Ulf Göransson
Professor vid Institutionen för farmaceutisk biovetenskap; Forskning; Farmakognosi
- Telefon:
- 018-471 50 31
- Mobiltelefon:
- 073-469 77 15
- E-post:
- ulf.goransson@uu.se
- Besöksadress:
- BMC, Husargatan 3
75124 Uppsala - Postadress:
- Box 591
75124 Uppsala
- Akademiska meriter:
- FarmD
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Kort presentation
Min forskning är inriktad mot peptiders biologi och kemi, med speciellt fokus på cykliska och antimikrobiella peptider.
Länk till min forskargrupp: http://www.ilk.uu.se/research/fkog_en/peptide-chemical-biology/
Nyckelord
- antimicrobial peptides
- circular proteins
- mass spectrometry
- natural products
- peptide synthesis
- peptides
- pharmacognosy
- phytochemistry
- plant peptides
Biografi
Denna text finns inte på svenska, därför visas den engelska versionen.
Ulf Göransson obtained his PhD in 2002 (Uppsala University, Dept Pharmacy, Div Pharmacognosy) on a theses focussing on the discovery of a new family of circular plant peptides, named cyclotides. He did his Post Doc in the Structural Biology laboratory of Prof David J. Craik at the Institute of Molecular Bioscience, University of Queensland, before returning to Uppsala in 2004. His laboratory focus on the discovery of biologically active peptides from plants and animals; the development of novel techniques for synthesis of ultra stable peptide structures; and design of antimicrobial peptides. The Göransson lab maintains state of the art equipment for peptide analysis, synthesis and biological assays. His international network includes leading expertise in the synthesis and structural determination of peptides.
Göransson obtained an Assistant Professorship from the Swedish Research Council (Biotechnology) in 2008, and became an Associate Professor in 2011, and Full Professor in 2014. His research has attracted substantial external funding from e.g. the Swedish Research Council and the Swedish Foundation for Strategic Research.
Link to the Göransson Group homepage at the Div of Pharmacognosy: http://www.ilk.uu.se/research/fkog_en/peptide-chemical-biology/
Publikationer
Urval av publikationer
- Stabilized Cyclic Peptides as Scavengers of Autoantibodies (2018)
- Alanine and Lysine Scans of the LL-37-Derived Peptide Fragment KR-12 Reveal Key Residues for Antimicrobial Activity (2018)
- Peptide ion channel toxins from the bootlace worm, the longest animal on Earth (2018)
- Resistance to the Cyclotide Cycloviolacin O2 in Salmonella enterica Caused by Different Mutations That Often Confer Cross-Resistance or Collateral Sensitivity to Other Antimicrobial Peptides (2017)
- A Cactus-Derived Toxin-Like Cystine Knot Peptide with Selective Antimicrobial Activity (2015)
- Isolation, Characterization, and Synthesis of the Barrettides (2015)
- Ribosomally synthesized and post-translationally modified peptide natural products (2013)
- Making Ends Meet (2013)
- Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design (2013)
- Circular Proteins from Plants and Fungi (2012)
Senaste publikationer
- Kalata B1 Enhances Temozolomide Toxicity to Glioblastoma Cells (2024)
- Peptide toxins from the Antarctica (2024)
- Screening for antibacterial and cytotoxic activities of Sri Lankan marine sponges through microfractionation (2024)
- The involvement of cyclotides in the heavy metal tolerance of Viola spp. (2024)
- On the structures of the penduflorines from Tabernaemontana penduliflora (2023)
Alla publikationer
Artiklar
- Kalata B1 Enhances Temozolomide Toxicity to Glioblastoma Cells (2024)
- Peptide toxins from the Antarctica (2024)
- Screening for antibacterial and cytotoxic activities of Sri Lankan marine sponges through microfractionation (2024)
- The involvement of cyclotides in the heavy metal tolerance of Viola spp. (2024)
- On the structures of the penduflorines from Tabernaemontana penduliflora (2023)
- KR-12 derivatives endow nanocellulose with antibacterial and anti-inflammatory properties (2023)
- Epitopes displayed in a cyclic peptide scaffold bind SARS-CoV-2 antibodies (2023)
- A Synthetic Cyclized Antimicrobial Peptide with Potent Effects against Drug-Resistant Skin Pathogens (2023)
- Differential Blood-Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro (2023)
- Exploring the limits of cyanobactin macrocyclase PatGmac (2023)
- Transforming Cross-Linked Cyclic Dimers of KR-12 into Stable and Potent Antimicrobial Drug Leads (2023)
- Antibacterial eremophilane sesquiterpenoids from Xylaria feejeensis, an endophytic fungi of the medicinal plant Geophila repens (2023)
- Screening for Cyclotides in Sri Lankan Medicinal Plants (2023)
- Where traditional Chinese medicine meets Western medicine in the prevention of rheumatoid arthritis (2022)
- Spatial Distribution and Stability of Cholinesterase Inhibitory Protoberberine Alkaloids from Papaver setiferum (2022)
- The Influence of Plant Stress Hormones and Biotic Elicitors on Cyclotide Production in Viola uliginosa Cell Suspension Cultures (2022)
- The involvement of cyclotides in mutual interactions of violets and the two-spotted spider mite (2022)
- A stable cyclized antimicrobial peptide derived from LL-37 with host immunomodulatory effects and activity against uropathogens (2022)
- Functional characterization of the nemertide alpha family of peptide toxins (2021)
- Solution NMR and racemic crystallography provide insights into a novel structural class of cyclic plant peptides (2021)
- Tropical vibes from Sri Lanka - cyclotides from Viola betonicifolia by transcriptome and mass spectrometry analysis (2021)
- Antimicrobial and antioxidant activity of Evernia prunastri extracts and their isolates (2021)
- Cyclotide host-defense tailored for species and environments in violets from the Canary Islands (2021)
- Barrettides (2021)
- Editorial (2021)
- Kaempferia galanga L. (2021)
- Antioxidant properties and phenolic profiling by UPLC-QTOF-MS of Ajwah, Safawy and Sukkari cultivars of date palm (2021)
- Ethnobotany and Antimicrobial Peptides From Plants of the Solanaceae Family (2020)
- Backbone Cyclization and Dimerization of LL-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability (2020)
- Recent insights into chemical and pharmacological studies of bee bread (2020)
- Screening for bioactive secondary metabolites in Sri Lankan medicinal plants by microfractionation and targeted isolation of antimicrobial flavonoids from Derris scandens (2020)
- Sulfadiazine Masquerading as a Natural Product from Scilla madeirensis (Scilloideae) (2020)
- The life cycle of cyclotides (2020)
- The Toxins of Nemertean Worms (2019)
- Marine Natural Products (2019)
- Stabilized Cyclic Peptides as Scavengers of Autoantibodies (2018)
- Alanine and Lysine Scans of the LL-37-Derived Peptide Fragment KR-12 Reveal Key Residues for Antimicrobial Activity (2018)
- Peptide ion channel toxins from the bootlace worm, the longest animal on Earth (2018)
- How Does the Sweet Violet (Viola odorata L.) Fight Pathogens and Pests - Cyclotides as a Comprehensive Plant Host Defense System (2018)
- Repertoire Studies in Rheumatoid Arthritis Reveal B-Cell Distortions and Baseline Shifts in Unmutated IgG (2018)
- 35 Years of Marine Natural Product Research in Sweden (2017)
- Chemical Proteomics for Target Discovery of Head-to-Tail Cyclized Mini-Proteins (2017)
- The "PepSAVI-MS" Pipeline for Natural Product Bioactive Peptide Discovery (2017)
- Resistance to the Cyclotide Cycloviolacin O2 in Salmonella enterica Caused by Different Mutations That Often Confer Cross-Resistance or Collateral Sensitivity to Other Antimicrobial Peptides (2017)
- Cyclotide Evolution (2017)
- Bactericidal activity of cyclotides where phosphatidylethanolamine-lipid selectivity determines antimicrobial spectra (2017)
- Single-step purification of cyclotides using affinity chromatography (2017)
- The toxicity of ribbon worms (2016)
- Fungi as a source for antibacterial compounds (2016)
- Nomenclature of homodetic cyclic peptides produced from ribosomal precursors (2016)
- Synthesis of cyclic citrullinated peptides targeting rheumatoid arthritis autoantibodies based on sunflower trypsin inhibitors (2016)
- Circular disulfide-rich peptide scaffolds as anti-citrullinated peptide antibody inhibitors (2016)
- Anti-Citrullinated Peptide Antibody Inhibitors Based On Sunflower Trypsin Inhibitor-1 Scaffold For Potential Anti-Rheumatoid Arthritis Activity (2016)
- Peptide biodiscovery from plants and animals (2016)
- Peptide toxins from the longest animal on earth (2016)
- Bacterial Resistance To A Cyclic Antimicrobial Peptide (2016)
- Improved method for quantitative analysis of the cyclotide kalata B1 in plasma and brain homogenate (2016)
- Engineering Of A Minimalized Domain Derived From Human Host Defense Peptide LL-37 Into A Stable And Potent Antimicrobial Drug Lead (2016)
- Engineering of KR-12 (2016)
- Immunolocalization of cyclotides in plant cells, tissues and organ supports their role in host defense (2016)
- The Bacterial (Vibrio alginolyticus) Production of Tetrodotoxin in the Ribbon Worm Lineus longissimus-Just a False Positive? (2016)
- Selective membrane disruption by the cyclotide kalata B7: complex ions and essential functional groups in the phosphatidylethanolamine binding pocket (2016)
- Oral activity of a nature-derived cyclic peptide for the treatment of multiple sclerosis. (2016)
- A Cactus-Derived Toxin-Like Cystine Knot Peptide with Selective Antimicrobial Activity (2015)
- Synthesis, Structural Characterization, and Bioactivity of the Stable Peptide RCB-1 from Ricinus communis (2015)
- Distribution of circular proteins in plants (2015)
- Isolation, Characterization, and Synthesis of the Barrettides (2015)
- Affinity states of biocides determine bioavailability and release rates in marine paints (2015)
- Targeting of anti-citrullinated protein/peptide antibodies in rheumatoid arthritis using peptides mimicking endogenously citrullinated fibrinogen antigens (2015)
- Poisoning with Cicuta virosa in Sweden (2015)
- Exogenous plant hormones and cyclotide expression in Viola uliginosa (Violaceae) (2015)
- Micropropagation of Viola uliginosa (Violaceae) for endangered species conservation and for somaclonal variation-enhanced cyclotide biosynthesis (2015)
- Penicillium nalgiovense Laxa isolated from Antarctica is a new source of the antifungal metabolite amphotericin B (2015)
- Antigenotoxic and antioxidant effects of the Mongolian medicinal plant Leptopyrum fumarioides (L) (2014)
- Chemistry and Biology of Cyclotides (2014)
- Backbone-Cyclized Peptide Dimers Derived from Human Cathelicidin Peptide LL-37 Mediate Potent Antimicrobial Activity (2014)
- Structure and Activity Relationship of the Echinochloa Crus-Galli Antimicrobial Peptide 1 (2014)
- Characterization of Resitant Mutants Points Towards Mechanism of Action of Cyclotides (2014)
- Cyclotide Structure-Activity Relationships (2014)
- Induction of Gliotoxin Secretion in Aspergillus fumigatus by Bacteria-Associated Molecules (2014)
- Ribosomally synthesized and post-translationally modified peptide natural products (2013)
- An in vitro Study on the DNA Damaging Effects of Phytochemicals Partially Isolated from an Extract of Glinus lotoides (2013)
- The traditional medical uses and cytotoxic activities of sixty-one Egyptian plants (2013)
- A Systematic Approach to Document Cyclotide Distribution in Plant Species from Genomic, Transcriptomic, and Peptidomic Analysis (2013)
- Cycloviolacin O2 (CyO2) Suppresses Productive Infection and Augments the Antiviral Efficacy of Nelfinavir in HIV-1 Infected Monocytic Cells (2013)
- Making Ends Meet (2013)
- Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design (2013)
- Bioassay-guided Supercritical Fluid Extraction of Cyclooxygenase-2 Inhibiting Substances in Plantago major L. (2013)
- Strategies and methods for a sustainable search for bioactive compounds (2012)
- Biosynthesis, natural sources, dietary intake, pharmacokinetic properties, and biological activities of hydroxycinnamic acids (2012)
- Anti-schistosomiasis triterpene glycoside from the Egyptian medicinal plant Asparagus stipularis (2012)
- Chemical Composition and Repellency of Essential Oils From Four Medicinal Plants Against Ixodes ricinus Nymphs (Acari Ixodidae) (2012)
- Fmoc-SPPS based synthesis of bioactive cyclic peptides via N-acylurea intermediates (2012)
- Circular Proteins from Plants and Fungi (2012)
- The search for new antibiotic substances from filamentous fungi (2012)
- Antimicrobial activity of filamentous fungi isolated from highly antibiotic-contaminated river sediment (2012)
- Optimization of cyclotide extraction parameters (2012)
- Genotoxicity and Cellular Uptake of Cyclotides (2012)
- Interlocking disulfides in circular proteins (2011)
- Cytotoxic potency of small macrocyclic knot proteins (2011)
- Cyclotide-membrane interactions: defining factors of membrane binding, depletion and disruption (2011)
- A liquid chromatography-electrospray ionization-mass spectrometry method for quantification of cyclotides in plants avoiding sorption during sample preparation (2011)
- Biomedicine in the environment (2011)
- Two Brominated Cyclic Dipeptides Released by the Coldwater Marine Sponge Geodia barretti Act in Synergy As Chemical Defense (2011)
- Cyclotides from an Extreme Habitat (2011)
- Natural products in modern life science (2010)
- Cyclotide proteins and precursors from the genus Gloeospermum (2010)
- Evaluation of toxicity and anti-tumour activity of cycloviolacin O2 in mice. (2010)
- Recent insights into the biosynthesis and biological activities of natural xanthones (2010)
- Isolation, Characterization, and Bioactivity of Cyclotides from the Micronesian Plant Psychotria leptothyrsa (2010)
- Anticancer and Chemosensitizing Abilities of Cycloviolacin O2 from Viola odorata and Psyle Cyclotides from Psychotria leptothyrsa (2010)
- Microwave-assisted total synthesis of macrocyclic cystine knot miniproteins (2010)
- An Efficient Approach for the Total Synthesis of Cyclotides by Microwave Assisted Fmoc-SPPS (2010)
- The cyclotide cycloviolacin O2 from Viola odorata has potent bactericidal activity against Gram-negative bacteria (2010)
- Plant cyclotides from an extreme habitat (2010)
- Naturally occurring xanthones; latest investigations (2009)
- The Conserved Glu in the Cyclotide Cycloviolacin O2 Has a Key Structural Role (2009)
- Combined X-ray and NMR Analysis of the Stability of the Cyclotide Cystine Knot Fold That Underpins Its Insecticidal Activity and Potential Use as a Drug Scaffold (2009)
- Synthesis and folding of the circular cystine knotted cyclotide cycloviolacin O2. (2008)
- Cyclotides (2008)
- Distribution and evolution of circular miniproteins in flowering plants (2008)
- Antifouling activity of a dibrominated cyclopeptide from the marine sponge Geodia barretti (2008)
- The alpine violet, Viola biflora, is a rich source of novel cyclotides with potent cytotoxic cytotoxicity (2008)
- Ultra-stable peptide scaffolds for protein engineering-synthesis and folding of the circular cystine knotted cyclotide cycloviolacin O2 (2008)
- The flavouring phytochemical 2-pentanone reduces prostaglandin production and COX-2 expression in colon cancer cells (2008)
- Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis (2008)
- Modern pharmacognosy (2007)
- The cyclotide fingerprint in Oldenlandia affinis (2007)
- Mechanism of action of cytotoxic cyclotides (2007)
- Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands (2006)
- Key role of glutamic acid for the cytotoxic activity of the cyclotide cycloviolacin O2 (2006)
- Key role of glutamic acid for the cytotoxic activity of the cyclotide cycloviolacin O2 (2006)
- Antifouling activity of synthesized peptide analogs of the sponge metabolite barettin (2006)
- A continent of plant defense peptide diversity (2005)
- Reversible Antifouling Effect of the Cyclotide Cycloviolacin O2 against Barnacles. (2004)
- Novel strategies for isolation and characterization of cyclotides (2004)
- Recruitment in the field of Balanus improvisus and Mytilus edulis in response to the antifouling cyclopeptides barettin and 8,9-dihydrobarettin from the marine sponge Geodia barretti. (2004)
- Recruiment in the field of Balanus improvisus and Mytilus edulis in response to the antifouling cyclopeptides barettin and 8,9-dihydrobarettin from the marine sponge Geodia barretti (2004)
- Antifouling Activity of Brominated Cyclopeptides from the Marine Sponge Geodia barretti (2004)
- Antifouling activity of brominated cyclopeptides from the marine sponge Geodia barretti (2004)
- Cytotoxic cyclotides from Viola tricolor (2004)
- Variations in cyclotide expression in viola species (2004)
- Expression of Viola cyclotides by liquid chromatography-mass spectrometry and tandem mass spectrometry sequencing of intercysteine loops after introduction of charges and cleavage sites by aminoethylation (2003)
- Disulfide mapping of the cyclotide kalata B1 (2003)
- Primary and 3-D modelled structures of two cyclotides from Viola odorata (2003)
- A neutrophil multitarget functional bioassay to detect anti-inflammatory natural products (2002)
- Selective cytotoxicity evaluation in anticancer drug screening of fractionated plant extracts (2002)
- Cyclotides (2002)
- Spasmolytic effects of baccharis conferta and some of its constituents (2002)
- First cyclotide from Hybanthus (Violaceae) (2001)
- First cyclotide from Hybanthus (Violaceae) (2001)
- Seven novel macrocyclic polypeptides from Viola arvensis (1999)
- Fractionation protocol for the isolation of polypeptides from plant biomass (1998)
- Fractionation protocol for the isolation of polypeptides from plant biomass (1998)
- Membrane integrity as a target for cyclotide cytotoxic activity
- Assessment of SARS-CoV-2 antibodies by antibody proximity extension assay employing peptide epitopes derived from spike protein
- Cysteine-rich peptide from the gigantic edible mushroom Kusaghiporia usambarensis (Laetiporaceae)
- Exploring the biological safety and the potential application of nemertide alpha-1 as a biopesticide on green peach aphids Myzus persicae.
- Discovery of a novel nemertean peptide toxin subfamily (delta-nemertides) from the epidermal mucus of Lineus viridis.
- Alanine mutagenesis identifies specific amino acids of nemertide alpha-1 activity and its binding to target receptors.
- Exploring the potential biopesticide application of nemertide alpha-1 on parasitic and disease vector mosquitos.
- Dual behavior of cyclic peptides at the blood-brain barrier vs brain cellular uptake: Importance for CNS drug development
- Cellular uptake and intra-brain distribution of cyclic cell penetrating peptides: why tissue and cell type matters
- Immobilisation of semi-pure butelase 1 and its applications to produce head-to-tail cyclic peptides
- Transformation of KR-12 derived cross-linked cyclic dimers into stable and potent antimicrobial drug leads
- Insights into cyclotide evolution from transcriptomic analyses and studies on their distribution in violets
- Bis(methyl)gliotoxin and gliotoxin in bronchoalveolar lavage fluids are not suitable markers for invasive aspergillosis
- Impact of scaffolds for epitope display
Kapitel
Konferenser
- Functionalization of nanocellulose with host defense peptides: towards the modulation of the inflammatory response in chronic wounds (2022)
- Microwave-assisted solid phase peptide synthesis of Asteropine A (2014)
- Bioassay-guided fractionation of acetonitrile extract from Evernia prinastri (L.) Ach. (2014)
- Synthesis, Cyclization and Oxidative folding of backbone engineered Cyclotides (2010)
- Synthesis and Oxidative Folding of Cyclic Cystine Knot Peptides: Towards Backbone Engineering (2010)
- Strategies for macrocyclic cyclotide synthesis (2010)
- Synthesis and folding of the circular cystine knotted cyclotide cycloviolacin O2 (2008)
- Mapping of small cysteine rich defense proteins in Violaceae (2008)
