contains BMAA: A study of free and total concentrations with UHPLC-MS/MS and dansyl chloride derivatization

Acute vasodilator response to vardenafil and clinical outcome in patients with pulmonary hypertension

Sandqvist, Anna; Henrohn, Dan; Egeröd, Hanna; Hedeland, Mikael et al.

Ingår i European Journal of Clinical Pharmacology, s. 1165-1173, 2015

• DOI för Acute vasodilator response to vardenafil and clinical outcome in patients with pulmonary hypertension

A novel trapping system for the detection of reactive drug metabolites using the fungus Cunninghamella elegans and high resolution mass spectrometry

Rydevik, Axel; Hansson, Annelie; Hellqvist, Anna; Bondesson, Ulf et al.

Ingår i Drug Testing and Analysis, s. 626-633, 2015

• DOI för A novel trapping system for the detection of reactive drug metabolites using the fungus Cunninghamella elegans and high resolution mass spectrometry

Rapid chiral separation of atenolol, metoprolol, propranolol and the zwitterionic metoprolol acid using supercritical fluid chromatography-tandem mass spectrometry - Application to wetland microcosms

Svan, Alfred; Hedeland, Mikael; Arvidsson, Torbjorn; Jasper, Justin T. et al.

Ingår i Journal of Chromatography A, s. 251-258, 2015

• DOI för Rapid chiral separation of atenolol, metoprolol, propranolol and the zwitterionic metoprolol acid using supercritical fluid chromatography-tandem mass spectrometry - Application to wetland microcosms

Characterization of equine urinary metabolites of selective androgen receptor modulators (SARMs) S1, S4 and S22 for doping control purposes

Hansson, Annelie; Knych, Heather; Stanley, Scott; Thevis, Mario et al.

Ingår i Drug Testing and Analysis, s. 673-683, 2015

• DOI för Characterization of equine urinary metabolites of selective androgen receptor modulators (SARMs) S1, S4 and S22 for doping control purposes

Plasma concentration-dependent suppression of endogenous hydrocortisone in the horse after intramuscular administration of dexamethasone-21-isonicotinate

Ekstrand, C.; Bondesson, Ulf; Gabrielsson, J.; Hedeland, Mikael et al.

Ingår i Journal of Veterinary Pharmacology and Therapeutics, s. 235-242, 2015

• DOI för Plasma concentration-dependent suppression of endogenous hydrocortisone in the horse after intramuscular administration of dexamethasone-21-isonicotinate

Characterization of a non-approved selective androgen receptor modulator drug candidate sold via the Internet and identification of in vitro generated phase-I metabolites for human sports drug testing

Thevis, Mario; Lagojda, Andreas; Kuehne, Dirk; Thomas, Andreas et al.

Ingår i Rapid Communications in Mass Spectrometry, s. 991-999, 2015

• DOI för Characterization of a non-approved selective androgen receptor modulator drug candidate sold via the Internet and identification of in vitro generated phase-I metabolites for human sports drug testing

Validation of the Endopep-MS method for qualitative detection of active botulinum neurotoxins in human and chicken serum

Bjornstad, Kristian; Åberg, Annica Tevell; Kalb, Suzanne R.; Wang, Dongxia et al.

Ingår i Analytical and Bioanalytical Chemistry, s. 7149-7161, 2014

• DOI för Validation of the Endopep-MS method for qualitative detection of active botulinum neurotoxins in human and chicken serum

The Effects of Lipiodol and Cyclosporin A on the Hepatobiliary Disposition of Doxorubicin in Pigs

Dubbelboer, Ilse R; Lilienberg, Elsa; Hedeland, Mikael; Bondesson, Ulf et al.

Ingår i Molecular Pharmaceutics, s. 1301-1313, 2014

• DOI för The Effects of Lipiodol and Cyclosporin A on the Hepatobiliary Disposition of Doxorubicin in Pigs

Isolation and characterization of a beta-glucuronide of hydroxylated SARM S1 produced using a combination of biotransformation and chemical oxidation

Rydevik, Axel; Lagojda, Andreas; Thevis, Mario; Bondesson, Ulf et al.

Ingår i Journal of Pharmaceutical and Biomedical Analysis, s. 36-39, 2014

• DOI för Isolation and characterization of a beta-glucuronide of hydroxylated SARM S1 produced using a combination of biotransformation and chemical oxidation

High-resolution mass spectrometric investigation of the phase I and II metabolites of finasteride in pig plasma, urine and bile

Lundahl, Anna; Åberg, Annica Tevell; Bondesson, Ulf; Lennernäs, Hans et al.

Ingår i Xenobiotica, s. 498-510, 2014

• DOI för High-resolution mass spectrometric investigation of the phase I and II metabolites of finasteride in pig plasma, urine and bile

Effects of verapamil on the pharmacokinetics and hepatobiliary disposition of fexofenadine in pigs

Sjögren, Erik; Hedeland, Mikael; Bondesson, Ulf; Lennernäs, Hans

Ingår i European Journal of Pharmaceutical Sciences, s. 214-223, 2014

• DOI för Effects of verapamil on the pharmacokinetics and hepatobiliary disposition of fexofenadine in pigs

Investigation of Hepatobiliary Disposition of Doxorubicin Following Intrahepatic Delivery of Different Dosage Forms

Lilienberg, Elsa; Ebeling-Barbier, Charlotte; Nyman, Rickard; Hedeland, Mikael et al.

Ingår i Molecular Pharmaceutics, s. 131-144, 2014

• DOI för Investigation of Hepatobiliary Disposition of Doxorubicin Following Intrahepatic Delivery of Different Dosage Forms

The fungus Cunninghamella elegans can produce human and equine metabolites of selective androgen receptor modulators (SARMs)

Rydevik, Axel; Thevis, Mario; Krug, Oliver; Bondesson, Ulf et al.

Ingår i Xenobiotica, s. 409-420, 2013

• DOI för The fungus Cunninghamella elegans can produce human and equine metabolites of selective androgen receptor modulators (SARMs)

Mass Spectrometric Detection of Protein-Based Toxins

Tevell Åberg, Annica; Björnstad, Kristian; Hedeland, Mikael

Ingår i Biosecurity and bioterrorism, 2013

• DOI för Mass Spectrometric Detection of Protein-Based Toxins

High inter-individual variability of vardenafil pharmacokinetics in patients with pulmonary hypertension

Sandqvist, A. M.; Henrohn, Dan; Schneede, J.; Hedeland, Mikael et al.

Ingår i European Journal of Clinical Pharmacology, s. 197-207, 2013

• DOI för High inter-individual variability of vardenafil pharmacokinetics in patients with pulmonary hypertension

Synthesis, characterization, and detection of new oxandrolone metabolites as long-term markers in sports drug testing

Guddat, S.; Fusshoeller, G.; Beuck, S.; Thomas, A. et al.

Ingår i Analytical and Bioanalytical Chemistry, s. 8285-8294, 2013

• DOI för Synthesis, characterization, and detection of new oxandrolone metabolites as long-term markers in sports drug testing

Mass spectrometric characterization of glucuronides formed by a new concept, combining Cunninghamella elegans with TEMPO

Rydevik, Axel; Bondesson, Ulf; Thevis, Mario; Hedeland, Mikael

Ingår i Journal of Pharmaceutical and Biomedical Analysis, s. 278-284, 2013

• DOI för Mass spectrometric characterization of glucuronides formed by a new concept, combining Cunninghamella elegans with TEMPO

Acute haemodynamic response in relation to plasma vardenafil concentrations in patients with pulmonary hypertension

Henrohn, Dan; Sandqvist, Anna; Hedeland, Mikael; Egeröd, Hanna et al.

Ingår i British Journal of Clinical Pharmacology, s. 990-998, 2012

• DOI för Acute haemodynamic response in relation to plasma vardenafil concentrations in patients with pulmonary hypertension

Structural elucidation of phase I and II metabolites of bupivacaine in horse urine and fungi of the Cunninghamella species using liquid chromatography/multi-stage mass spectrometry

Rydevik, Axel; Bondesson, Ulf; Mikael, Hedeland

Ingår i Rapid Communications in Mass Spectrometry, s. 1338-1346, 2012

• DOI för Structural elucidation of phase I and II metabolites of bupivacaine in horse urine and fungi of the Cunninghamella species using liquid chromatography/multi-stage mass spectrometry

Characterization of In Vitro Synthesized Equine Metabolites of the Selective Androgen Receptor Modulators S24 and S4

Krug, Oliver; Thomas, Andreas; Beuck, Simon; Schenk, Ina et al.

Ingår i Journal of Equine Veterinary Science, s. 562-568, 2012

• DOI för Characterization of In Vitro Synthesized Equine Metabolites of the Selective Androgen Receptor Modulators S24 and S4

In Vivo Investigation in Pigs of Intestinal Absorption, Hepatobiliary Disposition, and Metabolism of the 5 alpha-Reductase Inhibitor Finasteride and the Effects of Coadministered Ketoconazole

Lundahl, Anna; Hedeland, Mikael; Bondesson, Ulf; Lennernäs, Hans

Ingår i Drug Metabolism And Disposition, s. 847-857, 2011

• DOI för In Vivo Investigation in Pigs of Intestinal Absorption, Hepatobiliary Disposition, and Metabolism of the 5 alpha-Reductase Inhibitor Finasteride and the Effects of Coadministered Ketoconazole

Confirmation of botulism in birds and cattle by the mouse bioassay and Endopep-MS

Hedeland, Mikael; Moura, Hercules; Båverud, Viveca; Woolfitt, Adrian R et al.

Ingår i Journal of Medical Microbiology, s. 1299-1305, 2011

• DOI för Confirmation of botulism in birds and cattle by the mouse bioassay and Endopep-MS

Effect of a Single Gemfibrozil Dose on the Pharmacokinetics of Rosuvastatin in Bile and Plasma in Healthy Volunteers

Bergman, Ebba; Matsson, Elin M; Hedeland, Mikael; Bondesson, Ulf et al.

Ingår i Journal of clinical pharmacology, s. 1039-1049, 2010

• DOI för Effect of a Single Gemfibrozil Dose on the Pharmacokinetics of Rosuvastatin in Bile and Plasma in Healthy Volunteers

The Effect of Acute Administration of Rifampicin and Imatinib on the Enterohepatic Transport of Rosuvastatin In Vivo

Bergman, Ebba; Hedeland, Mikael; Bondesson, Ulf; Lennernäs, Hans

Ingår i Xenobiotica, s. 558-568, 2010

• DOI för The Effect of Acute Administration of Rifampicin and Imatinib on the Enterohepatic Transport of Rosuvastatin In Vivo

Structural elucidation of N-oxidized clemastine metabolites by liquid chromatography/tandem mass spectrometry and the use of Cunninghamella elegans to facilitate drug metabolite identification

Tevell Åberg, Annica; Löfgren, Helena; Bondesson, Ulf; Hedeland, Mikael

Ingår i Rapid Communications in Mass Spectrometry, s. 1447-1456, 2010

• DOI för Structural elucidation of N-oxidized clemastine metabolites by liquid chromatography/tandem mass spectrometry and the use of Cunninghamella elegans to facilitate drug metabolite identification

In vitro formation of phase I and II metabolites of propranolol and determination of their structures using chemical derivatization and liquid chromatography tandem mass spectrometry

Lampinen Salomonsson, Matilda; Bondesson, Ulf; Hedeland, Mikael

Ingår i Journal of Mass Spectrometry, s. 742-754, 2009

• DOI för In vitro formation of phase I and II metabolites of propranolol and determination of their structures using chemical derivatization and liquid chromatography tandem mass spectrometry

A mass spectromeric study on meloxicam metabolism in horses and the fungus Cunninghamella elegans, and the relevance of this microbial system as a model of drug metabolism in the horse

Tevell Åberg, Annica; Olsson, Charlotte; Bondesson, Ulf; Hedeland, Mikael

Ingår i Journal of Mass Spectrometry, s. 1026-1037, 2009

• DOI för A mass spectromeric study on meloxicam metabolism in horses and the fungus Cunninghamella elegans, and the relevance of this microbial system as a model of drug metabolism in the horse

The effect of St. John's wort on the pharmacokinetics, metabolism and biliary excretion of finasteride and its metabolites in healthy men

Lundahl, Anna; Hedeland, Mikael; Bondesson, Ulf; Knutson, Lars et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 433-443, 2009

• DOI för The effect of St. John's wort on the pharmacokinetics, metabolism and biliary excretion of finasteride and its metabolites in healthy men

Identification of Finasteride Metabolites in Human Bile and Urine by High-Performance Liquid Chromatography/Tandem Mass Spectrometry

Lundahl, Anna; Lennernäs, Hans; Knutson, Lars; Bondesson, Ulf et al.

Ingår i Drug Metabolism And Disposition, s. 2008-2017, 2009

• DOI för Identification of Finasteride Metabolites in Human Bile and Urine by High-Performance Liquid Chromatography/Tandem Mass Spectrometry

Different effects of ketoconazole on the stereoselective first-pass metabolism of R/S-verapamil in the intestine and the liver: important for the mechanistic understanding of first-pass drug-drug interactions

Thörn, Helena Anna; Hedeland, Mikael; Bondesson, Ulf; Knutson, Lars et al.

Ingår i Drug Metabolism And Disposition, s. 2186-2196, 2009

• DOI för Different effects of ketoconazole on the stereoselective first-pass metabolism of R/S-verapamil in the intestine and the liver: important for the mechanistic understanding of first-pass drug-drug interactions

The Enterohepatic Disposition of Rosuvastatin in Pigs and The Impact of Concomitant Dosing with Cyclosporine and Gemfibrozil

Bergman, Ebba; Lundahl, Anna; Fridblom, Patrik; Hedeland, Mikael et al.

Ingår i Drug Metabolism And Disposition, s. 2349-2358, 2009

• DOI för The Enterohepatic Disposition of Rosuvastatin in Pigs and The Impact of Concomitant Dosing with Cyclosporine and Gemfibrozil

Structural evaluation of the glucuronides of morphine and formoterol using chemical derivatization with 1,2-dimethylimidazole-4-sulfonyl chloride and liquid chromatography/ion trap mass spectrometry

Lampinen Salomonsson, Matilda; Bondesson, Ulf; Hedeland, Mikael

Ingår i Rapid Communications in Mass Spectrometry, s. 2685-2697, 2008

• DOI för Structural evaluation of the glucuronides of morphine and formoterol using chemical derivatization with 1,2-dimethylimidazole-4-sulfonyl chloride and liquid chromatography/ion trap mass spectrometry

Biliary secretion of rosuvastatin and bile acids in humans during the absorption phase.

Bergman, Ebba; Forsell, Patrik; Tevell, Annica; Persson, Eva M et al.

Ingår i Eur J Pharm Sci, s. 205-14, 2006

First-pass effects of verapamil on the intestinal absorption and liver disposition of fexofenadine in the porcine model.

Petri, Niclas; Bergman, Ebba; Forsell, Patrik; Hedeland, Mikael et al.

Ingår i Drug Metab Dispos, s. 1182-9, 2006

Flutamide metabolism in four different species in vitro and identification of flutamide metabolites in human patient urine by high performance liquid chromatography/tandem mass spectrometry.

Tevell, Annica; Lennernäs, Hans; Jönsson, Mats; Norlin, Maria et al.

Ingår i Drug Metab Dispos, s. 984-92, 2006

Differentiation of estriol glucuronide isomers by chemical derivatization and electrospray tandem mass spectrometry

Lampinen-Salomonsson, Matilda; Bondesson, Ulf; Petersson, Carl; Hedeland, Mikael

Ingår i Rapid Commun Mass Spectrom, s. 1429-40, 2006

Detection of altrenogest and its metabolites in post administration horse urine using liquid chromatography tandem mass spectrometry-increased sensitivity by chemical derivatisation of the glucuronic acid conjugate.

Lampinen-Salomonsson, Matilda; Beckman, Elin; Bondesson, Ulf; Hedeland, Mikael

Ingår i J Chromatogr B Analyt Technol Biomed Life Sci, s. 245-56, 2006

Effect of erythromycin on the absorption of fexofenadine in the jejunum, ileum and colon determined using local intubation in healthy volunteers.

Petri, N; Borga, O; Nyberg, L; Hedeland, M et al.

Ingår i Int J Clin Pharmacol Ther, s. 71-9, 2006

St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism

Tannergren, Christer; Engman, Helena; Knutson, Lars; Hedeland, Mikael et al.

Ingår i Clinical Pharmacology and Therapeutics, s. 298-309, 2004

• DOI för St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism

Simultaneous quantification of the enantiomers of verapamil and its N-demethylated metabolite in human plasma using liquid chromatography-tandem mass spectrometry

Hedeland, Mikael; Fredriksson, Elisabeth; Lennernäs, Hans; Bondesson, Ulf

Ingår i Journal of chromatography. B, s. 303-311, 2004

• DOI för Simultaneous quantification of the enantiomers of verapamil and its N-demethylated metabolite in human plasma using liquid chromatography-tandem mass spectrometry

Identification of some new clemastine metabolites in dog, horse, and human urine with liquid chromatography/tandem mass spectrometry.

Tevell, Annica; Bondesson, Ulf; Törneke, Karolina; Hedeland, Mikael

Ingår i Rapid Commun Mass Spectrom, s. 2267-72, 2004

Clinical pharmacology of clemastine in healthy dogs.

Hansson, H; Bergvall, K; Bondesson, U; Hedeland, M et al.

Ingår i Vet Dermatol, s. 152-8, 2004

Development of a chiral non-aqueous capillary electrophoretic system using the partial filling technique with UV and mass spectrometric detection

Lodén, Henrik; Hedeland, Ylva; Hedeland, Mikael; Bondesson, Ulf et al.

Ingår i Journal of Chromatography A, s. 143-152, 2003

• DOI för Development of a chiral non-aqueous capillary electrophoretic system using the partial filling technique with UV and mass spectrometric detection

Chiral separation of amines with N-benzoxycarbonylglycyl-L-proline as selector in non-aqueous capillary electrophoresis using methanol and 1,2-dichloroethane in the background electrolyte

Hedeland, Ylva; Hedeland, Mikael; Bondesson, Ulf; Pettersson, Curt

Ingår i Journal of Chromatography A, s. 261-271, 2003

• DOI för Chiral separation of amines with N-benzoxycarbonylglycyl-L-proline as selector in non-aqueous capillary electrophoresis using methanol and 1,2-dichloroethane in the background electrolyte

Multiple transport mechanisms involved in the intestinal absorption and first-pass extraction of fexofenadine.

Tannergren, Christer; Petri, Niclas; Knutson, Lars; Hedeland, Mikael et al.

Ingår i Clin Pharmacol Ther, s. 423-36, 2003

Non-aquoeus capillary electrophoretic separation of enantiomeric amines with (-)-2,3:4,6-di-O-isopropylidene-2-keto-L-gulonic acid as chiral counter ion

Carlsson, Ylva; Hedeland, Mikael; Bondesson, Ulf; Pettersson, Curt

Ingår i Journal of Chromatography A, s. 303-311, 2001

• DOI för Non-aquoeus capillary electrophoretic separation of enantiomeric amines with (-)-2,3:4,6-di-O-isopropylidene-2-keto-L-gulonic acid as chiral counter ion

Non-aqueous capillary electrophoretic separation of enantiomeric amineswith (-)-2,3:4,6-di-O-isopropylidene-2-keto-L-gulonic acid as chiralcounter ion.

Carlsson, Y; Hedeland, M; Bondesson, U; Pettersson, C

Ingår i J Chromatogr A, s. 303, 2001

Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

Ingår i European journal of pharmaceutics and biopharmaceutics

Developing reactive oxygen species-sensitive cellulose nanofibers for chronic wound care

Palo Nieto, Carlos; Blasi Romero, Anna; Balgoma, David; Hedeland, Mikael et al.

2022

The differences in matrix effects between supercritical fluid chromatography and reversed phase liquid chromatography coupled to ESI/MS analyzing blood plasma

Svan, Alfred; Hedeland, Mikael; Arvidsson, Torbjörn; Pettersson, Curt

2017

Matrix effects: Do they differ between SFC/ESI-MS and LC/ESI-MS

Svan, Alfred; Hedeland, Mikael; Arvidsson, Torbjörn; Pettersson, Curt

2016

Characterization of a Selective Androgen Receptor Modulator Drug Candidate and Identification of In Vitro Generated Metabolites for Sports Drug Testing

Hansson, Annelie; Thevis, Mario; Lagodja, Andreas; Thomas, Andreas et al.

2015

Antihistamine effect of cetirizine after oral administrator in the dog

Ekstrand, Carl; Ingvast-Larsson, Carina; Bondesson, Ulf; Hedeland, Mikael et al.

2015

A quantitative approach to analysing hydrocortisone response in the horse

Ekstrand, Carl; Ingvast-Larsson, Carina; Olsén, Lena; Hedeland, Mikael et al.

2015

Quantification of SARMs S1, S4 and S22 and detection of their metabolites in equine plasma usning UHPLC-Q-TOF

Hansson, Annelie; Knych, Heather; Stanley, Scott; Thevis, Mario et al.

2015

Quantification of SARMs S1, S4 and S22 and detection of their metabolites in equine plasma using UHPLC-Q-TOF

Hansson, Annelie; Knych, Heather; Stanley, Scott; Thevis, Mario et al.

2015

Charactierization of a selective androgen receptor modulator drug candidate and identification of in vitro generated metabolites for sports drug testing

Thevis, Mario; Lagojda, Andreas; Thomas, Andreas; Dib, Josef et al.

2015

In vivo metabolism of selective androgen receptor modulators (SARMs) in the horse

Hedeland, Mikael; Hansson, Annelie; Rydevik, Axel; Krug, Oliver et al.

2014

In vivo metabolism of Selective Androgen Receptor Modulators (SARMs) in the horse

Hedeland, Mikael; Hansson, Annelie; Rydevik, Axel; Krug, Oliver et al.

2014

Chiral separation of three beta-blocking pharmaceuticals and a major metabolite using SFC-MS

Svan, Alfred; Hedeland, Mikael; Arvidsson, Torbjörn; Pettersson, Curt

2014

Validation of the endopep-MS method for qualitative detection of active botulinum neurotoxins in human or chicken serum

Björnstad, Kristian; Tevell Åberg, Annica; Kalb, Suzanne; Wang, Dongxia et al.

2014

Additional evidence for dexamethasone screening limits

Ekstrand, Carl; Bondesson, Ulf; Falkenö, Ulrika; Gabrielsson, Johan et al.

2014

Turning drug glucosides into glucuronides - making fungal incubations work together with chemical derivatization

Rydevik, Axel; Bondesson, Ulf; Thevis, Mario; Hedeland, Mikael

2013

Drug glucuronides synthesized using a new concept combining Cunninghamella elegans with TEMPO

Rydevik, Axel; Bondesson, Ulf; Thevis, Mario; Hedeland, Mikael

2013

Evaluation of the fungus Cunninghamella elegans as a model for the formation of reactive metabolites using glutathione trapping and UHPLCC/HRMS

Rydevik, Axel; Hellqvist, Anna; Bondesson, Ulf; Hedeland, Mikael

2013

Chiral separation of three β-blocking pharmaceuticals and a majormetabolite using SFC-MS

Svan, Alfred; Hedeland, Mikael; Arvidsson, Torbjörn; Pettersson, Curt

2013

Verapamil Affects the Pharmacokinetics and the Hepatic Disposition of Fexofenadine in Pigs

Sjögren, E; Hedeland, Mikael; Bondesson, Ulf; Lennernäs, H

2012

Mass spectrometric study of the metabolism of Selective Androgen Receptor Modulators (SARMs) in the fungus Cunninghamella elegans

Hedeland, Mikael; Rydevik, Axel; Krug, O; Thevis, M et al.

2012

Comparison of vardenafil and adenosine for vasoreactivity testing in patients with pulmonary hypertension

Sandqvist, A; Henrohn, D; Schneede, J; Egerod, H et al.

2012

A mass spectrometric study of bupivacaine metabolites found in fungi and horse

Rydevik, Axel; Hedeland, Mikael; Bondesson, Ulf

2012

Mass spectrometric study of the metabolism of Selective Androgen Receptor Modulators (SARMs) in the fungus Cunninghamella elegans

Hedeland, Mikael; Rydevik, Axel; Krug, O; Thevis, M et al.

2012

Mass spectrometric study of the metabolism of Selective Androgen Receptor Modulators (SARMs) in the fungus Cunninghamella elegans

Hedeland, Mikael; Rydevik, Axel; Krug, O; Thevis, M et al.

2012

A mass spectrometric study of bupivacaine metabolites found in fungi and horse

Rydevik, Axel; Bondesson, Ulf; Hedeland, Mikael

2012

Local and sustained release in the treatment of primary liver cancer? Pharmacokinetic understanding of two formulations for intra arterial injection

Lilienberg, E; Ebeling Barbier, C; Nyman, C; Hedeland, Mikael et al.

2012

Improved Pharmacokinetic Understanding of Two Formulations for Intra-arterial Injection

Lilienberg, E; Ebeling Barbier, C; Nyman, R; Hedeland, Mikael et al.

2012

Improved Pharmacokinetic Understanding of Two Formulations for Intra-arterial Injection

Lilienberg, E; Ebeling Barbier, C; Nyman, R; Hedeland, Mikael et al.

2012

The relevance of using a fungus as a model of equine metabolism

Hedeland, Mikael; Tevell Åberg, Annica; Bondesson, Ulf

2010

Metabolite identification by mass spectrometry of the 5α-reductase inhibitor finasteride in vitro and in vivo

Lundahl, A; Tevell Åberg, Annica; Bondesson, Ulf; Hedeland, Mikael et al.

2009

The effect of gemfibrozil on the biliary excretion of rosuvastatin in pig and man

Bergman, E; Lundahl, A; Forsell, P; Hedeland, Mikael et al.

2009

The hepatobiliary disposition of rosuvastatin in pigs and the impact of concomitant dosing with cyclosporine.

Bergman, E; Lundahl, A; Forsell, P; Hedeland, Mikael et al.

2009

Identification of hydroxylated and glucuronidated metabolites of finasteride in human bile and urine

Lundahl, A; Lennernäs, H; Knutson, L; Bondesson, Ulf et al.

2009

Different effects of ketoconazole on the stereoselective first-pass metabolism of R/S-verapamil in the intestine and the liver

Thörn, H; Hedeland, Mikael; Bondesson, Ulf; Knutson, L et al.

2009

Metabolitidentifiering av finasterid i human galla och urin

Lundahl, A; Hedeland, Mikael; Bondesson, Ulf; Knutson, L et al.

2009

Preparation of Drug Metabolites

Hedeland, Mikael

2009

Characterization of C- and N-oxidized Clemastine Metabolites using LC-MSⁿ

Tevell Åberg, Annica; Bondesson, Ulf; Hedeland, Mikael

2008

The effect of St John's Wort on the pharmacokinetics and metabolism of finasteride in healthy men

Lundahl, A; Hedeland, Mikael; Bondesson, Ulf; Knutsson, L et al.

2008

The biliary excretion of rosuvastatin and gemfibrozil in healthy humans

Bergman, E; Sjödin, E; Forsell, P; Hedeland, Mikael et al.

2008

The effect of St John’s Wort treatment on finasteride metabolism and identification of new finasteride metabolites in humans

Lundahl, A; Hedeland, Mikael; Bondesson, Ulf; Knutson, L et al.

2008

The effect of St. John’s wort treatment on finasteride pharmacokinetics and identification of new phase I and phase II metabolites in humans

Lundahl, A; Hedeland, Mikael; Bondesson, Ulf; Knutson, L et al.

2008

The biliary excretion of rosuvastatin and gemfibrozil in healthy humans

Bergman, E; Sjödin, E; Forsell, P; Hedeland, Mikael et al.

2008

Intestinal and liver CYP3A4-mediated metabolism of R/S-verapamil in pigs

Eriksson, H; Hedeland, Mikael; Bondesson, Ulf; Knutson, L et al.

2008

The effect of St John’s wort on the pharmacokinetics and metabolism of finasteride in man

Lundahl, A; Hedeland, Mikael; Bondesson, Ulf; Knutson, L et al.

2008

Structural evaluation of glucuronides of morphine and formoterol using chemical derivatization with 1,2-dimethylimidazole-4-sulfonyl chloride and LC-MSⁿ

Salomonsson, Matilda; Bondesson, Ulf; Hedeland, Mikael

2008

LCMS-based untargeted metabolomics of guinea pig perilymph using a novel separation method for sequential analysis of hydrophilic and lipophilic compounds: Studying the effect of hydrogen gas on noise-induced hearing loss

Pirttilä, Kristian; Fransson, Anette Elisabeth; Videhult Pierre, Pernilla; Laurell, Göran et al.

Optimization of In Vitro Microsome Incubations for Improved Drug Metabolite Yield Utilizing Experimental Design

Nilsson Broberg, Malin; Haglöf, Jakob; Bondesson, Ulf; Pettersson, Curt et al.