Helena Jernberg Wiklund

Dual targeting of G9a and DNMTs induces antitumor effects in multiple myeloma

Nylund, Patrick; Garrido-Zabala, Berta; Tziola, Stefania Iliana; Mohajershojai, Tabassom et al.

Ingår i Blood Advances, s. 4825-4841, 2025

• DOI för Dual targeting of G9a and DNMTs induces antitumor effects in multiple myeloma
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Combinatorial DNMTs and EZH2 inhibition reprograms the H3K27me3 and DNAme-mediated onco-epigenome to suppress multiple myeloma proliferation

Atienza Párraga, Alba; Nylund, Patrick; Diamanti, Klev; Garrido-Zabala, Berta et al.

Ingår i Scientific Reports, 2025

• DOI för Combinatorial DNMTs and EZH2 inhibition reprograms the H3K27me3 and DNAme-mediated onco-epigenome to suppress multiple myeloma proliferation
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PVT1 interacts with the polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma

Nylund, Patrick; Garrido-Zabala, Berta; Atienza Párraga, Alba; Vasquez, Louella et al.

Ingår i Haematologica, s. 567-577, 2024

• DOI för PVT1 interacts with the polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma
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The complex nature of lncRNA-mediated chromatin dynamics in multiple myeloma

Nylund, Patrick; Garrido-Zabala, Berta; Kalushkova, Antonia; Jernberg Wiklund, Helena

Ingår i Frontiers in Oncology, 2023

• DOI för The complex nature of lncRNA-mediated chromatin dynamics in multiple myeloma
• Ladda ner fulltext (pdf) av The complex nature of lncRNA-mediated chromatin dynamics in multiple myeloma

Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma

Borgenvik, Anna; Holmberg, Karl O.; Bolin, Sara; Zhao, Miao et al.

Ingår i Cancer Research, s. 4586-4603, 2022

• DOI för Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma
• Ladda ner fulltext (pdf) av Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma

Dual targeting of G9a and DNMTs induces antitumor effects in multiple myeloma

Nylund, Patrick; Garrido-Zabala, Berta; Tziola, Stefania Iliana; Mohajershojai, Tabassom et al.

Ingår i Blood Advances, s. 4825-4841, 2025

• DOI för Dual targeting of G9a and DNMTs induces antitumor effects in multiple myeloma
• Ladda ner fulltext (pdf) av Dual targeting of G9a and DNMTs induces antitumor effects in multiple myeloma

Combinatorial DNMTs and EZH2 inhibition reprograms the H3K27me3 and DNAme-mediated onco-epigenome to suppress multiple myeloma proliferation

Atienza Párraga, Alba; Nylund, Patrick; Diamanti, Klev; Garrido-Zabala, Berta et al.

Ingår i Scientific Reports, 2025

• DOI för Combinatorial DNMTs and EZH2 inhibition reprograms the H3K27me3 and DNAme-mediated onco-epigenome to suppress multiple myeloma proliferation
• Ladda ner fulltext (pdf) av Combinatorial DNMTs and EZH2 inhibition reprograms the H3K27me3 and DNAme-mediated onco-epigenome to suppress multiple myeloma proliferation

PVT1 interacts with the polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma

Nylund, Patrick; Garrido-Zabala, Berta; Atienza Párraga, Alba; Vasquez, Louella et al.

Ingår i Haematologica, s. 567-577, 2024

• DOI för PVT1 interacts with the polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma
• Ladda ner fulltext (pdf) av PVT1 interacts with the polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma

Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma

Borgenvik, Anna; Holmberg, Karl O.; Bolin, Sara; Zhao, Miao et al.

Ingår i Cancer Research, s. 4586-4603, 2022

• DOI för Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma
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One Omics Approach Does Not Rule Them All: The Metabolome and the Epigenome Join Forces in Haematological Malignancies

Kalushkova, Antonia; Nylund, Patrick; Atienza Párraga, Alba; Lennartsson, Andreas et al.

Ingår i EPIGENOMES, 2021

• DOI för One Omics Approach Does Not Rule Them All: The Metabolome and the Epigenome Join Forces in Haematological Malignancies
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A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma

Nylund, Patrick; Atienza Párraga, Alba; Haglöf, Jakob; De Bruyne, Elke et al.

Ingår i Cell Death and Disease, 2021

• DOI för A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma
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Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40

Wenthe, Jessica; Naseri, Sedigheh; Hellström, Ann-Charlotte; Jernberg Wiklund, Helena et al.

Ingår i Cancer Gene Therapy, s. 948-959, 2020

• DOI för Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40
• Ladda ner fulltext (pdf) av Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40

GMYC: A Novel Inducible Transgenic Model of Group 3 Medulloblastoma

Weishaupt, Holger; Mainwaring, Oliver; Hutter, Sonja; Kalushkova, Antonia et al.

Ingår i Neuro-Oncology, s. 137-137, 2018

• DOI för GMYC: A Novel Inducible Transgenic Model of Group 3 Medulloblastoma

The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomain

Alzrigat, Mohammad; Párraga, Alba Atienza; Majumder, Muntasir; Ma, Anqi et al.

Ingår i Oncotarget, s. 103731-103743, 2017

• DOI för The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomain
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EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.

Alzrigat, Mohammad; Párraga, Alba Atienza; Agarwal, Prasoon; Zureigat, Hadil et al.

Ingår i Oncotarget, s. 10213-10224, 2017

• DOI för EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.
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SUMO-modified insulin-like growth factor 1 receptor (IGF-1R) increases cell cycle progression and cell proliferation

Lin, Yingbo; Liu, Hongyu; Waraky, Ahmed; Haglund, Felix et al.

Ingår i Journal of Cellular Physiology, s. 2722-2730, 2017

• DOI för SUMO-modified insulin-like growth factor 1 receptor (IGF-1R) increases cell cycle progression and cell proliferation
• Ladda ner fulltext (pdf) av SUMO-modified insulin-like growth factor 1 receptor (IGF-1R) increases cell cycle progression and cell proliferation

Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target.

Agarwal, Prasoon; Alzrigat, Mohammad; Párraga, Alba Atienza; Enroth, Stefan et al.

Ingår i Oncotarget, s. 6809-6923, 2016

• DOI för Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target.

Growth signals employ CGGBP1 to suppress transcription of Alu-SINEs

Agarwal, Prasoon; Enroth, Stefan; Teichmann, Martin; Jernberg Wiklund, Helena et al.

Ingår i Cell Cycle, s. 1558-1571, 2016

• DOI för Growth signals employ CGGBP1 to suppress transcription of Alu-SINEs
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A Role for the Chromatin-Remodeling Factor BAZ1A in Neurodevelopment

Zaghlool, Ammar; Halvardson, Jonatan; Zhao, Jin J.; Etemadikhah, Mitra et al.

Ingår i Human Mutation, s. 964-975, 2016

• DOI för A Role for the Chromatin-Remodeling Factor BAZ1A in Neurodevelopment
• Ladda ner fulltext (pdf) av A Role for the Chromatin-Remodeling Factor BAZ1A in Neurodevelopment

CGGBP1 mitigates cytosine methylation at repetitive DNA sequences

Agarwal, Prasoon; Collier, Paul; Fritz, Markus Hsi-Yang; Benes, Vladimir et al.

Ingår i BMC Genomics, 2015

• DOI för CGGBP1 mitigates cytosine methylation at repetitive DNA sequences
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Increased resistance to proteaome inhibitors in multiple myeloma mediated by cIAP2: implications for a combinatorial treatment

Fristedt Duvefelt, Charlotte; Lub, Susanne; Prasoon, Agarwal; Arngården, Linda et al.

Ingår i Oncotarget, s. 20621-20635, 2015

Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia

Mansouri, Larry; Sutton, Lesley-Ann; Ljungström, Viktor; Bondza, Sina et al.

Ingår i Journal of Experimental Medicine, s. 833-843, 2015

• DOI för Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia
• Ladda ner fulltext (pdf) av Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia

The IGF-1 receptor inhibitor picropodophyllin potentiates the anti-myeloma activity of a BH3-mimetic

Bieghs, Liesbeth; Lub, Susanne; Fostier, Karel; Maes, Ken et al.

Ingår i Oncotarget, s. 11193-11208, 2014

• Ladda ner fulltext (pdf) av The IGF-1 receptor inhibitor picropodophyllin potentiates the anti-myeloma activity of a BH3-mimetic

Recurrent Mutations within the Nfkbie gene: A Novel Mechanism for NF-kappa B Deregulation in Aggressive Chronic Lymphocytic Leukemia

Mansouri, Larry; Sutton, Lesley-Ann; Ljungström, Viktor; Bondza, Sina et al.

Ingår i Blood, 2014

Taming the cancer cell: Introduction

Jernberg Wiklund, Helena; Westermark, Bengt

Ingår i Journal of Internal Medicine, s. 2-4, 2014

• DOI för Taming the cancer cell: Introduction

An Epigenomic Map of Multiple Myeloma Reveals the Importance of Polycomb Gene Silencing for the Malignancy

Agarwal, Prasoon; Kalushkova, Antonia; Enroth, Stefan; Alzrigat, Mohammad et al.

Ingår i Blood, 2014

Combining CAR T cells and the Bcl-2 family apoptosis inhibitor ABT-737 for treating B-cell malignancy

Karlsson, S. C. Hannah; Lindqvist, A. C.; Fransson, Moa; Paul-Wetterberg, Gabriella et al.

Ingår i Cancer Gene Therapy, s. 386-393, 2013

• DOI för Combining CAR T cells and the Bcl-2 family apoptosis inhibitor ABT-737 for treating B-cell malignancy

Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma

Dimberg, Lina Y.; Dimberg, Anna; Ivarsson, Karolina; Fryknäs, Mårten et al.

Ingår i BMC Cancer, s. 318, 2012

• DOI för Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma
• Ladda ner fulltext (pdf) av Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma

Mantle cell lymphoma displays a homogenous methylation profile: A comparative analysis with chronic lymphocytic leukemia

Halldorsdottir, Anna Margret; Kanduri, Meena; Marincevic, Millaray; Mansouri, Larry et al.

Ingår i American Journal of Hematology, s. 361-367, 2012

• DOI för Mantle cell lymphoma displays a homogenous methylation profile: A comparative analysis with chronic lymphocytic leukemia

Sorafenib Has Potent Antitumor Activity against Multiple Myeloma In Vitro, Ex Vivo, and In Vivo in the 5T33MM Mouse Model

Kharaziha, Pedram; De Raeve, Hendrik; Fristedt, Charlotte; Li, Qiao et al.

Ingår i Cancer Research, s. 5348-5362, 2012

• DOI för Sorafenib Has Potent Antitumor Activity against Multiple Myeloma In Vitro, Ex Vivo, and In Vivo in the 5T33MM Mouse Model

Tumor-initiating capacity of CD138- and CD138+ tumor cells in the 5T33 multiple myeloma model

Van Valckenborgh, E.; Matsui, W.; Agarwal, Prasoon; Lub, S. et al.

Ingår i Leukemia, s. 1436-1439, 2012

• DOI för Tumor-initiating capacity of CD138- and CD138+ tumor cells in the 5T33 multiple myeloma model

The HDAC Inhibitor LBH589 Enhances the Antimyeloma Effects of the IGF-1RTK Inhibitor Picropodophyllin

Lemaire, Miguel; Fristedt, Charlotte; Agarwal, Prasoon; Menu, Eline et al.

Ingår i Clinical Cancer Research, s. 2230-2239, 2012

• DOI för The HDAC Inhibitor LBH589 Enhances the Antimyeloma Effects of the IGF-1RTK Inhibitor Picropodophyllin

Over-accumulation of nuclear IGF-1 receptor in tumor cells requires elevated expression of the receptor and the SUMO-conjugating enzyme Ubc9

Deng, Hua; Lin, Yingbo; Badin, Margherita; Vasilcanu, Daiana et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 667-671, 2011

• DOI för Over-accumulation of nuclear IGF-1 receptor in tumor cells requires elevated expression of the receptor and the SUMO-conjugating enzyme Ubc9

Molecular Characterization of Acquired Tolerance of Tumor Cells to Picropodophyllin (PPP)

Hashemi, Jamileh; Worrall, Claire; Vasilcanu, Daiana; Fryknäs, Mårten et al.

Ingår i PLOS ONE, 2011

• DOI för Molecular Characterization of Acquired Tolerance of Tumor Cells to Picropodophyllin (PPP)

Polycomb target genes are silenced in multiple myeloma

Kalushkova, Antonia; Fryknäs, Mårten; Lemaire, Miguel; Fristedt, Charlotte et al.

Ingår i PLOS ONE, 2010

• DOI för Polycomb target genes are silenced in multiple myeloma
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IGF-1 suppresses Bim expression in multiple myeloma via epigenetic and posttranslational mechanisms

De Bruyne, Elke; Bos, Tomas J.; Schuit, Frans; Van Valckenborgh, Els et al.

Ingår i Blood, s. 2430-2440, 2010

• DOI för IGF-1 suppresses Bim expression in multiple myeloma via epigenetic and posttranslational mechanisms

Epigenetic silencing of the interferon regulatory factor ICSBP/IRF8 in human multiple myeloma

Tshuikina, Marina; Jernberg-Wiklund, Helena; Nilsson, Kenneth; Öberg, Fredrik

Ingår i Experimental Hematology, s. 1673-1681, 2008

• DOI för Epigenetic silencing of the interferon regulatory factor ICSBP/IRF8 in human multiple myeloma

Expression of erythropoietin receptor and in vitro functional effects of epoetins in B-cell malignancies

Kokhaei, Parviz; Abdalla, Amir Osman; Hansson, Lotta; Mikaelsson, Eva et al.

Ingår i Clinical Cancer Research, s. 3536-3544, 2007

• DOI för Expression of erythropoietin receptor and in vitro functional effects of epoetins in B-cell malignancies

Targeting the IGF-1R using picropodophyllin in the therapeutical 5T2MM mouse model of multiple myeloma: beneficial effects on tumor growth, angiogenesis, bone disease and survival

Menu, Eline; Jernberg-Wiklund, Helena; De Raeve, Hendrik; De Leenheer, Evy et al.

Ingår i International Journal of Cancer, s. 1857-1861, 2007

• DOI för Targeting the IGF-1R using picropodophyllin in the therapeutical 5T2MM mouse model of multiple myeloma: beneficial effects on tumor growth, angiogenesis, bone disease and survival

Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model.

Menu, Eline; Jernberg-Wiklund, Helena; Stromberg, Thomas; De Raeve, Hendrik et al.

Ingår i Blood, s. 655-60, 2006

Interferon-induced sensitization to apoptosis is associated with repressed transcriptional activity of the hTERT promoter in multiple myeloma.

Lindkvist, Anna; Ivarsson, Karolina; Jernberg-Wiklund, Helena; Paulsson-Karlsson, Ylva

Ingår i Biochem Biophys Res Commun, s. 1141-8, 2006

The G(-248)A polymorphism in the promoter region of the Bax gene does not correlate with prognostic markers or overall survival in chronic lymphocytic leukemia.

Skogsberg, S; Tobin, G; Kröber, A; Kienle, D et al.

Ingår i Leukemia, s. 77-81, 2006

IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells.

Strömberg, Thomas; Ekman, Simon; Girnita, Leonard; Dimberg, Lina Y et al.

Ingår i Blood, s. 669-78, 2006

Ectopic and IFN-induced expression of Fas overcomes resistance to Fas-mediated apoptosis in multiple myeloma cells

Dimberg, Lina; Dimberg, Anna; Ivarsson, Karolina; Strömberg, Thomas et al.

Ingår i Blood, s. 1346-1354, 2005

• DOI för Ectopic and IFN-induced expression of Fas overcomes resistance to Fas-mediated apoptosis in multiple myeloma cells

Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone.

Strömberg, Thomas; Dimberg, Anna; Hammarberg, Anna; Carlson, Kristina et al.

Ingår i Blood, s. 3138-47, 2004

Cytotoxic effect in vivo and in vitro of CHS 828 on human myeloma cell lines.

Hovstadius, Peter; Lindhagen, Elin; Hassan, Sadia; Nilsson, Kenneth et al.

Ingår i Anticancer Drugs, s. 63-70, 2004

Expression of the bcl-2 family of pro- and anti-apoptotic genes in multiple myeloma and normal plasma cells: regulation during interleukin-6(IL-6)-induced growth and survival.

Spets, Helena; Strömberg, Thomas; Georgii-Hemming, Patrik; Siljason, Jan et al.

Ingår i Eur J Haematol, s. 76-89, 2002

The somatostatin analog octreotide inhibits growth of interleukin-6 (IL-dent and IL-6-independent human multiple myeloma cell lines.

Georgii-Hemming, P; Stromberg, T; Tiensuu Janson, E; Stridsberg, M et al.

Ingår i Blood, s. 1724, 1999

Fas/APO-1 (CD95)-mediated apoptosis is activated by interferon-gammanterleukin-6 (IL-6)-dependent and IL-6-independent multiple myeloma cell lines.

Spets, H; Georgii-Hemming, P; Siljason, J; Nilsson, K et al.

Ingår i Blood, s. 2914, 1998

The effects on growth and survival of IL-6 can be dissociated in the U-266-1970/U-266-1984 and HL407E/HL407L human multiple myeloma cell lines.

Spets, H; Jernberg-Wiklund, H; Sambade, C; Soderberg, O et al.

Ingår i Br J Haematol, s. 126, 1997

Insulin-like growth factor I is a growth- and survival factor in human multiple myeloma cell lines.

Georgii-Hemming, P; Jernberg-Wiklund, H; Ljunggren, Ö; Nilsson, K

Ingår i Blood, s. 2250, 1996

Cellular death in neuroblastoma: in situ correlation of apoptosis and Bcl-2 expression

Hoehner, Jeff; Hedborg, Fredrik; Jernberg Wiklund, Helena; Olsen, Leif et al.

Ingår i Int J Cancer, s. 19, 1995

A novel human B cell line (U-2904) bearing t(8;14) and t(14;18) translocations.

Sambade, C; Sallstrom, J; Wiklund, H Jernberg; Enblad, G et al.

Ingår i Int J Cancer, s. 710, 1995

Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: Implications for the pathogenesis of insulin-dependent diabetes mellitus.

Welsh, N; Margulis, B; Borg, L A H; Jernberg Wiklund, H et al.

Ingår i Mol Medicine, s. 806, 1995

The complex nature of lncRNA-mediated chromatin dynamics in multiple myeloma

Nylund, Patrick; Garrido-Zabala, Berta; Kalushkova, Antonia; Jernberg Wiklund, Helena

Ingår i Frontiers in Oncology, 2023

• DOI för The complex nature of lncRNA-mediated chromatin dynamics in multiple myeloma
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Targeting EZH2 in Multiple Myeloma-Multifaceted Anti-Tumor Activity

Alzrigat, Mohammad; Jernberg Wiklund, Helena; Licht, Jonathan D.

Ingår i EPIGENOMES, 2018

• DOI för Targeting EZH2 in Multiple Myeloma-Multifaceted Anti-Tumor Activity
• Ladda ner fulltext (pdf) av Targeting EZH2 in Multiple Myeloma-Multifaceted Anti-Tumor Activity

Epigenetics in multiple myeloma: From mechanisms to therapy

Alzrigat, Mohammad; Párraga, Alba Atienza; Jernberg-Wiklund, Helena

Ingår i Seminars in Cancer Biology, s. 101-115, 2018

• DOI för Epigenetics in multiple myeloma: From mechanisms to therapy

Control of Apoptosis in Human Multiple Myeloma by Insulin-like Growth Factor I (IGF-I)

Jernberg-Wiklund, Helena; Nilsson, Kenneth

Ingår i Advances in Cancer Research, s. 139-165, 2007

• DOI för Control of Apoptosis in Human Multiple Myeloma by Insulin-like Growth Factor I (IGF-I)

Plasma Cell and Myeloma Cell Lines

Jernberg Wiklund, Helena; Nilsson, Kenneth

Ingår i Human Cell Culture, Kluwer Academic Publishers, 2000

The epigenomic map of multiple myeloma reveals the importance of Polycomb gene silencing for the malignancy

Agarwal, Prasoon; Kalushkova, Antonia; Enroth, Stefan; Österborg, Anders et al.

The lncRNA PCAT1 recruits the Polycomb repressive complex 2 to target genomic regions and induce H3K27me3-mediated gene silencing in multiple myeloma

Garrido-Zabala, Berta; Tziola, Stefania Iliana; Nylund, Patrick; Karlsson, Torbjörn et al.

Single-cell transcriptomic profiling identifies developmental haematopoietic program enrichment in KMT2A-rearranged infant acute lymphoblastic leukaemia

Garrido-Zabala, Berta; Pushkaran Pulinkala, Girish; Nylund, Patrick; Tziola, Stefania Iliana et al.

Toward a rational combinaTORial therapy for multiple myeloma

Jernberg Wiklund, Helena; Nilsson, Kenneth

Ingår i Blood, s. 3845-3846, 2004

The control of proliferation, survival and apoptosis in human multiple myeloma cells in vitro

Nilsson, K; Georgii-Hemming, P; Spets, H; Jernberg-Wiklund, H

Ingår i MECHANISMS OF B CELL NEOPLASIA 1998, s. 325-333, 1999